Pkd1l3 polycystic kidney disease 1 like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pkd1l3provided by MGI
Official Full Name: polycystic kidney disease 1 like 3provided by MGI
Primary source: MGI:MGI:2664670
See related: Ensembl:ENSMUSG00000048827 AllianceGenome:MGI:2664670
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables transmembrane transporter binding activity. Contributes to monoatomic cation channel activity and sour taste receptor activity. Involved in cellular response to acidic pH; detection of chemical stimulus involved in sensory perception of sour taste; and monoatomic cation transport. Part of cation channel complex and receptor complex. Colocalizes with cell surface. Is expressed in circumvallate papillae; cochlea; foliate papillae; and testis. Orthologous to human PKD1L3 (polycystin 1 like 3, transient receptor potential channel interacting). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 11.3), lung adult (RPKM 2.7) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 57.14 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (110340828..110399305)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (109614190..109672673)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PKD1L3 is cleaved at the N-terminal G protein-coupled receptor proteolytic site.Leucine-708 and Serine-709 are crucial for G protein-coupled receptor proteolytic site cleavage in mouse PKD1L3.
Title: A PKD1L3 splice variant in taste buds is not cleaved at the G protein-coupled receptor proteolytic site.
These results demonstrate that Asp(523) in PKD2L1 is a key determinant of Ca(2+) permeation into the PKD1L3/PKD2L1 complex and that PKD2L1 contributes to forming the pore of the PKD1L3/PKD2L1 channel.
Title: The single pore residue Asp523 in PKD2L1 determines Ca2+ permeation of the PKD1L3/PKD2L1 complex.
results suggest that the interaction between PKD1L3 and PKD2L1 through their transmembrane domains is essential for proper trafficking of the channels to the cell surface in taste cells of circumvallate and foliate papillae and in cultured cells
Title: Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae.
the PKD2L1-PKD1L3 complex is involved in acid sensing in vivo
Title: Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells.
PKD1L3-PKD2L1 channel activation by acetic acid was pH-dependent and occurred when the ambient pH was <3.1.
Title: Acetic acid activates PKD1L3-PKD2L1 channel--a candidate sour taste receptor.
The off-response property of PKD1L3-PKD2L1 channels might explain the physiological phenomena occurring during sour taste sensation.
Title: Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1.
genes are mapped to chromosomes and gene structures are characterized; protein structure is predicted and contains strong ion channel signature motifs that suggest their possible function as components of cation channel pores
Title: Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes.
Pkd1l3 and Pkd2l1 are co-expressed in a select subset of taste receptor cells and therefore may, like other PKD channels, function as a heteromer
Title: Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells.
These results suggest that PKD1L3 and PKD2L1 heteromers may function as sour taste receptors.
Title: Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pkd1l3 (e-PCR), detects polymorphism
- UniSTS:531221

NoName (e-PCR)
- UniSTS:224337

AW536298 (e-PCR)
- UniSTS:179818

NoName (e-PCR)
- UniSTS:225182

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-activated cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
contributes_to monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to monoatomic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables pH-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables pH-gated monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to sour taste receptor activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables sour taste receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to acidic pH	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in cellular response to acidic pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of sour taste	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in detection of chemical stimulus involved in sensory perception of sour taste	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of mechanical stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of sour taste	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of cation channel complex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: polycystin-1-like protein 3

Names: PC1-like 3 protein; polycystic kidney disease protein 1-like 3; polycystin-1L3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039700.3 → NP_001034789.2 polycystin-1-like protein 3 isoform a

See identical proteins and their annotated locations for NP_001034789.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest variant and encodes the longest isoform (a).

