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Conserved domains on  [gi|30680751|ref|NP_850768|]
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translocon at the outer envelope membrane of chloroplasts 34 [Arabidopsis thaliana]

Protein Classification

ABC transporter ATP-binding protein; betaine/proline/choline family ABC transporter ATP-binding protein( domain architecture ID 10795612)

ABC transporter ATP-binding protein is the ATPase catalytic subunit of an ATP transporter complex responsible for coupling the energy of ATP hydrolysis to the import of one or more from a variety of substrates| betaine/proline/choline family ABC transporter ATP-binding protein with two tandem repeats of the cystathionine beta-synthase (CBS pair) domain, is the ATPase catalytic subunit of an ATP transporter complex responsible for coupling the energy of ATP hydrolysis to the import of one or more from a variety of substrates

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
1-313 0e+00

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


:

Pssm-ID: 130064  Cd Length: 313  Bit Score: 628.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751     1 MAALQTLREWIGIQQFPPATQSKLLEILGKYKEEDVSSLTVLVMGKGGVGKSSTVNSVIGEKAAAVSTFQSEGLRPTLVS 80
Cdd:TIGR00991   1 MASPQTPREWVGIQQFPPATQTKLLELLGKLKEEDVSSLTILVMGKGGVGKSSTVNSIIGERIATVSAFQSEGLRPMMVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751    81 RTRSGFTLNIIDTPGLIEGGYVNDQAINIIKRFLLNMTIDVLLYVDRLDVYRVDDLDRQVVGAITDAFGKEIWKKSALVL 160
Cdd:TIGR00991  81 RTRAGFTLNIIDTPGLIEGGYINDQAVNIIKRFLLGKTIDVLLYVDRLDAYRVDTLDGQVIRAITDSFGKDIWRKSLVVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751   161 THAQFSPPDGLNYNHFVSKRSNALLKVIQTGAQLKKQDLQGFSIPVILVENSGRCHKNESDEKILPCGTSWIPNLFNKIT 240
Cdd:TIGR00991 161 THAQFSPPDGLEYNDFFSKRSEALLRVIHSGAGLKKRDYQDFPIPVALVENSGRCKKNESDEKILPDGTPWIPKLMKEIT 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30680751   241 EISFNGNKAIHVDKKLVEGPNPNERGKKLIPLMFAFQYLLVMKPLVRAIKSDVSRESKPAWELRDSGLASRRS 313
Cdd:TIGR00991 241 EVISNGSKPIHVDKKLIDGPNPNNRGKMFIPLIFAVQYLLVVKPIRRAIHADIANEKKDAWEQRDRGLVNRKA 313
 
Name Accession Description Interval E-value
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
1-313 0e+00

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 628.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751     1 MAALQTLREWIGIQQFPPATQSKLLEILGKYKEEDVSSLTVLVMGKGGVGKSSTVNSVIGEKAAAVSTFQSEGLRPTLVS 80
Cdd:TIGR00991   1 MASPQTPREWVGIQQFPPATQTKLLELLGKLKEEDVSSLTILVMGKGGVGKSSTVNSIIGERIATVSAFQSEGLRPMMVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751    81 RTRSGFTLNIIDTPGLIEGGYVNDQAINIIKRFLLNMTIDVLLYVDRLDVYRVDDLDRQVVGAITDAFGKEIWKKSALVL 160
Cdd:TIGR00991  81 RTRAGFTLNIIDTPGLIEGGYINDQAVNIIKRFLLGKTIDVLLYVDRLDAYRVDTLDGQVIRAITDSFGKDIWRKSLVVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751   161 THAQFSPPDGLNYNHFVSKRSNALLKVIQTGAQLKKQDLQGFSIPVILVENSGRCHKNESDEKILPCGTSWIPNLFNKIT 240
Cdd:TIGR00991 161 THAQFSPPDGLEYNDFFSKRSEALLRVIHSGAGLKKRDYQDFPIPVALVENSGRCKKNESDEKILPDGTPWIPKLMKEIT 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30680751   241 EISFNGNKAIHVDKKLVEGPNPNERGKKLIPLMFAFQYLLVMKPLVRAIKSDVSRESKPAWELRDSGLASRRS 313
Cdd:TIGR00991 241 EVISNGSKPIHVDKKLIDGPNPNNRGKMFIPLIFAVQYLLVVKPIRRAIHADIANEKKDAWEQRDRGLVNRKA 313
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
8-253 1.89e-123

