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Conserved domains on  [gi|240255603|ref|NP_190745|]
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tetratricopeptide repeat (TPR)-containing protein [Arabidopsis thaliana]

Protein Classification

ETO1 family protein( domain architecture ID 13031935)

ETO1 family protein similar to Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) that is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 243-325 2.93e-39

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 139.96  E-value: 2.93e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 243 DMSFCIGDEEVRCVRYKIASLSRPFKAMLYGGFREMKRATINFTQNGISVEGMRAAEIFSRTNRLDNFPPNVVLELLKLA 322
Cdd:cd18190    1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIEAMRAVIDFSVTGRLDLFSVENVHEVLELA 80


                 ...
gi 240255603 323 NRF 325
Cdd:cd18190   81 SKF 83
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
773-938 1.58e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.41  E-value: 1.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 773 QALNNLGSVYVDCEKLDLAADCYTNALTIK--HTRAHQGLARVYHLKNQRKAAYDEMTKLIEKAQNNASAYekrseycdr 850
Cdd:COG0457    9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDpdDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEAL--------- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 851 emaqsdlclatqldplrtypyRYRAAVLMDDHKESEAIDELSRAISFKP-DLQLLHLRAAFYDSMGEGASAIKDCEAALC 929
Cdd:COG0457   80 ---------------------NNLGLALQALGRYEEALEDYDKALELDPdDAEALYNLGLALLELGRYDEAIEAYERALE 138


                 ....*....
gi 240255603 930 IDPGHADTL 938
Cdd:COG0457  139 LDPDDADAL 147
PEP_TPR_lipo super family cl37187
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 428-934 1.43e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


The actual alignment was detected with superfamily member TIGR02917:

Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 62.02  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  428 LLERLVECAVDSWEKQLAYHQL-GVVMLERKEYKDAQRWFNAA--VEAGHLYSLVGVARTKFKRDHRYSAYKIINSLIS- 503
Cdd:TIGR02917 109 VLDELPGKTLLDDEGAAELLALrGLAYLGLGQLELAQKSYEQAlaIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTa 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  504 ---DHKAtgWMHQERSLYCSGK--EKLLDLDTATEFDPTLTFPYKFRAVALVEENQFGAAIAELNKILG-FKASPDCLEM 577
Cdd:TIGR02917 189 dpgNVDA--LLLKGDLLLSLGNieLALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKkAPNSPLAHYL 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  578 RAWISIGMEDYEGALKDIRALLTLEPNFM---------MF---NWKIHGDHMVELL----------RPLA------QQWS 629
Cdd:TIGR02917 267 KALVDFQKKNYEDARETLQDALKSAPEYLpalllagasEYqlgNLEQAYQYLNQILkyapnshqarRLLAsiqlrlGRVD 346

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  630 QADCWMQLYDRWSSVD------------DIGSLAVVHHMLA----NDPGKSLLRFRQSLLLLRLNCQKAAMRSLRLArnh 693
Cdd:TIGR02917 347 EAIATLSPALGLDPDDpaalsllgeaylALGDFEKAAEYLAkateLDPENAAARTQLGISKLSQGDPSEAIADLETA--- 423

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  694 SKSEHErLVYEGWILYDTGHREEALAKAeesISIQRSFEA--------FFLKAYALADSTlDPDSSNyviQLLQEALKCP 765
Cdd:TIGR02917 424 AQLDPE-LGRADLLLILSYLRSGQFDKA---LAAAKKLEKkqpdnaslHNLLGAIYLGKG-DLAKAR---EAFEKALSIE 495

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  766 SDGLrkgQALNNLGSVYVDCEKLDLAADCYTNALTI--KHTRAHQGLARVYHLKNQRKA-------AYDEMTKLIEKAQN 836
Cdd:TIGR02917 496 PDFF---PAAANLARIDIQEGNPDDAIQRFEKVLTIdpKNLRAILALAGLYLRTGNEEEavawlekAAELNPQEIEPALA 572

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  837 NASAYEKRSEyCDREMAQSDLCLATQLDPLRTYPYRYRAAVLMDDHKesEAIDELSRAISFKPDLQLLHLRAAF-YDSMG 915
Cdd:TIGR02917 573 LAQYYLGKGQ-LKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLN--KAVSSFKKLLALQPDSALALLLLADaYAVMK 649

                         570
                  ....*....|....*....
gi 240255603  916 EGASAIKDCEAALCIDPGH 934
Cdd:TIGR02917 650 NYAKAITSLKRALELKPDN 668
 
Name Accession Description Interval E-value
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 243-325 2.93e-39

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 139.96  E-value: 2.93e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 243 DMSFCIGDEEVRCVRYKIASLSRPFKAMLYGGFREMKRATINFTQNGISVEGMRAAEIFSRTNRLDNFPPNVVLELLKLA 322
Cdd:cd18190    1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIEAMRAVIDFSVTGRLDLFSVENVHEVLELA 80


                 ...
gi 240255603 323 NRF 325
Cdd:cd18190   81 SKF 83
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 243-341 6.55e-12

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 62.71  E-value: 6.55e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603   243 DMSFCIGDEEVRCVRYKIASLSRPFKAMLYGGFREMKRATINFtqNGISVEGMRAAEIFSRTNRLDnFPPNVVLELLKLA 322
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYL--DDVSPEDFRALLNFLYTGKLD-LPEENVEELLELA 77

