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Conserved domains on  [gi|85726455|ref|NP_611814|]
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phosphodiesterase 8, isoform E [Drosophila melanogaster]

Protein Classification

PAS and HDc domain-containing protein( domain architecture ID 12140958)

PAS and HDc domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
630-871 1.67e-83

3'5'-cyclic nucleotide phosphodiesterase;


:

Pssm-ID: 459723  Cd Length: 238  Bit Score: 267.88  E-value: 1.67e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455   630 YHNSTHAADVMQATGAFITQLTNKDMLvmDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAI 709
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVL--TDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCAT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455   710 TFKLtLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDhNPQTDEETSILMRRMLIKVA 789
Cdd:pfam00233  79 AFQI-LQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLD-FLENEEDRRLLLLSMLIKAA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455   790 DVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPiVMPMFDR-ATCSIPKSQIGFIEYIIQDMMHAWESFIdmPQLIT 868
Cdd:pfam00233 157 DISNPTRPWEISKKWADLVAEEFFRQGDLEKELGLP-VSPLMDReKKTSLPKSQIGFIDFIVLPLFEALAKLF--PELQP 233

                  ...
gi 85726455   869 YMQ 871
Cdd:pfam00233 234 LLD 236
NtrB super family cl34682
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
310-403 2.19e-07

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG3852:

Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 54.08  E-value: 2.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455 310 MSTQQALY-TALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSD------LSTISEQCKNIKEFDg 382
Cdd:COG3852   2 LRESEELLrAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDsplrelLERALAEGQPVTERE- 80
                        90       100
                ....*....|....*....|.
gi 85726455 383 iLTVRRKSQEGIPMHVRVVPV 403
Cdd:COG3852  81 -VTLRRKDGEERPVDVSVSPL 100
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
630-871 1.67e-83

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 267.88  E-value: 1.67e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455   630 YHNSTHAADVMQATGAFITQLTNKDMLvmDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAI 709
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVL--TDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCAT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455   710 TFKLtLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDhNPQTDEETSILMRRMLIKVA 789
Cdd:pfam00233  79 AFQI-LQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLD-FLENEEDRRLLLLSMLIKAA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455   790 DVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPiVMPMFDR-ATCSIPKSQIGFIEYIIQDMMHAWESFIdmPQLIT 868
Cdd:pfam00233 157 DISNPTRPWEISKKWADLVAEEFFRQGDLEKELGLP-VSPLMDReKKTSLPKSQIGFIDFIVLPLFEALAKLF--PELQP 233

                  ...
gi 85726455   869 YMQ 871
Cdd:pfam00233 234 LLD 236
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
310-403 2.19e-07

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 54.08  E-value: 2.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455 310 MSTQQALY-TALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSD------LSTISEQCKNIKEFDg 382
Cdd:COG3852   2 LRESEELLrAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDsplrelLERALAEGQPVTERE- 80
                        90       100
                ....*....|....*....|.
gi 85726455 383 iLTVRRKSQEGIPMHVRVVPV 403
Cdd:COG3852  81 -VTLRRKDGEERPVDVSVSPL 100
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
335-403 4.79e-05

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 42.83  E-value: 4.79e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 85726455   335 RIQYANRATERLLNMRLDEIISKQLEDIFV--SDLSTISEQCKNIK-EFDGILTVRRKSQEGIPMHVRVVPV 403
Cdd:pfam13426   3 RIIYVNDAALRLLGYTREELLGKSITDLFAepEDSERLREALREGKaVREFEVVLYRKDGEPFPVLVSLAPI 74
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
673-813 5.05e-05

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 44.25  E-value: 5.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455 673 HDVDHPGRSSAFlcnsndalavlYNDLTVLENHHAAITFKLtlgddkinifknLDKETYKSARSTIIDMILATEMtRHFE 752
Cdd:cd00077  38 HDIGKPGTPDAI-----------TEEESELEKDHAIVGAEI------------LRELLLEEVIKLIDELILAVDA-SHHE 93
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 85726455 753 HLAKfvsvFGGEEPRDHNPQTDEEtsilmrrMLIKVADVSNPARPMQF--CIEWARRIAEEYF 813
Cdd:cd00077  94 RLDG----LGYPDGLKGEEITLEA-------RIVKLADRLDALRRDSRekRRRIAEEDLEELL 145
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
323-403 2.84e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 41.08  E-value: 2.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455 323 LKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFV-SDLSTISEQCKN----IKEFDGILTVRRKSQEGIPMH 397
Cdd:cd00130   1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHpEDREELRERLENllsgGEPVTLEVRLRRKDGSVIWVL 80

                ....*.
gi 85726455 398 VRVVPV 403
Cdd:cd00130  81 VSLTPI 86
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
630-871 1.67e-83