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 353.55  E-value: 1.89e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751   8 REWIGIQQFPPATQSKLLEILGKYKEEDVSSLTVLVMGKGGVGKSSTVNSVIGEKAAAVSTFQSEGLRPTLVSRTRSGFT 87
Cdd:cd01853   1 REWVGFQFFPDATQTKLHELEAKLKKELDFSLTILVLGKTGVGKSSTINSIFGERKVSVSAFQSETLRPREVSRTVDGFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751  88 LNIIDTPGLIEG--GYVNDQAINIIKRFLLNMTIDVLLYVDRLDVYRVDDLDRQVVGAITDAFGKEIWKKSALVLTHAQF 165
Cdd:cd01853  81 LNIIDTPGLLESqdQRVNRKILSIIKRFLKKKTIDVVLYVDRLDMYRVDNLDVPLLRAITDSFGPSIWRNAIVVLTHAQS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751 166 SPPDGLNYNHFVSKRSNALLKVIQTGAQLKKQDLQGFSIPVILVENSGRCHKNESDEKILPCGTSWIPNLFNKITEISFN 245
Cdd:cd01853 161 SPPDGPNGTPFSYDRFVAQRKHIVQQAIQQAAGDPDLENPVVLVENSPRCKKNRQGEKVLPNGTVWLPQLLLLCTSVKLL 240

                ....*...
gi 30680751 246 GNKAIHVD 253
Cdd:cd01853 241 SEANILLD 248
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
39-233 5.99e-60

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 190.13  E-value: 5.99e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751    39 LTVLVMGKGGVGKSSTVNSVIGEKAaavstFQSEG------LRPTLVSRTRSGFTLNIIDTPGLIEGGYVNDQAIN-IIK 111
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKA-----FESKLraqgvtKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKeIIR 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751   112 RFLLNMT-IDVLLYVdrLDVYRVDDLDRQVVGAITDAFGKEIWKKSALVLTHAQFSPPDGLnyNHFVSKRSN-ALLKVIQ 189
Cdd:pfam04548  76 CLLLAEPgPHAVLLV--LSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSL--DDYLSDGCPeFLKEVLR 151
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 30680751   190 TGAQLKKQD-LQGF--SIPVILVENSGRCHKNESDEKILPCGTSWIP 233
Cdd:pfam04548 152 TADGEEKEEqVQQLlaLVEAIVKENGGKPYTNDLYEKIKEEGERLRE 198
YeeP COG3596
Predicted GTPase [General function prediction only];
13-209 2.35e-13

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 69.41  E-value: 2.35e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751  13 IQQFPPATQSKLLEILGKYKEEDvSSLTVLVMGKGGVGKSSTVNSVIGEKAAAVS------------TFQSEGLRptlvs 80
Cdd:COG3596  15 LKRLPQVLRELLAEALERLLVEL-PPPVIALVGKTGAGKSSLINALFGAEVAEVGvgrpctreiqryRLESDGLP----- 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751  81 rtrsgfTLNIIDTPGLIEGGYvNDQAINIIKRFLLNmtIDVLLYV-DRLDVYRvdDLDRQVVGAITDAFGKeiwKKSALV 159
Cdd:COG3596  89 ------GLVLLDTPGLGEVNE-RDREYRELRELLPE--ADLILWVvKADDRAL--ATDEEFLQALRAQYPD---PPVLVV 154
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 30680751 160 LTHAQFSPPdGLNYNHFVSKRSNALLKVIQTGAQLKKQDLQGFSIPVILV 209
Cdd:COG3596 155 LTQVDRLEP-EREWDPPYNWPSPPKEQNIRRALEAIAEQLGVPIDRVIPV 203
PRK01889 PRK01889
GTPase RsgA; Reviewed
40-98 8.04e-05

