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Conserved domains on  [gi|557128996|ref|NP_001273383|]
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polycystin-1-like protein 3 isoform c [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1120-1238 9.70e-56

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238850  Cd Length: 120  Bit Score: 189.79  E-value: 9.70e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996 1120 HYLIQVYTGYRRRAATTAKVVITLYGSEGHSEPHHLCDPEKTVFERGALDVFLLSTGSWLGDLHGLRLWHDNSGDSPSWY 1199
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPIFERGSVDSFLLTTPFPLGELQSIRLWHDNSGLSPSWY 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 557128996 1200 VSQVIVSDMTTRKKWHFQCNCWLAVDLGNCERDRVFTPA 1238
Cdd:cd01752    82 LSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPVA 120
Polycystin_dom super family cl48672
Polycystin domain; This domain represents the polycystin domain from group II of Transient ...
 1698-1883 1.17e-35

Polycystin domain; This domain represents the polycystin domain from group II of Transient receptor potential (TRP) channels (TRPP) including PKD1, PKD2, PKD2L and mucolipins. The polycystin domain display a sandwich-like shape with five beta-sheets in the tilted middle layer, three alpha-helices on one side and a large loop with two short antiparallel beta-sheets on the other.


The actual alignment was detected with superfamily member pfam20519:

Pssm-ID: 466668  Cd Length: 199  Bit Score: 135.24  E-value: 1.17e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  1698 FSEIKTVEDFYPWANGTLLPNLYGD-----YRGFITDGNSFLLGNVLIRQTRIPNDIFFPGSLHKQMKSPPQHQ-----E 1767
Cdd:pfam20519    2 LLTVTDLDDIWDWLSSVLLPALHSNktpsgLPGSFIAYESLLLGVPRLRQLRVRNSSCLVHDKFVREINECHAGysppsE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  1768 DRENYGAGWVPPDTNITKvdSIWHYQNQESLGGYPIQGELATYSGGGYVVRLGRNHSAATRVLQHLEQRRWLDHCTKALF 1847
Cdd:pfam20519   82 DRKLYSALPYKPVHYGSK--YWFIYTPPGLLMGYDHWGHLASYPSGGYVVLLPSSREESLKRLAYLQDNNWLDRGTRAVF 159

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 557128996  1848 VEFTVFNANVNLLCAVTLILESSGVGTFLTSLQLDS 1883
Cdd:pfam20519  160 VDFTLYNADINLFCVVTLRVEFPPTGGVLPSPSVQS 195
PKD_channel super family cl37568
Polycystin cation channel; This family contains the cation channel region from group II of ...
 1888-2108 4.30e-34

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


The actual alignment was detected with superfamily member pfam08016:

Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 131.63  E-value: 4.30e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  1888 QSSERGFAWIVSQVVYYLLVCYYAFIQGCRLKRQRLAFFTRKRNLLDTSIVLISFSILGLSMQSLSLLHKKMQQYHCDRD 1967
Cdd:pfam08016    2 YVTNRSLFILLCEIVFVVFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVLNIYRDFLADRLIKSVEASPV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  1968 RFISFYEALRVNSAVTHLRGFLLLFATVRVWDLLRHHAQLQVINKTLSKAWDEVLGFILIIVVLLSSYAMTFNLLFGWSI 2047
Cdd:pfam08016   82 TFIDFDRVAQLDNLYRIILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQA 161

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 557128996  2048 SDYQSFFRSIVTVVGLLMGTSKHKEVIALYPILGSLLVLSSIILMGLVIINLFVSAILIAF 2108
Cdd:pfam08016  162 PNFSNFVKSILTLFRTILGDFGYNEIFSGNRVLGPLLFLTFVFLVIFILLNLFLAIINDSY 222
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 325-652 9.45e-26

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 116.17  E-value: 9.45e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   325 PASSSPpqVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSP-PQGTSETPASNSP-PQGTSET 402
Cdd:pfam05109  461 PASTGP--TVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPtPNATSPTPAVTTPtPNATSPT 538

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   403 PGFSSPPQ-VTTATLVSSSP-PQVTSETPASSSPT--------QVTSETPASSSPTqVTSDTPASNSPPQ---GTSDTPG 469
Cdd:pfam05109  539 LGKTSPTSaVTTPTPNATSPtPAVTTPTPNATIPTlgktsptsAVTTPTPNATSPT-VGETSPQANTTNHtlgGTSSTPV 617

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   470 FSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASS 549
Cdd:pfam05109  618 VTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTS 697

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   550 SPPQVTSETPASSSPTNmtSDTPASSSPTNMTSDTPasssPTNMTS-DTPASSSPPWPVITEVTRPESTIPAGRSLANIT 628
Cdd:pfam05109  698 SPAPRPGTTSQASGPGN--SSTSTKPGEVNVTKGTP----PKNATSpQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHG 771

                          330       340
                   ....*....|....*....|....*.
gi 557128996   629 SKAQED--SPLGVISTHPQMSFQSST 652
Cdd:pfam05109  772 ARTSTEptTDYGGDSTTPRTRYNATT 797
GPS pfam01825
GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for ...
 1010-1048 8.46e-07

GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for auto-proteolysis, so is thus named, GPS. The GPS motif is a conserved sequence of ~40 amino acids containing canonical cysteine and tryptophan residues, and is the most highly conserved part of the domain. In most, if not all, cell-adhesion GPCRs these undergo autoproteolysis in the GPS between a conserved aliphatic residue (usually a leucine) and a threonine, serine, or cysteine residue. In higher eukaryotes this motif is found embedded in the C-terminal beta-stranded part of a GAIN domain - GPCR-Autoproteolysis INducing (GAIN). The GAIN-GPS domain adopts a fold in which the GPS motif, at the C-terminus, forms five beta-strands that are tightly integrated into the overall GAIN domain. The GPS motif, evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations. The GAIN-GPS domain is both necessary and sufficient functionally for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment in the GPS to catalyze peptide bond hydrolysis. In the cell-adhesion GPCRs and PKD proteins, the GPS motif is always located at the end of their long N-terminal extracellular regions, immediately before the first transmembrane helix of the respective protein.


:

Pssm-ID: 460350  Cd Length: 44  Bit Score: 47.30  E-value: 8.46e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 557128996  1010 QCYFWDRYNRT---WKSDGCQVGPKSTiLKTQCLCDHLTFFS 1048
Cdd:pfam01825    2 QCVFWDFTNSTtgrWSTEGCTTVSLND-THTVCSCNHLTSFA 42
CLECT cd00037
C-type lectin (CTL)/C-type lectin-like (CTLD) domain; CLECT: C-type lectin (CTL)/C-type ...
 37-142 9.29e-07

C-type lectin (CTL)/C-type lectin-like (CTLD) domain; CLECT: C-type lectin (CTL)/C-type lectin-like (CTLD) domain; protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. This group is chiefly comprised of eukaryotic CTLDs, but contains some, as yet functionally uncharacterized, bacterial CTLDs. Many CTLDs are calcium-dependent carbohydrate binding modules; other CTLDs bind protein ligands, lipids, and inorganic surfaces, including CaCO3 and ice. Animal C-type lectins are involved in such functions as extracellular matrix organization, endocytosis, complement activation, pathogen recognition, and cell-cell interactions. For example: mannose-binding lectin and lung surfactant proteins A and D bind carbohydrates on surfaces (e.g. pathogens, allergens, necrotic, and apoptotic cells) and mediate functions associated with killing and phagocytosis; P (platlet)-, E (endothelial)-, and L (leukocyte)- selectins (sels) mediate the initial attachment, tethering, and rolling of lymphocytes on inflamed vascular walls enabling subsequent lymphocyte adhesion and transmigration. CTLDs may bind a variety of carbohydrate ligands including mannose, N-acetylglucosamine, galactose, N-acetylgalactosamine, and fucose. Several CTLDs bind to protein ligands, and only some of these binding interactions are Ca2+-dependent; including the CTLDs of Coagulation Factors IX/X (IX/X) and Von Willebrand Factor (VWF) binding proteins, and natural killer cell receptors. C-type lectins, such as lithostathine, and some type II antifreeze glycoproteins function in a Ca2+-independent manner to bind inorganic surfaces. Many proteins in this group contain a single CTLD; these CTLDs associate with each other through several different surfaces to form dimers, trimers, or tetramers, from which ligand-binding sites project in different orientations. Various vertebrate type 1 transmembrane proteins including macrophage mannose receptor, endo180, phospholipase A2 receptor, and dendritic and epithelial cell receptor (DEC205) have extracellular domains containing 8 or more CTLDs; these CTLDs remain in the parent model. In some members (IX/X and VWF binding proteins), a loop extends to the adjoining domain to form a loop-swapped dimer. A similar conformation is seen in the macrophage mannose receptor CRD4's putative non-sugar bound form of the domain in the acid environment of the endosome. Lineage specific expansions of CTLDs have occurred in several animal lineages including Drosophila melanogaster and Caenorhabditis elegans; these CTLDs also remain in the parent model.


:

Pssm-ID: 153057 [Multi-domain]  Cd Length: 116  Bit Score: 49.54  E-value: 9.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   37 SCYQLNRLFCDFQEADNYCHAQRGRLAHTWNPKLRGFLKSFL---NEETVW-------------WVRGNLTLPGSHPGIN 100
Cdd:cd00037     1 SCYKFSTEKLTWEEAQEYCRSLGGHLASIHSEEENDFLASLLkksSSSDVWiglndlssegtwkWSDGSPLVDYTNWAPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 557128996  101 QTGGDDvlrnqkPGECpsvVTHSNAVFSRWN--LCIEKHHFICQ 142
Cdd:cd00037    81 EPNPGG------SEDC---VVLSSSSDGKWNdvSCSSKLPFICE 115
Chi1 super family cl43877
Chitinase [Carbohydrate transport and metabolism];
224-422 1.51e-05

Chitinase [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG3469:

Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 50.14  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  224 TGRPQVTSDTLASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSS 303
Cdd:COG3469    12 AGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  304 PPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSS--SSPPQGTSDTPASSS 381
Cdd:COG3469    92 TSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSgtETATGGTTTTSTTTT 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 557128996  382 PPQGTSETPASNSPPQGTSETPGFSSPP-QVTTATLVSSSPP 422
Cdd:COG3469   172 TTSASTTPSATTTATATTASGATTPSATtTATTTGPPTPGLP 213
 
Name Accession Description Interval E-value
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1120-1238 9.70e-56

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 189.79  E-value: 9.70e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996 1120 HYLIQVYTGYRRRAATTAKVVITLYGSEGHSEPHHLCDPEKTVFERGALDVFLLSTGSWLGDLHGLRLWHDNSGDSPSWY 1199
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPIFERGSVDSFLLTTPFPLGELQSIRLWHDNSGLSPSWY 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 557128996 1200 VSQVIVSDMTTRKKWHFQCNCWLAVDLGNCERDRVFTPA 1238
Cdd:cd01752    82 LSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPVA 120
Polycystin_dom pfam20519
Polycystin domain; This domain represents the polycystin domain from group II of Transient ...
 1698-1883 1.17e-35

Polycystin domain; This domain represents the polycystin domain from group II of Transient receptor potential (TRP) channels (TRPP) including PKD1, PKD2, PKD2L and mucolipins. The polycystin domain display a sandwich-like shape with five beta-sheets in the tilted middle layer, three alpha-helices on one side and a large loop with two short antiparallel beta-sheets on the other.


Pssm-ID: 466668  Cd Length: 199  Bit Score: 135.24  E-value: 1.17e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  1698 FSEIKTVEDFYPWANGTLLPNLYGD-----YRGFITDGNSFLLGNVLIRQTRIPNDIFFPGSLHKQMKSPPQHQ-----E 1767
Cdd:pfam20519    2 LLTVTDLDDIWDWLSSVLLPALHSNktpsgLPGSFIAYESLLLGVPRLRQLRVRNSSCLVHDKFVREINECHAGysppsE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  1768 DRENYGAGWVPPDTNITKvdSIWHYQNQESLGGYPIQGELATYSGGGYVVRLGRNHSAATRVLQHLEQRRWLDHCTKALF 1847
Cdd:pfam20519   82 DRKLYSALPYKPVHYGSK--YWFIYTPPGLLMGYDHWGHLASYPSGGYVVLLPSSREESLKRLAYLQDNNWLDRGTRAVF 159

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 557128996  1848 VEFTVFNANVNLLCAVTLILESSGVGTFLTSLQLDS 1883
Cdd:pfam20519  160 VDFTLYNADINLFCVVTLRVEFPPTGGVLPSPSVQS 195
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 1888-2108 4.30e-34

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 131.63  E-value: 4.30e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  1888 QSSERGFAWIVSQVVYYLLVCYYAFIQGCRLKRQRLAFFTRKRNLLDTSIVLISFSILGLSMQSLSLLHKKMQQYHCDRD 1967
Cdd:pfam08016    2 YVTNRSLFILLCEIVFVVFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVLNIYRDFLADRLIKSVEASPV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  1968 RFISFYEALRVNSAVTHLRGFLLLFATVRVWDLLRHHAQLQVINKTLSKAWDEVLGFILIIVVLLSSYAMTFNLLFGWSI 2047
Cdd:pfam08016   82 TFIDFDRVAQLDNLYRIILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQA 161

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 557128996  2048 SDYQSFFRSIVTVVGLLMGTSKHKEVIALYPILGSLLVLSSIILMGLVIINLFVSAILIAF 2108
Cdd:pfam08016  162 PNFSNFVKSILTLFRTILGDFGYNEIFSGNRVLGPLLFLTFVFLVIFILLNLFLAIINDSY 222
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 325-652 9.45e-26

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 116.17  E-value: 9.45e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   325 PASSSPpqVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSP-PQGTSETPASNSP-PQGTSET 402
Cdd:pfam05109  461 PASTGP--TVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPtPNATSPTPAVTTPtPNATSPT 538