Source sequence(s)

AC125162

Consensus CDS

CCDS40472.1

UniProtKB/Swiss-Prot

E9QPA5, Q2EG93, Q2EG94, Q2EG95, Q2EG96, Q2EG97, Q2EG98, Q2EG99, Q7TN87

Related

ENSMUSP00000104865.2, ENSMUST00000109242.8

Conserved Domains (7) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cd01752
Location:1130 → 1248

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam01825
Location:1020 → 1058

GPS; GPCR proteolysis site, GPS, motif

pfam03546
Location:208 → 666

Treacle; Treacher Collins syndrome protein Treacle

pfam08016
Location:1708 → 2118

PKD_channel; Polycystin cation channel

pfam15229
Location:345 → 499

POM121; POM121 family

pfam15265
Location:413 → 611

FAM196; FAM196 family
NM_001286454.2 → NP_001273383.1 polycystin-1-like protein 3 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.

Source sequence(s)

AC125162

Consensus CDS

CCDS85608.1

UniProtKB/Swiss-Prot

Q2EG98

UniProtKB/TrEMBL

A2A258

Related

ENSMUSP00000148592.2, ENSMUST00000212537.2

Conserved Domains (7) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cd01752
Location:1120 → 1238

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam01825
Location:1010 → 1048

GPS; GPCR proteolysis site, GPS, motif

pfam03546
Location:208 → 666

Treacle; Treacher Collins syndrome protein Treacle

pfam08016
Location:1698 → 2108

PKD_channel; Polycystin cation channel

pfam15229
Location:345 → 499

POM121; POM121 family

pfam15265
Location:413 → 611

FAM196; FAM196 family
NM_181544.3 → NP_853522.2 polycystin-1-like protein 3 isoform b

See identical proteins and their annotated locations for NP_853522.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the coding region and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a shorter protein (isoform b) that has a distinct C-terminus, compared to isoform a.

Source sequence(s)

AC125162

Consensus CDS

CCDS22654.1

UniProtKB/TrEMBL

A2A258

Related

ENSMUSP00000051512.3, ENSMUST00000057344.3

Conserved Domains (7) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cd01752
Location:1120 → 1238

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam01825
Location:1010 → 1048

GPS; GPCR proteolysis site, GPS, motif

pfam03546
Location:208 → 666

Treacle; Treacher Collins syndrome protein Treacle

pfam08016
Location:1698 → 2108

PKD_channel; Polycystin cation channel

pfam15229
Location:345 → 499

POM121; POM121 family

pfam15265
Location:413 → 611

FAM196; FAM196 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

110340828..110399305

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017312829.3 → XP_017168318.1 polycystin-1-like protein 3 isoform X8

Conserved Domains (6) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

PHA03307
Location:147 → 513

PHA03307; transcriptional regulator ICP4; Provisional

cd01752
Location:1130 → 1248

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam05109
Location:351 → 729

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01825
Location:1020 → 1058

GPS; GPCR proteolysis site, GPS, motif

pfam08016
Location:1708 → 2118

PKD_channel; Polycystin cation channel
XM_036154041.1 → XP_036009934.1 polycystin-1-like protein 3 isoform X9

Conserved Domains (6) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

PHA03307
Location:147 → 513

PHA03307; transcriptional regulator ICP4; Provisional

cd01752
Location:1151 → 1269

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam05109
Location:347 → 705

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01825
Location:1041 → 1079

GPS; GPCR proteolysis site, GPS, motif

pfam08016
Location:1729 → 1909

PKD_channel; Polycystin cation channel
XM_017312825.3 → XP_017168314.1 polycystin-1-like protein 3 isoform X4

Conserved Domains (6) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cd01752
Location:1151 → 1269

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam05109
Location:325 → 652

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01825
Location:1041 → 1079

GPS; GPCR proteolysis site, GPS, motif

pfam03154
Location:137 → 472

Atrophin-1; Atrophin-1 family

pfam08016
Location:1728 → 2138

PKD_channel; Polycystin cation channel
XM_017312821.3 → XP_017168310.1 polycystin-1-like protein 3 isoform X1

Conserved Domains (6) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cd01752
Location:1151 → 1269

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam05109
Location:325 → 652

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01825
Location:1041 → 1079

GPS; GPCR proteolysis site, GPS, motif

pfam03154
Location:137 → 472

Atrophin-1; Atrophin-1 family

pfam08016
Location:1729 → 2139

PKD_channel; Polycystin cation channel
XM_017312823.3 → XP_017168312.1 polycystin-1-like protein 3 isoform X3

