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    TOC34 translocon at the outer envelope membrane of chloroplasts 34 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830382, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TOC34
    Official Full Name
    translocon at the outer envelope membrane of chloroplasts 34
    Primary source
    TAIR:AT5G05000
    Locus tag
    AT5G05000
    See related
    Araport:AT5G05000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA TRANSLOCON AT THE OUTER ENVELOPE MEMBRANE OF CHLOROPLASTS 34; ATTOC34; MUG13.14; MUG13_14; OEP34; translocon at the outer envelope membrane of chloroplasts 34
    Summary
    Outer membrane GTPase protein that may function in import of nuclear encoded proteins into the chloroplast. Phosphorylation of the G-domains regulate translocon assembly.
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    Genomic context

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    See TOC34 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (1474027..1476434, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily Neighboring gene DNAse I-like superfamily protein Neighboring gene SAD1/UNC-84 domain protein 1 Neighboring gene clathrin adaptor complexes medium subunit family protein Neighboring gene Pollen Ole e 1 allergen and extensin family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel chloroplastic outer membrane-targeting signal that functions at both termini of passenger polypeptides. Li Hm, et al. J Biol Chem, 1997 Apr 18. PMID 9099756
    2. Insertion of atToc34 into the chloroplastic outer membrane is assisted by at least two proteinaceous components in the import system. Tsai LY, et al. J Biol Chem, 1999 Jun 25. PMID 10373488
    3. An Arabidopsis mutant defective in the plastid general protein import apparatus. Jarvis P, et al. Science, 1998 Oct 2. PMID 9756470
    4. Phosphorylation regulates the assembly of chloroplast import machinery. Oreb M, et al. J Exp Bot, 2008. PMID 18487635, Free PMC Article
    5. The GTPase cycle of the chloroplast import receptors Toc33/Toc34: implications from monomeric and dimeric structures. Koenig P, et al. Structure, 2008 Apr. PMID 18400179

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Toc33-R130A mutation reduces homodimerization and affects the interaction of Toc33 with Toc159 during protein import into chloroplasts.
      Title: Toc receptor dimerization participates in the initiation of membrane translocation during protein import into chloroplasts.
    2. analysis of Arabidopsis Toc33, Toc34, and Toc159-GTPase homodimers
      Title: On the significance of Toc-GTPase homodimers.
    3. Phosphorylation disturbs the association of Toc34, but not of Toc159 with the translocation pore proteins.
      Title: Phosphorylation regulates the assembly of chloroplast import machinery.
    4. Embryo development in the atToc33/34 mutants proceeded slowly and was arrested at the transition to the globular stage.
      Title: Deletion of core components of the plastid protein import machinery causes differential arrest of embryo development in Arabidopsis thaliana.
    5. By combining these models with the measured enzymatic properties of the Toc GTPases, we provide new insights of how the chloroplast protein import cycle may be regulated
      Title: In vitro comparative kinetic analysis of the chloroplast Toc GTPases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_120582.5
    NM_180437.2
    NM_203003.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTP binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-transporting ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein targeting to chloroplast TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast outer membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in intracellular anatomical structure TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    translocon at the outer envelope membrane of chloroplasts 34
    NP_196119.1
    • translocon at the outer envelope membrane of chloroplasts 34 (TOC34); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: protein targeting to chloroplast, chloroplast localization; LOCATED IN: chloroplast outer membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: AIG1 (InterPro:IPR006703), Chloroplast protein import component Toc34 (InterPro:IPR005688); BEST Arabidopsis thaliana protein match is: translocon at the outer envelope membrane of chloroplasts 33 (TAIR:AT1G02280.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_850768.1
    • translocon at the outer envelope membrane of chloroplasts 34 (TOC34); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: protein targeting to chloroplast, chloroplast localization; LOCATED IN: chloroplast outer membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: AIG1 (InterPro:IPR006703), Chloroplast protein import component Toc34 (InterPro:IPR005688); BEST Arabidopsis thaliana protein match is: translocon at the outer envelope membrane of chloroplasts 33 (TAIR:AT1G02280.2); Has 1080 Blast hits to 1073 proteins in 236 species: Archae - 0; Bacteria - 349; Metazoa - 327; Fungi - 8; Plants - 333; Viruses - 0; Other Eukaryotes - 63 (source: NCBI BLink).
    NP_974732.1
    • translocon at the outer envelope membrane of chloroplasts 34 (TOC34); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: protein targeting to chloroplast, chloroplast localization; LOCATED IN: chloroplast outer membrane, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: AIG1 (InterPro:IPR006703), Chloroplast protein import component Toc34 (InterPro:IPR005688); BEST Arabidopsis thaliana protein match is: translocon at the outer envelope membrane of chloroplasts 33 (TAIR:AT1G02280.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1474027..1476434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120582.5 → NP_196119.1  translocon at the outer envelope membrane of chloroplasts 34 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196119.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNL4, Q38906, Q8L9G5, Q9FF74, Q9GDD2
      UniProtKB/TrEMBL
      A0A178UIF8, A0A384KNY4, A0A5S9Y2B5, B5RID3
      Conserved Domains (1) summary
      TIGR00991
      Location:1 → 313
      3a0901s02IAP34; GTP-binding protein (Chloroplast Envelope Protein Translocase)

    2. NM_203003.3 → NP_974732.1  translocon at the outer envelope membrane of chloroplasts 34 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974732.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNL4, Q38906, Q8L9G5, Q9FF74, Q9GDD2
      UniProtKB/TrEMBL
      A0A178UIF8, A0A384KNY4, A0A5S9Y2B5, B5RID3
      Conserved Domains (1) summary
      TIGR00991
      Location:1 → 313
      3a0901s02IAP34; GTP-binding protein (Chloroplast Envelope Protein Translocase)

    3. NM_180437.2 → NP_850768.1  translocon at the outer envelope membrane of chloroplasts 34 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850768.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNL4, Q38906, Q8L9G5, Q9FF74, Q9GDD2
      UniProtKB/TrEMBL
      A0A178UIF8, A0A384KNY4, A0A5S9Y2B5, B5RID3
      Conserved Domains (1) summary
      TIGR00991
      Location:1 → 313
      3a0901s02IAP34; GTP-binding protein (Chloroplast Envelope Protein Translocase)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38906.2

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