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   403 PGFSSPPQ-VTTATLVSSSP-PQVTSETPASSSPT--------QVTSETPASSSPTqVTSDTPASNSPPQ---GTSDTPG 469
Cdd:pfam05109  539 LGKTSPTSaVTTPTPNATSPtPAVTTPTPNATIPTlgktsptsAVTTPTPNATSPT-VGETSPQANTTNHtlgGTSSTPV 617

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   470 FSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASS 549
Cdd:pfam05109  618 VTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTS 697

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   550 SPPQVTSETPASSSPTNmtSDTPASSSPTNMTSDTPasssPTNMTS-DTPASSSPPWPVITEVTRPESTIPAGRSLANIT 628
Cdd:pfam05109  698 SPAPRPGTTSQASGPGN--SSTSTKPGEVNVTKGTP----PKNATSpQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHG 771

                          330       340
                   ....*....|....*....|....*.
gi 557128996   629 SKAQED--SPLGVISTHPQMSFQSST 652
Cdd:pfam05109  772 ARTSTEptTDYGGDSTTPRTRYNATT 797
PHA03247 PHA03247
large tegument protein UL36; Provisional
 159-660 2.21e-23

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 109.64  E-value: 2.21e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  159 GPGPLLPMKRRGAETERHMipgngPPlamcHQPAPPelfetlcfPIDPASSAppkATHRMTITSLTGRPQVTSDtlaSSS 238
Cdd:PHA03247 2550 DPPPPLPPAAPPAAPDRSV-----PP----PRPAPR--------PSEPAVTS---RARRPDAPPQSARPRAPVD---DRG 2606

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  239 PPQGTSdtPASSSPPQVTSAtsasssppqgtsDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSpp 318
Cdd:PHA03247 2607 DPRGPA--PPSPLPPDTHAP------------DPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRL-- 2670

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  319 qgtSDTPASSSPPQvtsatsasssppqgtSDTPASSSPPQGTLdTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQG 398
Cdd:PHA03247 2671 ---GRAAQASSPPQ---------------RPRRRAARPTVGSL-TSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQA 2731

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  399 TSETPGFSSPPQVTTATLVSSSP-----PQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSP 473
Cdd:PHA03247 2732 SPALPAAPAPPAVPAGPATPGGParparPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV 2811

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  474 TQVTTATLVSSSP----PQVTSDTPASSSPPQVTSDTP-------------ASSSPPQVTSETPASSSPPQVTSDTSASI 536
Cdd:PHA03247 2812 LAPAAALPPAASPagplPPPTSAQPTAPPPPPGPPPPSlplggsvapggdvRRRPPSRSPAAKPAAPARPPVRRLARPAV 2891

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  537 SPPQVISDTPASSSPPQvtsETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSP----PWPVITEVT 612
Cdd:PHA03247 2892 SRSTESFALPPDQPERP---PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPsgavPQPWLGALV 2968

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 557128996  613 RPESTIPAGRSLANITSKAQEDSPLGVISTHPQMSFQS-STSQALDETA 660
Cdd:PHA03247 2969 PGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSwASSLALHEET 3017
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1121-1236 6.17e-23

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 95.58  E-value: 6.17e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  1121 YLIQVYTGYRRRAATTAKVVITLYGSEGHS--EPHHLCDPEktvFERGALDVFLLSTGSWLGDLHGLRLWHDNSGDSPSW 1198
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESaqLEITLDNPD---FERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 557128996  1199 YVSQVIV-SDMTTRKKWHFQCNCWLAVDLGNcERDRVFT 1236
Cdd:pfam01477   78 FLKSITVeVPGETGGKYTFPCNSWVYGSKKY-KETRVFF 115
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
373-609 5.12e-15

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 80.57  E-value: 5.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  373 TSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTS 452
Cdd:COG3469     1 SSSVSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  453 DTPASNSPPqgtsdtpgfSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPpqVTSDT 532
Cdd:COG3469    81 TATAAAAAA---------TSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSA--GSTTT 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 557128996  533 SASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSsptnmtsdTPASSSPPWPVIT 609
Cdd:COG3469   150 TTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTT--------GPPTPGLPKHVLV 218
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1120-1225 4.97e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 64.20  E-value: 4.97e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   1120 HYLIQVYTGYRRRAATTAKVVITLYGSEGHSEPHHLCDPEKTVFERGALDVFLLSTGSWLGDLHGLRLWHDNsgDSPSWY 1199
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEH--RHPEWF 79

                            90       100
                    ....*....|....*....|....*.
gi 557128996   1200 VSQVIVSDMTTRKKWHFQCNCWLAVD 1225
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYPD 105
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 347-676 3.41e-09

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 62.32  E-value: 3.41e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   347 TSDTPASSSPPQGTLDTPSSSSPPQGTS------DTPassSPPQGTSE-TPAS----NSP-PQGT----SETPgfSSPPQ 410
Cdd:TIGR00927   76 SSDPPKSSSEMEGEMLAPQATVGRDEATpsiameNTP---SPPRRTAKiTPTTpknnYSPtAAGTervkEDTP--ATPSR 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   411 VTTATLVSSSPPQVTSETPA------SSSPTQVTSE----TPaSSSPTQVTSDTPAS-NSPPQGTSDTPGFSSPTQVTTA 479
Cdd:TIGR00927  151 ALNHYISTSGRQRVKSYTPKprgevkSSSPTQTREKvrkyTP-SPLGRMVNSYAPSTfMTMPRSHGITPRTTVKDSEITA 229

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   480 T---LVSSSPPQV---TSDTP----ASSSPPQVTSDTPAS--SSPPQVTsETPASSSPPQVTSDTSA---------SISP 538
Cdd:TIGR00927  230 TykmLETNPSKRTagkTTPTPlkgmTDNTPTFLTREVETDllTSPRSVV-EKNTLTTPRRVESNSSTnhwglvgknNLTT 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   539 PQ--VISDTPASSSPpQVTSETPASSSPTnmtsDTPASSSPTNMTSDTPASSSPTNMTsdtpaSSSPPWPVITEVTRPES 616
Cdd:TIGR00927  309 PQgtVLEHTPATSEG-QVTISIMTGSSPA----ETKASTAAWKIRNPLSRTSAPAVRI-----ASATFRGLEKNPSTAPS 378

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 557128996   617 TIPAGRSLANITSKAQE---DSPLGVISTHPQMSFQSST-SQALDETAGERVPTIPDFQAHSEF 676
Cdd:TIGR00927  379 TPATPRVRAVLTTQVHHcvvVKPAPAVPTTPSPSLTTALfPEAPSPSPSALPPGQPDLHPKAEY 442
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 240-589 2.34e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.46  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  240 PQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQ 319
Cdd:NF033609  558 PEDSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSA 637

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  320 GTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGT 399
Cdd:NF033609  638 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 717

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  400 SETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDTPA-SNSPPQGTSDTPGFSSPTQVTT 478
Cdd:NF033609  718 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSD 797

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  479 ATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSET 558
Cdd:NF033609  798 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNS 877

                         330       340       350
                  ....*....|....*....|....*....|..
gi 557128996  559 PASSSPTNMTSDTPASSSPTNMT-SDTPASSS 589
Cdd:NF033609  878 PKNGTNASNKNEAKDSKEPLPDTgSEDEANTS 909
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 349-601 2.36e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.46  E-value: 2.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  349 DTPASSSPPqgtlDTPSSSSP-PQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSE 427
Cdd:NF033609  540 DKPVVPEQP----DEPGEIEPiPEDSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASD 615

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  428 TPASSSPTQVTSETPASSSPTQVTSDtpaSNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTP 507
Cdd:NF033609  616 SDSASDSDSASDSDSASDSDSASDSD---SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 692

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  508 ASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASS-SPTNMTSDTPA 586
Cdd:NF033609  693 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDS 772

                         250
                  ....*....|....*.
gi 557128996  587 -SSSPTNMTSDTPASS 601
Cdd:NF033609  773 dSDSDSDSDSDSDSDS 788
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 439-631 3.04e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.07  E-value: 3.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  439 SETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQvtSDTPASSSPPQVTSE 518
Cdd:NF033609   33 SSKEADASENSVTQSDSASNESKSNDSSSVSAAPKTDDTNVSDTKTSSNTNNGETSVAQNPAQ--QETTQSASTNATTEE 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  519 TPASSsppQVTSDTSASISPPQVI--SDTPASSSPPQVTSETpaSSSPTNMTSDTpasSSPTN--------MTSDTPASS 588
Cdd:NF033609  111 TPVTG---EATTTATNQANTPATTqsSNTNAEELVNQTSNET--TSNDTNTVSSV---NSPQNstnaenvsTTQDTSTEA 182

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 557128996  589 SPTNMTSDTPASSSPPWPVITEVTRPESTIPAGRSLANITSKA 631
Cdd:NF033609  183 TPSNNESAPQSTDASNKDVVNQAVNTSAPRMRAFSLAAVAADA 225
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 270-604 4.02e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.69  E-value: 4.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  270 SDT-PASSSPPQVTSATSASSSPPQGTSDTPASSSppqvtsatsasssppqgtSDTPASSSPPQVTSATSASSSPPQGTS 348
Cdd:NF033609  561 SDSdPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSA------------------SDSDSASDSDSASDSDSASDSDSASDS 622

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  349 DTPASSSPPQGTldtpSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSET 428
Cdd:NF033609  623 DSASDSDSASDS----DSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 698

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  429 PASSSPTQVTSETPASSSPTQVTSDTpASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDtpaSSSPPQVTSDTPA 508
Cdd:NF033609  699 DSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD---SDSDSDSDSDSDS 774

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  509 SSSPPQVTSETPASSSPPQVTSDT-SASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPAS 587
Cdd:NF033609  775 DSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 854

                         330       340
                  ....*....|....*....|.
gi 557128996  588 SSPTNMTSDTPASSS----PP 604
Cdd:NF033609  855 DSESDSNSDSESGSNnnvvPP 875
GPS pfam01825
GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for ...
 1010-1048 8.46e-07

GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for auto-proteolysis, so is thus named, GPS. The GPS motif is a conserved sequence of ~40 amino acids containing canonical cysteine and tryptophan residues, and is the most highly conserved part of the domain. In most, if not all, cell-adhesion GPCRs these undergo autoproteolysis in the GPS between a conserved aliphatic residue (usually a leucine) and a threonine, serine, or cysteine residue. In higher eukaryotes this motif is found embedded in the C-terminal beta-stranded part of a GAIN domain - GPCR-Autoproteolysis INducing (GAIN). The GAIN-GPS domain adopts a fold in which the GPS motif, at the C-terminus, forms five beta-strands that are tightly integrated into the overall GAIN domain. The GPS motif, evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations. The GAIN-GPS domain is both necessary and sufficient functionally for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment in the GPS to catalyze peptide bond hydrolysis. In the cell-adhesion GPCRs and PKD proteins, the GPS motif is always located at the end of their long N-terminal extracellular regions, immediately before the first transmembrane helix of the respective protein.


Pssm-ID: 460350  Cd Length: 44  Bit Score: 47.30  E-value: 8.46e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 557128996  1010 QCYFWDRYNRT---WKSDGCQVGPKSTiLKTQCLCDHLTFFS 1048
Cdd:pfam01825    2 QCVFWDFTNSTtgrWSTEGCTTVSLND-THTVCSCNHLTSFA 42
SP2_N cd22540
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ...
 351-619 9.22e-07

N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.


Pssm-ID: 411776 [Multi-domain]  Cd Length: 511  Bit Score: 53.78  E-value: 9.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  351 PASSSPPQGTLDTPSSSS------PPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSS---- 420
Cdd:cd22540    66 PLPLGPGKNSIGFLSAKGniiqlqGSQLSSSAPGGQQVFAIQNPTMIIKGSQTRSSTNQQYQISPQIQAAGQINNSgqiq 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  421 -----------PPQVTSETPASSSPTQVTsetPASSSPTQVTSDTPASN-------SPPQGTSDTP-----GFSSPTQVT 477
Cdd:cd22540   146 iipgtnqaiitPVQVLQQPQQAHKPVPIK---PAPLQTSNTNSASLQVPgnviklqSGGNVALTLPvnnlvGTQDGATQL 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  478 TATLVSSSPPQVTSDTPASSSPPQVTS--------------------------DTPASSSPPQV--------TSETPASS 523
Cdd:cd22540   223 QLAAAPSKPSKKIRKKSAQAAQPAVTVaeqvetvliettadniiqagnnllivQSPGTGQPAVLqqvqvlqpKQEQQVVQ 302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  524 SPP------QVTSDTSASI--SPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTS 595
Cdd:cd22540   303 IPQqalrvvQAASATLPTVpqKPLQNIQIQNSEPTPTQVYIKTPSGEVQTVLLQEAPAATATPSSSTSTVQQQVTANNGT 382

                         330       340
                  ....*....|....*....|....
gi 557128996  596 DTPASSSPpwpvitevTRPESTIP 619
Cdd:cd22540   383 GTSKPNYN--------VRKERTLP 398
CLECT cd00037
C-type lectin (CTL)/C-type lectin-like (CTLD) domain; CLECT: C-type lectin (CTL)/C-type ...
 37-142 9.29e-07

C-type lectin (CTL)/C-type lectin-like (CTLD) domain; CLECT: C-type lectin (CTL)/C-type lectin-like (CTLD) domain; protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. This group is chiefly comprised of eukaryotic CTLDs, but contains some, as yet functionally uncharacterized, bacterial CTLDs. Many CTLDs are calcium-dependent carbohydrate binding modules; other CTLDs bind protein ligands, lipids, and inorganic surfaces, including CaCO3 and ice. Animal C-type lectins are involved in such functions as extracellular matrix organization, endocytosis, complement activation, pathogen recognition, and cell-cell interactions. For example: mannose-binding lectin and lung surfactant proteins A and D bind carbohydrates on surfaces (e.g. pathogens, allergens, necrotic, and apoptotic cells) and mediate functions associated with killing and phagocytosis; P (platlet)-, E (endothelial)-, and L (leukocyte)- selectins (sels) mediate the initial attachment, tethering, and rolling of lymphocytes on inflamed vascular walls enabling subsequent lymphocyte adhesion and transmigration. CTLDs may bind a variety of carbohydrate ligands including mannose, N-acetylglucosamine, galactose, N-acetylgalactosamine, and fucose. Several CTLDs bind to protein ligands, and only some of these binding interactions are Ca2+-dependent; including the CTLDs of Coagulation Factors IX/X (IX/X) and Von Willebrand Factor (VWF) binding proteins, and natural killer cell receptors. C-type lectins, such as lithostathine, and some type II antifreeze glycoproteins function in a Ca2+-independent manner to bind inorganic surfaces. Many proteins in this group contain a single CTLD; these CTLDs associate with each other through several different surfaces to form dimers, trimers, or tetramers, from which ligand-binding sites project in different orientations. Various vertebrate type 1 transmembrane proteins including macrophage mannose receptor, endo180, phospholipase A2 receptor, and dendritic and epithelial cell receptor (DEC205) have extracellular domains containing 8 or more CTLDs; these CTLDs remain in the parent model. In some members (IX/X and VWF binding proteins), a loop extends to the adjoining domain to form a loop-swapped dimer. A similar conformation is seen in the macrophage mannose receptor CRD4's putative non-sugar bound form of the domain in the acid environment of the endosome. Lineage specific expansions of CTLDs have occurred in several animal lineages including Drosophila melanogaster and Caenorhabditis elegans; these CTLDs also remain in the parent model.