GTPase RsgA; Reviewed


Pssm-ID: 234988 [Multi-domain]  Cd Length: 356  Bit Score: 43.77  E-value: 8.04e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30680751   40 TVLVMGKGGVGKSSTVNSVIGEKAAAVSTFQ---SEGlRPTLVSR----TRSGFTLniIDTPGLIE 98
Cdd:PRK01889 197 TVALLGSSGVGKSTLVNALLGEEVQKTGAVReddSKG-RHTTTHRelhpLPSGGLL--IDTPGMRE 259
 
Name Accession Description Interval E-value
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
1-313 0e+00

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 628.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751     1 MAALQTLREWIGIQQFPPATQSKLLEILGKYKEEDVSSLTVLVMGKGGVGKSSTVNSVIGEKAAAVSTFQSEGLRPTLVS 80
Cdd:TIGR00991   1 MASPQTPREWVGIQQFPPATQTKLLELLGKLKEEDVSSLTILVMGKGGVGKSSTVNSIIGERIATVSAFQSEGLRPMMVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751    81 RTRSGFTLNIIDTPGLIEGGYVNDQAINIIKRFLLNMTIDVLLYVDRLDVYRVDDLDRQVVGAITDAFGKEIWKKSALVL 160
Cdd:TIGR00991  81 RTRAGFTLNIIDTPGLIEGGYINDQAVNIIKRFLLGKTIDVLLYVDRLDAYRVDTLDGQVIRAITDSFGKDIWRKSLVVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751   161 THAQFSPPDGLNYNHFVSKRSNALLKVIQTGAQLKKQDLQGFSIPVILVENSGRCHKNESDEKILPCGTSWIPNLFNKIT 240
Cdd:TIGR00991 161 THAQFSPPDGLEYNDFFSKRSEALLRVIHSGAGLKKRDYQDFPIPVALVENSGRCKKNESDEKILPDGTPWIPKLMKEIT 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30680751   241 EISFNGNKAIHVDKKLVEGPNPNERGKKLIPLMFAFQYLLVMKPLVRAIKSDVSRESKPAWELRDSGLASRRS 313
Cdd:TIGR00991 241 EVISNGSKPIHVDKKLIDGPNPNNRGKMFIPLIFAVQYLLVVKPIRRAIHADIANEKKDAWEQRDRGLVNRKA 313
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
8-253 1.89e-123

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 353.55  E-value: 1.89e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751   8 REWIGIQQFPPATQSKLLEILGKYKEEDVSSLTVLVMGKGGVGKSSTVNSVIGEKAAAVSTFQSEGLRPTLVSRTRSGFT 87
Cdd:cd01853   1 REWVGFQFFPDATQTKLHELEAKLKKELDFSLTILVLGKTGVGKSSTINSIFGERKVSVSAFQSETLRPREVSRTVDGFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751  88 LNIIDTPGLIEG--GYVNDQAINIIKRFLLNMTIDVLLYVDRLDVYRVDDLDRQVVGAITDAFGKEIWKKSALVLTHAQF 165
Cdd:cd01853  81 LNIIDTPGLLESqdQRVNRKILSIIKRFLKKKTIDVVLYVDRLDMYRVDNLDVPLLRAITDSFGPSIWRNAIVVLTHAQS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751 166 SPPDGLNYNHFVSKRSNALLKVIQTGAQLKKQDLQGFSIPVILVENSGRCHKNESDEKILPCGTSWIPNLFNKITEISFN 245
Cdd:cd01853 161 SPPDGPNGTPFSYDRFVAQRKHIVQQAIQQAAGDPDLENPVVLVENSPRCKKNRQGEKVLPNGTVWLPQLLLLCTSVKLL 240