                           90
                   ....*....|....*....
gi 240255603   323 NRFCCDELKSACDSHLAHL 341
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKL 96
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
773-938 1.58e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.41  E-value: 1.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 773 QALNNLGSVYVDCEKLDLAADCYTNALTIK--HTRAHQGLARVYHLKNQRKAAYDEMTKLIEKAQNNASAYekrseycdr 850
Cdd:COG0457    9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDpdDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEAL--------- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 851 emaqsdlclatqldplrtypyRYRAAVLMDDHKESEAIDELSRAISFKP-DLQLLHLRAAFYDSMGEGASAIKDCEAALC 929
Cdd:COG0457   80 ---------------------NNLGLALQALGRYEEALEDYDKALELDPdDAEALYNLGLALLELGRYDEAIEAYERALE 138


                 ....*....
gi 240255603 930 IDPGHADTL 938
Cdd:COG0457  139 LDPDDADAL 147
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 428-934 1.43e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 62.02  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  428 LLERLVECAVDSWEKQLAYHQL-GVVMLERKEYKDAQRWFNAA--VEAGHLYSLVGVARTKFKRDHRYSAYKIINSLIS- 503
Cdd:TIGR02917 109 VLDELPGKTLLDDEGAAELLALrGLAYLGLGQLELAQKSYEQAlaIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTa 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  504 ---DHKAtgWMHQERSLYCSGK--EKLLDLDTATEFDPTLTFPYKFRAVALVEENQFGAAIAELNKILG-FKASPDCLEM 577
Cdd:TIGR02917 189 dpgNVDA--LLLKGDLLLSLGNieLALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKkAPNSPLAHYL 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  578 RAWISIGMEDYEGALKDIRALLTLEPNFM---------MF---NWKIHGDHMVELL----------RPLA------QQWS 629
Cdd:TIGR02917 267 KALVDFQKKNYEDARETLQDALKSAPEYLpalllagasEYqlgNLEQAYQYLNQILkyapnshqarRLLAsiqlrlGRVD 346

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  630 QADCWMQLYDRWSSVD------------DIGSLAVVHHMLA----NDPGKSLLRFRQSLLLLRLNCQKAAMRSLRLArnh 693
Cdd:TIGR02917 347 EAIATLSPALGLDPDDpaalsllgeaylALGDFEKAAEYLAkateLDPENAAARTQLGISKLSQGDPSEAIADLETA--- 423

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  694 SKSEHErLVYEGWILYDTGHREEALAKAeesISIQRSFEA--------FFLKAYALADSTlDPDSSNyviQLLQEALKCP 765
Cdd:TIGR02917 424 AQLDPE-LGRADLLLILSYLRSGQFDKA---LAAAKKLEKkqpdnaslHNLLGAIYLGKG-DLAKAR---EAFEKALSIE 495

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  766 SDGLrkgQALNNLGSVYVDCEKLDLAADCYTNALTI--KHTRAHQGLARVYHLKNQRKA-------AYDEMTKLIEKAQN 836
Cdd:TIGR02917 496 PDFF---PAAANLARIDIQEGNPDDAIQRFEKVLTIdpKNLRAILALAGLYLRTGNEEEavawlekAAELNPQEIEPALA 572

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  837 NASAYEKRSEyCDREMAQSDLCLATQLDPLRTYPYRYRAAVLMDDHKesEAIDELSRAISFKPDLQLLHLRAAF-YDSMG 915
Cdd:TIGR02917 573 LAQYYLGKGQ-LKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLN--KAVSSFKKLLALQPDSALALLLLADaYAVMK 649

                         570
                  ....*....|....*....
gi 240255603  916 EGASAIKDCEAALCIDPGH 934
Cdd:TIGR02917 650 NYAKAITSLKRALELKPDN 668
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 654-841 1.21e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.77  E-value: 1.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 654 HHMLANDPGKSLLRFRQSLLLLRLNCQKAAMRSLRLARNHSKSEHERLVYEGWILYDTGHREEALAKAEESISIQ-RSFE 732
Cdd:COG3914   34 AAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNpDNAE 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 733 AFFLKAYALADSTLDPDSsnyvIQLLQEALKCPSDGLrkgQALNNLGSVYVDCEKLDLAADCYTNALTIK--HTRAHQGL 810
Cdd:COG3914  114 ALFNLGNLLLALGRLEEA----LAALRRALALNPDFA---EAYLNLGEALRRLGRLEEAIAALRRALELDpdNAEALNNL 186

                        170       180       190
                 ....*....|....*....|....*....|.
gi 240255603 811 ARVYHLKNQRKAAYDEMTKLIEKAQNNASAY 841
Cdd:COG3914  187 GNALQDLGRLEEAIAAYRRALELDPDNADAH 217
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 809-932 2.21e-04

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 44.97  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  809 GLARVY--HLKNQRKAAYDEMTKLIEKA-------QNNASAYEKRSEY-C---DREMAQSDLCLATQLDPLRTYPYRYRA 875
Cdd:TIGR00990 293 GQLQLGlkSPESKADESYEEAARAFEKAldlgklgEKEAIALNLRGTFkClkgKHLEALADLSKSIELDPRVTQSYIKRA 372