Pssm-ID: 153057 [Multi-domain]  Cd Length: 116  Bit Score: 49.54  E-value: 9.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   37 SCYQLNRLFCDFQEADNYCHAQRGRLAHTWNPKLRGFLKSFL---NEETVW-------------WVRGNLTLPGSHPGIN 100
Cdd:cd00037     1 SCYKFSTEKLTWEEAQEYCRSLGGHLASIHSEEENDFLASLLkksSSSDVWiglndlssegtwkWSDGSPLVDYTNWAPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 557128996  101 QTGGDDvlrnqkPGECpsvVTHSNAVFSRWN--LCIEKHHFICQ 142
Cdd:cd00037    81 EPNPGG------SEDC---VVLSSSSDGKWNdvSCSSKLPFICE 115
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 190-576 3.63e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 52.60  E-value: 3.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  190 QPAPPELFEtlcfPIDPASSAPPKathrmtitSLTGRPQVTSDTlASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGT 269
Cdd:NF033609  547 QPDEPGEIE----PIPEDSDSDPG--------SDSGSDSSNSDS-GSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSA 613

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  270 SDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSD 349
Cdd:NF033609  614 SDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 693

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  350 TPASSSPpqgtlDTPS-SSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSET 428
Cdd:NF033609  694 SDSDSDS-----DSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 768

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  429 PASSSPTQVTSETPASSSPTQVTSDTPA-SNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSppqvtSDTP 507
Cdd:NF033609  769 DSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-----SDSD 843

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  508 ASSSPPQVTSETPASSSPPQVTSDTSASISPPqvisDTPASSSPPQVTSETPASSSPTNMT-SDTPASSS 576
Cdd:NF033609  844 SDSDSDSDSDSDSESDSNSDSESGSNNNVVPP----NSPKNGTNASNKNEAKDSKEPLPDTgSEDEANTS 909
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
 1985-2140 6.69e-06

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 51.87  E-value: 6.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996 1985 LRGFLLLFATVRVWDLLRHHAQLQVINKTLSKAWDEVLGFILIIVVLLSSYAMTFNLLFGWSISDYQSFFRSIVTVVGLL 2064
Cdd:PLN03223 1294 LSGINIILLLGRILKLMDFQPRLGVITRTLWLAGADLMHFFVIFGMVFVGYAFIGHVIFGNASVHFSDMTDSINSLFENL 1373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996 2065 MG-----TSKHKEVIALYPILGSLLVLSSIILMGLVIINLFVSAILIAFGkERKACEKEAT-----LTDMLLQKLSSLLG 2134
Cdd:PLN03223 1374 LGdityfNEDLKNLTGLQFVVGMIYFYSYNIFVFMILFNFLLAIICDAFG-EVKANAAETVsvhteLFPMLRDKWRSMFK 1452


                  ....*.
gi 557128996 2135 IRLHQN 2140
Cdd:PLN03223 1453 GWFYKN 1458
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
 1009-1048 9.44e-06

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


Pssm-ID: 197639  Cd Length: 49  Bit Score: 44.69  E-value: 9.44e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 557128996   1009 TQCYFWDRYNRTWKSDGCQVGPKS-TIlkTQCLCDHLTFFS 1048
Cdd:smart00303    3 PICVFWDESSGEWSTRGCELLETNgTH--TTCSCNHLTTFA 41
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
224-422 1.51e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 50.14  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  224 TGRPQVTSDTLASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSS 303
Cdd:COG3469    12 AGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  304 PPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSS--SSPPQGTSDTPASSS 381
Cdd:COG3469    92 TSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSgtETATGGTTTTSTTTT 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 557128996  382 PPQGTSETPASNSPPQGTSETPGFSSPP-QVTTATLVSSSPP 422
Cdd:COG3469   172 TTSASTTPSATTTATATTASGATTPSATtTATTTGPPTPGLP 213
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 321-609 9.15e-05

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 47.46  E-value: 9.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  321 TSDTPA-------SSSPPQVTSATSASSSPPQGTSDTPASSSPPQgtLDTPSSSSPPQgtSDTPASSSPPQgtSETPASN 393
Cdd:NF033839  280 TQDTPKepgnkkpSAPKPGMQPSPQPEKKEVKPEPETPKPEVKPQ--LEKPKPEVKPQ--PEKPKPEVKPQ--LETPKPE 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  394 SPPQGTSETPGFSSPPQvttaTLVSSSPPQVTSETPasssptQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFsSP 473
Cdd:NF033839  354 VKPQPEKPKPEVKPQPE----KPKPEVKPQPETPKP------EVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEV-KP 422

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  474 TQVTTATLVSSSPPqvtsdTPASSSPPQvtSDTPASSSPPQvtSETPASSSPPQVtsdtsasisppqvisDTPASSSPPQ 553
Cdd:NF033839  423 QPEKPKPEVKPQPE-----KPKPEVKPQ--PEKPKPEVKPQ--PETPKPEVKPQP---------------EKPKPEVKPQ 478

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 557128996  554 VTSETPASSSPtnmTSDTPASSSPTNMTSDTPAS--SSPTNMTSDTPASSSPPWPVIT 609
Cdd:NF033839  479 PEKPKPDNSKP---QADDKKPSTPNNLSKDKQPSnqASTNEKATNKPKKSLPSTGSIS 533
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 147-433 2.16e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.68  E-value: 2.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   147 PPQGASIWRNEF-GPGPLLPmkRRGAETERHMIPGNGPPLAMCHQPAPPElfETlcfPIDPASSAPPKATHRMTiTSLTG 225
Cdd:pfam03154  294 PPQPFPLTPQSSqSQVPPGP--SPAAPGQSQQRIHTPPSQSQLQSQQPPR--EQ---PLPPAPLSMPHIKPPPT-TPIPQ 365

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   226 RPQVTSDT----LASSSPPQGTSDTPAsssPPQVTSATSAsssppqgTSDTPASSSPPQVTSATsasssppQGTSDTPAS 301
Cdd:pfam03154  366 LPNPQSHKhpphLSGPSPFQMNSNLPP---PPALKPLSSL-------STHHPPSAHPPPLQLMP-------QSQQLPPPP 428

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   302 SSPPQVTsatsasssppQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSS 381
Cdd:pfam03154  429 AQPPVLT----------QSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSA 498

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 557128996   382 PPQGTSETPASNS---PP-QGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSS 433
Cdd:pfam03154  499 SVSSSGPVPAAVScplPPvQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTPSHAS 554
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 204-410 4.69e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 4.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  204 IDPASSAPPKATHRMTITSLTGRPQVTSDTLASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQvts 283
Cdd:PRK07764  588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD--- 664

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  284 atSASSSPPQGTSDTPASSSPPQVtsatsasssppQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDT 363
Cdd:PRK07764  665 --GGDGWPAKAGGAAPAAPPPAPA-----------PAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAP 731

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 557128996  364 PSSSS---PPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQ 410
Cdd:PRK07764  732 SPAADdpvPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSE 781
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 397-662 1.80e-03

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 43.46  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  397 QGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASS---SPTQVTSET-PASSSPTQVTSDTPA-SNSPPQGTSDTPGFS 471
Cdd:NF033849  247 VGHSTSQGQSHSVGTSESHSVGTSQSQSHTTGHGSTrgwSHTQSTSESeSTGQSSSVGTSESQShGTTEGTSTTDSSSHS 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  472 SPTQVTTATLVSSSpPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDT-------SASISPPQVISD 544
Cdd:NF033849  327 QSSSYNVSSGTGVS-SSHSDGTSQSTSISHSESSSESTGTSVGHSTSSSVSSSESSSRSSSsgvsggfSGGIAGGGVTSE 405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  545 TPASSsppQVTSET-PASSSPTNMTSDTPASSSPTNMTSDTPASS-SPTNMTSDTpASSSPPWPVITEVTRPESTipaGR 622
Cdd:NF033849  406 GLGAS---QGGSEGwGSGDSVQSVSQSYGSSSSTGTSSGHSDSSShSTSSGQADS-VSQGTSWSEGTGTSQGQSV---GT 478

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 557128996  623 SLANITSKAQEDSPLGVISTHPQMSFQSSTSQALDETAGE 662
Cdd:NF033849  479 SESWSTSQSETDSVGDSTGTSESVSQGDGRSTGRSESQGT 518
CTD smart01104
Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription ...
 426-535 2.16e-03

Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe. The repeat has a characteristic TPA motif.


Pssm-ID: 215026 [Multi-domain]  Cd Length: 121  Bit Score: 40.20  E-value: 2.16e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996    426 SETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSdTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSD 505
Cdd:smart01104   12 SKTPAWGSRTPGTAAGGAPTARGGSGSRTPAWGGAGSRTP-AWGGAGPTGSRTPAWGGASAWGNKSSEGSASSWAAGPGG 90

                            90       100       110
                    ....*....|....*....|....*....|..
gi 557128996    506 TPASSSP--PQVTSeTPASSSPPQVTSDTSAS 535
Cdd:smart01104   91 AYGAPTPgyGGTPS-AYGPATPGGGAMAGSAS 121
CLECT smart00034
C-type lectin (CTL) or carbohydrate-recognition domain (CRD); Many of these domains function ...
 35-142 8.52e-03

C-type lectin (CTL) or carbohydrate-recognition domain (CRD); Many of these domains function as calcium-dependent carbohydrate binding modules.


Pssm-ID: 214480 [Multi-domain]  Cd Length: 124  Bit Score: 38.35  E-value: 8.52e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996     35 GNSCYQLNRLFCDFQEADNYCHAQRGRLA-------HTWnpkLRGFLKSFLNEETVW-------------WVRGNLTLPG 94
Cdd:smart00034    9 GGKCYKFSTEKKTWEDAQAFCQSLGGHLAsihseaeNDF---VASLLKNSGSSDYYWiglsdpdsngswqWSDGSGPVSY 85

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|
gi 557128996     95 SHPGINQTggddvlrNQKPGECPSVVTHSNavfsRWNL--CIEKHHFICQ 142
Cdd:smart00034   86 SNWAPGEP-------NNSSGDCVVLSTSGG----KWNDvsCTSKLPFVCE 124
 
Name Accession Description Interval E-value
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1120-1238 9.70e-56

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 189.79  E-value: 9.70e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996 1120 HYLIQVYTGYRRRAATTAKVVITLYGSEGHSEPHHLCDPEKTVFERGALDVFLLSTGSWLGDLHGLRLWHDNSGDSPSWY 1199
Cdd:cd01752     2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPIFERGSVDSFLLTTPFPLGELQSIRLWHDNSGLSPSWY 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 557128996 1200 VSQVIVSDMTTRKKWHFQCNCWLAVDLGNCERDRVFTPA 1238
Cdd:cd01752    82 LSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPVA 120
Polycystin_dom pfam20519
Polycystin domain; This domain represents the polycystin domain from group II of Transient ...
 1698-1883 1.17e-35

Polycystin domain; This domain represents the polycystin domain from group II of Transient receptor potential (TRP) channels (TRPP) including PKD1, PKD2, PKD2L and mucolipins. The polycystin domain display a sandwich-like shape with five beta-sheets in the tilted middle layer, three alpha-helices on one side and a large loop with two short antiparallel beta-sheets on the other.


