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Conserved domains on  [gi|168480120|ref|NP_084444|]
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rapamycin-insensitive companion of mTOR [Mus musculus]

Protein Classification

RICTOR_N and RICTOR_M domain-containing protein( domain architecture ID 10630570)

protein containing domains RICTOR_N, RICTOR_M, RasGEF_N_2, and RICTOR_phospho

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
RICTOR_N pfam14664
Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding ...
 58-437 2.97e-127

Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the N-terminal conserved section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


:

Pssm-ID: 464246  Cd Length: 372  Bit Score: 402.68  E-value: 2.97e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120    58 GHLNNFTKLLCDigHSEEKLGFNYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQ 137
Cdd:pfam14664    1 EKANDLVDLLKR--HPTLKYDLVLSDFLLRIQPMLLSESKEVRAAGYRILRYLISDEESLQLLRKLHLDIFIIRSLSKDN 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   138 SNEVERTQALRLVRKMITVNA--SLFPSSVANSLIAVGNdglQERDRMVRACIAIICELALQNPEVVALRGGLNTILKNV 215
Cdd:pfam14664   79 KNEVEREQALKLIRAFLEIKDgvSEISRGVVRALVAIAE---HEDDRLRRICLETLCELALLDPELVVRCGGLRVLLDAL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   216 IDcQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDfhyrhspDTAEGQLKEDREARFLASKMGIIATFRSW 295
Cdd:pfam14664  156 LE-GSFELAESLLGALLYLLDSPRTRKYLRPGFDLEVLLSPFTD-------SLDANTKGDSNEERLQASAKAISSLLKSW 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   296 AGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVTDEFIEALLSVdPGRFQDSWRLSDGFVAAEAKT 375
Cdd:pfam14664  228 PGLMYLSMNDFRPLRSLVDSLRLPSLEVREAILDLLFDLLRIKPPSWTSSFLALTTYG-RVANLDSWSLSEGFVAAEFKS 306

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 168480120   376 ILPHRAR-SRPDLMDNYLALILSAFIRNGLLEGLVEVI-TNSDDHISVRATILLGELLHMANTI 437
Cdd:pfam14664  307 ILPSESSfSRENLVNHYLALLLLVFIEAGLLEALVEVIeESSDSSLSRKATLLLGELLHLANRL 370
RICTOR_M pfam14666
Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a ...
 637-740 1.88e-40

Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


:

Pssm-ID: 464248  Cd Length: 104  Bit Score: 144.91  E-value: 1.88e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   637 SSGVKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLIKLTVSSLDYSRDGLARVI 716
Cdd:pfam14666    1 SGITAGDPLFSKQRLETTLSRGYFLFIGVLSSSKNGLKLLEKWNIFTILYHIVELKSRDDLLKLILSSLDYSLDGHPRII 80

                           90       100
                   ....*....|....*....|....
gi 168480120   717 LSKILTAATDACRLYATKHLRVLL 740
Cdd:pfam14666   81 LSKALTSSSESIRLYATKHLRVLL 104
RasGEF_N_2 pfam14663
Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a ...
 747-853 2.05e-38

Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


:

Pssm-ID: 464245  Cd Length: 107  Bit Score: 139.26  E-value: 2.05e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   747 FNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAK 826
Cdd:pfam14663    1 FEEWGIELLVTQLYDPSPEVVAAAVDVLYEACDDKENLESLVSLRPSLDHLGEIGSPLLLRFLSTPSGFKYLNELGFVEN 80

                           90       100
                   ....*....|....*....|....*..
gi 168480120   827 QLEKWHKEYNSKYVDLIEEQLNEALTT 853
Cdd:pfam14663   81 ELDKWFEERNLEYVLKVEEFLAEALTD 107
RICTOR_phospho pfam14665
Rapamycin-insensitive companion of mTOR, phosphorylation-site; Rictor appears to serve as a ...
 1085-1187 4.17e-38

Rapamycin-insensitive companion of mTOR, phosphorylation-site; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient- and growth-factor signalling. This short region is the phoshorylation site. Rictor does interact with 14-3-3 in a Thr1135-dependent manner. Rictor can be inhibited by short-term rapamycin treatment showing that Thr1135 is an mTORC1-regulated site.