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 240255603  876 AVLMDDHKESEAIDELSRAISFKP-DLQLLHLRAAFYDSMGEGASAIKDCEAALCIDP 932
Cdd:TIGR00990 373 SMNLELGDPDKAEEDFDKALKLNSeDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDP 430
 
Name Accession Description Interval E-value
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 243-325 2.93e-39

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 139.96  E-value: 2.93e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 243 DMSFCIGDEEVRCVRYKIASLSRPFKAMLYGGFREMKRATINFTQNGISVEGMRAAEIFSRTNRLDNFPPNVVLELLKLA 322
Cdd:cd18190    1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIEAMRAVIDFSVTGRLDLFSVENVHEVLELA 80


                 ...
gi 240255603 323 NRF 325
Cdd:cd18190   81 SKF 83
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 244-325 4.33e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 71.16  E-value: 4.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 244 MSFCIGDEEVRCVRYKIASLSRPFKAMLYGGFREMKRATINFTqnGISVEGMRAAEIFSRTNRLDNFPPNvVLELLKLAN 323
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLR--DISPEDFRALLEFLYGGKRDLDASN-LLELLEAAN 77


                 ..
gi 240255603 324 RF 325
Cdd:cd01165   78 FL 79
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 243-341 6.55e-12

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 62.71  E-value: 6.55e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603   243 DMSFCIGDEEVRCVRYKIASLSRPFKAMLYGGFREMKRATINFtqNGISVEGMRAAEIFSRTNRLDnFPPNVVLELLKLA 322
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYL--DDVSPEDFRALLNFLYTGKLD-LPEENVEELLELA 77

                           90
                   ....*....|....*....
gi 240255603   323 NRFCCDELKSACDSHLAHL 341
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKL 96
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
773-938 1.58e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.41  E-value: 1.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 773 QALNNLGSVYVDCEKLDLAADCYTNALTIK--HTRAHQGLARVYHLKNQRKAAYDEMTKLIEKAQNNASAYekrseycdr 850
Cdd:COG0457    9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDpdDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEAL--------- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 851 emaqsdlclatqldplrtypyRYRAAVLMDDHKESEAIDELSRAISFKP-DLQLLHLRAAFYDSMGEGASAIKDCEAALC 929
Cdd:COG0457   80 ---------------------NNLGLALQALGRYEEALEDYDKALELDPdDAEALYNLGLALLELGRYDEAIEAYERALE 138


                 ....*....
gi 240255603 930 IDPGHADTL 938
Cdd:COG0457  139 LDPDDADAL 147
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 755-951 2.23e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 65.52  E-value: 2.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 755 IQLLQEALKCPSDglrKGQALNNLGSVYVDCEKLDLAADCYTNALTI--KHTRAHQGLARVYHLKNQRKAAYDEMTKLIE 832
Cdd:COG2956   62 IRIHQKLLERDPD---RAEALLELAQDYLKAGLLDRAEELLEKLLELdpDDAEALRLLAEIYEQEGDWEKAIEVLERLLK 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 833 KAQNN-------ASAYEKRSEYcdrEMAQSDLCLATQLDPLRTYPYRYRAAVLMDDHKESEAIDELSRAISFKPD-LQLL 904
Cdd:COG2956  139 LGPENahaycelAELYLEQGDY---DEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDyLPAL 215

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 240255603 905 HLRAAFYDSMGEGASAIKDCEAALCIDPGHADTLELYHKAREPNDQK 951
Cdd:COG2956  216 PRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLE 262
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
705-909 5.60e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.79  E-value: 5.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 705 GWILYDTGHREEALAKAEESISIQRSF-EAFFLKAYALADSTLDPDSsnyvIQLLQEALK-CPSDGlrkgQALNNLGSVY 782
Cdd:COG0457   15 GLAYRRLGRYEEAIEDYEKALELDPDDaEALYNLGLAYLRLGRYEEA----LADYEQALElDPDDA----EALNNLGLAL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 783 VDCEKLDLAADCYTNALTI--KHTRAHQGLARVYHLKNQRKAAYDEMTKLIEKAQNNASAYEKRSEYCDR--------EM 852
Cdd:COG0457   87 QALGRYEEALEDYDKALELdpDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKlgryeealEL 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 240255603 853 AQSDLCLATQLDPLRTYPYRYRAAVLMDDHKESEAIDELSRAISFKPDLQLLHLRAA 909
Cdd:COG0457  167 LEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELL 223
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 428-934 1.43e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 62.02  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  428 LLERLVECAVDSWEKQLAYHQL-GVVMLERKEYKDAQRWFNAA--VEAGHLYSLVGVARTKFKRDHRYSAYKIINSLIS- 503
Cdd:TIGR02917 109 VLDELPGKTLLDDEGAAELLALrGLAYLGLGQLELAQKSYEQAlaIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTa 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  504 ---DHKAtgWMHQERSLYCSGK--EKLLDLDTATEFDPTLTFPYKFRAVALVEENQFGAAIAELNKILG-FKASPDCLEM 577
Cdd:TIGR02917 189 dpgNVDA--LLLKGDLLLSLGNieLALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKkAPNSPLAHYL 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  578 RAWISIGMEDYEGALKDIRALLTLEPNFM---------MF---NWKIHGDHMVELL----------RPLA------QQWS 629
Cdd:TIGR02917 267 KALVDFQKKNYEDARETLQDALKSAPEYLpalllagasEYqlgNLEQAYQYLNQILkyapnshqarRLLAsiqlrlGRVD 346