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 267.88  E-value: 1.67e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455   630 YHNSTHAADVMQATGAFITQLTNKDMLvmDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAI 709
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVL--TDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCAT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455   710 TFKLtLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDhNPQTDEETSILMRRMLIKVA 789
Cdd:pfam00233  79 AFQI-LQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLD-FLENEEDRRLLLLSMLIKAA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455   790 DVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPiVMPMFDR-ATCSIPKSQIGFIEYIIQDMMHAWESFIdmPQLIT 868
Cdd:pfam00233 157 DISNPTRPWEISKKWADLVAEEFFRQGDLEKELGLP-VSPLMDReKKTSLPKSQIGFIDFIVLPLFEALAKLF--PELQP 233

                  ...
gi 85726455   869 YMQ 871
Cdd:pfam00233 234 LLD 236
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
310-403 2.19e-07

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 54.08  E-value: 2.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455 310 MSTQQALY-TALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSD------LSTISEQCKNIKEFDg 382
Cdd:COG3852   2 LRESEELLrAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDsplrelLERALAEGQPVTERE- 80
                        90       100
                ....*....|....*....|.
gi 85726455 383 iLTVRRKSQEGIPMHVRVVPV 403
Cdd:COG3852  81 -VTLRRKDGEERPVDVSVSPL 100
PAS COG2202
PAS domain [Signal transduction mechanisms];
313-403 3.93e-05

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 46.17  E-value: 3.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455 313 QQALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFVSD-----LSTISEQCKNIKEFDGILTVR 387
Cdd:COG2202  10 ERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEdddefLELLRAALAGGGVWRGELRNR 89
                        90
                ....*....|....*.
gi 85726455 388 RKSQEGIPMHVRVVPV 403
Cdd:COG2202  90 RKDGSLFWVELSISPV 105
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
335-403 4.79e-05

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 42.83  E-value: 4.79e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 85726455   335 RIQYANRATERLLNMRLDEIISKQLEDIFV--SDLSTISEQCKNIK-EFDGILTVRRKSQEGIPMHVRVVPV 403
Cdd:pfam13426   3 RIIYVNDAALRLLGYTREELLGKSITDLFAepEDSERLREALREGKaVREFEVVLYRKDGEPFPVLVSLAPI 74
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
673-813 5.05e-05

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 44.25  E-value: 5.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455 673 HDVDHPGRSSAFlcnsndalavlYNDLTVLENHHAAITFKLtlgddkinifknLDKETYKSARSTIIDMILATEMtRHFE 752
Cdd:cd00077  38 HDIGKPGTPDAI-----------TEEESELEKDHAIVGAEI------------LRELLLEEVIKLIDELILAVDA-SHHE 93
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 85726455 753 HLAKfvsvFGGEEPRDHNPQTDEEtsilmrrMLIKVADVSNPARPMQF--CIEWARRIAEEYF 813
Cdd:cd00077  94 RLDG----LGYPDGLKGEEITLEA-------RIVKLADRLDALRRDSRekRRRIAEEDLEELL 145
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
327-417 1.16e-04

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 42.40  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455   327 VLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFV----SDLSTISEQCKNIKEFDGILTVRRKSQEG--IPMHVRV 400
Cdd:pfam00989  14 IFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPeeddAEVAELLRQALLQGEESRGFEVSFRVPDGrpRHVEVRA 93
                          90
                  ....*....|....*..
gi 85726455   401 VPVACIGSAPTHLIFNF 417
Cdd:pfam00989  94 SPVRDAGGEILGFLGVL 110
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
323-403 2.84e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 41.08  E-value: 2.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455 323 LKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFV-SDLSTISEQCKN----IKEFDGILTVRRKSQEGIPMH 397
Cdd:cd00130   1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHpEDREELRERLENllsgGEPVTLEVRLRRKDGSVIWVL 80

                ....*.
gi 85726455 398 VRVVPV 403
Cdd:cd00130  81 VSLTPI 86
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
307-403 6.87e-04

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 43.22  E-value: 6.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455 307 HNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIF-VSDLSTISEQCKNIKEFdgilt 385
Cdd:COG3829   4 LELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIpNSPLLEVLKTGKPVTGV----- 78
                        90
                ....*....|....*...
gi 85726455 386 VRRKSQEGIPMHVRVVPV 403
Cdd:COG3829  79 IQKTGGKGKTVIVTAIPI 96
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
327-407 7.29e-03

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 39.95  E-value: 7.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85726455 327 VLITDDLLRIQYANRATERLLNMRLDEIISKQLEDIFvsDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACI 406
Cdd:COG5000 103 VIVLDADGRITLANPAAERLLGIPLEELIGKPLEELL--PELDLAELLREALERGWQEEIELTRDGRRTLLVRASPLRDD 180

                .
gi 85726455 407 G 407
Cdd:COG5000 181 G 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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