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    Anxa7 annexin A7 [ Mus musculus (house mouse) ]

    Gene ID: 11750, updated on 3-Dec-2024

    Summary

    Official Symbol
    Anxa7provided by MGI
    Official Full Name
    annexin A7provided by MGI
    Primary source
    MGI:MGI:88031
    See related
    Ensembl:ENSMUSG00000021814 AllianceGenome:MGI:88031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Anx7; synexin
    Summary
    Enables GTPase-dependent fusogenic activity. Acts upstream of or within with a positive effect on G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion. Acts upstream of or within several processes, including glial cell proliferation; intracellular calcium ion homeostasis; and intracellular water homeostasis. Located in several cellular components, including cytosol; nuclear envelope; and vesicle. Orthologous to human ANXA7 (annexin A7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 48.4), bladder adult (RPKM 40.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Anxa7 in Genome Data Viewer
    Location:
    14 A3; 14 11.53 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20505344..20530009, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20455261..20480133, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3105 Neighboring gene RIKEN cDNA 7330404K18 gene Neighboring gene mitochondrial ribosomal protein S16 Neighboring gene cilia and flagella associated protein 70 Neighboring gene STARR-seq mESC enhancer starr_36110 Neighboring gene MSS51 mitochondrial translational activator Neighboring gene STARR-seq mESC enhancer starr_36112 Neighboring gene protein phosphatase 3, catalytic subunit, beta isoform Neighboring gene RIKEN cDNA 1810062O18 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase-dependent fusogenic activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GTPase-dependent fusogenic activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of establishment of localization in cell IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hemostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of insulin secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intracellular water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect ion channel modulating, G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect ligand-gated ion channel signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within_positive_effect phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with chromaffin granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    annexin A7
    Names
    annexin VII
    annexin-7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110794.2NP_001104264.1  annexin A7 isoform 1

      See identical proteins and their annotated locations for NP_001104264.1

      Status: VALIDATED

      Source sequence(s)
      AC121801
      Consensus CDS
      CCDS26845.1
      UniProtKB/Swiss-Prot
      Q07076, Q3TT33
      UniProtKB/TrEMBL
      Q922A2
      Related
      ENSMUSP00000066035.10, ENSMUST00000065504.17
      Conserved Domains (1) summary
      pfam00191
      Location:164229
      Annexin; Annexin
    2. NM_001374757.1NP_001361686.1  annexin A7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121801
      Consensus CDS
      CCDS88585.1
      UniProtKB/TrEMBL
      A0A2C9F2D2, Q3UYL7
      Conserved Domains (1) summary
      pfam00191
      Location:186251
      Annexin
    3. NM_001422107.1NP_001409036.1  annexin A7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121801
      UniProtKB/TrEMBL
      A0A2C9F2D2, Q3UYL7
      Related
      ENSMUSP00000098405.6, ENSMUST00000100844.6
    4. NM_001422108.1NP_001409037.1  annexin A7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121801
      UniProtKB/Swiss-Prot
      Q07076, Q3TT33
      UniProtKB/TrEMBL
      Q922A2
    5. NM_001422109.1NP_001409038.1  annexin A7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121801
      UniProtKB/TrEMBL
      Q922A2
    6. NM_001422110.1NP_001409039.1  annexin A7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC121801
    7. NM_009674.4NP_033804.2  annexin A7 isoform 1

      See identical proteins and their annotated locations for NP_033804.2

      Status: VALIDATED

      Source sequence(s)
      AC121801
      Consensus CDS
      CCDS26845.1
      UniProtKB/Swiss-Prot
      Q07076, Q3TT33
      UniProtKB/TrEMBL
      Q922A2
      Related
      ENSMUSP00000153669.2, ENSMUST00000224975.2
      Conserved Domains (1) summary
      pfam00191
      Location:164229
      Annexin; Annexin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      20505344..20530009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)