Pssm-ID: 466668  Cd Length: 199  Bit Score: 135.24  E-value: 1.17e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  1698 FSEIKTVEDFYPWANGTLLPNLYGD-----YRGFITDGNSFLLGNVLIRQTRIPNDIFFPGSLHKQMKSPPQHQ-----E 1767
Cdd:pfam20519    2 LLTVTDLDDIWDWLSSVLLPALHSNktpsgLPGSFIAYESLLLGVPRLRQLRVRNSSCLVHDKFVREINECHAGysppsE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  1768 DRENYGAGWVPPDTNITKvdSIWHYQNQESLGGYPIQGELATYSGGGYVVRLGRNHSAATRVLQHLEQRRWLDHCTKALF 1847
Cdd:pfam20519   82 DRKLYSALPYKPVHYGSK--YWFIYTPPGLLMGYDHWGHLASYPSGGYVVLLPSSREESLKRLAYLQDNNWLDRGTRAVF 159

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 557128996  1848 VEFTVFNANVNLLCAVTLILESSGVGTFLTSLQLDS 1883
Cdd:pfam20519  160 VDFTLYNADINLFCVVTLRVEFPPTGGVLPSPSVQS 195
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 1888-2108 4.30e-34

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 131.63  E-value: 4.30e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  1888 QSSERGFAWIVSQVVYYLLVCYYAFIQGCRLKRQRLAFFTRKRNLLDTSIVLISFSILGLSMQSLSLLHKKMQQYHCDRD 1967
Cdd:pfam08016    2 YVTNRSLFILLCEIVFVVFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVLNIYRDFLADRLIKSVEASPV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  1968 RFISFYEALRVNSAVTHLRGFLLLFATVRVWDLLRHHAQLQVINKTLSKAWDEVLGFILIIVVLLSSYAMTFNLLFGWSI 2047
Cdd:pfam08016   82 TFIDFDRVAQLDNLYRIILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQA 161

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 557128996  2048 SDYQSFFRSIVTVVGLLMGTSKHKEVIALYPILGSLLVLSSIILMGLVIINLFVSAILIAF 2108
Cdd:pfam08016  162 PNFSNFVKSILTLFRTILGDFGYNEIFSGNRVLGPLLFLTFVFLVIFILLNLFLAIINDSY 222
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1121-1238 5.80e-29

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 113.03  E-value: 5.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996 1121 YLIQVYTGYRRRAATTAKVVITLYGSEGHSEPHHLCDPEKTV-FERGALDVFLLSTGSwLGDLHGLRLWHDNSGDSPSWY 1199
Cdd:cd01756     3 YEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNkFERGQTDKFTVEAVD-LGKLKKIRIGHDNSGLGAGWF 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 557128996 1200 VSQVIVSDMTTRKKWHFQCNCWLAVDLGNCERDRVFTPA 1238
Cdd:cd01756    82 LDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 325-652 9.45e-26

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 116.17  E-value: 9.45e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   325 PASSSPpqVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSP-PQGTSETPASNSP-PQGTSET 402
Cdd:pfam05109  461 PASTGP--TVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPtPNATSPTPAVTTPtPNATSPT 538

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   403 PGFSSPPQ-VTTATLVSSSP-PQVTSETPASSSPT--------QVTSETPASSSPTqVTSDTPASNSPPQ---GTSDTPG 469
Cdd:pfam05109  539 LGKTSPTSaVTTPTPNATSPtPAVTTPTPNATIPTlgktsptsAVTTPTPNATSPT-VGETSPQANTTNHtlgGTSSTPV 617

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   470 FSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASS 549
Cdd:pfam05109  618 VTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTS 697

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   550 SPPQVTSETPASSSPTNmtSDTPASSSPTNMTSDTPasssPTNMTS-DTPASSSPPWPVITEVTRPESTIPAGRSLANIT 628
Cdd:pfam05109  698 SPAPRPGTTSQASGPGN--SSTSTKPGEVNVTKGTP----PKNATSpQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHG 771

                          330       340
                   ....*....|....*....|....*.
gi 557128996   629 SKAQED--SPLGVISTHPQMSFQSST 652
Cdd:pfam05109  772 ARTSTEptTDYGGDSTTPRTRYNATT 797
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 355-662 1.79e-24

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 112.32  E-value: 1.79e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   355 SPPQGTLDTPSSSSPPQGTSdTPASSSPPQGTSETpaSNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSP 434
Cdd:pfam05109  440 AAPNTTTGLPSSTHVPTNLT-APASTGPTVSTADV--TSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTP 516

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   435 T-QVTSETPASSSPT-QVTSDTPASNSP--------PQGTSDTPGFSSPT-QVTTATLVSSSPPQ-VTSDTPASSSP--- 499
Cdd:pfam05109  517 TpNATSPTPAVTTPTpNATSPTLGKTSPtsavttptPNATSPTPAVTTPTpNATIPTLGKTSPTSaVTTPTPNATSPtvg 596

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   500 ---PQV---------TSDTPASSSPPQvTSETPASSSPPQVTSDTSASIS-PPQVISDTPASSSPPQVTSETP--ASSSP 564
Cdd:pfam05109  597 etsPQAnttnhtlggTSSTPVVTSPPK-NATSAVTTGQHNITSSSTSSMSlRPSSISETLSPSTSDNSTSHMPllTSAHP 675

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   565 T---NMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSPPwpvitevTRP-ESTIPAGRSLANITSKaqeDSPLGVI 640
Cdd:pfam05109  676 TggeNITQVTPASTSTHHVSTSSPAPRPGTTSQASGPGNSSTS-------TKPgEVNVTKGTPPKNATSP---QAPSGQK 745

                          330       340
                   ....*....|....*....|..
gi 557128996   641 STHPQMSfqSSTSQALDETAGE 662
Cdd:pfam05109  746 TAVPTVT--STGGKANSTTGGK 765
PHA03247 PHA03247
large tegument protein UL36; Provisional
 159-660 2.21e-23

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 109.64  E-value: 2.21e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  159 GPGPLLPMKRRGAETERHMipgngPPlamcHQPAPPelfetlcfPIDPASSAppkATHRMTITSLTGRPQVTSDtlaSSS 238
Cdd:PHA03247 2550 DPPPPLPPAAPPAAPDRSV-----PP----PRPAPR--------PSEPAVTS---RARRPDAPPQSARPRAPVD---DRG 2606

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  239 PPQGTSdtPASSSPPQVTSAtsasssppqgtsDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSpp 318
Cdd:PHA03247 2607 DPRGPA--PPSPLPPDTHAP------------DPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRL-- 2670

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  319 qgtSDTPASSSPPQvtsatsasssppqgtSDTPASSSPPQGTLdTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQG 398
Cdd:PHA03247 2671 ---GRAAQASSPPQ---------------RPRRRAARPTVGSL-TSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQA 2731

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  399 TSETPGFSSPPQVTTATLVSSSP-----PQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSP 473
Cdd:PHA03247 2732 SPALPAAPAPPAVPAGPATPGGParparPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV 2811

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  474 TQVTTATLVSSSP----PQVTSDTPASSSPPQVTSDTP-------------ASSSPPQVTSETPASSSPPQVTSDTSASI 536
Cdd:PHA03247 2812 LAPAAALPPAASPagplPPPTSAQPTAPPPPPGPPPPSlplggsvapggdvRRRPPSRSPAAKPAAPARPPVRRLARPAV 2891

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  537 SPPQVISDTPASSSPPQvtsETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSP----PWPVITEVT 612
Cdd:PHA03247 2892 SRSTESFALPPDQPERP---PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPsgavPQPWLGALV 2968

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 557128996  613 RPESTIPAGRSLANITSKAQEDSPLGVISTHPQMSFQS-STSQALDETA 660
Cdd:PHA03247 2969 PGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSwASSLALHEET 3017
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1121-1236 6.17e-23

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 95.58  E-value: 6.17e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  1121 YLIQVYTGYRRRAATTAKVVITLYGSEGHS--EPHHLCDPEktvFERGALDVFLLSTGSWLGDLHGLRLWHDNSGDSPSW 1198
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESaqLEITLDNPD---FERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 557128996  1199 YVSQVIV-SDMTTRKKWHFQCNCWLAVDLGNcERDRVFT 1236
Cdd:pfam01477   78 FLKSITVeVPGETGGKYTFPCNSWVYGSKKY-KETRVFF 115
PHA03247 PHA03247
large tegument protein UL36; Provisional
 142-629 1.83e-20

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 100.01  E-value: 1.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  142 QAAAFPPQGASIWRNEFGPGPllpmkrRGAETERHMIPGNGPPLAMCHQPAPPELF---ETLCFPIDPASSAPPKATHRM 218
Cdd:PHA03247 2613 PPSPLPPDTHAPDPPPPSPSP------AANEPDPHPPPTVPPPERPRDDPAPGRVSrprRARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  219 TItsltgRPQVTSDTLASSSPPQGTsdTPASSSPPQVTSATSASSSPPQGTSD--TPASSSPPQVTSATSA----SSSPP 292
Cdd:PHA03247 2687 AA-----RPTVGSLTSLADPPPPPP--TPEPAPHALVSATPLPPGPAAARQASpaLPAAPAPPAVPAGPATpggpARPAR 2759

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  293 QGTSDTPASSSPPQVtsatsasssppqgtsdtPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPqg 372
Cdd:PHA03247 2760 PPTTAGPPAPAPPAA-----------------PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP-- 2820

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  373 tSDTPASSSPPQgTSETPASNSPPQG---TSETPGFSSPPqvtTATLVSSSPPQVTSETPASSSPTQVTS-ETPASSSPT 448
Cdd:PHA03247 2821 -AASPAGPLPPP-TSAQPTAPPPPPGpppPSLPLGGSVAP---GGDVRRRPPSRSPAAKPAAPARPPVRRlARPAVSRST 2895

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  449 QVTSDTPASNSPPQgtsdTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQV 528
Cdd:PHA03247 2896 ESFALPPDQPERPP----QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGR 2971

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  529 TSDTSASISPPQVISDTPASSSPPQVTSETP-----ASSSPTNMTSDTPASSSPTNM--TSDTPASSSPTNMTSDTPASS 601
Cdd:PHA03247 2972 VAVPRFRVPQPAPSREAPASSTPPLTGHSLSrvsswASSLALHEETDPPPVSLKQTLwpPDDTEDSDADSLFDSDSERSD 3051

                         490       500       510
                  ....*....|....*....|....*....|....
gi 557128996  602 S------PPWPVITEVTRPESTIPAGRSLANITS 629
Cdd:PHA03247 3052 LealdplPPEPHDPFAHEPDPATPEAGARESPSS 3085
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 345-619 2.67e-20

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 96.95  E-value: 2.67e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   345 QGTSDTPASSSPPqgtldTPSSSSPPQGTSDTPASSS-PPQGTSETPASNSPPQGTSETPgfSSPPQVTTATLVSSSPPQ 423
Cdd:pfam17823  104 EGAADGAASRALA-----AAASSSPSSAAQSLPAAIAaLPSEAFSAPRAAACRANASAAP--RAAIAAASAPHAASPAPR 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   424 V--------TSETPASSSPTQVTSETPASSSPTQVTSD------TPAS--------NSPPQGTSDTPGFSSPTQVTTATL 481
Cdd:pfam17823  177 TaassttaaSSTTAASSAPTTAASSAPATLTPARGISTaatatgHPAAgtalaavgNSSPAAGTVTAAVGTVTPAALATL 256

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   482 VSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSasisppQVISDTPASSSPPQVTSetpaS 561
Cdd:pfam17823  257 AAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPII------QVSTDQPVHNTAGEPTP----S 326

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 557128996   562 SSPTNMTSDTPASSSPTNMTSDTpasssPTNMTSDTPASSSPPWPVITEVTRPESTIP 619
Cdd:pfam17823  327 PSNTTLEPNTPKSVASTNLAVVT-----TTKAQAKEPSASPVPVLHTSMIPEVEATSP 379
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 179-604 2.76e-20

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 99.09  E-value: 2.76e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  179 PGNGPPLAMCHQPAPPELFETLCFPIDPASSAPPKATHrmtitSLTGRPQVTSDTLASSSPPQGTSDTPASSSPPQVTSA 258
Cdd:PHA03307   67 PPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREG-----SPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPV 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  259 TSASSSPPQGTSDTPASSSPPQvtsatsasssppqGTSDTPASSSPPQvtsatsasssppQGTSDTPASSSPPQVTSATS 338
Cdd:PHA03307  142 GSPGPPPAASPPAAGASPAAVA-------------SDAASSRQAALPL------------SSPEETARAPSSPPAEPPPS 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  339 ASSSPPQGTSdtPASSSPPQGTLDTPSSSSPPQGTSDTPASSSppqGTSETPASNSPPQGTSETPGFSSPPQVTTATLVS 418
Cdd:PHA03307  197 TPPAAASPRP--PRRSSPISASASSPAPAPGRSAADDAGASSS---DSSSSESSGCGWGPENECPLPRPAPITLPTRIWE 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  419 SSPPQVTSETPASSSPtqVTSETPASSSPTQVTSDTPASNSPPQGTSDtpGFSSPTQVTTATLVSSSPPQVTSDTPASSS 498
Cdd:PHA03307  272 ASGWNGPSSRPGPASS--SSSPRERSPSPSPSSPGSGPAPSSPRASSS--SSSSRESSSSSTSSSSESSRGAAVSPGPSP 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  499 PPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPT 578
Cdd:PHA03307  348 SRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFY 427

                         410       420
                  ....*....|....*....|....*.
gi 557128996  579 NMTSDTPASSSPtnmtsdTPASSSPP 604
Cdd:PHA03307  428 ARYPLLTPSGEP------WPGSPPPP 447
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 237-636 8.77e-20

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 97.16  E-value: 8.77e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  237 SSPPQGTSDTPASSSPPQVtsatsasssppqGTSDTPASSSPPQVTSATSASSSPPQGtsdtPASSSPPQVTSATSASSS 316
Cdd:PHA03307   25 PATPGDAADDLLSGSQGQL------------VSDSAELAAVTVVAGAAACDRFEPPTG----PPPGPGTEAPANESRSTP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  317 PPQGTSDTPASSSPPQvtsatsaSSSPPQGTSDTPA-SSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSP 395
Cdd:PHA03307   89 TWSLSTLAPASPAREG-------SPTPPGPSSPDPPpPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  396 PQGTSETPGFSSPP-QVTTATLVSSSPPQvtSETPASSSPTQVTSETPASSSPTQVTSDTPASnSPPQGTSDTPGFSSPT 474
Cdd:PHA03307  162 VASDAASSRQAALPlSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAP-APGRSAADDAGASSSD 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  475 QVTTATLVSSSPPQvtSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPqVISDTPASSSPPQV 554
Cdd:PHA03307  239 SSSSESSGCGWGPE--NECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPS-SPGSGPAPSSPRAS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  555 TSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSPP--------WPVITEVTRPESTIPAGRSLAN 626
Cdd:PHA03307  316 SSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPrkrprpsrAPSSPAASAGRPTRRRARAAVA 395

