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    NRAMP2 NRAMP metal ion transporter 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841127, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NRAMP2
    Official Full Name
    NRAMP metal ion transporter 2
    Primary source
    TAIR:AT1G47240
    Locus tag
    AT1G47240
    See related
    Araport:AT1G47240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNRAMP2; F8G22.4; F8G22_4; NRAMP metal ion transporter 2
    Summary
    Member of the NRAMP2 gene family of metal ion transporters.
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    Genomic context

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    See NRAMP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (17308803..17311505, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene cyclin-dependent protein kinase 3;2 Neighboring gene Cyclin A3;3 Neighboring gene CYCLIN A3;4 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intracellular Distribution of Manganese by the Trans-Golgi Network Transporter NRAMP2 Is Critical for Photosynthesis and Cellular Redox Homeostasis. Alejandro S, et al. Plant Cell, 2017 Dec. PMID 29180598, Free PMC Article
    2. NRAMP2, a trans-Golgi network-localized manganese transporter, is required for Arabidopsis root growth under manganese deficiency. Gao H, et al. New Phytol, 2018 Jan. PMID 28913895
    3. Phylogenetic relationships within cation transporter families of Arabidopsis. Mäser P, et al. Plant Physiol, 2001 Aug. PMID 11500563, Free PMC Article
    4. A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2. Lalonde S, et al. Front Physiol, 2010. PMID 21423366, Free PMC Article
    5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NRAMP2 is required for the detoxification of reactive oxygen species.
      Title: Intracellular Distribution of Manganese by the Trans-Golgi Network Transporter NRAMP2 Is Critical for Photosynthesis and Cellular Redox Homeostasis.
    2. Under Mn-deficient conditions, increased accumulation of hydrogen peroxide (H2 O2 ) is partially responsible for the root growth inhibition and NRAMP2 is involved in remobilization of manganese (Mn) in Golgi for root growth.
      Title: NRAMP2, a trans-Golgi network-localized manganese transporter, is required for Arabidopsis root growth under manganese deficiency.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_103618.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inorganic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables manganese ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables metal ion transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to manganese ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular monoatomic cation homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within manganese ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within manganese ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within metal ion transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of unidimensional cell growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within root morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NRAMP metal ion transporter 2
    NP_175157.1
    • NRAMP metal ion transporter 2 (NRAMP2); FUNCTIONS IN: inorganic anion transmembrane transporter activity, metal ion transmembrane transporter activity; INVOLVED IN: cellular metal ion homeostasis, metal ion transport; LOCATED IN: membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Natural resistance-associated macrophage protein (InterPro:IPR001046); BEST Arabidopsis thaliana protein match is: natural resistance-associated macrophage protein 3 (TAIR:AT2G23150.1); Has 4906 Blast hits to 4864 proteins in 1503 species: Archae - 114; Bacteria - 3503; Metazoa - 369; Fungi - 260; Plants - 341; Viruses - 0; Other Eukaryotes - 319 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      17308803..17311505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103618.3 → NP_175157.1  NRAMP metal ion transporter 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175157.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C6B2, Q9XH62
      UniProtKB/TrEMBL
      A0A178W904, A0A5S9WJW8
      Conserved Domains (2) summary
      pfam01566
      Location:88 → 451
      Nramp; Natural resistance-associated macrophage protein
      cl00456
      Location:66 → 444
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C6B2.1

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