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    ETO1 tetratricopeptide repeat (TPR)-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824340, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ETO1
    Official Full Name
    tetratricopeptide repeat (TPR)-containing protein
    Primary source
    TAIR:AT3G51770
    Locus tag
    AT3G51770
    See related
    Araport:AT3G51770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS ETHYLENE OVERPRODUCER 1; ATEOL1; ETHYLENE OVERPRODUCER 1; ETHYLENE OVERPRODUCER1
    Summary
    Encodes a negative regulator of 1-aminocyclopropane-1-carboxylic acid synthase5(ACS5), which catalyze the rate-limiting step in ethylene biosynthesis. ETO1 directly interacts with ACS5 and inhibits its enzyme activity and targets it for degradation via proteasome-dependent pathway. It also interacts with CUL3 (a component of ubiquitin ligase complexes). eto1 (and eto3) mutations elevate ethylene biosynthesis by affecting the posttranscriptional regulation of ACS
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    Genomic context

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    See ETO1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (19199750..19204464, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene hypothetical protein (DUF688) Neighboring gene BCL-2-associated athanogene 4 Neighboring gene transmembrane protein G1P-related 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GLABRA 2 regulates ETHYLENE OVERPRODUCER 1 accumulation during nutrient deficiency-induced root hair growth. Cheng J, et al. Plant Physiol, 2024 Jun 28. PMID 38497551
    2. The Arabidopsis gene hypersensitive to phosphate starvation 3 encodes ethylene overproduction 1. Wang L, et al. Plant Cell Physiol, 2012 Jun. PMID 22623414
    3. Ethylene directs auxin to control root cell expansion. Strader LC, et al. Plant J, 2010 Dec. PMID 21105933, Free PMC Article
    4. Arabidopsis ETO1 specifically interacts with and negatively regulates type 2 1-aminocyclopropane-1-carboxylate synthases. Yoshida H, et al. BMC Plant Biol, 2005 Aug 10. PMID 16091151, Free PMC Article
    5. Salt of the earth: ethylene promotes salt tolerance by enhancing Na/K homeostasis. Lockhart J. Plant Cell, 2013 Sep. PMID 24064767, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lack of ETO1 function confers soil-salinity tolerance through improved shoot Na/K homeostasis, effected via the ethylene resistant1-constitutive triple response1 ethylene signaling pathway.
      Title: An Arabidopsis soil-salinity-tolerance mutation confers ethylene-mediated enhancement of sodium/potassium homeostasis.
    2. The mutant exhibits enhanced ethylene production via loss of function of ETHYLENE OVERPRODUCER1 (ETO1; whose normal function is to reduce ethylene production by degrading ethylene biosynthetic enzymes).
      Title: Salt of the earth: ethylene promotes salt tolerance by enhancing Na/K homeostasis.
    3. Treatment of etiolated Arabidopsis seedlings with light rapidly increases the stability of ACS5 protein and destabilizes the ETO1/EOLs proteins.
      Title: ACC synthase and its cognate E3 ligase are inversely regulated by light.
    4. The level of ETHYLENE-OVERPRODUCER1 (ETO1)/ETO1-LIKE (EOLs) in vivo plays a role in mediating ACS (1-aminocyclopropane-1-carboxylate synthase) protein turnover, with increased levels leading to a decrease in ACS protein levels.
      Title: 14-3-3 regulates 1-aminocyclopropane-1-carboxylate synthase protein turnover in Arabidopsis.
    5. In Arabidopsis, ETO1 encodes a negative regulator of ethylene biosynthesis, and mutation of ETO1 causes Arabidopsis seedlings to overproduce ethylene.
      Title: The Arabidopsis gene hypersensitive to phosphate starvation 3 encodes ethylene overproduction 1.
    6. Ethylene overproduction partially restores auxin responsiveness to auxin-resistant mutants of ETO1.
      Title: Ethylene directs auxin to control root cell expansion.
    7. In contrast to the wild type and ein3-1 mutants, both etr1-1 and eto1-1 mutants showed a sharp (up to 5-fold) increase in alpha-tocopherol levels during leaf aging.
      Title: Ethylene signaling may be involved in the regulation of tocopherol biosynthesis in Arabidopsis thaliana.
    8. ETO1, EOL1 and EOL2 work together to negatively regulate ethylene synthesis, by helping degrade type-2 ACC synthases.
      Title: The BTB ubiquitin ligases ETO1, EOL1 and EOL2 act collectively to regulate ethylene biosynthesis in Arabidopsis by controlling type-2 ACC synthase levels.
    9. ETO1 (ETHYLENE-OVERPRODUCER1) is a negative regulator of type 2 1-aminocyclopropane-1-carboxylate synthases(ACC synthase). [ETO1]
      Title: Arabidopsis ETO1 specifically interacts with and negatively regulates type 2 1-aminocyclopropane-1-carboxylate synthases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035762.6
    NM_115036.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to phosphate starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ethylene biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in negative regulation of ethylene-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of ethylene biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of post-embryonic root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to organophosphorus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to potassium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sugar mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat (TPR)-containing protein
    NP_001030839.5
    • ETHYLENE OVERPRODUCER 1 (ETO1); CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), BTB/POZ fold (InterPro:IPR011333), BTB/POZ-like (InterPro:IPR000210), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: ETO1-like 2 (TAIR:AT5G58550.1); Has 1321 Blast hits to 1075 proteins in 262 species: Archae - 34; Bacteria - 623; Metazoa - 134; Fungi - 2; Plants - 202; Viruses - 0; Other Eukaryotes - 326 (source: NCBI BLink).
    NP_190745.6
    • ETHYLENE OVERPRODUCER 1 (ETO1); CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), BTB/POZ fold (InterPro:IPR011333), BTB/POZ-like (InterPro:IPR000210), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: ETO1-like 2 (TAIR:AT5G58550.1); Has 1321 Blast hits to 1075 proteins in 262 species: Archae - 34; Bacteria - 623; Metazoa - 134; Fungi - 2; Plants - 202; Viruses - 0; Other Eukaryotes - 326 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19199750..19204464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001035762.6 → NP_001030839.5  tetratricopeptide repeat (TPR)-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030839.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4J4J0, O65020, Q6PWY3
      UniProtKB/TrEMBL
      A0A178VGM1, A0A384KPH2, F4J4I9
      Conserved Domains (3) summary
      TIGR02917
      Location:436 → 942
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:781 → 808
      TPR; TPR repeat [structural motif]
      cd18190
      Location:251 → 333
      BTB_POZ_ETO1-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins

    2. NM_115036.7 → NP_190745.6  tetratricopeptide repeat (TPR)-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190745.6

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4J4J0, O65020, Q6PWY3
      UniProtKB/TrEMBL
      A0A7G2EWI9
      Conserved Domains (3) summary
      TIGR02917
      Location:428 → 934
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:773 → 800
      TPR; TPR repeat [structural motif]
      cd18190
      Location:243 → 325
      BTB_POZ_ETO1-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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