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  630 QADCWMQLYDRWSSVD------------DIGSLAVVHHMLA----NDPGKSLLRFRQSLLLLRLNCQKAAMRSLRLArnh 693
Cdd:TIGR02917 347 EAIATLSPALGLDPDDpaalsllgeaylALGDFEKAAEYLAkateLDPENAAARTQLGISKLSQGDPSEAIADLETA--- 423

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  694 SKSEHErLVYEGWILYDTGHREEALAKAeesISIQRSFEA--------FFLKAYALADSTlDPDSSNyviQLLQEALKCP 765
Cdd:TIGR02917 424 AQLDPE-LGRADLLLILSYLRSGQFDKA---LAAAKKLEKkqpdnaslHNLLGAIYLGKG-DLAKAR---EAFEKALSIE 495

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  766 SDGLrkgQALNNLGSVYVDCEKLDLAADCYTNALTI--KHTRAHQGLARVYHLKNQRKA-------AYDEMTKLIEKAQN 836
Cdd:TIGR02917 496 PDFF---PAAANLARIDIQEGNPDDAIQRFEKVLTIdpKNLRAILALAGLYLRTGNEEEavawlekAAELNPQEIEPALA 572

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  837 NASAYEKRSEyCDREMAQSDLCLATQLDPLRTYPYRYRAAVLMDDHKesEAIDELSRAISFKPDLQLLHLRAAF-YDSMG 915
Cdd:TIGR02917 573 LAQYYLGKGQ-LKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLN--KAVSSFKKLLALQPDSALALLLLADaYAVMK 649

                         570
                  ....*....|....*....
gi 240255603  916 EGASAIKDCEAALCIDPGH 934
Cdd:TIGR02917 650 NYAKAITSLKRALELKPDN 668
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
755-923 3.23e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.48  E-value: 3.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 755 IQLLQEALKCPSDglrKGQALNNLGSVYVDCEKLDLAADCYTNALTIK--HTRAHQGLARVYHLKNQRKAAYDEMTKLIE 832
Cdd:COG0457   28 IEDYEKALELDPD---DAEALYNLGLAYLRLGRYEEALADYEQALELDpdDAEALNNLGLALQALGRYEEALEDYDKALE 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 833 KAQNNASAYEKRSEYC----DREMAQSDLCLATQLDPLRTYPYRYRAAVLMDDHKESEAIDELSRAISFKPDLQLLHLRA 908
Cdd:COG0457  105 LDPDDAEALYNLGLALlelgRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALG 184

                        170
                 ....*....|....*
gi 240255603 909 AFYDSMGEGASAIKD 923
Cdd:COG0457  185 EAALALAAAEVLLAL 199
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
657-909 4.68e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.09  E-value: 4.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 657 LANDPGKSLLRFRQSLLLLRLNCQKAAMRSLRLARNHSKSEHERLVYEGWILYDTGHREEALAKAEESISIQ-RSFEAFF 735
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDpDDAEALN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 736 LKAYALADsTLDPDSSnyvIQLLQEALKCPSDglrKGQALNNLGSVYVDCEKLDLAADCYTNALTIK--HTRAHQGLARV 813
Cdd:COG0457   81 NLGLALQA-LGRYEEA---LEDYDKALELDPD---DAEALYNLGLALLELGRYDEAIEAYERALELDpdDADALYNLGIA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 814 YHLKNQrkaaYDEMTKLIEKAQNNASAYEKRSEYCDREMAQSDLCLATQLDPLRTYPYRYRAAVLMDDHKESEAIDELSR 893
Cdd:COG0457  154 LEKLGR----YEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALAL 229

                        250
                 ....*....|....*.
gi 240255603 894 AISFKPDLQLLHLRAA 909
Cdd:COG0457  230 LLALRLAALALYQYRA 245
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 436-928 8.35e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 59.71  E-value: 8.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  436 AVDSWEKQ-----LAYHQLGVVMLERKEYKDAQRWFNAA--VEAGHLYSLVGVARTKFKRDH------RYSaykiiNSLI 502
Cdd:TIGR02917 453 AAKKLEKKqpdnaSLHNLLGAIYLGKGDLAKAREAFEKAlsIEPDFFPAAANLARIDIQEGNpddaiqRFE-----KVLT 527

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  503 SDHKATGWMHQERSLYC-SGKEK--LLDLDTATEFDPTLTFPYKFRAVALVEENQFGAAIAELNKILG-FKASPDCLEMR 578
Cdd:TIGR02917 528 IDPKNLRAILALAGLYLrTGNEEeaVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADaAPDSPEAWLML 607

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  579 AWISIGMEDYEGALKDIRALLTLEPnfmmfnwkihgDHMVELLRPLAQQWSQADcwmqlYDrwssvddiGSLAVVHHMLA 658
Cdd:TIGR02917 608 GRAQLAAGDLNKAVSSFKKLLALQP-----------DSALALLLLADAYAVMKN-----YA--------KAITSLKRALE 663

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  659 NDPGKSLLRFRQSLLLLRLNCQKAAMRSLRLARNHSKSEHERLVYEGWILYDTGHREEALAKaeesisiqrsfeafFLKA 738
Cdd:TIGR02917 664 LKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQA--------------YRKA 729

