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Conserved domains on  [gi|160707958|ref|NP_001104264|]
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annexin A7 isoform 1 [Mus musculus]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

CATH:  1.10.220.10
Gene Ontology:  GO:0005509|GO:0005544|GO:0048306|GO:0003723
PubMed:  15059252|1646719
SCOP:  4001063
TCDB:  1.A.31

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 164-229 2.55e-30

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 111.80  E-value: 2.55e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160707958  164 RDAEILRKAMKGFGTDEQAIVDVVSNRSNDQRQQIKAAFKTMYGKDLIKDLKSELSGNMEELILAL 229
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 236-301 4.37e-28

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 106.02  E-value: 4.37e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160707958  236 YDAWSLRKAMQGAGTQERVLIEILCTRTNQEIRDIVRCYQLEFGRDLEKDIRSDTSGHFERLLVSM 301
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 395-460 1.56e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 101.78  E-value: 1.56e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160707958  395 FFAERLYYSMKGAGTDDSTLVRIVVTRSEIDLVQIKQMFTQMYQKTLSTMIASDTSGDYRKLLLAI 460
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 320-385 9.96e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 79.82  E-value: 9.96e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160707958  320 DAQRLYQAgEGRLGTDESCFNMILATRSFPQLKATMEAYSRMANRDLLSSVSREFSGYVESGLKTI 385
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
COG3416 super family cl47320
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
103-149 4.60e-03

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


The actual alignment was detected with superfamily member COG3416:

Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 38.46  E-value: 4.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 160707958 103 PQPPAQSYGGGPAQVPVPGGFPGGQMPSQYPGGQAPYPSQPASMTQG 149
Cdd:COG3416   96 PPPAPQPSQPGPQQQPAPPSGPWGQAAPQQPGYGQPQYGQPAAGPSG 142
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 164-229 2.55e-30

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 111.80  E-value: 2.55e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160707958  164 RDAEILRKAMKGFGTDEQAIVDVVSNRSNDQRQQIKAAFKTMYGKDLIKDLKSELSGNMEELILAL 229
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 236-301 4.37e-28

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 106.02  E-value: 4.37e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160707958  236 YDAWSLRKAMQGAGTQERVLIEILCTRTNQEIRDIVRCYQLEFGRDLEKDIRSDTSGHFERLLVSM 301
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 395-460 1.56e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 101.78  E-value: 1.56e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160707958  395 FFAERLYYSMKGAGTDDSTLVRIVVTRSEIDLVQIKQMFTQMYQKTLSTMIASDTSGDYRKLLLAI 460
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
177-229 2.78e-23

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 92.09  E-value: 2.78e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 160707958   177 GTDEQAIVDVVSNRSNDQRQQIKAAFKTMYGKDLIKDLKSELSGNMEELILAL 229
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
249-301 4.76e-22

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 88.62  E-value: 4.76e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 160707958   249 GTQERVLIEILCTRTNQEIRDIVRCYQLEFGRDLEKDIRSDTSGHFERLLVSM 301
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
408-460 3.57e-21

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 86.31  E-value: 3.57e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 160707958   408 GTDDSTLVRIVVTRSEIDLVQIKQMFTQMYQKTLSTMIASDTSGDYRKLLLAI 460
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 320-385 9.96e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 79.82  E-value: 9.96e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160707958  320 DAQRLYQAgEGRLGTDESCFNMILATRSFPQLKATMEAYSRMANRDLLSSVSREFSGYVESGLKTI 385
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
333-382 9.67e-11

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 57.03  E-value: 9.67e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 160707958   333 GTDESCFNMILATRSFPQLKATMEAYSRMANRDLLSSVSREFSGYVESGL 382
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLL 50
COG3416 COG3416
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
103-149 4.60e-03

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 38.46  E-value: 4.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 160707958 103 PQPPAQSYGGGPAQVPVPGGFPGGQMPSQYPGGQAPYPSQPASMTQG 149
Cdd:COG3416   96 PPPAPQPSQPGPQQQPAPPSGPWGQAAPQQPGYGQPQYGQPAAGPSG 142
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 164-229 2.55e-30

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 111.80  E-value: 2.55e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160707958  164 RDAEILRKAMKGFGTDEQAIVDVVSNRSNDQRQQIKAAFKTMYGKDLIKDLKSELSGNMEELILAL 229
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 236-301 4.37e-28

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 106.02  E-value: 4.37e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160707958  236 YDAWSLRKAMQGAGTQERVLIEILCTRTNQEIRDIVRCYQLEFGRDLEKDIRSDTSGHFERLLVSM 301
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 395-460 1.56e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 101.78  E-value: 1.56e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160707958  395 FFAERLYYSMKGAGTDDSTLVRIVVTRSEIDLVQIKQMFTQMYQKTLSTMIASDTSGDYRKLLLAI 460
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
177-229 2.78e-23

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 92.09  E-value: 2.78e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 160707958   177 GTDEQAIVDVVSNRSNDQRQQIKAAFKTMYGKDLIKDLKSELSGNMEELILAL 229
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
249-301 4.76e-22

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 88.62  E-value: 4.76e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 160707958   249 GTQERVLIEILCTRTNQEIRDIVRCYQLEFGRDLEKDIRSDTSGHFERLLVSM 301
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
408-460 3.57e-21

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 86.31  E-value: 3.57e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 160707958   408 GTDDSTLVRIVVTRSEIDLVQIKQMFTQMYQKTLSTMIASDTSGDYRKLLLAI 460
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 320-385 9.96e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 79.82  E-value: 9.96e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 160707958  320 DAQRLYQAgEGRLGTDESCFNMILATRSFPQLKATMEAYSRMANRDLLSSVSREFSGYVESGLKTI 385
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
333-382 9.67e-11

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 57.03  E-value: 9.67e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 160707958   333 GTDESCFNMILATRSFPQLKATMEAYSRMANRDLLSSVSREFSGYVESGL 382
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLL 50
COG3416 COG3416
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
103-149 4.60e-03

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 38.46  E-value: 4.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 160707958 103 PQPPAQSYGGGPAQVPVPGGFPGGQMPSQYPGGQAPYPSQPASMTQG 149
Cdd:COG3416   96 PPPAPQPSQPGPQQQPAPPSGPWGQAAPQQPGYGQPQYGQPAAGPSG 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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