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    Pde8 Phosphodiesterase 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37741, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pde8provided by FlyBase
    Official Full Name
    Phosphodiesterase 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0266377
    Locus tag
    Dmel_CG45019
    See related
    AllianceGenome:FB:FBgn0266377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG42241; CG45019; CG5411; Dmel\CG45019; pde8; PDE8
    Old locus tag
    Dmel_CG42241; Dmel_CG5411
    Summary
    Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in mesoderm development and positive regulation of ERK1 and ERK2 cascade. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including adult fat body; adult head; embryonic anal pad; gut section; and salivary gland body primordium. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease 3. Orthologous to human PDE8A (phosphodiesterase 8A) and PDE8B (phosphodiesterase 8B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Pde8 in Genome Data Viewer
    Location:
    59F5-59F6; 2-104 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23657567..23680844)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19545090..19568367)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Entomoglyceroporin 2 Neighboring gene Entomoglyceroporin 4 Neighboring gene long non-coding RNA:CR45153 Neighboring gene retained Neighboring gene lethal (2) essential for life Neighboring gene Sulfotransferase 1 Neighboring gene Sulfotransferase 3

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cAMP metabolic process PubMed 
    involved_in cAMP-mediated signaling  
    involved_in mesoderm development PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in signal transduction  

    General protein information

    Preferred Names
    phosphodiesterase 8
    Names
    CG45019-PA
    CG45019-PB
    CG45019-PC
    CG45019-PD
    CG45019-PE
    CG45019-PI
    CG45019-PK
    CG45019-PN
    CG45019-PO
    CG45019-PP
    CG45019-PQ
    CG45019-PR
    Pde8-PA
    Pde8-PB
    Pde8-PC
    Pde8-PD
    Pde8-PE
    Pde8-PI
    Pde8-PK
    Pde8-PN
    Pde8-PO
    Pde8-PP
    Pde8-PQ
    Pde8-PR
    NP_001163274.1
    NP_001163275.2
    NP_001163276.1
    NP_001163278.2
    NP_001400989.1
    NP_001401020.1
    NP_001401021.1
    NP_611814.3
    NP_726350.1
    NP_726351.1
    NP_726352.1
    NP_726353.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23657567..23680844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166616.3 → NP_726350.1  phosphodiesterase 8, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726350.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JGU3, Q5BI98, Q6NNF2, Q8MLR0, Q95T53, Q9W1L9
      Related
      FBpp0310592
      Conserved Domains (2) summary
      pfam00233
      Location:639 → 871
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:327 → 403
      PAS_9; PAS domain
    2. NM_001169807.2 → NP_001163278.2  phosphodiesterase 8, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163278.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGU6
      Conserved Domains (3) summary
      cd00130
      Location:323 → 403
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:639 → 880
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:327 → 403
      PAS_9; PAS domain
    3. NM_137970.5 → NP_611814.3  phosphodiesterase 8, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611814.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NNF2
      Conserved Domains (2) summary
      pfam00233
      Location:630 → 862
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:327 → 403
      PAS_9; PAS domain
    4. NM_001169803.2 → NP_001163274.1  phosphodiesterase 8, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JGU3, Q5BI98, Q6NNF2, Q8MLR0, Q95T53, Q9W1L9
      Conserved Domains (2) summary
      pfam00233
      Location:639 → 871
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:327 → 403
      PAS_9; PAS domain
    5. NM_001414110.1 → NP_001400989.1  phosphodiesterase 8, isoform P [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PDF0
    6. NM_001169805.2 → NP_001163276.1  phosphodiesterase 8, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163276.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JGU3, Q5BI98, Q6NNF2, Q8MLR0, Q95T53, Q9W1L9
      Conserved Domains (2) summary
      pfam00233
      Location:639 → 871
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:327 → 403
      PAS_9; PAS domain
    7. NM_001414112.1 → NP_001401021.1  phosphodiesterase 8, isoform R [Drosophila melanogaster]

      Status: REVIEWED

    8. NM_001414111.1 → NP_001401020.1  phosphodiesterase 8, isoform Q [Drosophila melanogaster]

      Status: REVIEWED

    9. NM_166618.3 → NP_726352.1  phosphodiesterase 8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726352.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NNF2
      Related
      FBpp0310591
      Conserved Domains (3) summary
      cd00130
      Location:313 → 393
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:629 → 870
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:317 → 393
      PAS_9; PAS domain
    10. NM_166617.2 → NP_726351.1  phosphodiesterase 8, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726351.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MLR1
      Related
      FBpp0310589
      Conserved Domains (3) summary
      cd00130
      Location:214 → 294
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:530 → 771
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:218 → 294
      PAS_9; PAS domain
    11. NM_001169804.2 → NP_001163275.2  phosphodiesterase 8, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163275.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NNF2
      Conserved Domains (3) summary
      cd00130
      Location:459 → 539
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:775 → 1016
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:463 → 539
      PAS_9; PAS domain
    12. NM_166619.2 → NP_726353.1  phosphodiesterase 8, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726353.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NNF2
      Related
      FBpp0310588
      Conserved Domains (1) summary
      pfam00233
      Location:125 → 366
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
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