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    Cby2 chibby family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 67926, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cby2provided by MGI
    Official Full Name
    chibby family member 2provided by MGI
    Primary source
    MGI:MGI:1915176
    See related
    Ensembl:ENSMUSG00000034913 AllianceGenome:MGI:1915176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nurit; Spert; 1700086N05Rik
    Summary
    Predicted to enable identical protein binding activity. Located in cytoplasmic vesicle. Is expressed in seminiferous tubule; spermatid; and testis. Orthologous to human CBY2 (chibby family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 310.1) See more
    Orthologs
    human all
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    Genomic context

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    See Cby2 in Genome Data Viewer
    Location:
    14 D3; 14 40.23 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (75820274..75830616, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (75582834..75593177, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene siah E3 ubiquitin protein ligase family member 3 Neighboring gene predicted gene, 35966 Neighboring gene predicted gene, 36060 Neighboring gene predicted gene, 36219 Neighboring gene glutamate rich 6B Neighboring gene predicted gene, 23622

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nurit, a novel leucine-zipper protein, expressed uniquely in the spermatid flower-like structure. Feige E, et al. Mech Dev, 2002 Sep. PMID 12204287
    2. CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice. Oyama Y, et al. Asian J Androl, 2022 May-Jun. PMID 34290169, Free PMC Article
    3. A targeted mutation of Nkd1 impairs mouse spermatogenesis. Li Q, et al. J Biol Chem, 2005 Jan 28. PMID 15546883
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129307

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein chibby homolog 2
    Names
    novel leucine zipper testicular protein
    protein nurit
    spermatid associated
    spermatid-associated protein
    testis-specific leucine zipper protein nurit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164139.1 → NP_001157611.1  protein chibby homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_001157611.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC125205
      Consensus CDS
      CCDS49543.1
      UniProtKB/Swiss-Prot
      Q32MG2, Q8CIV5, Q9D9E6, Q9D9Z0
      Related
      ENSMUSP00000127439.2, ENSMUST00000164082.9
      Conserved Domains (2) summary
      cd07429
      Location:76 → 191
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
      cl12007
      Location:302 → 424
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

    2. NM_001164140.1 → NP_001157612.1  protein chibby homolog 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC125205
      Consensus CDS
      CCDS49542.1
      UniProtKB/TrEMBL
      E9Q4B1
      Related
      ENSMUSP00000129616.2, ENSMUST00000169658.9
      Conserved Domains (2) summary
      cd07429
      Location:49 → 164
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
      cl12007
      Location:275 → 397
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

    3. NM_001164141.1 → NP_001157613.1  protein chibby homolog 2 isoform 3

      See identical proteins and their annotated locations for NP_001157613.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC125205
      Consensus CDS
      CCDS49541.1
      UniProtKB/Swiss-Prot
      Q32MG2
      Related
      ENSMUSP00000131347.2, ENSMUST00000165569.3
      Conserved Domains (2) summary
      cd07429
      Location:2 → 113
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
      cl12007
      Location:290 → 346
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

    4. NM_026457.2 → NP_080733.2  protein chibby homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_080733.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK005703, AK006329, AK007022
      Consensus CDS
      CCDS27279.1
      UniProtKB/Swiss-Prot
      Q32MG2
      Related
      ENSMUSP00000046259.4, ENSMUST00000035243.5
      Conserved Domains (2) summary
      cd07429
      Location:40 → 155
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
      cl12007
      Location:266 → 388
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      75820274..75830616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247977.2 → XP_030103837.1  protein chibby homolog 2 isoform X1

      Conserved Domains (2) summary
      cd07429
      Location:2 → 113
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
      cl12007
      Location:290 → 346
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

    2. XM_011245167.2 → XP_011243469.1  protein chibby homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_011243469.1

      UniProtKB/Swiss-Prot
      Q32MG2
      Conserved Domains (2) summary
      cd07429
      Location:2 → 113
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
      cl12007
      Location:290 → 346
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

    3. XM_011245168.2 → XP_011243470.1  protein chibby homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_011243470.1

      UniProtKB/Swiss-Prot
      Q32MG2
      Conserved Domains (2) summary
      cd07429
      Location:2 → 113
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
      cl12007
      Location:290 → 346
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

    4. XM_030247978.2 → XP_030103838.1  protein chibby homolog 2 isoform X1

      Conserved Domains (2) summary
      cd07429
      Location:2 → 113
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
      cl12007
      Location:290 → 346
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

    5. XM_030247981.1 → XP_030103841.1  protein chibby homolog 2 isoform X1

      Conserved Domains (2) summary
      cd07429
      Location:2 → 113
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
      cl12007
      Location:290 → 346
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

    6. XM_030247979.1 → XP_030103839.1  protein chibby homolog 2 isoform X1

      Conserved Domains (2) summary
      cd07429
      Location:2 → 113
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
      cl12007
      Location:290 → 346
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

    7. XM_030247980.1 → XP_030103840.1  protein chibby homolog 2 isoform X1

      Conserved Domains (2) summary
      cd07429
      Location:2 → 113
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
      cl12007
      Location:290 → 346
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32MG2.2 GenPept UniProtKB/Swiss-Prot:Q32MG2

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