:

Pssm-ID: 464247  Cd Length: 108  Bit Score: 138.46  E-value: 4.17e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120  1085 FPFFGSSKLVKNRILNSLTLPTKKHRSSSDPKGGKLSSENKTSNRRIRTLTEPSVDLNHSEDFTSSS----AQKSLQLEP 1160
Cdd:pfam14665    2 FTFLSSSRVVRNRFLNSLTLPKKKLRSSSDPKGGKSSSNKKSGLRRNRTVTEPSSDDNHSGDFFPPVfrvpKSPTQSLET 81

                           90       100
                   ....*....|....*....|....*..
gi 168480120  1161 SFVGNKHLEDAGSTPSIGENDLKFPKS 1187
Cdd:pfam14665   82 SFVGSKIEEDGGSTPSIGENDLKLPRL 108
RICTOR_V pfam14668
Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding ...
 922-991 2.89e-33

Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. These long eukaryotic proteins carry several well-conserved domains, and this is No.5.


:

Pssm-ID: 464249  Cd Length: 71  Bit Score: 123.33  E-value: 2.89e-33
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   922 KLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCHSWD 991
Cdd:pfam14668    2 KLKAALWAIGHIGSSPLGIQLLEEYDIVEDIVKIAEESPVLSLRGTAFYVLGLISSTEEGAEILDELGWE 71
 
Name Accession Description Interval E-value
RICTOR_N pfam14664
Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding ...
 58-437 2.97e-127

Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the N-terminal conserved section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464246  Cd Length: 372  Bit Score: 402.68  E-value: 2.97e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120    58 GHLNNFTKLLCDigHSEEKLGFNYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQ 137
Cdd:pfam14664    1 EKANDLVDLLKR--HPTLKYDLVLSDFLLRIQPMLLSESKEVRAAGYRILRYLISDEESLQLLRKLHLDIFIIRSLSKDN 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   138 SNEVERTQALRLVRKMITVNA--SLFPSSVANSLIAVGNdglQERDRMVRACIAIICELALQNPEVVALRGGLNTILKNV 215
Cdd:pfam14664   79 KNEVEREQALKLIRAFLEIKDgvSEISRGVVRALVAIAE---HEDDRLRRICLETLCELALLDPELVVRCGGLRVLLDAL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   216 IDcQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDfhyrhspDTAEGQLKEDREARFLASKMGIIATFRSW 295
Cdd:pfam14664  156 LE-GSFELAESLLGALLYLLDSPRTRKYLRPGFDLEVLLSPFTD-------SLDANTKGDSNEERLQASAKAISSLLKSW 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   296 AGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVTDEFIEALLSVdPGRFQDSWRLSDGFVAAEAKT 375
Cdd:pfam14664  228 PGLMYLSMNDFRPLRSLVDSLRLPSLEVREAILDLLFDLLRIKPPSWTSSFLALTTYG-RVANLDSWSLSEGFVAAEFKS 306

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 168480120   376 ILPHRAR-SRPDLMDNYLALILSAFIRNGLLEGLVEVI-TNSDDHISVRATILLGELLHMANTI 437
Cdd:pfam14664  307 ILPSESSfSRENLVNHYLALLLLVFIEAGLLEALVEVIeESSDSSLSRKATLLLGELLHLANRL 370
RICTOR_M pfam14666
Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a ...
 637-740 1.88e-40

Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464248  Cd Length: 104  Bit Score: 144.91  E-value: 1.88e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   637 SSGVKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLIKLTVSSLDYSRDGLARVI 716
Cdd:pfam14666    1 SGITAGDPLFSKQRLETTLSRGYFLFIGVLSSSKNGLKLLEKWNIFTILYHIVELKSRDDLLKLILSSLDYSLDGHPRII 80

