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    Rictor RPTOR independent companion of MTOR, complex 2 [ Mus musculus (house mouse) ]

    Gene ID: 78757, updated on 17-Dec-2024

    Summary

    Official Symbol
    Rictorprovided by MGI
    Official Full Name
    RPTOR independent companion of MTOR, complex 2provided by MGI
    Primary source
    MGI:MGI:1926007
    See related
    Ensembl:ENSMUSG00000050310 AllianceGenome:MGI:1926007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AVO3; 4921505C17Rik; 6030405M08Rik; D530039E11Rik
    Summary
    Enables ribosome binding activity. Involved in embryo development; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of protein phosphorylation. Acts upstream of or within several processes, including positive regulation of actin filament polymerization; regulation of establishment of cell polarity; and regulation of protein phosphorylation. Part of TORC2 complex. Is expressed in early conceptus; embryo; and oocyte. Human ortholog(s) of this gene implicated in breast ductal carcinoma; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human RICTOR (RPTOR independent companion of MTOR complex 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 3.9), cerebellum adult (RPKM 2.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rictor in Genome Data Viewer
    Location:
    15 A1; 15 3.25 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (6737827..6829882)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (6708349..6800401)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene complement component 9 Neighboring gene STARR-seq mESC enhancer starr_37861 Neighboring gene FYN binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_37865 Neighboring gene predicted gene 2245 Neighboring gene STARR-seq mESC enhancer starr_37866 Neighboring gene prohibitin pseudogene Neighboring gene STARR-seq mESC enhancer starr_37870 Neighboring gene predicted gene, 53882 Neighboring gene oncostatin M receptor Neighboring gene STARR-seq mESC enhancer starr_37871 Neighboring gene STARR-seq mESC enhancer starr_37872 Neighboring gene predicted gene, 41261 Neighboring gene predicted gene, 30559

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables enzyme-substrate adaptor activity  
    enables molecular adaptor activity  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein serine/threonine kinase activator activity  
    enables protein serine/threonine kinase activator activity  
    enables protein serine/threonine kinase activator activity  
    enables ribosome binding PubMed 
    enables zinc ion binding  
    Items 1 - 25 of 33
    Process Evidence Code Pubs
    involved_in TORC2 signaling  
    involved_in TORC2 signaling PubMed 
    involved_in TORC2 signaling PubMed 
    involved_in TORC2 signaling  
    involved_in TORC2 signaling  
    involved_in actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    involved_in cellular response to nutrient levels PubMed 
    involved_in cytoskeleton organization PubMed 
    involved_in embryo development ending in birth or egg hatching PubMed 
    involved_in lipid biosynthetic process PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in peptidyl-serine phosphorylation  
    involved_in positive regulation of TOR signaling  
    involved_in positive regulation of TOR signaling  
    acts_upstream_of_or_within positive regulation of actin filament polymerization PubMed 
    involved_in positive regulation of cell growth PubMed 
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of endothelial cell proliferation  
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within regulation of GTPase activity PubMed 
    involved_in regulation of actin cytoskeleton organization  
    acts_upstream_of_or_within regulation of establishment of cell polarity PubMed 
    acts_upstream_of_or_within regulation of gene expression PubMed 
    acts_upstream_of_or_within regulation of inflammatory response PubMed 
    acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation PubMed 
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in regulation of phosphorylation  
    involved_in regulation of protein phosphorylation PubMed 
    Items 1 - 25 of 33
    Component Evidence Code Pubs
    part_of TORC2 complex  
    part_of TORC2 complex PubMed 
    part_of TORC2 complex PubMed 
    part_of TORC2 complex  
    is_active_in endoplasmic reticulum  
    is_active_in lysosome  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    rapamycin-insensitive companion of mTOR
    Names
    AVO3 homolog
    mAVO3
    protein pianissimo

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030168.3NP_084444.3  rapamycin-insensitive companion of mTOR

      See identical proteins and their annotated locations for NP_084444.3

      Status: VALIDATED

      Source sequence(s)
      AI854883, AK036149, AK173326, BC120903
      Consensus CDS
      CCDS37032.1
      UniProtKB/Swiss-Prot
      E9QPE0, Q0VAV4, Q69Z40, Q6PDL2, Q6QI06, Q6RI74, Q8BPH9, Q8CBF2
      Related
      ENSMUSP00000051809.7, ENSMUST00000061656.8
      Conserved Domains (5) summary
      pfam14663
      Location:747853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:58437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:10841187
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922991
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      6737827..6829882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520003.2XP_006520066.1  rapamycin-insensitive companion of mTOR isoform X1

      Conserved Domains (5) summary
      pfam14663
      Location:747853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:60437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:10851187
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922988
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    2. XM_036159639.1XP_036015532.1  rapamycin-insensitive companion of mTOR isoform X2

      Conserved Domains (5) summary
      pfam14663
      Location:465571
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:14155
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:803905
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:355458
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:640709
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    RNA

    1. XR_004938879.1 RNA Sequence

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