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  739 YALAdstldpdssnyviqllqealkcPSDglrkgQALNNLGSVYVDCEKLDLAADCYTNALT--IKHTRAHQGLARVYHL 816
Cdd:TIGR02917 730 LKRA----------------------PSS-----QNAIKLHRALLASGNTAEAVKTLEAWLKthPNDAVLRTALAELYLA 782

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  817 KNQRKAAYDEMTKLIEKAQNNASA-------YEKRSEYCDREMAQSDLCLATQLDP-LRTYpyryrAAVLMDDHKESEAI 888
Cdd:TIGR02917 783 QKDYDKAIKHYQTVVKKAPDNAVVlnnlawlYLELKDPRALEYAERALKLAPNIPAiLDTL-----GWLLVEKGEADRAL 857

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 240255603  889 DELSRAISFKP---DLQlLHLRAAFYDSmGEGASAIKDCEAAL 928
Cdd:TIGR02917 858 PLLRKAVNIAPeaaAIR-YHLALALLAT-GRKAEARKELDKLL 898
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 713-936 1.20e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.77  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 713 HREEALAKAEESISIQRSFEAFFLKAYALADSTLDPDSSNYVIQLLQEALKCPSDGLRKGQALNNLGSVYVDCEKLDLAA 792
Cdd:COG3914   19 AAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEAL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 793 DCYTNALTI--KHTRAHQGLARVYHLKNQRKAAydemtkliekaqnnASAYEKrseycdremaqsdlclATQLDPLRTYP 870
Cdd:COG3914   99 ALYRRALALnpDNAEALFNLGNLLLALGRLEEA--------------LAALRR----------------ALALNPDFAEA 148

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 240255603 871 YRYRAAVLMDDHKESEAIDELSRAISFKPDLQLLHL-RAAFYDSMGEGASAIKDCEAALCIDPGHAD 936
Cdd:COG3914  149 YLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNnLGNALQDLGRLEEAIAAYRRALELDPDNAD 215
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 654-841 1.21e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.77  E-value: 1.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 654 HHMLANDPGKSLLRFRQSLLLLRLNCQKAAMRSLRLARNHSKSEHERLVYEGWILYDTGHREEALAKAEESISIQ-RSFE 732
Cdd:COG3914   34 AAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNpDNAE 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 733 AFFLKAYALADSTLDPDSsnyvIQLLQEALKCPSDGLrkgQALNNLGSVYVDCEKLDLAADCYTNALTIK--HTRAHQGL 810
Cdd:COG3914  114 ALFNLGNLLLALGRLEEA----LAALRRALALNPDFA---EAYLNLGEALRRLGRLEEAIAALRRALELDpdNAEALNNL 186

                        170       180       190
                 ....*....|....*....|....*....|.
gi 240255603 811 ARVYHLKNQRKAAYDEMTKLIEKAQNNASAY 841
Cdd:COG3914  187 GNALQDLGRLEEAIAAYRRALELDPDNADAH 217
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 243-338 3.55e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 49.93  E-value: 3.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 243 DMSFCIGDEEVRCVRYKIASLSRPFKAMLYGGFREMKRATInfTQNGISVEGMRAAEIFSRTNRLD--NFPPNVVLELLK 320
Cdd:cd18287   24 DVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEI--ELKDTNAEAFKALLKYIYTGRLTltDLKEDVLLDVLG 101

                         90
                 ....*....|....*...
gi 240255603 321 LANRFCCDELKSACDSHL 338
Cdd:cd18287  102 LAHQYGFEELEAAISDYL 119
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 805-934 1.16e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.03  E-value: 1.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 805 RAHQGLARVYHLKNQRKAAYDEMTKLIEKAQNNASAYEKRSEYC----DREMAQSDLCLATQLDPLRTYPYRYRAAVLMD 880
Cdd:COG4783    5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILlqlgDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 240255603 881 DHKESEAIDELSRAISFKP-DLQLLHLRAAFYDSMGEGASAIKDCEAALCIDPGH 934
Cdd:COG4783   85 AGDYDEALALLEKALKLDPeHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 755-928 1.99e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.50  E-value: 1.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 755 IQLLQEALKCPSDGLrkgQALNNLGSVYVDCEKLDLAADCYTNALTIKHTRAH--QGLARVYHLKNQRKAAYDEMTKLIE 832
Cdd:COG2956   96 EELLEKLLELDPDDA---EALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHayCELAELYLEQGDYDEAIEALEKALK 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 833 KAQNNASAYEKRSEYC----DREMAQSDLCLATQLDPLRTYPYRYRAAVLMDDHKESEAIDELSRAISFKPDLQLLHLRA 908
Cdd:COG2956  173 LDPDCARALLLLAELYleqgDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALA 252