                         410
                  ....*....|
gi 557128996  627 ITSKAQEDSP 636
Cdd:PHA03307  396 GRARRRDATG 405
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 171-619 1.76e-19

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 95.75  E-value: 1.76e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   171 AETERHMIPGNGPPLAMCHQPAppelFETLCFPIDPASSAPPKATH---RMTITSLTGRPQVTSDTlaSSSPPQGTSDTP 247
Cdd:pfam05109  412 ATTTTHKVIFSKAPESTTTSPT----LNTTGFAAPNTTTGLPSSTHvptNLTAPASTGPTVSTADV--TSPTPAGTTSGA 485

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   248 ASSSPPQVTSATSASSSPPQGTSDTPASSSPpqvtsatsasssPPQGTSDTPASSSPpqvtsatsasssPPQGTSDTPAS 327
Cdd:pfam05109  486 SPVTPSPSPRDNGTESKAPDMTSPTSAVTTP------------TPNATSPTPAVTTP------------TPNATSPTLGK 541

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   328 SSPpqvtsATSASSSPPQGTSDTPASSSP-PQGTLDTPSSSSPPQG-TSDTPASSSPPQGTSETPA--SNSPPQGTSETP 403
Cdd:pfam05109  542 TSP-----TSAVTTPTPNATSPTPAVTTPtPNATIPTLGKTSPTSAvTTPTPNATSPTVGETSPQAntTNHTLGGTSSTP 616

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   404 GFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSsptqvTSDTPASNSPPQGTSDTPGFSSPTQVTTAtlvS 483
Cdd:pfam05109  617 VVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPS-----TSDNSTSHMPLLTSAHPTGGENITQVTPA---S 688

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   484 SSPPQVTSDTPASSSPPQVTSDTPASSSppqvTSETPASSSPPQVTSDTSAsiSPPQVISDTpaSSSPPQVTSETPASSS 563
Cdd:pfam05109  689 TSTHHVSTSSPAPRPGTTSQASGPGNSS----TSTKPGEVNVTKGTPPKNA--TSPQAPSGQ--KTAVPTVTSTGGKANS 760

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557128996   564 PTNMTSDT----PASSSP-TNMTSDTPASSSPTNMTSDTPASSS----PPWPVIT-EVTRPESTIP 619
Cdd:pfam05109  761 TTGGKHTTghgaRTSTEPtTDYGGDSTTPRTRYNATTYLPPSTSsklrPRWTFTSpPVTTAQATVP 826
PHA03247 PHA03247
large tegument protein UL36; Provisional
 144-607 1.86e-19

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 96.55  E-value: 1.86e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  144 AAFPPQGasiWRNEFGPGPLLPMkrrgAETERHMIPGNGPplamchQPAPPELFetlcfPIDPASSAPPKATHRMTITSL 223
Cdd:PHA03247 2676 ASSPPQR---PRRRAARPTVGSL----TSLADPPPPPPTP------EPAPHALV-----SATPLPPGPAAARQASPALPA 2737

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  224 TGRPQVTSDTLASSSPPQGTSDTPASSSPPQVTSATSasssppqgtsdtPASSSPPQVTSATSASSSPPQGTSDTPASSS 303
Cdd:PHA03247 2738 APAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA------------PAAGPPRRLTRPAVASLSESRESLPSPWDPA 2805

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  304 PPQVTSATSASSSPpqgTSDTPASSSPPQvtsatsasssppqgTSDTPASSSPPQGtldtPSSSSPPQGTSDTP----AS 379
Cdd:PHA03247 2806 DPPAAVLAPAAALP---PAASPAGPLPPP--------------TSAQPTAPPPPPG----PPPPSLPLGGSVAPggdvRR 2864

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  380 SSPPQGTSETPASNS-PPQGTSETPGFSSPPQvttaTLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASN 458
Cdd:PHA03247 2865 RPPSRSPAAKPAAPArPPVRRLARPAVSRSTE----SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ 2940

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  459 SPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISP 538
Cdd:PHA03247 2941 PPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPP 3020

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557128996  539 PQVISDT---PASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSPPWPV 607
Cdd:PHA03247 3021 PVSLKQTlwpPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPL 3092
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1120-1222 5.89e-19

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 84.31  E-value: 5.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996 1120 HYLIQVYTGYRRRAATTAKVVITLYGSEGHSEPHhLCDPEKTVFERGALDVFLLSTGSWLGDLHGLRLWHDNSGDSPSWY 1199
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDI-PILDGPGSFERGSTDTFQIDLKLDIGDITKVYLRRDGSGLSDGWY 80

                          90       100
                  ....*....|....*....|...
gi 557128996 1200 VSQVIVSDMTTRKKWHFQCNCWL 1222
Cdd:cd00113    81 CESITVQALGTKKVYTFPVNRWV 103
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 192-622 4.26e-18

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 91.77  E-value: 4.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  192 APPELFETLCFPIDPASSAPPKATHRMTITSLTGRPQVTSDTLASSSPPQGTSDTPASSSPPqvtsATSASSSPPQGTSD 271
Cdd:PHA03307   53 VTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSP----DPPPPTPPPASPPP 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  272 TPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQvtsatsasssppqGTSDTPASSSPPQvtsatsasSSPPQgTSDTP 351
Cdd:PHA03307  129 SPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA-------------SDAASSRQAALPL--------SSPEE-TARAP 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  352 ASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQ-----VTTATLVSSSPPQVTS 426
Cdd:PHA03307  187 SSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSgcgwgPENECPLPRPAPITLP 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  427 ETPASSSPTQVTSETPASSSPtqVTSDTPASNSPPQGTSDTPGFSSPtqvttATLVSSSPPQVTSDTPASSSPPQVTSDT 506
Cdd:PHA03307  267 TRIWEASGWNGPSSRPGPASS--SSSPRERSPSPSPSSPGSGPAPSS-----PRASSSSSSSRESSSSSTSSSSESSRGA 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  507 PASSSPPQVTSETPASSSPPQVTSDTSASISP---PQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSD 583
Cdd:PHA03307  340 AVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPsraPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDA 419

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 557128996  584 TPASSSPTNMTSDTPASSSpPWPvitEVTRPestiPAGR 622
Cdd:PHA03307  420 GAASGAFYARYPLLTPSGE-PWP---GSPPP----PPGR 450
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 207-576 4.17e-17

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 86.94  E-value: 4.17e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   207 ASSAPP------KATHRMTITSLTGRPQVTSDTLASSSPP--QGTSDTPASSSPpqvtsATSASSSPPQGTSDTPASSSP 278
Cdd:pfam17823   62 AATAAPapvtltKGTSAAHLNSTEVTAEHTPHGTDLSEPAtrEGAADGAASRAL-----AAAASSSPSSAAQSLPAAIAA 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   279 PQVTSATSASSSPPQgtsdTPASSSPpqvtsatsasSSPPQGTSDTPASSSPPQvtsatSASSSPPQGTSDTPASSSPPQ 358
Cdd:pfam17823  137 LPSEAFSAPRAAACR----ANASAAP----------RAAIAAASAPHAASPAPR-----TAASSTTAASSTTAASSAPTT 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   359 GTLDTPSSSSPPQGTSDTPASSSPPQ---GTSETPASNSPPQGTSETPGFSSPPQV-----------TTATLVSSSPPQV 424
Cdd:pfam17823  198 AASSAPATLTPARGISTAATATGHPAagtALAAVGNSSPAAGTVTAAVGTVTPAALatlaaaagtvaSAAGTINMGDPHA 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   425 TSETPASSSPTQVTSETPASSS------PT-QVTSDTPASNSPPQGTSdTPGFSSPTQVTTATLVSSSPPQVTSDTPASS 497
Cdd:pfam17823  278 RRLSPAKHMPSDTMARNPAAPMgaqaqgPIiQVSTDQPVHNTAGEPTP-SPSNTTLEPNTPKSVASTNLAVVTTTKAQAK 356

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   498 SPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQvisdtpassSPPQVTSE-TP--ASSSPTNMTS---DT 571
Cdd:pfam17823  357 EPSASPVPVLHTSMIPEVEATSPTTQPSPLLPTQGAAGPGILL---------APEQVATEaTAgtASAGPTPRSSgdpKT 427


                   ....*
gi 557128996   572 PASSS 576
Cdd:pfam17823  428 LAMAS 432
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 182-564 4.31e-17

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 88.05  E-value: 4.31e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   182 GPPLAMCHQPAP-PELFETLCFPIDPASSAPPKATHrmtitslTGRPQVTSDTLASSSP-PQGTSDTPASSSPpqvtsat 259
Cdd:pfam05109  465 GPTVSTADVTSPtPAGTTSGASPVTPSPSPRDNGTE-------SKAPDMTSPTSAVTTPtPNATSPTPAVTTP------- 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   260 sasssPPQGTSDTPASSSPpqvtsATSASSSPPQGTSDTPASSSP-PQVTSATSASSSPPQG-TSDTPASSSPP--QVTS 335
Cdd:pfam05109  531 -----TPNATSPTLGKTSP-----TSAVTTPTPNATSPTPAVTTPtPNATIPTLGKTSPTSAvTTPTPNATSPTvgETSP 600

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   336 ATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSP-----PQ 410
Cdd:pfam05109  601 QANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAhptggEN 680

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   411 VTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPT------QVTSDTPASN-SPPQGTSDTPGfSSPTQVTTATLVS 483
Cdd:pfam05109  681 ITQVTPASTSTHHVSTSSPAPRPGTTSQASGPGNSSTStkpgevNVTKGTPPKNaTSPQAPSGQKT-AVPTVTSTGGKAN 759

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   484 SSPPQVTSDTPASSSPPQVTSDTPASSSPPQvTSETPASSSPPQvtsdTSASISPPQVISDTPASSSppQVTSETPASSS 563
Cdd:pfam05109  760 STTGGKHTTGHGARTSTEPTTDYGGDSTTPR-TRYNATTYLPPS----TSSKLRPRWTFTSPPVTTA--QATVPVPPTSQ 832


                   .
gi 557128996   564 P 564
Cdd:pfam05109  833 P 833
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 376-668 5.06e-17

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 86.94  E-value: 5.06e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   376 TPASSSPPQGTSETPAS--NSPPQGTSETP---GFSSPP-QVTTATLVSSSPPQvtseTPASSSPTQVTSETPASSS-PT 448
Cdd:pfam17823   63 ATAAPAPVTLTKGTSAAhlNSTEVTAEHTPhgtDLSEPAtREGAADGAASRALA----AAASSSPSSAAQSLPAAIAaLP 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   449 QVTSDTPASNSPPQGTSDTPgfSSPTQVTTATLVSSSPPQVtsdtpASSSPPQVTSDTPASSSPPQVTSETPASSSP--P 526
Cdd:pfam17823  139 SEAFSAPRAAACRANASAAP--RAAIAAASAPHAASPAPRT-----AASSTTAASSTTAASSAPTTAASSAPATLTParG 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   527 QVTSDT-----SASISPPQVISDTPAS-SSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSD------TPASSSPTNMT 594
Cdd:pfam17823  212 ISTAATatghpAAGTALAAVGNSSPAAgTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDpharrlSPAKHMPSDTM 291

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   595 SDTPASSSPP------------WPVITEVTRPeSTIPAGRSLANITSKAQEDSPLGVISThpqmsfqsSTSQALDETAGE 662
Cdd:pfam17823  292 ARNPAAPMGAqaqgpiiqvstdQPVHNTAGEP-TPSPSNTTLEPNTPKSVASTNLAVVTT--------TKAQAKEPSASP 362


                   ....*.
gi 557128996   663 rVPTIP 668
Cdd:pfam17823  363 -VPVLH 367
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 179-576 6.88e-17

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 87.51  E-value: 6.88e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   179 PGNGPPLAMChQPAPPELFETLCFPIDPASSAPPKATHRMT--ITSLTGRPQVTSDTLASSSPP--QGTSDTPASSSPPQ 254
Cdd:pfam03154  186 PPPPGTTQAA-TAGPTPSAPSVPPQGSPATSQPPNQTQSTAapHTLIQQTPTLHPQRLPSPHPPlqPMTQPPPPSQVSPQ 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   255 VTSATSASssppqgtSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQvt 334
Cdd:pfam03154  265 PLPQPSLH-------GQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQ-- 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   335 satsasssppqgtSDTPASSSP-PQGTLDTPSSSSPPQgtsdTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTT 413
Cdd:pfam03154  336 -------------SQQPPREQPlPPAPLSMPHIKPPPT----TPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKP 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   414 ATLVSSSPPQVTSETPASSSPTQVTSETPASSSP--TQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTS 491
Cdd:pfam03154  399 LSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPvlTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPP 478

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   492 DTPASSSPPQVTSDTPASSSPPQVTSETPASssppqvtsdTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDT 571
Cdd:pfam03154  479 SGPPTSTSSAMPGIQPPSSASVSSSGPVPAA---------VSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNT 549


                   ....*
gi 557128996   572 PASSS 576
Cdd:pfam03154  550 PSHAS 554
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 206-577 8.42e-17

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 87.28  E-value: 8.42e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   206 PASSAPPKATHRMTITSLTGRPQVTSDTLASSSPPQGTSDtpaSSSPPQVTSATSASSSPPQGTSDTPASSSPpqvtsat 285
Cdd:pfam05109  461 PASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTE---SKAPDMTSPTSAVTTPTPNATSPTPAVTTP------- 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   286 sasssPPQGTSDTPASSSPpqvtsATSASSSPPQGTSDTPASSSP-PQVTSATSASSSPPQG-TSDTPASSSPPQGTlDT 363
Cdd:pfam05109  531 -----TPNATSPTLGKTSP-----TSAVTTPTPNATSPTPAVTTPtPNATIPTLGKTSPTSAvTTPTPNATSPTVGE-TS 599

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   364 PSSSSPPQ---GTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETP--ASSSPT--- 435
Cdd:pfam05109  600 PQANTTNHtlgGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPllTSAHPTgge 679

