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Conserved domains on  [gi|256017230|ref|NP_001157613|]
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protein chibby homolog 2 isoform 3 [Mus musculus]

Protein Classification

Cby_like and SMC_prok_B domain-containing protein( domain architecture ID 10164867)

Cby_like and SMC_prok_B domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cby_like cd07429
Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; ...
 2-113 7.60e-28

Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; Chibby(Cby) is a well-conserved nuclear protein that functions as part of the Wnt/beta-catenin signaling pathway. Specifically, Cby binds directly to beta-catenin by interacting with its central region, which harbors armadillo repeats. Cby-beta-catenin interactions may also involve 14-3-3 proteins. By competing with other binding partners of beta-catenin, the Tcf/Lef transcription factors, Cby inhibits transcriptional activation. Cby has been shown to play a role in adipocyte differentiation. The C-terminal region of Cby appears to contain an alpha-helical coiled-coil motif.


:

Pssm-ID: 143631  Cd Length: 108  Bit Score: 105.11  E-value: 7.60e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256017230   2 SRRVASQHSYPLNRFSSMPFDPMERPTSQADLELDYNPPRVQLSDEMFVFQDGRWVNESCRlqppyfSPPSSFHHKLHHR 81
Cdd:cd07429    5 GRKFSPKKTPPRKSASLSNLRLLDRSTRQAELGLDYGPIRLKLGGQELVFEDGRWISESGG------SSGVSGREVLRLK 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 256017230  82 RlaKEYQLQEENKSLRDENRALRDENKALRKE 113
Cdd:cd07429   79 K--KNQQLEEENNLLKLKIEVLLDMLAETTAE 108
MreC super family cl46468
rod shape-determining protein MreC; MreC (murein formation C) is involved in the rod shape ...
 283-342 1.62e-03

rod shape-determining protein MreC; MreC (murein formation C) is involved in the rod shape determination in E. coli, and more generally in cell shape determination of bacteria whether or not they are rod-shaped.


The actual alignment was detected with superfamily member COG1792:

Pssm-ID: 480808  Cd Length: 282  Bit Score: 39.86  E-value: 1.62e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256017230 283 QALQALQEENRLLQEENRALHILREEHRVFQEENKALweNNKLKLQQRLVIDTVT-EVTAR 342
Cdd:COG1792   68 RSLFNLREENERLKEENAELRAELQRLEELEAENARL--RELLDLKERLDYKFVAaEVIGR 126
 
Name Accession Description Interval E-value
Cby_like cd07429
Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; ...
 2-113 7.60e-28

Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; Chibby(Cby) is a well-conserved nuclear protein that functions as part of the Wnt/beta-catenin signaling pathway. Specifically, Cby binds directly to beta-catenin by interacting with its central region, which harbors armadillo repeats. Cby-beta-catenin interactions may also involve 14-3-3 proteins. By competing with other binding partners of beta-catenin, the Tcf/Lef transcription factors, Cby inhibits transcriptional activation. Cby has been shown to play a role in adipocyte differentiation. The C-terminal region of Cby appears to contain an alpha-helical coiled-coil motif.


Pssm-ID: 143631  Cd Length: 108  Bit Score: 105.11  E-value: 7.60e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256017230   2 SRRVASQHSYPLNRFSSMPFDPMERPTSQADLELDYNPPRVQLSDEMFVFQDGRWVNESCRlqppyfSPPSSFHHKLHHR 81
Cdd:cd07429    5 GRKFSPKKTPPRKSASLSNLRLLDRSTRQAELGLDYGPIRLKLGGQELVFEDGRWISESGG------SSGVSGREVLRLK 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 256017230  82 RlaKEYQLQEENKSLRDENRALRDENKALRKE 113
Cdd:cd07429   79 K--KNQQLEEENNLLKLKIEVLLDMLAETTAE 108
Chibby pfam14645
Chibby family; This family includes the eukaryotic chibby proteins. These proteins inhibit the ...
 12-119 1.52e-09

Chibby family; This family includes the eukaryotic chibby proteins. These proteins inhibit the wingless/Wnt pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation. Chibby is Japanese for small, and is named after the RNAi phenotype seen in Drosophila.