                ....*...
gi 30680751 246 GNKAIHVD 253
Cdd:cd01853 241 SEANILLD 248
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
39-233 5.99e-60

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 190.13  E-value: 5.99e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751    39 LTVLVMGKGGVGKSSTVNSVIGEKAaavstFQSEG------LRPTLVSRTRSGFTLNIIDTPGLIEGGYVNDQAIN-IIK 111
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKA-----FESKLraqgvtKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKeIIR 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751   112 RFLLNMT-IDVLLYVdrLDVYRVDDLDRQVVGAITDAFGKEIWKKSALVLTHAQFSPPDGLnyNHFVSKRSN-ALLKVIQ 189
Cdd:pfam04548  76 CLLLAEPgPHAVLLV--LSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSL--DDYLSDGCPeFLKEVLR 151
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 30680751   190 TGAQLKKQD-LQGF--SIPVILVENSGRCHKNESDEKILPCGTSWIP 233
Cdd:pfam04548 152 TADGEEKEEqVQQLlaLVEAIVKENGGKPYTNDLYEKIKEEGERLRE 198
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
32-236 7.66e-41

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 151.26  E-value: 7.66e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751    32 KEEDVSSLTVLVMGKGGVGKSSTVNSVIGEKAAAVSTFQSEGLRPTLVSRTRSGFTLNIIDTPGLIEGGY---VNDQAIN 108
Cdd:TIGR00993 112 QDPLDFSLNILVLGKSGVGKSATINSIFGEVKFSTDAFGMGTTSVQEIEGLVQGVKIRVIDTPGLKSSASdqsKNEKILS 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751   109 IIKRFLLNMTIDVLLYVDRLDVYRVDDLDRQVVGAITDAFGKEIWKKSALVLTHAQFSPPDG-----LNYNHFVSKRSNA 183
Cdd:TIGR00993 192 SVKKFIKKNPPDIVLYVDRLDMQTRDSNDLPLLRTITDVLGPSIWFNAIVTLTHAASAPPDGpngtpLSYDVFVAQRSHI 271
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 30680751   184 LLKVI-QTGAQLKKQDLQGFSiPVILVENSGRCHKNESDEKILPCGTSWIPNLF 236
Cdd:TIGR00993 272 VQQAIgQAVGDLRLMNPNLMN-PVSLVENHPACRKNRAGQKVLPNGQVWKPHLL 324
YeeP COG3596
Predicted GTPase [General function prediction only];
13-209 2.35e-13

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 69.41  E-value: 2.35e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751  13 IQQFPPATQSKLLEILGKYKEEDvSSLTVLVMGKGGVGKSSTVNSVIGEKAAAVS------------TFQSEGLRptlvs 80
Cdd:COG3596  15 LKRLPQVLRELLAEALERLLVEL-PPPVIALVGKTGAGKSSLINALFGAEVAEVGvgrpctreiqryRLESDGLP----- 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751  81 rtrsgfTLNIIDTPGLIEGGYvNDQAINIIKRFLLNmtIDVLLYV-DRLDVYRvdDLDRQVVGAITDAFGKeiwKKSALV 159
Cdd:COG3596  89 ------GLVLLDTPGLGEVNE-RDREYRELRELLPE--ADLILWVvKADDRAL--ATDEEFLQALRAQYPD---PPVLVV 154
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 30680751 160 LTHAQFSPPdGLNYNHFVSKRSNALLKVIQTGAQLKKQDLQGFSIPVILV 209
Cdd:COG3596 155 LTQVDRLEP-EREWDPPYNWPSPPKEQNIRRALEAIAEQLGVPIDRVIPV 203
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
39-163 1.07e-11