                        170       180
                 ....*....|....*....|
gi 240255603 909 AFYDSMGEGASAIKDCEAAL 928
Cdd:COG2956  253 DLLERKEGLEAALALLERQL 272
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 656-895 2.86e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.11  E-value: 2.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 656 MLANDPGKSLLRFRQSLLLLRLNCQKAAMRSLRLARNHSKSEHERLVYEGWILYDTGHREEALAKAEESISIQ-RSFEAF 734
Cdd:COG2956   34 ALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDpDDAEAL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 735 FLKAYALADsTLDPDSSnyvIQLLQEALKcpsDGLRKGQALNNLGSVYVDCEKLDLAADCYTNALTI--KHTRAHQGLAR 812
Cdd:COG2956  114 RLLAEIYEQ-EGDWEKA---IEVLERLLK---LGPENAHAYCELAELYLEQGDYDEAIEALEKALKLdpDCARALLLLAE 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 813 VYHLKNQRKAAYDEMTKLIEKAQNNASAYEKRSEyCDREMAQSDLCLATQLDPLRTYP----YRYRAAVLMDDHKESEAI 888
Cdd:COG2956  187 LYLEQGDYEEAIAALERALEQDPDYLPALPRLAE-LYEKLGDPEEALELLRKALELDPsddlLLALADLLERKEGLEAAL 265


                 ....*..
gi 240255603 889 DELSRAI 895
Cdd:COG2956  266 ALLERQL 272
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 242-339 1.28e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 45.53  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 242 YDMSFCIGDEEVRCVRYKIASLSRPFKAMLYGGFRE--MKRATInftqNGISVEGMRAAEIFSRTNRLDNFPPNVVLeLL 319
Cdd:cd18250   22 FDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELREsrADRVVL----HGVSAEILGLLLDFSYTGRVTVTQDNVEA-LL 96

                         90       100
                 ....*....|....*....|
gi 240255603 320 KLANRFCCDELKSACDSHLA 339
Cdd:cd18250   97 RAADLFQFPSVKEACCAYLQ 116
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 428-688 2.39e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.03  E-value: 2.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 428 LLERLVECAVDSWEkqlAYHQLGVVMLERKEYKDAQRWFNAAVEAG--HLYSLVGVARTKFKRDHRYSAYKIINSLIS-D 504
Cdd:COG2956   30 LLEEALELDPETVE---AHLALGNLYRRRGEYDRAIRIHQKLLERDpdRAEALLELAQDYLKAGLLDRAEELLEKLLElD 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 505 HKATGWMHQERSLYCSGK--EKLLD-LDTATEFDPTLTFPYKFRAVALVEENQFGAAIAELNKILgfKASPDCLemRAWI 581
Cdd:COG2956  107 PDDAEALRLLAEIYEQEGdwEKAIEvLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKAL--KLDPDCA--RALL 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 582 SIG-----MEDYEGALKDIRALLTLEPNFMmfnwkihgdHMVELLRPLAQQWSQADCWMQLYDRWssvddigslavvhhm 656
Cdd:COG2956  183 LLAelyleQGDYEEAIAALERALEQDPDYL---------PALPRLAELYEKLGDPEEALELLRKA--------------- 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 240255603 657 LANDPGKSLLrFRQSLLLLRLNCQKAAMRSLR 688
Cdd:COG2956  239 LELDPSDDLL-LALADLLERKEGLEAALALLE 269
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 243-334 2.49e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 44.16  E-value: 2.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 243 DMSFCIGDE--EVRCVRYKIASLSRPFKAMLYGGFReMKRATINFTQNGISVEGMRAAEIFSRTNRLdNFPPNVVLELLK 320
Cdd:cd18294   16 DVKFLVGPErqEIFAHKCILAARCEVFRAMFLTGPQ-KESTQSPLVLSDIEPEVFRAVLEFIYTNCV-TLSNHTVIEVLA 93

                         90
                 ....*....|....
gi 240255603 321 LANRFCCDELKSAC 334
Cdd:cd18294   94 AAVEYGLDELRKLC 107
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
713-906 2.51e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.45  E-value: 2.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 713 HREEALAKAEESISIQRSFEAFFLKAYALADSTLDPDSSNYVIQLLQEALKCPSDGL-----RKGQALNNLGSVYVDCEK 787
Cdd:COG4785    9 LLALALAAAAASKAAILLAALLFAAVLALAIALADLALALAAAALAAAALAAERIDRalalpDLAQLYYERGVAYDSLGD 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 788 LDLAADCYTNALTIKHtrahqGLARVYhlkNQRKAAYdemtkliEKAQNNASAYEkrseYCDRemaqsdlclATQLDPLR 867
Cdd:COG4785   89 YDLAIADFDQALELDP-----DLAEAY---NNRGLAY-------LLLGDYDAALE----DFDR---------ALELDPDY 140

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 240255603 868 TYPYRYRAAVLMDDHKESEAIDELSRAISFKPDLQLLHL 906
Cdd:COG4785  141 AYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERAL 179
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
862-938 2.84e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.54  E-value: 2.84e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 240255603 862 QLDPLRTYPYRYRAAVLMDDHKESEAIDELSRAISFKPDL-QLLHLRAAFYDSMGEGASAIKDCEAALCIDPGHADTL 938
Cdd:COG0457    2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDaEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEAL 79
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
525-604 1.02e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 44.91  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 525 LLDLDTATEFDPTLTFPYKFRAVALVEENQFGAAIAELNKILgfKASPDCLEM---RAWISIGMEDYEGALKDIRALLTL 601
Cdd:COG4785   93 IADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRAL--ELDPDYAYAylnRGIALYYLGRYELAIADLEKALEL 170


                 ...
gi 240255603 602 EPN 604
Cdd:COG4785  171 DPN 173
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 809-932 2.21e-04