                           90       100
                   ....*....|....*....|....
gi 168480120   717 LSKILTAATDACRLYATKHLRVLL 740
Cdd:pfam14666   81 LSKALTSSSESIRLYATKHLRVLL 104
RasGEF_N_2 pfam14663
Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a ...
 747-853 2.05e-38

Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464245  Cd Length: 107  Bit Score: 139.26  E-value: 2.05e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   747 FNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAK 826
Cdd:pfam14663    1 FEEWGIELLVTQLYDPSPEVVAAAVDVLYEACDDKENLESLVSLRPSLDHLGEIGSPLLLRFLSTPSGFKYLNELGFVEN 80

                           90       100
                   ....*....|....*....|....*..
gi 168480120   827 QLEKWHKEYNSKYVDLIEEQLNEALTT 853
Cdd:pfam14663   81 ELDKWFEERNLEYVLKVEEFLAEALTD 107
RICTOR_phospho pfam14665
Rapamycin-insensitive companion of mTOR, phosphorylation-site; Rictor appears to serve as a ...
 1085-1187 4.17e-38

Rapamycin-insensitive companion of mTOR, phosphorylation-site; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient- and growth-factor signalling. This short region is the phoshorylation site. Rictor does interact with 14-3-3 in a Thr1135-dependent manner. Rictor can be inhibited by short-term rapamycin treatment showing that Thr1135 is an mTORC1-regulated site.


Pssm-ID: 464247  Cd Length: 108  Bit Score: 138.46  E-value: 4.17e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120  1085 FPFFGSSKLVKNRILNSLTLPTKKHRSSSDPKGGKLSSENKTSNRRIRTLTEPSVDLNHSEDFTSSS----AQKSLQLEP 1160
Cdd:pfam14665    2 FTFLSSSRVVRNRFLNSLTLPKKKLRSSSDPKGGKSSSNKKSGLRRNRTVTEPSSDDNHSGDFFPPVfrvpKSPTQSLET 81

                           90       100
                   ....*....|....*....|....*..
gi 168480120  1161 SFVGNKHLEDAGSTPSIGENDLKFPKS 1187
Cdd:pfam14665   82 SFVGSKIEEDGGSTPSIGENDLKLPRL 108
RICTOR_V pfam14668
Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding ...
 922-991 2.89e-33

Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. These long eukaryotic proteins carry several well-conserved domains, and this is No.5.


Pssm-ID: 464249  Cd Length: 71  Bit Score: 123.33  E-value: 2.89e-33
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   922 KLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCHSWD 991
Cdd:pfam14668    2 KLKAALWAIGHIGSSPLGIQLLEEYDIVEDIVKIAEESPVLSLRGTAFYVLGLISSTEEGAEILDELGWE 71
 
Name Accession Description Interval E-value
RICTOR_N pfam14664
Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding ...
 58-437 2.97e-127

Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the N-terminal conserved section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464246  Cd Length: 372  Bit Score: 402.68  E-value: 2.97e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120    58 GHLNNFTKLLCDigHSEEKLGFNYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQ 137
Cdd:pfam14664    1 EKANDLVDLLKR--HPTLKYDLVLSDFLLRIQPMLLSESKEVRAAGYRILRYLISDEESLQLLRKLHLDIFIIRSLSKDN 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   138 SNEVERTQALRLVRKMITVNA--SLFPSSVANSLIAVGNdglQERDRMVRACIAIICELALQNPEVVALRGGLNTILKNV 215
Cdd:pfam14664   79 KNEVEREQALKLIRAFLEIKDgvSEISRGVVRALVAIAE---HEDDRLRRICLETLCELALLDPELVVRCGGLRVLLDAL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   216 IDcQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDfhyrhspDTAEGQLKEDREARFLASKMGIIATFRSW 295
Cdd:pfam14664  156 LE-GSFELAESLLGALLYLLDSPRTRKYLRPGFDLEVLLSPFTD-------SLDANTKGDSNEERLQASAKAISSLLKSW 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   296 AGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVTDEFIEALLSVdPGRFQDSWRLSDGFVAAEAKT 375
Cdd:pfam14664  228 PGLMYLSMNDFRPLRSLVDSLRLPSLEVREAILDLLFDLLRIKPPSWTSSFLALTTYG-RVANLDSWSLSEGFVAAEFKS 306

