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    VPS46.1 vacuolar protein sorting 46.1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838349, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VPS46.1
    Official Full Name
    vacuolar protein sorting 46.1
    Primary source
    TAIR:AT1G17730
    Locus tag
    AT1G17730
    See related
    Araport:AT1G17730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CHARGED MULTIVESICULAR BODY PROTEIN/CHROMATIN MODIFYING PROTEIN1B; CHARGED MULTIVESICULAR BODY PROTEIN/CHROMATIN MODIFYING PROTEIN1B; CHMP1B; F11A6.7; F11A6_7; vacuolar protein sorting 46.1
    Summary
    Encodes an ESCRT-related protein: CHMP1A/AT1G73030; CHMP1B/AT1G17730. CHMP1A and B mediate multivesicular body sorting of auxin carriers and are required for plant development. ESCRT: Endosomal Sorting Complexes Required For Transport machinery; CHMP: Charged Multivesicular Body Protein/Chromatin Modifying Protein.
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    Genomic context

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    See VPS46.1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (6099039..6100397)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Pyridoxal phosphate phosphatase-related protein Neighboring gene Protein phosphatase 2A, regulatory subunit PR55 Neighboring gene uncharacterized protein Neighboring gene D-3-phosphoglycerate dehydrogenase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The endosomal protein CHARGED MULTIVESICULAR BODY PROTEIN1 regulates the autophagic turnover of plastids in Arabidopsis. Spitzer C, et al. Plant Cell, 2015 Feb. PMID 25649438, Free PMC Article
    2. The ESCRT-related CHMP1A and B proteins mediate multivesicular body sorting of auxin carriers in Arabidopsis and are required for plant development. Spitzer C, et al. Plant Cell, 2009 Mar. PMID 19304934, Free PMC Article
    3. The AAA-type ATPase AtSKD1 contributes to vacuolar maintenance of Arabidopsis thaliana. Shahriari M, et al. Plant J, 2010 Oct. PMID 20663085
    4. Exploring the ESCRTing machinery in eukaryotes. Winter V, et al. Trends Plant Sci, 2006 Mar. PMID 16488176, Free PMC Article
    5. Interactome of the plant-specific ESCRT-III component AtVPS2.2 in Arabidopsis thaliana. Ibl V, et al. J Proteome Res, 2012 Jan 1. PMID 22010978, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CHARGED MULTIVESICULAR BODY PROTEIN1 (CHMP1A) and CHMP1B are required for autophagic degradation of plastid proteins in Arabidopsis thaliana.
      Title: The endosomal protein CHARGED MULTIVESICULAR BODY PROTEIN1 regulates the autophagic turnover of plastids in Arabidopsis.
    2. Arabidopsis thaliana ESCRT-related charged multivesicular body protein/chromatin modifying protein1A(CHMP1A) and CHMP1B proteins are essential for embryo and seedling development. [CHMP1B]
      Title: The ESCRT-related CHMP1A and B proteins mediate multivesicular body sorting of auxin carriers in Arabidopsis and are required for plant development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_101635.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic axis specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within endosome transport via multivesicular body sorting pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within seedling development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    vacuolar protein sorting 46.1
    NP_173215.1
    • vacuolar protein sorting 46.1 (VPS46.1); CONTAINS InterPro DOMAIN/s: Snf7 (InterPro:IPR005024); BEST Arabidopsis thaliana protein match is: SNF7 family protein (TAIR:AT1G73030.1); Has 1319 Blast hits to 1319 proteins in 225 species: Archae - 2; Bacteria - 0; Metazoa - 503; Fungi - 283; Plants - 343; Viruses - 0; Other Eukaryotes - 188 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6099039..6100397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101635.5 → NP_173215.1  vacuolar protein sorting 46.1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173215.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LE58, Q9FZ60
      UniProtKB/TrEMBL
      A0A178W857, A0A5S9UYE2
      Conserved Domains (1) summary
      cl21588
      Location:19 → 166
      Snf7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LE58.1

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