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 62.94  E-value: 1.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751  39 LTVLVMGKGGVGKSSTVNSVIGEKAaavstFQSeGLRPTLV-------SRTRSGFTLNIIDTPGLIEGGYVNDQAINIIK 111
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKV-----FES-KLSASGVtktcqkeSAVWDGRRVNVIDTPGLFDTSVSPEQLSKEII 74
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 30680751 112 RfLLNMT---IDVLLYVDRLDvyRVDDLDRQVVGAITDAFGKEIWKKSALVLTHA 163
Cdd:cd01852  75 R-CLSLSapgPHAFLLVVPLG--RFTEEEEQAVEELQELFGEKVLDHTIVLFTRG 126
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
42-163 4.87e-10

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 57.47  E-value: 4.87e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751  42 LVMGKGGVGKSSTVNSVIGEKAAAVSTFQSEGLRPTLVSRT--RSGFTLNIIDTPGLIEGGYVNDQAinIIKRFLlnMTI 119
Cdd:cd00882   1 VVVGRGGVGKSSLLNALLGGEVGEVSDVPGTTRDPDVYVKEldKGKVKLVLVDTPGLDEFGGLGREE--LARLLL--RGA 76
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 30680751 120 DVLLYVDRLDVYRVDDLDRQVVGAITDAFGKEIwkksALVLTHA 163
Cdd:cd00882  77 DLILLVVDSTDRESEEDAKLLILRRLRKEGIPI----ILVGNKI 116
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
40-161 2.27e-09

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 54.16  E-value: 2.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751    40 TVLVMGKGGVGKSSTVNSVIGEKAAaVSTFQSEGLRPTLVSRTRSGFTLNIIDTPGLIEGgyvNDQAINIIKRFLLNMTI 119
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKAI-VSDYPGTTRDPNEGRLELKGKQIILVDTPGLIEG---ASEGEGLGRAFLAIIEA 76
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 30680751   120 DVLLYV-DRLDVYrvDDLDRQVVgaitdAFGKEIWKKSALVLT 161
Cdd:pfam01926  77 DLILFVvDSEEGI--TPLDEELL-----ELLRENKKPIILVLN 112
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
43-135 3.02e-06

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 46.47  E-value: 3.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751  43 VMGKGGVGKSSTVNSVIGEKAAAVSTFQSEGLRPTLVS-RTRSGFTLNIIDTPGLIEGGYV----NDQAINIIKRfllnm 117
Cdd:cd00880   2 IFGRPNVGKSSLLNALLGQNVGIVSPIPGTTRDPVRKEwELLPLGPVVLIDTPGLDEEGGLgrerVEEARQVADR----- 76
                        90
                ....*....|....*...
gi 30680751 118 tIDVLLYVDRLDVYRVDD 135
Cdd:cd00880  77 -ADLVLLVVDSDLTPVEE 93
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
41-165 1.90e-05

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 44.28  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751    41 VLVMGKGGVGKSSTVNSVIGEKAAAVST--FQSEGLRPTLVSRTRSGFTLNIIDTPGLIEGGYVNDQAINIIKRFLlnMT 118
Cdd:TIGR00231   4 IVIVGHPNVGKSTLLNSLLGNKGSITEYypGTTRNYVTTVIEEDGKTYKFNLLDTAGQEDYDAIRRLYYPQVERSL--RV 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 30680751   119 IDVLLYVDRL------DVYRVDDLDRQVVGAITdaFGKEIWKKSALVLTHAQF 165
Cdd:TIGR00231  82 FDIVILVLDVeeilekQTKEIIHHADSGVPIIL--VGNKIDLKDADLKTHVAS 132
PRK01889 PRK01889
GTPase RsgA; Reviewed
40-98 8.04e-05