Conserved Domains (6) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cd01752
Location:1151 → 1269

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam05109
Location:325 → 652

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01825
Location:1041 → 1079

GPS; GPCR proteolysis site, GPS, motif

pfam03154
Location:137 → 472

Atrophin-1; Atrophin-1 family

pfam08016
Location:1728 → 2138

PKD_channel; Polycystin cation channel
XM_017312832.3 → XP_017168321.1 polycystin-1-like protein 3 isoform X14

Conserved Domains (6) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cd01752
Location:1151 → 1269

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam05109
Location:325 → 652

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01825
Location:1041 → 1079

GPS; GPCR proteolysis site, GPS, motif

pfam03154
Location:137 → 472

Atrophin-1; Atrophin-1 family

pfam08016
Location:1728 → 2138

PKD_channel; Polycystin cation channel
XM_017312827.3 → XP_017168316.1 polycystin-1-like protein 3 isoform X6

Conserved Domains (6) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cd01752
Location:1151 → 1269

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam05109
Location:325 → 652

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01825
Location:1041 → 1079

GPS; GPCR proteolysis site, GPS, motif

pfam03154
Location:137 → 472

Atrophin-1; Atrophin-1 family

pfam08016
Location:1729 → 2139

PKD_channel; Polycystin cation channel
XM_017312828.3 → XP_017168317.1 polycystin-1-like protein 3 isoform X7

Conserved Domains (6) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cd01752
Location:1121 → 1239

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam05109
Location:325 → 652

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01825
Location:1011 → 1049

GPS; GPCR proteolysis site, GPS, motif

pfam03154
Location:137 → 472

Atrophin-1; Atrophin-1 family

pfam08016
Location:1699 → 2109

PKD_channel; Polycystin cation channel
XM_017312826.3 → XP_017168315.1 polycystin-1-like protein 3 isoform X5

Conserved Domains (6) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cd01752
Location:1131 → 1249

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam05109
Location:325 → 652

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01825
Location:1021 → 1059

GPS; GPCR proteolysis site, GPS, motif

pfam03154
Location:137 → 472

Atrophin-1; Atrophin-1 family

pfam08016
Location:1709 → 2119

PKD_channel; Polycystin cation channel
XM_017312822.3 → XP_017168311.1 polycystin-1-like protein 3 isoform X2

Conserved Domains (6) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

PHA03307
Location:147 → 513

PHA03307; transcriptional regulator ICP4; Provisional

cd01752
Location:1150 → 1268

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam05109
Location:351 → 662

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01825
Location:1040 → 1078

GPS; GPCR proteolysis site, GPS, motif

pfam08016
Location:1728 → 2138

PKD_channel; Polycystin cation channel
XM_011248385.4 → XP_011246687.1 polycystin-1-like protein 3 isoform X10

Conserved Domains (5) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

PRK07764
Location:204 → 410

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01752
Location:1151 → 1269

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam05109
Location:325 → 652

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01825
Location:1041 → 1079

GPS; GPCR proteolysis site, GPS, motif
XM_017312831.3 → XP_017168320.1 polycystin-1-like protein 3 isoform X12

Conserved Domains (5) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

PRK07764
Location:204 → 410

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01752
Location:1151 → 1269

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam05109
Location:325 → 652

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01825
Location:1041 → 1079

GPS; GPCR proteolysis site, GPS, motif
XM_011248386.4 → XP_011246688.1 polycystin-1-like protein 3 isoform X11

Conserved Domains (5) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

PRK07764
Location:204 → 410

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01752
Location:1151 → 1269

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam05109
Location:325 → 652

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01825
Location:1041 → 1079

GPS; GPCR proteolysis site, GPS, motif
XM_006531009.5 → XP_006531072.1 polycystin-1-like protein 3 isoform X13

Conserved Domains (5) summary

cd00037
Location:37 → 142

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

PRK07764
Location:204 → 410

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01752
Location:1120 → 1238

PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...

pfam05109
Location:325 → 652

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01825
Location:1010 → 1048

GPS; GPCR proteolysis site, GPS, motif