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 44.97  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  809 GLARVY--HLKNQRKAAYDEMTKLIEKA-------QNNASAYEKRSEY-C---DREMAQSDLCLATQLDPLRTYPYRYRA 875
Cdd:TIGR00990 293 GQLQLGlkSPESKADESYEEAARAFEKAldlgklgEKEAIALNLRGTFkClkgKHLEALADLSKSIELDPRVTQSYIKRA 372

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 240255603  876 AVLMDDHKESEAIDELSRAISFKP-DLQLLHLRAAFYDSMGEGASAIKDCEAALCIDP 932
Cdd:TIGR00990 373 SMNLELGDPDKAEEDFDKALKLNSeDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDP 430
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
849-951 2.50e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 43.37  E-value: 2.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 849 DREMAQSDLCLATQLDPLRTYPYRYRAAVLMDDHKESEAIDELSRAISFKPDLQLLHL-RAAFYDSMGEGASAIKDCEAA 927
Cdd:COG4785   88 DYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLnRGIALYYLGRYELAIADLEKA 167

                         90       100
                 ....*....|....*....|....*
gi 240255603 928 LCIDPGHADT-LELYHKAREPNDQK 951
Cdd:COG4785  168 LELDPNDPERaLWLYLAERKLDPEK 192
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
445-605 2.78e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.46  E-value: 2.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 445 AYHQLGVVMLERKEYKDAQRWFNAAVEaghlyslvgvartkFKRDHRYSAYKIinslisdhkatGWMHQERSLYcsgKEK 524
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALE--------------LDPDDAEALYNL-----------GLAYLRLGRY---EEA 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 525 LLDLDTATEFDPTLTFPYKFRAVALVEENQFGAAIAELNKILGFKAS-PDCLEMRAWISIGMEDYEGALKDIRALLTLEP 603
Cdd:COG0457   62 LADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDdAEALYNLGLALLELGRYDEAIEAYERALELDP 141


                 ..
gi 240255603 604 NF 605
Cdd:COG0457  142 DD 143
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
810-938 4.56e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 42.59  E-value: 4.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 810 LARVYHLKNQRKAAYDEMTKLIEKAQNNASAYEKRSEYCDREMAQSDLCLA----------TQLDPLRTYPYRYRAAVLM 879
Cdd:COG4785    5 ALALLLALALAAAAASKAAILLAALLFAAVLALAIALADLALALAAAALAAaalaaeridrALALPDLAQLYYERGVAYD 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 880 DDHKESEAIDELSRAISFKPDL-QLLHLRAAFYDSMGEGASAIKDCEAALCIDPGHADTL 938
Cdd:COG4785   85 SLGDYDLAIADFDQALELDPDLaEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAY 144
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 755-841 4.69e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.14  E-value: 4.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 755 IQLLQEALKC-PSDGlrkgQALNNLGSVYVDCEKLDLAADCYTNALTI--KHTRAHQGLARVYHLKNQRKAAYDEMTKLI 831
Cdd:COG4235    3 IARLRQALAAnPNDA----EGWLLLGRAYLRLGRYDEALAAYEKALRLdpDNADALLDLAEALLAAGDTEEAEELLERAL 78

                         90
                 ....*....|
gi 240255603 832 EKAQNNASAY 841
Cdd:COG4235   79 ALDPDNPEAL 88
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 849-947 5.89e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.95  E-value: 5.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 849 DREMAQSDLCLATQLDPLRTYPYRYRAAVLMDDHKESEAIDELSRAISFKPD-LQLLHLRAAFYDSMGEGASAIKDCEAA 927
Cdd:COG4783   19 DYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDePEARLNLGLALLKAGDYDEALALLEKA 98

                         90       100
                 ....*....|....*....|....
gi 240255603 928 LCIDPGHADTL----ELYHKAREP 947
Cdd:COG4783   99 LKLDPEHPEAYlrlaRAYRALGRP 122
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 662-837 6.23e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.95  E-value: 6.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 662 GKSLLRFRQSLLLLRLNCQKAAMRSLRLARNHSKSEHERLVYEGWILYDTGHREEALAKAEESISiqrsfeafflkayal 741
Cdd:COG4783    2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALE--------------- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 742 adstLDPDSSnyviqllqealkcpsdglrkgQALNNLGSVYVDCEKLDLAADCYTNALTI--KHTRAHQGLARVYHLKNQ 819
Cdd:COG4783   67 ----LDPDEP---------------------EARLNLGLALLKAGDYDEALALLEKALKLdpEHPEAYLRLARAYRALGR 121

                        170
                 ....*....|....*...
gi 240255603 820 RKAAYDEMTKLIEKAQNN 837
Cdd:COG4783  122 PDEAIAALEKALELDPDD 139
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 243-338 6.60e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 40.30  E-value: 6.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 243 DMSFCIGDEEVRCVRYKIASLSRPFKAMLYGGFREMKRATINFTqnGISVEGMRAAEIFSRTNRLDNFPPNVVLELLKLA 322
Cdd:cd18300   11 DVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELP--GVSKETFLALLEYLYTDQAPILEDGDCVGLIVLA 88

                         90
                 ....*....|....*.
gi 240255603 323 NRFCCDELKSACDSHL 338
Cdd:cd18300   89 NRLCLPRLVALCEQYI 104
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
515-605 1.15e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.44  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 515 RSLYCSGKEKLLDLDTATEFDPTLTFP-----YKFRAVALVEENQFGAAIAELNKILGFK-ASPDCLEMRAWISIGMEDY 588
Cdd:COG4785   44 LALALAAAALAAAALAAERIDRALALPdlaqlYYERGVAYDSLGDYDLAIADFDQALELDpDLAEAYNNRGLAYLLLGDY 123