Pssm-ID: 464233  Cd Length: 113  Bit Score: 55.01  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256017230   12 PLNRFSSMP-FDPMERPTSQADLELDYNPPRVQLSDEMFVFQDGRWVNEScrlqppyfsppssfhhklhhrrlakeyqlq 90
Cdd:pfam14645  13 PLRKSSSLSnLYLLDPSTREAELGLDYGPIKLRLGGQELVFEDGQWVSES------------------------------ 62

                          90       100
                  ....*....|....*....|....*....
gi 256017230   91 EENKSLRDENRALRDENKALRKENKILQV 119
Cdd:pfam14645  63 GGAGGTGKEMQRLKKRNQQLEEENNLLKL 91
MreC COG1792
Cell shape-determining protein MreC [Cell cycle control, cell division, chromosome ...
 283-342 1.62e-03

Cell shape-determining protein MreC [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 441397  Cd Length: 282  Bit Score: 39.86  E-value: 1.62e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256017230 283 QALQALQEENRLLQEENRALHILREEHRVFQEENKALweNNKLKLQQRLVIDTVT-EVTAR 342
Cdd:COG1792   68 RSLFNLREENERLKEENAELRAELQRLEELEAENARL--RELLDLKERLDYKFVAaEVIGR 126
 
Name Accession Description Interval E-value
Cby_like cd07429
Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; ...
 2-113 7.60e-28

Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; Chibby(Cby) is a well-conserved nuclear protein that functions as part of the Wnt/beta-catenin signaling pathway. Specifically, Cby binds directly to beta-catenin by interacting with its central region, which harbors armadillo repeats. Cby-beta-catenin interactions may also involve 14-3-3 proteins. By competing with other binding partners of beta-catenin, the Tcf/Lef transcription factors, Cby inhibits transcriptional activation. Cby has been shown to play a role in adipocyte differentiation. The C-terminal region of Cby appears to contain an alpha-helical coiled-coil motif.


Pssm-ID: 143631  Cd Length: 108  Bit Score: 105.11  E-value: 7.60e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256017230   2 SRRVASQHSYPLNRFSSMPFDPMERPTSQADLELDYNPPRVQLSDEMFVFQDGRWVNESCRlqppyfSPPSSFHHKLHHR 81
Cdd:cd07429    5 GRKFSPKKTPPRKSASLSNLRLLDRSTRQAELGLDYGPIRLKLGGQELVFEDGRWISESGG------SSGVSGREVLRLK 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 256017230  82 RlaKEYQLQEENKSLRDENRALRDENKALRKE 113
Cdd:cd07429   79 K--KNQQLEEENNLLKLKIEVLLDMLAETTAE 108
Chibby pfam14645
Chibby family; This family includes the eukaryotic chibby proteins. These proteins inhibit the ...
 12-119 1.52e-09

Chibby family; This family includes the eukaryotic chibby proteins. These proteins inhibit the wingless/Wnt pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation. Chibby is Japanese for small, and is named after the RNAi phenotype seen in Drosophila.


Pssm-ID: 464233  Cd Length: 113  Bit Score: 55.01  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256017230   12 PLNRFSSMP-FDPMERPTSQADLELDYNPPRVQLSDEMFVFQDGRWVNEScrlqppyfsppssfhhklhhrrlakeyqlq 90
Cdd:pfam14645  13 PLRKSSSLSnLYLLDPSTREAELGLDYGPIKLRLGGQELVFEDGQWVSES------------------------------ 62

                          90       100
                  ....*....|....*....|....*....
gi 256017230   91 EENKSLRDENRALRDENKALRKENKILQV 119
Cdd:pfam14645  63 GGAGGTGKEMQRLKKRNQQLEEENNLLKL 91
MreC COG1792
Cell shape-determining protein MreC [Cell cycle control, cell division, chromosome ...
 283-342 1.62e-03

Cell shape-determining protein MreC [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 441397  Cd Length: 282  Bit Score: 39.86  E-value: 1.62e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256017230 283 QALQALQEENRLLQEENRALHILREEHRVFQEENKALweNNKLKLQQRLVIDTVT-EVTAR 342
Cdd:COG1792   68 RSLFNLREENERLKEENAELRAELQRLEELEAENARL--RELLDLKERLDYKFVAaEVIGR 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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