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   436 QVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSS-PTQVTTATLVSSSPPQVTSDTPASS----SPPQVTSDTPASS 510
Cdd:pfam05109  680 NITQVTPASTSTHHVSTSSPAPRPGTTSQASGPGNSStSTKPGEVNVTKGTPPKNATSPQAPSgqktAVPTVTSTGGKAN 759

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 557128996   511 SP---PQVTSETPASSSPPqvTSDTSASISPPQVISDT-----PASSSP--PQVTSETPASSSpTNMTSDTPASSSP 577
Cdd:pfam05109  760 STtggKHTTGHGARTSTEP--TTDYGGDSTTPRTRYNAttylpPSTSSKlrPRWTFTSPPVTT-AQATVPVPPTSQP 833
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
203-603 8.42e-16

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 83.20  E-value: 8.42e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   203 PIDPASSAPPKATHRMTITSLTGRPQVTSDTlaSSSPPQGTSDTPA----SSSPPQV-----TSATSASSSPPQGTSDTP 273
Cdd:pfam03546   67 PRKGAPPVPPGKTGPAAAQAQAGKPEEDSES--SSEESDSDGETPAaatlTTSPAQVkplgkNSQVRPASTVGKGPSGKG 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   274 ASSSPPQVTSATSASSSPPQGTSDTPASS--------SPPQVTSATSASSSPPQGTSDTP---ASSSPPQVTSATSASSS 342
Cdd:pfam03546  145 ANPAPPGKAGSAAPLVQVGKKEEDSESSSeesdsegeAPPAATQAKPSGKILQVRPASGPakgAAPAPPQKAGPVATQVK 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   343 PPQGTSDT-------------PASSSPPQG--TLDTPSS-SSPPQGTSDTPASSSPPQGTSETPASNSppQGTSETPGFS 406
Cdd:pfam03546  225 AERSKEDSesseessdseeeaPAAATPAQAkpALKTPQTkASPRKGTPITPTSAKVPPVRVGTPAPWK--AGTVTSPACA 302

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   407 SPPQVTTAT----LVSSSPPQVTSETPASSSPTQVTSET-------PASSSPTQVTSDTPASNSPPQGTSdtpgfSSPTQ 475
Cdd:pfam03546  303 SSPAVARGAqrpeEDSSSSEESESEEETAPAAAVGQAKSvgkglqgKAASAPTKGPSGQGTAPVPPGKTG-----PAVAQ 377

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   476 VTTATLVSSSPPQVTSD------TPASSSPPQVTSDTPASSSPPQVTSETPASSSP-------PQVTSDTSASISPPQVI 542
Cdd:pfam03546  378 VKAEAQEDSESSEEESDseeaaaTPAQVKASGKTPQAKANPAPTKASSAKGAASAPgkvvaaaAQAKQGSPAKVKPPART 457

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557128996   543 SDTPASSSPPQ---------VTSETPASSSPTNMTSDTPASSSPTNMTSD--TPASSSPTNMTSDTPASSSP 603
Cdd:pfam03546  458 PQNSAISVRGQasvpavgkaVATAAQAQKGPVGGPQEEDSESSEEESDSEeeAPAQAKPSGKTPQVRAASAP 529
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 211-608 1.36e-15

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 83.28  E-value: 1.36e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   211 PPKATHRMTITSLTGRPQVTSDTLASSSPPQGTSDTpASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSS 290
Cdd:pfam03154   94 PERATAKKSKTQEISRPNSPSEGEGESSDGRSVNDE-GSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPP 172

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   291 PPQGTSDTPASSSPPQVTSATSASSSPPQGTSD-----TPASSSPPQVTSATSASSSPPQGTSDT-----PASSSPPQG- 359
Cdd:pfam03154  173 VLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSvppqgSPATSQPPNQTQSTAAPHTLIQQTPTLhpqrlPSPHPPLQPm 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   360 TLDTPSSSSPPQGTSDT-------PASSS------------PPQG---TSETPASNSPPQGTSETPGFSSPPQVTTATLV 417
Cdd:pfam03154  253 TQPPPPSQVSPQPLPQPslhgqmpPMPHSlqtgpshmqhpvPPQPfplTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQS 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   418 SSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPgFSSPTQVTT-------ATLVSSSPP--- 487
Cdd:pfam03154  333 QLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSP-FQMNSNLPPppalkplSSLSTHHPPsah 411

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   488 ----QVTSDTPASSSPP-------QVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTS 556
Cdd:pfam03154  412 ppplQLMPQSQQLPPPPaqppvltQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPG 491

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 557128996   557 ETPASSSPTNMTSDTPASSS----PTNMTSDTPASSSPTNMTSDTPASSSPPWPVI 608
Cdd:pfam03154  492 IQPPSSASVSSSGPVPAAVScplpPVQIKEEALDEAEEPESPPPPPRSPSPEPTVV 547
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
323-672 3.72e-15

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 80.89  E-value: 3.72e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   323 DTPASSSPPQVTSATSASSSppQGTSdTPASSSPPQGTLDTPSSSSPPQGTS--------DTPASSSPPQGTSETPASNS 394
Cdd:pfam03546   37 ETPAAKTPLQAKPSGKTPQV--RAAS-APAKESPRKGAPPVPPGKTGPAAAQaqagkpeeDSESSSEESDSDGETPAAAT 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   395 PPQGTSETPGFSSPPQVTTATLVSSSP------PQVTSETPASSSPTQVTSETPASSSPTQvTSDTPASNSPPQGTSDTP 468
Cdd:pfam03546  114 LTTSPAQVKPLGKNSQVRPASTVGKGPsgkganPAPPGKAGSAAPLVQVGKKEEDSESSSE-ESDSEGEAPPAATQAKPS 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   469 GFSSPTQVTT--ATLVSSSPPQVTSdtPASSsppQVTSDTP---ASSSPPQVTSE-------TPASSSPPQVTSDTSAsi 536
Cdd:pfam03546  193 GKILQVRPASgpAKGAAPAPPQKAG--PVAT---QVKAERSkedSESSEESSDSEeeapaaaTPAQAKPALKTPQTKA-- 265

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   537 SPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSPPWPVIT------- 609
Cdd:pfam03546  266 SPRKGTPITPTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVARGAQRPEEDSSSSEESESEEETAPAAAVGQaksvgkg 345

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 557128996   610 ---------------EVTRPESTIPAGRSLANITSKAQEDSplgvisthpQMSFQSSTSQALDETAGERVPTIPDFQA 672
Cdd:pfam03546  346 lqgkaasaptkgpsgQGTAPVPPGKTGPAVAQVKAEAQEDS---------ESSEEESDSEEAAATPAQVKASGKTPQA 414
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
373-609 5.12e-15

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 80.57  E-value: 5.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  373 TSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTS 452
Cdd:COG3469     1 SSSVSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  453 DTPASNSPPqgtsdtpgfSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPpqVTSDT 532
Cdd:COG3469    81 TATAAAAAA---------TSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSA--GSTTT 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 557128996  533 SASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSsptnmtsdTPASSSPPWPVIT 609
Cdd:COG3469   150 TTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTT--------GPPTPGLPKHVLV 218
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 183-623 3.01e-14

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 79.04  E-value: 3.01e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   183 PPLAMCHQPAPPelfetlcfpidPASSAPPKAThrmtitsltgrpqvtsdTLASSSPPQGTSDTPASSSPPqvtsatsaS 262
Cdd:pfam03154  171 PPVLQAQSGAAS-----------PPSPPPPGTT-----------------QAATAGPTPSAPSVPPQGSPA--------T 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   263 SSPPQGTSDTPASSSPPQvtsatsasssppQGTSDTPASSSPPQvtsatsasSSPPQGTSDTPASSSPPQvtsatsasss 342
Cdd:pfam03154  215 SQPPNQTQSTAAPHTLIQ------------QTPTLHPQRLPSPH--------PPLQPMTQPPPPSQVSPQ---------- 264

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   343 ppqgtSDTPASSSPPQGTLDTPSSSSPPQgtSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPP 422
Cdd:pfam03154  265 -----PLPQPSLHGQMPPMPHSLQTGPSH--MQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQ 337

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   423 QVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPgFSSPtqvttatlvSSSPPqvtsdTPASSSPPQV 502
Cdd:pfam03154  338 QPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSP-FQMN---------SNLPP-----PPALKPLSSL 402

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   503 TSDTPASSSPP--QVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETP-------ASSSPTNMTSDTPA 573
Cdd:pfam03154  403 STHHPPSAHPPplQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPfpqhpfvPGGPPPITPPSGPP 482

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 557128996   574 SSSPTNMTSDTPASSSPTNMTSDTPASSSPPWPVIT-------EVTRPESTIPAGRS 623
Cdd:pfam03154  483 TSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQikeealdEAEEPESPPPPPRS 539
SPT5 COG5164
Transcription elongation factor SPT5 [Transcription];
320-632 6.43e-14

Transcription elongation factor SPT5 [Transcription];


Pssm-ID: 444063 [Multi-domain]  Cd Length: 495  Bit Score: 76.99  E-value: 6.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  320 GTSDTPA----SSSPPQvtsatsasssppQGTSDTPASSSPPQGTLDTPSSSSPPQGT-SDTPA----SSSPPQGT-SET 389
Cdd:COG5164    24 QGSTKPAqnqgSTRPAG------------NTGGTRPAQNQGSTTPAGNTGGTRPAGNQgATGPAqnqgGTTPAQNQgGTR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  390 PASNSPPQGTSETPGFSSPPQVTTATLV-----SSSPPQVTSETPASssPTQVTSETPASSSPTQVTsdTPASNSPPQGT 464
Cdd:COG5164    92 PAGNTGGTTPAGDGGATGPPDDGGATGPpddggSTTPPSGGSTTPPG--DGGSTPPGPGSTGPGGST--TPPGDGGSTTP 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  465 SDTPGFSSPTQVTTATlvssSPPqvtsdTPASSSPPQVTSDTPAS--SSPPQVTSETPASSSPPQVTSDTSASispPQVI 542
Cdd:COG5164   168 PGPGGSTTPPDDGGST----TPP-----NKGETGTDIPTGGTPRQgpDGPVKKDDKNGKGNPPDDRGGKTGPK---DQRP 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  543 SDTPASSSPPQVTSETPASSSPTNmTSDTPASSSPTNMTSDTPASSS--PTNMTSDTPASSSPPWPVITEVTRPESTIPA 620
Cdd:COG5164   236 KTNPIERRGPERPEAAALPAELTA-LEAENRAANPEPATKTIPETTTvkDLATVLGKKGSDLVTNLMKKGKGTNINAALD 314

                         330
                  ....*....|..
gi 557128996  621 GRSLANITSKAQ 632
Cdd:COG5164   315 FETAATIALEGN 326
PHA03247 PHA03247
large tegument protein UL36; Provisional
 325-631 1.09e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 77.67  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  325 PASSSPPQVTSATSASSSPPQGTSDTPASSSPPqgtldTPSSSSPPQGTSDTPASSSPPQ------GTSET-------PA 391
Cdd:PHA03247 2478 PVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPP-----APSRLAPAILPDEPVGEPVHPRmltwirGLEELasddagdPP 2552

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  392 SNSPPQGTSETPGFSSP----------PQVTTATLVSSSPPQVTS-ETPASSSPTQVTSETPASSSPTQVTSDTPASNSP 460
Cdd:PHA03247 2553 PPLPPAAPPAAPDRSVPpprpaprpsePAVTSRARRPDAPPQSARpRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPS 2632

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  461 PQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSppqvtSDTPASSSPPQVTSETPAsssPPQVTSDTSASISPPQ 540
Cdd:PHA03247 2633 PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRL-----GRAAQASSPPQRPRRRAA---RPTVGSLTSLADPPPP 2704

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  541 visDTPASSSPPQVTSETPASSSPTNMTSDTPASSS-----PTNMTSDTPASSS--PTNMTSDTPASSSPPW-PVITevT 612
Cdd:PHA03247 2705 ---PPTPEPAPHALVSATPLPPGPAAARQASPALPAapappAVPAGPATPGGPArpARPPTTAGPPAPAPPAaPAAG--P 2779

                         330
                  ....*....|....*....
gi 557128996  613 RPESTIPAGRSLANITSKA 631
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESL 2798
Not5 COG5665
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
194-637 2.80e-13

CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];


Pssm-ID: 444384 [Multi-domain]  Cd Length: 874  Bit Score: 75.47  E-value: 2.80e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  194 PELFETLCFPIDP-ASSAPPKATHRMTITSLTGRPQVTSDTLASSSPPQGTSDTpassSPPQVTSATSASSSPPQGT--- 269
Cdd:COG5665   168 PVAVVVTTMIAVPsAPAAPPNAVDYSVLVPIAAQDPAASVSTPQAFNASATSGR----SQHIVQAAKRVGVEWWGDPsll 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  270 SDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPpqvTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGT-- 347
Cdd:COG5665   244 ATPPATPATEEKSSQQPKSQPTSPSGGTTPPSTNQ---LTTSNTPTSTAKAQPQPPTKKQPAKEPPSDTASGNPSAPSvl 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  348 --SDTPASSSPPqgtldTPSSSSPPQGTSDTPASSSPpqgtsetpasnsppqgtsetpgfSSPPQVTTATLVSSSPPQVT 425
Cdd:COG5665   321 inSDSPTSEDPA-----TASVPTTEETTAFTTPSSVP-----------------------STPAEKDTPATDLATPVSPT 372

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  426 SetPASSSPTQVTSETPASSSPTQVTSDTPASNSPP---QGTSDTPGFSSPTQvtTATLVSSSPPQvtsdTPASSSPPQV 502
Cdd:COG5665   373 P--PETSVDKKVSPDSATSSTKSEKEGGTASSPMPPniaIGAKDDVDATDPSQ--EAKEYTKNAPM----TPEADSAPES 444