GTPase RsgA; Reviewed


Pssm-ID: 234988 [Multi-domain]  Cd Length: 356  Bit Score: 43.77  E-value: 8.04e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30680751   40 TVLVMGKGGVGKSSTVNSVIGEKAAAVSTFQ---SEGlRPTLVSR----TRSGFTLniIDTPGLIE 98
Cdd:PRK01889 197 TVALLGSSGVGKSTLVNALLGEEVQKTGAVReddSKG-RHTTTHRelhpLPSGGLL--IDTPGMRE 259
CDC3 COG5019
Septin family protein [Cell cycle control, cell division, chromosome partitioning, ...
39-114 1.16e-04

Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 227352 [Multi-domain]  Cd Length: 373  Bit Score: 43.47  E-value: 1.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751  39 LTVLVMGKGGVGKSSTVNSVIG---EKAAAVSTFQSEGLRPTLVSRTRS------GF--TLNIIDTPGLIEgGYVNDQAI 107
Cdd:COG5019  24 FTIMVVGESGLGKTTFINTLFGtslVDETEIDDIRAEGTSPTLEIKITKaeleedGFhlNLTVIDTPGFGD-FIDNSKCW 102

                ....*..
gi 30680751 108 NIIKRFL 114
Cdd:COG5019 103 EPIVDYI 109
YlqF_related_GTPase cd01849
Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, ...
30-96 2.09e-04

Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, and archaea. They all exhibit a circular permutation of the GTPase signature motifs so that the order of the conserved G box motifs is G4-G5-G1-G2-G3, with G4 and G5 being permuted from the C-terminal region of proteins in the Ras superfamily to the N-terminus of YlqF-related GTPases.


Pssm-ID: 206746 [Multi-domain]  Cd Length: 146  Bit Score: 40.83  E-value: 2.09e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30680751  30 KYKEEDVSSLTVLVMGKGGVGKSSTVNSVIGEKAAAVSTFQSEGLRPTLVsrtRSGFTLNIIDTPGL 96
Cdd:cd01849  83 KLKLKYKKGIRVGVVGLPNVGKSSFINALLNKFKLKVGSIPGTTKLQQDV---KLDKEIYLYDTPGI 146
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
38-98 4.36e-04

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 40.35  E-value: 4.36e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30680751  38 SLTVLVMGKGGVGKSSTVNSVIGEKaaaVSTFQSEGLRPTLVSRTR-----SGFTLNIIDTPGLIE 98
Cdd:COG1100   3 EKKIVVVGTGGVGKTSLVNRLVGDI---FSLEKYLSTNGVTIDKKElkldgLDVDLVIWDTPGQDE 65
YfjP cd11383
YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several ...
42-125 5.75e-04

YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several uncharacterized bacterial GTPases that are similar to Era. They generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain.


Pssm-ID: 206743 [Multi-domain]  Cd Length: 140  Bit Score: 39.63  E-value: 5.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751  42 LVMGKGGVGKSSTVNSVIGEKAAAVStfqseGLRPTLVSRTR-----SGFTLNIIDTPGlIEGGYVNDQAINIIKRFLLN 116
Cdd:cd11383   1 GLMGKTGAGKSSLCNALFGTEVAAVG-----DRRPTTRAAQAyvwqtGGDGLVLLDLPG-VGERGRRDREYEELYRRLLP 74

                ....*....
gi 30680751 117 MtIDVLLYV 125
Cdd:cd11383  75 E-ADLVLWL 82
TIGR00157 TIGR00157
ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and ...
20-113 7.12e-04

ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and are now designated RsgA (ribosome small subunit-dependent GTPase A). The strongest motif in the alignment of these proteins is GXSGVGKS[ST], a classic P-loop for nucleotide binding. This protein has been shown to cleave GTP and remain bound to GDP. A role as a regulator of translation has been suggested. The Aquifex aeolicus ortholog is split into consecutive open reading frames. Consequently, this model was build in fragment mode (-f option). [Protein synthesis, Translation factors]