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 168480120   376 ILPHRAR-SRPDLMDNYLALILSAFIRNGLLEGLVEVI-TNSDDHISVRATILLGELLHMANTI 437
Cdd:pfam14664  307 ILPSESSfSRENLVNHYLALLLLVFIEAGLLEALVEVIeESSDSSLSRKATLLLGELLHLANRL 370
RICTOR_M pfam14666
Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a ...
 637-740 1.88e-40

Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464248  Cd Length: 104  Bit Score: 144.91  E-value: 1.88e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   637 SSGVKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLIKLTVSSLDYSRDGLARVI 716
Cdd:pfam14666    1 SGITAGDPLFSKQRLETTLSRGYFLFIGVLSSSKNGLKLLEKWNIFTILYHIVELKSRDDLLKLILSSLDYSLDGHPRII 80

                           90       100
                   ....*....|....*....|....
gi 168480120   717 LSKILTAATDACRLYATKHLRVLL 740
Cdd:pfam14666   81 LSKALTSSSESIRLYATKHLRVLL 104
RasGEF_N_2 pfam14663
Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a ...
 747-853 2.05e-38

Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464245  Cd Length: 107  Bit Score: 139.26  E-value: 2.05e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   747 FNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAK 826
Cdd:pfam14663    1 FEEWGIELLVTQLYDPSPEVVAAAVDVLYEACDDKENLESLVSLRPSLDHLGEIGSPLLLRFLSTPSGFKYLNELGFVEN 80

                           90       100
                   ....*....|....*....|....*..
gi 168480120   827 QLEKWHKEYNSKYVDLIEEQLNEALTT 853
Cdd:pfam14663   81 ELDKWFEERNLEYVLKVEEFLAEALTD 107
RICTOR_phospho pfam14665
Rapamycin-insensitive companion of mTOR, phosphorylation-site; Rictor appears to serve as a ...
 1085-1187 4.17e-38

Rapamycin-insensitive companion of mTOR, phosphorylation-site; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient- and growth-factor signalling. This short region is the phoshorylation site. Rictor does interact with 14-3-3 in a Thr1135-dependent manner. Rictor can be inhibited by short-term rapamycin treatment showing that Thr1135 is an mTORC1-regulated site.


Pssm-ID: 464247  Cd Length: 108  Bit Score: 138.46  E-value: 4.17e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120  1085 FPFFGSSKLVKNRILNSLTLPTKKHRSSSDPKGGKLSSENKTSNRRIRTLTEPSVDLNHSEDFTSSS----AQKSLQLEP 1160
Cdd:pfam14665    2 FTFLSSSRVVRNRFLNSLTLPKKKLRSSSDPKGGKSSSNKKSGLRRNRTVTEPSSDDNHSGDFFPPVfrvpKSPTQSLET 81

                           90       100
                   ....*....|....*....|....*..
gi 168480120  1161 SFVGNKHLEDAGSTPSIGENDLKFPKS 1187
Cdd:pfam14665   82 SFVGSKIEEDGGSTPSIGENDLKLPRL 108
RICTOR_V pfam14668
Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding ...
 922-991 2.89e-33

Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. These long eukaryotic proteins carry several well-conserved domains, and this is No.5.


Pssm-ID: 464249  Cd Length: 71  Bit Score: 123.33  E-value: 2.89e-33
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480120   922 KLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCHSWD 991
Cdd:pfam14668    2 KLKAALWAIGHIGSSPLGIQLLEEYDIVEDIVKIAEESPVLSLRGTAFYVLGLISSTEEGAEILDELGWE 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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