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  503 TSDTPAS---SSPPQVTSET---------PASSSPPQVTSDTSAS-----ISPPQVISDTPASSSPPQVTSETPASSSPT 565
Cdd:COG5665   445 SVRTEASpsaGSDLEPENTTlrdpapnaiPPPEDPSTIGRLSSGDklaneTGPPVIRRDSTPSSTADQSIVGVLAFGLDQ 524

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557128996  566 NMTSdtpASSSPTNMTSDTPASSSPTNMTSDTpaSSSPPWPvITEVTRPESTIpAGRSLANITSKAQEDSPL 637
Cdd:COG5665   525 RTQA---EISVEAASRSNPLLNSQVKSFPLGK--RSEGAKG-KTQTDRGISNA-LVNASALITNLKSAARRS 589
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
351-605 3.76e-13

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 75.27  E-value: 3.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  351 PASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQ---VTSE 427
Cdd:PRK07003  362 VTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPAtadRGDD 441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  428 TPASSSPTQVTSETPASSSPT-QVTSDTPASNSPPQG--TSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTS 504
Cdd:PRK07003  442 AADGDAPVPAKANARASADSRcDERDAQPPADSGSASapASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDA 521

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  505 DTPASSSPPQVTSETPASSSPPQVTSDTSASI-----SPPQVISD------TPASSSPPQVTSETPASSSPtnmTSDTPA 573
Cdd:PRK07003  522 PAAAAPPAPEARPPTPAAAAPAARAGGAAAALdvlrnAGMRVSSDrgaraaAAAKPAAAPAAAPKPAAPRV---AVQVPT 598

                         250       260       270
                  ....*....|....*....|....*....|..
gi 557128996  574 SSSPTNMTSDTPASSSPTNMTSDTPaSSSPPW 605
Cdd:PRK07003  599 PRARAATGDAPPNGAARAEQAAESR-GAPPPW 629
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 414-668 5.10e-13

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 74.23  E-value: 5.10e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   414 ATLVSSSPPQVTSETPASS-SPTQVTSETpassSPTQVTSDTPASNsppQGTSDTPGFSSPTQVTtatlvSSSPPQVTSD 492
Cdd:pfam17823   62 AATAAPAPVTLTKGTSAAHlNSTEVTAEH----TPHGTDLSEPATR---EGAADGAASRALAAAA-----SSSPSSAAQS 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   493 TPASSSPPQvtsdTPASSSPPQVTSETPASSSPPQVTSDTSAsispPQVISDTP--ASSSPPQVTSETPASSSPTNMTSD 570
Cdd:pfam17823  130 LPAAIAALP----SEAFSAPRAAACRANASAAPRAAIAAASA----PHAASPAPrtAASSTTAASSTTAASSAPTTAASS 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   571 TPASSSPTNMTSdTPASSSPTNMTSDTPASSSPPWPVITEVTRPESTIPAGrSLANITSKAQE-DSPLGVISTHPQMSFQ 649
Cdd:pfam17823  202 APATLTPARGIS-TAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPA-ALATLAAAAGTvASAAGTINMGDPHARR 279

                          250
                   ....*....|....*....
gi 557128996   650 SSTSQALDETAGERVPTIP 668
Cdd:pfam17823  280 LSPAKHMPSDTMARNPAAP 298
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
209-603 1.19e-12

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 72.80  E-value: 1.19e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   209 SAPPKATHRMTITSLTGRPQVTSDtlaSSSPPQGTSD--TPASSSPPQVTSATSASSSppQGTSdTPASSSP-----PQV 281
Cdd:pfam03546    2 PATPGKAGPAATQAKAGKPEEDSE---SSSEEESDSEeeTPAAKTPLQAKPSGKTPQV--RAAS-APAKESPrkgapPVP 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   282 TSATSASSSPPQ-GTSDTPASSSPPQVTSATSASSSPPQGTSdtPASSSP----PQVTSATSASS-SPPQGTSDTPASSS 355
Cdd:pfam03546   76 PGKTGPAAAQAQaGKPEEDSESSSEESDSDGETPAAATLTTS--PAQVKPlgknSQVRPASTVGKgPSGKGANPAPPGKA 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   356 PPQGTL------DTPSSSSPPQGTSDTPAsssPPQGTSETPASNSPPQGTSETP---GFSSPPQVT--TATLVSSSPPQV 424
Cdd:pfam03546  154 GSAAPLvqvgkkEEDSESSSEESDSEGEA---PPAATQAKPSGKILQVRPASGPakgAAPAPPQKAgpVATQVKAERSKE 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   425 TSETPASSSPTQ---VTSETPASSSPTQVTSDTPAsnSPPQGTSDTPgfsSPTQVTTATLVSSSPPQV-TSDTPASSSPP 500
Cdd:pfam03546  231 DSESSEESSDSEeeaPAAATPAQAKPALKTPQTKA--SPRKGTPITP---TSAKVPPVRVGTPAPWKAgTVTSPACASSP 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   501 QVTSDT--PASSSPPQVTSETPASSSPP----QVTS-----DTSASISPPQVISDTPASSSPP--------QVTSETPAS 561
Cdd:pfam03546  306 AVARGAqrPEEDSSSSEESESEEETAPAaavgQAKSvgkglQGKAASAPTKGPSGQGTAPVPPgktgpavaQVKAEAQED 385

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*...
gi 557128996   562 SSPTNMTSD------TPASSSPTNMTSDTPASSSPTNMTSDTPASSSP 603
Cdd:pfam03546  386 SESSEEESDseeaaaTPAQVKASGKTPQAKANPAPTKASSAKGAASAP 433
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1120-1225 4.97e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 64.20  E-value: 4.97e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   1120 HYLIQVYTGYRRRAATTAKVVITLYGSEGHSEPHHLCDPEKTVFERGALDVFLLSTGSWLGDLHGLRLWHDNsgDSPSWY 1199
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEH--RHPEWF 79

                            90       100
                    ....*....|....*....|....*.
gi 557128996   1200 VSQVIVSDMTTRKKWHFQCNCWLAVD 1225
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYPD 105
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 147-513 5.09e-12

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 71.74  E-value: 5.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  147 PPQGASIWRNEFGPGPLLP--MKRRGAETERHMIPGNGPPlAMCHQPAPPELFETLCFPIDPASSAPPKATHRMTITSLT 224
Cdd:PHA03307   79 APANESRSTPTWSLSTLAPasPAREGSPTPPGPSSPDPPP-PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGA 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  225 GRPQVTSDT-------LASSSPPQG--TSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSP---------------PQ 280
Cdd:PHA03307  158 SPAAVASDAassrqaaLPLSSPEETarAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPapapgrsaaddagasSS 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  281 VTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPqvtsatsassSPPQGTSDTPASSSPPQGT 360
Cdd:PHA03307  238 DSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSS----------SSPRERSPSPSPSSPGSGP 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  361 LDTPSS-----SSPPQGTSDTPASSSPPqgtSETPASnSPPQGTSETPGFSSPPqvttatlvSSSPPQVTSETPASSSPT 435
Cdd:PHA03307  308 APSSPRassssSSSRESSSSSTSSSSES---SRGAAV-SPGPSPSRSPSPSRPP--------PPADPSSPRKRPRPSRAP 375

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 557128996  436 QVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPpqvtsdTPASSSPP 513
Cdd:PHA03307  376 SSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTPSGEP------WPGSPPPP 447
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 232-643 1.23e-11

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 70.40  E-value: 1.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  232 DTLASSSPPQGTSDTPASSSPPQvtsatsasssppqgTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSAT 311
Cdd:PRK07764  379 ERLERRLGVAGGAGAPAAAAPSA--------------AAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  312 SASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPA-SSSPPQ------ 384
Cdd:PRK07764  445 AGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATlRERWPEilaavp 524

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  385 -------GTSETPASNSPPQGTSETPGFSSPP------QVTTATLVSSSPPQVTSET----------PASSSPTQVTSET 441
Cdd:PRK07764  525 krsrktwAILLPEATVLGVRGDTLVLGFSTGGlarrfaSPGNAEVLVTALAEELGGDwqveavvgpaPGAAGGEGPPAPA 604

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  442 PASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPA 521
Cdd:PRK07764  605 SSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPA 684

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  522 SSSPPQVtsdTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTP---------ASSSPTN 592
Cdd:PRK07764  685 PAPAAPA---APAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPddppdpagaPAQPPPP 761

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 557128996  593 MTSDTPASSSPPWPVITEVTRPESTIPAGRSLANITSKAQEDSPLGVISTH 643
Cdd:PRK07764  762 PAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLEEE 812
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 442-612 1.69e-11

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 69.22  E-value: 1.69e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   442 PASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPpqvTSDTPASSSPPQVTSETP- 520
Cdd:pfam17823   48 PRADNKSSEQ*NFCAATAAPAPVTLTKGTSAAHLNSTEVTAEHTPHGTDLSEPATREG---AADGAASRALAAAASSSPs 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   521 --ASSSPPQVTSDTSASISPPQvisdTPASSSPPQVTSETP--ASSSPTNMTSDT-PASSSPTNMTSDTPASSSPTNMTS 595
Cdd:pfam17823  125 saAQSLPAAIAALPSEAFSAPR----AAACRANASAAPRAAiaAASAPHAASPAPrTAASSTTAASSTTAASSAPTTAAS 200

                          170
                   ....*....|....*..
gi 557128996   596 DTPASSSPPWPVITEVT 612
Cdd:pfam17823  201 SAPATLTPARGISTAAT 217
SPT5 COG5164
Transcription elongation factor SPT5 [Transcription];
203-656 2.34e-11

Transcription elongation factor SPT5 [Transcription];


Pssm-ID: 444063 [Multi-domain]  Cd Length: 495  Bit Score: 68.52  E-value: 2.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  203 PIDPASSAPPKATHRMTITSLTGRPQVTSDTLASSSPPQGTSDTPA----SSSPPQvtsatsasssppQGTSDTPA---- 274
Cdd:COG5164     3 LYGPGKTGPSDPGGVTTPAGSQGSTKPAQNQGSTRPAGNTGGTRPAqnqgSTTPAG------------NTGGTRPAgnqg 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  275 SSSPPQvtsatsasssppqGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASS 354
Cdd:COG5164    71 ATGPAQnqg--------gtTPAQNQGGTRPAGNTGGTTPAGDGGATGPPDDGGATGPPDDGGSTTPPSGGSTTPPGDGGS 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  355 SPPQGTLDTPSSSSPPQGtsDTPASSSPPQGTSETPA----SNSPPQGTSETPGfssPPQVTTATLVSSSPPQVTSETPA 430
Cdd:COG5164   143 TPPGPGSTGPGGSTTPPG--DGGSTTPPGPGGSTTPPddggSTTPPNKGETGTD---IPTGGTPRQGPDGPVKKDDKNGK 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  431 SSSPTQVTSETPAsSSPTQVTSdtPASNSPPQGTSDTPGFSSPTQvttatlvSSSPPQVTSDTPASSSPPQVTSDTPASS 510
Cdd:COG5164   218 GNPPDDRGGKTGP-KDQRPKTN--PIERRGPERPEAAALPAELTA-------LEAENRAANPEPATKTIPETTTVKDLAT 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  511 SPPQVTSETPASS------SPPQVTSDTsasiSPPQVISDTpassspPQVTSETPASSSPT-NMTSDTPASSSPTNMTSD 583
Cdd:COG5164   288 VLGKKGSDLVTNLmkkgkgTNINAALDF----ETAATIALE------GNVITEKEIEADIMeTVTTEEQETDSLLEETPP 357

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 557128996  584 TPasssPTNMTSDTPASSSPPWPVITEVTRPESTIP-----AGRSLANITSKAQEDSPLGVISTHPQMSFQSSTSQAL 656
Cdd:COG5164   358 VP----VVMGHVDHGKTSLLDAIRHSDVTDGEVGTIsqhigAYTVQIAGTPITFLDTPGFESFTAMAMRVAQITDIAI 431
DUF2967 pfam11179
Protein of unknown function (DUF2967); This family of proteins with unknown function appears ...
 353-683 2.81e-11

Protein of unknown function (DUF2967); This family of proteins with unknown function appears to be restricted to Drosophila.


Pssm-ID: 402654 [Multi-domain]  Cd Length: 954  Bit Score: 69.29  E-value: 2.81e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   353 SSSPPQGTLDTPSSSsPPQGTSDTPASSSPPQGTSET--PASNSPPQGTSETPgfSSPPQVTTATLVSSSPPQVTSetpa 430
Cdd:pfam11179   15 SSAPPHAALAGPITA-APTGAAAAAATSTAAASAASStiTAPGAGPGGTPTSR--SRGAQAMTASLAHAAQGNANA---- 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   431 ssspTQVTSETPASSSPTQVTSDTPAsnsppqgtsdtpGFSSptqVTTATLVSSSPPQVTSDTpaSSSPPQvtsdTPASS 510
Cdd:pfam11179   88 ----NKSTRNNSNSSNNNGKPKPLAA------------CYMS---TRSAAMMALALGQQSGEK--KDKKPA----AGKAA 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   511 SPPQVTSETPASSSPPQvTSDTSASISPPQVISDTPASSSPPQV-----TSETPASSSPTNMTSDTPASSSPTNMTSDTP 585
Cdd:pfam11179  143 SPAQSQSQSQSQNASPH-TNNRAVSMTRPAATRRLPNAAAMSNVnaansTCTATATSLPSNRARSKPSTPTATRAAAQLN 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   586 AS---SSPTNMT-SDTPASSSPPWPVITEVTRpeSTIPAGRSLAN-ITSKAQEDSPLGVISTHPQMS-FQSSTSQAL--- 656
Cdd:pfam11179  222 GMgifSGGSNSSgSDNDGFSASGSSAATALRR--LYFKSGRSIKNkINASTSSSTPLNGLPLNAVSNaFHNSVGGATamh 299

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 557128996   657 DETAGERVP----------TIPDFQAHSEFQKACAIL 683
Cdd:pfam11179  300 AMGTAGGVPklvvmgtssaSIPDTTINTSTDSACTLI 336
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 352-604 2.82e-11

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 67.89  E-value: 2.82e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   352 ASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQvTSETPAS 431
Cdd:pfam13254   58 PGLSPTKLSREGSPESTSRPSSSHSEATIVRHSKDDERPSTPDEGFVKPALPRHSRSSSALSNTGSEEDSPS-LPTSPPS 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   432 SSPTQVT---SETPAS---------SSPTQvtSDTPASNSPP------------QGTSDTPGFSSPTQVTTATLVSSSPP 487
Cdd:pfam13254  137 PSKTMDPkrwSPTKSSwlesalnrpESPKP--KAQPSQPAQPawmkelnkirqsRASVDLGRPNSFKEVTPVGLMRSPAP 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   488 QVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTS--ASISPPQVISDTPASS-----SPPQVTSETPA 560
Cdd:pfam13254  215 GGHSKSPSVSGISADSSPTKEEPSEEADTLSTDKEQSPAPTSASEPppKTKELPKDSEEPAAPSksaeaSTEKKEPDTES 294

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 557128996   561 SSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSPP 604
Cdd:pfam13254  295 SPETSSEKSAPSLLSPVSKASIDKPLSSPDRDPLSPKPKPQSPP 338
DUF2967 pfam11179
Protein of unknown function (DUF2967); This family of proteins with unknown function appears ...
 236-731 2.83e-11

Protein of unknown function (DUF2967); This family of proteins with unknown function appears to be restricted to Drosophila.