Pssm-ID: 272934 [Multi-domain]  Cd Length: 245  Bit Score: 40.48  E-value: 7.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680751    20 TQSKLLEILGKYKEEDVSSLTVLvMGKGGVGKSSTVN---SVIGEKAAAVSTFQSEGLRPTLVSR---TRSGFtlnIIDT 93
Cdd:TIGR00157 103 TSSKNQDGLKELIEALQNRISVF-AGQSGVGKSSLINaldPSVKQQVNDISSKLGLGKHTTTHVElfhFHGGL---IADT 178
                          90       100
                  ....*....|....*....|
gi 30680751    94 PGLIEGGYVNDQAINIIKRF 113
Cdd:TIGR00157 179 PGFNEFGLWHLEPEQLTQGF 198
YjeQ_EngC cd01854
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; ...
40-95 3.01e-03

Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.


Pssm-ID: 206747 [Multi-domain]  Cd Length: 211  Bit Score: 38.15  E-value: 3.01e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30680751  40 TVLVMGKGGVGKSSTVNSVIGE---KAAAVSTFQSEGlRPTlvSRTRSGFTLN----IIDTPG 95
Cdd:cd01854  87 TSVLVGQSGVGKSTLLNALLPElvlATGEISEKLGRG-RHT--TTHRELFPLPggglIIDTPG 146
RsgA_GTPase pfam03193
RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are ...
40-95 3.51e-03

RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of RsgA is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern.


Pssm-ID: 427191 [Multi-domain]  Cd Length: 174  Bit Score: 37.52  E-value: 3.51e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30680751    40 TVLVMGKGGVGKSSTVNSVIGE---KAAAVSTFQSEGlRPTlvSRTRSGFTLN----IIDTPG 95
Cdd:pfam03193 108 TTVLAGQSGVGKSTLLNALLPEldlRTGEISEKLGRG-RHT--TTHVELFPLPggglLIDTPG 167
RsgA COG1162
Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];
40-95 7.80e-03

Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440776 [Multi-domain]  Cd Length: 300  Bit Score: 37.40  E-value: 7.80e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30680751  40 TVLVMGKGGVGKSSTVNSVIGEKAAA---VSTFQSEGlRPTlvSRTRSGFTLN----IIDTPG 95
Cdd:COG1162 168 TSVLVGQSGVGKSTLINALLPDADLAtgeISEKLGRG-RHT--TTHAELYPLPgggwLIDTPG 227
Nucleostemin_like cd04178
A circularly permuted subfamily of the Ras GTPases; Nucleostemin (NS) is a nucleolar protein ...
22-67 8.41e-03

A circularly permuted subfamily of the Ras GTPases; Nucleostemin (NS) is a nucleolar protein that functions as a regulator of cell growth and proliferation in stem cells and in several types of cancer cells, but is not expressed in the differentiated cells of most mammalian adult tissues. NS shuttles between the nucleolus and nucleoplasm bidirectionally at a rate that is fast and independent of cell type. Lowering GTP levels decreases the nucleolar retention of NS, and expression of NS is abruptly down-regulated during differentiation prior to terminal cell division. Found only in eukaryotes, NS consists of an N-terminal basic domain, a coiled-coil domain, a GTP-binding domain, an intermediate domain, and a C-terminal acidic domain. Experimental evidence indicates that NS uses its GTP-binding property as a molecular switch to control the transition between the nucleolus and nucleoplasm, and this process involves interaction between the basic, GTP-binding, and intermediate domains of the protein.


Pssm-ID: 206753 [Multi-domain]  Cd Length: 171  Bit Score: 36.40  E-value: 8.41e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 30680751  22 SKLLEILGKY--KEEDVSSLTVLVMGKGGVGKSSTVNSVIGEKAAAVS 67
Cdd:cd04178  98 DALLKLLKNYarNKGIKTSITVGVVGYPNVGKSSVINSLKRSRACNVG 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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