                         90
                 ....*....|....*..
gi 240255603 589 EGALKDIRALLTLEPNF 605
Cdd:COG4785  124 DAALEDFDRALELDPDY 140
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 243-334 2.01e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 38.48  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 243 DMSFCIGDEEVRCVRYKIASLSRPFKAMLYGGFREMkratinfTQNGISVEGMRaAEIFSR------TNRLDNFPPNvVL 316
Cdd:cd18314    8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIES-------NLKEVTLEDVE-PEIFETvlkymyTGQVTLSEEN-VL 78

                         90
                 ....*....|....*...
gi 240255603 317 ELLKLANRFCCDELKSAC 334
Cdd:cd18314   79 DLLMLASKYQVPDLEKLC 96
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 579-935 2.38e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.99  E-value: 2.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  579 AWISIGMEDYEGALKDIRALLTLEPnfmmfnwkihgdhmvellrplaqqwSQADCWMQLYD-RWSSVDDIGSLAVVHHML 657
Cdd:TIGR02917 166 AQLALAENRFDEARALIDEVLTADP-------------------------GNVDALLLKGDlLLSLGNIELALAAYRKAI 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  658 ANDPGKSLLRFRQSLLLLRLNCQKAAMRSL----RLARNHSKSEHerlvYEGWILYDTGHREEALAKAEESISIQRSF-E 732
Cdd:TIGR02917 221 ALRPNNIAVLLALATILIEAGEFEEAEKHAdallKKAPNSPLAHY----LKALVDFQKKNYEDARETLQDALKSAPEYlP 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  733 AFFL------------KAYALADSTLDPDSSN-YVIQLL---QEALKCPSDGLRKGQALnnLGSVYVDCEKLDLAADCYT 796
Cdd:TIGR02917 297 ALLLagaseyqlgnleQAYQYLNQILKYAPNShQARRLLasiQLRLGRVDEAIATLSPA--LGLDPDDPAALSLLGEAYL 374

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603  797 NALtiKHTRAHQGLARVYHLKNQRKAAYDE--MTKLiekAQNnasayekrseycDREMAQSDLCLATQLDPLRTYPYRYR 874
Cdd:TIGR02917 375 ALG--DFEKAAEYLAKATELDPENAAARTQlgISKL---SQG------------DPSEAIADLETAAQLDPELGRADLLL 437

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 240255603  875 AAVLMDDHKESEAIDELSRAISFKPDLQLLH-LRAAFYDSMGEGASAIKDCEAALCIDPGHA 935
Cdd:TIGR02917 438 ILSYLRSGQFDKALAAAKKLEKKQPDNASLHnLLGAIYLGKGDLAKAREAFEKALSIEPDFF 499
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
849-932 2.39e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.23  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 849 DREMAQSDLCLATQLDPLRTYPYRYRAAVLMDDHKESEAIdELSRAISFKPDL-QLLHLRAAFYDSMGEGASAIKDCEAA 927
Cdd:COG3063    7 DLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNaEALLNLAELLLELGDYDEALAYLERA 85


                 ....*
gi 240255603 928 LCIDP 932
Cdd:COG3063   86 LELDP 90
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 802-940 5.16e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.06  E-value: 5.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 802 KHTRAHQGLARVYHLKNQRKAAYDemtkliekaqnnasAYEKrseycdremaqsdlclATQLDPLRTYPYRYRAAVLMDD 881
Cdd:COG4235   15 NDAEGWLLLGRAYLRLGRYDEALA--------------AYEK----------------ALRLDPDNADALLDLAEALLAA 64

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 882 HKESEAIDELSRAISFKPD-LQLLHLRAAFYDSMGEGASAIKDCEAALCIDPGHADTLEL 940
Cdd:COG4235   65 GDTEEAEELLERALALDPDnPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLL 124
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 243-288 5.70e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 38.07  E-value: 5.70e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 240255603 243 DMSFCIGDEEVRCVRYKIASLSRPFKAMLYGGFREMKRATINFTQN 288
Cdd:cd18254   24 DVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDS 69
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 755-832 6.81e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.40  E-value: 6.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 755 IQLLQEALKC-PSDGlrkgQALNNLGSVYVDCEKLDLAADCYTNALTIK--HTRAHQGLARVYHLKNQRKAAYDEMTKLI 831
Cdd:COG5010   74 LALLEQALQLdPNNP----ELYYNLALLYSRSGDKDEAKEYYEKALALSpdNPNAYSNLAALLLSLGQDDEAKAALQRAL 149


                 .
gi 240255603 832 E 832
Cdd:COG5010  150 G 150
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 261-343 7.68e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 37.25  E-value: 7.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255603 261 ASLSRPFKAMLYGGFREMKRATINFTQNGISVEGMRAAEIFSRTNRLDNFPPNVVLELLKLANRFCCDELKSACDSHLAH 340
Cdd:cd18297   32 VTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESLDVAQDDALELLRAASFFQLDGLKRHCEILLSQ 111


                 ...
gi 240255603 341 LVN 343
Cdd:cd18297  112 QID 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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