Pssm-ID: 402654 [Multi-domain]  Cd Length: 954  Bit Score: 69.29  E-value: 2.83e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   236 SSSPPQGTSDTPASSsPPQVTSATSASSSPPQGTSDTPASSspPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASS 315
Cdd:pfam11179   15 SSAPPHAALAGPITA-APTGAAAAAATSTAAASAASSTITA--PGAGPGGTPTSRSRGAQAMTASLAHAAQGNANANKST 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   316 SPPQGTSDTPASSSPPQ---VTSATSASSSPPQGTSDTPASSSPPQgtldTPSSSSPPQGTSDTPASSSPPQgTSETPAS 392
Cdd:pfam11179   92 RNNSNSSNNNGKPKPLAacyMSTRSAAMMALALGQQSGEKKDKKPA----AGKAASPAQSQSQSQSQNASPH-TNNRAVS 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   393 NSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTsetpASSSPTQVTSDTPASNSPPQGTSDTPGFS- 471
Cdd:pfam11179  167 MTRPAATRRLPNAAAMSNVNAANSTCTATATSLPSNRARSKPSTPT----ATRAAAQLNGMGIFSGGSNSSGSDNDGFSa 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   472 --SPTQVTTATLVSSSPPQVTSDTPASSsppqvTSDTPASSSPPQVTSET--PASSSPPQVTSDTSASISPPQVISDTpA 547
Cdd:pfam11179  243 sgSSAATALRRLYFKSGRSIKNKINAST-----SSSTPLNGLPLNAVSNAfhNSVGGATAMHAMGTAGGVPKLVVMGT-S 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   548 SSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNmtsdtPASSSPPWPVITEVT-----RPESTIPAGR 622
Cdd:pfam11179  317 SASIPDTTINTSTDSACTLITNVTHTDTSETCDSLDLGDNSGPSE-----PLFSSLEEPLLTAIHidsehEGFGGMAGGR 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   623 SLANITSKAQ-EDSPLGVISTHPQMSFQSST-SQ--ALDETAGERVPTIPDFQAHSEFQKACAILQRLRDFLPTSPTSAQ 698
Cdd:pfam11179  392 GGANGRGATElELTSCSRYPPRPDMNLQDSTeSQesCLSILTGEPSSTTPLLSSQRRHPTGGHSPGSQRQEERRERKERE 471

                          490       500       510
                   ....*....|....*....|....*....|...
gi 557128996   699 VSVANLLIDLSEQLLVLPFQKNNSWSSQTPAVS 731
Cdd:pfam11179  472 PSTAPPPTRGREHFTFDPPQSPKSARSSEKARS 504
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 364-621 3.05e-11

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 68.41  E-value: 3.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  364 PSSSSPPQ--GTSDTPASSSPPQGTSETPASNS---PPQGTSETPGFSSPpqvtTATLVSSSPPqvTSETPASssptqvT 438
Cdd:PLN03209  324 PSQRVPPKesDAADGPKPVPTKPVTPEAPSPPIeeePPQPKAVVPRPLSP----YTAYEDLKPP--TSPIPTP------P 391

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  439 SETPASSSPTQVTS--DTPASNSPPQGTSDTPGfSSPTQVTTATLVSSSPPQVTSDTPASSSPpqvtSDTPASSSPPQVT 516
Cdd:PLN03209  392 SSSPASSKSVDAVAkpAEPDVVPSPGSASNVPE-VEPAQVEAKKTRPLSPYARYEDLKPPTSP----SPTAPTGVSPSVS 466

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  517 SETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPA-SSSPTNMTS 595
Cdd:PLN03209  467 STSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSApPTALADEQH 546

                         250       260
                  ....*....|....*....|....*...
gi 557128996  596 DTPASSSP--PWPVITEVTRPESTIPAG 621
Cdd:PLN03209  547 HAQPKPRPlsPYTMYEDLKPPTSPTPSP 574
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 294-676 3.49e-11

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 68.86  E-value: 3.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  294 GTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGT 373
Cdd:PRK07764  401 AAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAP 480

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  374 SDTPASSSPPQGTSETPASNSPPQGTSETPGF-SSPPQV----------------TTATLVSSSPPQVT--SETPAS--- 431
Cdd:PRK07764  481 APAPPAAPAPAAAPAAPAAPAAPAGADDAATLrERWPEIlaavpkrsrktwaillPEATVLGVRGDTLVlgFSTGGLarr 560

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  432 -SSP-------TQVTSETPASSSPTqVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVT 503
Cdd:PRK07764  561 fASPgnaevlvTALAEELGGDWQVE-AVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEA 639

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  504 SDTPASSS-PPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPtnmTSDTPASSSPTNMTS 582
Cdd:PRK07764  640 SAAPAPGVaAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQP---APAPAATPPAGQADD 716

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  583 DTPASSSPTNMTSDTPASSSPPWPVITEVTRPESTIPAGRSLANITSKAQEDSPlgviSTHPQMSFQSSTSQALDETAGE 662
Cdd:PRK07764  717 PAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAP----AAAPPPSPPSEEEEMAEDDAPS 792

                         410
                  ....*....|....
gi 557128996  663 RVPtiPDFQAHSEF 676
Cdd:PRK07764  793 MDD--EDRRDAEEV 804
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
417-595 5.67e-11

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 67.00  E-value: 5.67e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   417 VSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTpgfssptqvTTATLVSSSPPQVTSDTPAS 496
Cdd:pfam05539  157 LRGKDVSCCKEPKTAVTTSKTTSWPTEVSHPTYPSQVTPQSQPATQGHQTA---------TANQRLSSTEPVGTQGTTTS 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   497 SSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQvisDTPASSSPPQVTSETPASSSPTNMTSDTPASSS 576
Cdd:pfam05539  228 SNPEPQTEPPPSQRGPSGSPQHPPSTTSQDQSTTGDGQEHTQRR---KTPPATSNRRSPHSTATPPPTTKRQETGRPTPR 304

                          170       180
                   ....*....|....*....|....*
gi 557128996   577 PTNMT--SDTPASSSPT----NMTS 595
Cdd:pfam05539  305 PTATTqsGSSPPHSSPPgvqaNPTT 329
PHA03378 PHA03378
EBNA-3B; Provisional
 183-624 1.53e-10

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 66.63  E-value: 1.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  183 PPLAMCHQPAPPELFETLCFPID-PASSAPPKAThrmtITSLTGRPQVTSDTLASSSPPQGTSDTPASSSPPQVTSATSA 261
Cdd:PHA03378  529 PPQPRAGRRAPCVYTEDLDIESDePASTEPVHDQ----LLPAPGLGPLQIQPLTSPTTSQLASSAPSYAQTPWPVPHPSQ 604

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  262 SSSPPQGTSDTPASSSPPQ----VTSATSASSSPPQGTSDTPASSSP---PQVTSATSASSSPPQGTSDTPASSSPPQVT 334
Cdd:PHA03378  605 TPEPPTTQSHIPETSAPRQwpmpLRPIPMRPLRMQPITFNVLVFPTPhqpPQVEITPYKPTWTQIGHIPYQPSPTGANTM 684

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  335 SATSASSSPPQGTSDTPASSSPPQGtldTPSSSSPPQGtsdTPASSSPPQGtseTPASNSPPQGtseTPGFSSPPQvttA 414
Cdd:PHA03378  685 LPIQWAPGTMQPPPRAPTPMRPPAA---PPGRAQRPAA---ATGRARPPAA---APGRARPPAA---APGRARPPA---A 749

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  415 TLVSSSPPQvtsetpASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGtsdTPGFSSPTQVTTATLVSSSPPQVTSDTP 494
Cdd:PHA03378  750 APGRARPPA------AAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRG---APTPQPPPQAGPTSMQLMPRAAPGQQGP 820

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  495 ASSSPPQ-----VTSDTPASSSPPQVTSETPASSSP-PQvtSDTSASISPPQVIsdTPASSSPPQVtsetpasssPTNMT 568
Cdd:PHA03378  821 TKQILRQlltggVKRGRPSLKKPAALERQAAAGPTPsPG--SGTSDKIVQAPVF--YPPVLQPIQV---------MRQLG 887

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557128996  569 SDTPASSSptnmtsdtPASSSPTNMTSDTPASSSPPWPVITEVTR------PESTIPAGRSL 624
Cdd:PHA03378  888 SVRAAAAS--------TVTQAPTEYTGERRGVGPMHPTDIPPSKRaktdayVESQPPHGGQS 941
PHA03255 PHA03255
BDLF3; Provisional
 438-608 2.66e-10

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 63.00  E-value: 2.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  438 TSETPASSSPTQVTSDTPAsnsppqgTSDTPGFSSPTQVTTATLVSSSPPqVTSDTPASSSPPQVTSdTPASSSPPQVTS 517
Cdd:PHA03255   25 TSSGSSTASAGNVTGTTAV-------TTPSPSASGPSTNQSTTLTTTSAP-ITTTAILSTNTTTVTS-TGTTVTPVPTTS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  518 ETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDT 597
Cdd:PHA03255   96 NASTINVTTKVTAQNITATEAGTGTSTGVTSNVTTRSSSTTSATTRITNATTLAPTLSSKGTSNATKTTAELPTVPDERQ 175

                         170
                  ....*....|...
gi 557128996  598 PASSS--PPWPVI 608
Cdd:PHA03255  176 PSLSYglPLWTLV 188
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 420-634 6.13e-10

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 64.18  E-value: 6.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  420 SPPQ-VTSETPASSSPTQVTSETPASssptqvtsdtPASNSPPQGTSDTPGFSSPTqvttATLVSSSPPQVTSDTPASSS 498
Cdd:PLN03209  329 PPKEsDAADGPKPVPTKPVTPEAPSP----------PIEEEPPQPKAVVPRPLSPY----TAYEDLKPPTSPIPTPPSSS 394

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  499 PPQVTS-------DTPASSSPPQVTSETPASSsPPQVTSDTSASISPPQVISD--TPASSSP-PQVTSETPASSSPT-NM 567
Cdd:PLN03209  395 PASSKSvdavakpAEPDVVPSPGSASNVPEVE-PAQVEAKKTRPLSPYARYEDlkPPTSPSPtAPTGVSPSVSSTSSvPA 473

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557128996  568 TSDTPASSSPTNMTSDTPASSSPTNMTS-----DTPASSSPPWPVITEVTRPESTIPAGRSLANITSKAQED 634
Cdd:PLN03209  474 VPDTAPATAATDAAAPPPANMRPLSPYAvyddlKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQ 545
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1922-2113 8.32e-10

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 61.51  E-value: 8.32e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  1922 RLAFFTRKRNLLDTSIVLISFSILGLSMQSLSLLhkkmqqyhcdrdrfisfyeaLRVnsavthLRGFLLLfatvRVWDLL 2001
Cdd:pfam00520   60 KKRYFRSPWNILDFVVVLPSLISLVLSSVGSLSG--------------------LRV------LRLLRLL----RLLRLI 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  2002 RHHAQLQVINKTLSKAWDEVLGFILIIVVLLSSYAMTFNLLFG----------WSISDYQSFFRSIVTVVGLL----MGT 2067
Cdd:pfam00520  110 RRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGgklktwenpdNGRTNFDNFPNAFLWLFQTMttegWGD 189

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 557128996  2068 SKHKEVIALYPILGSLLVLSSIILMGLVIINLFVSAILIAFGKERK 2113
Cdd:pfam00520  190 IMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
364-577 1.02e-09

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 63.14  E-value: 1.02e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   364 PSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETpgfssppqvTTATLVSSSPPQVTSETPASSSPTQVTSETPA 443
Cdd:pfam05539  169 KTAVTTSKTTSWPTEVSHPTYPSQVTPQSQPATQGHQTA---------TANQRLSSTEPVGTQGTTTSSNPEPQTEPPPS 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   444 SSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVT-------TATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQvT 516
Cdd:pfam05539  240 QRGPSGSPQHPPSTTSQDQSTTGDGQEHTQRRKTppatsnrRSPHSTATPPPTTKRQETGRPTPRPTATTQSGSSPPH-S 318

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557128996   517 SETPASSSPPQVTSDTSASISPPQVIS-----DTPASSSPPQVTSETPASSSPTNMTSDTPASSSP 577
Cdd:pfam05539  319 SPPGVQANPTTQNLVDCKELDPPKPNSicygvGIYNEALPRGCDIVVPLCSTYTIMCMDTYYSKPF 384
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
345-514 1.44e-09

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 62.76  E-value: 1.44e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   345 QGTSDTPASSSPPQGTLDTPSSSSPPQG----TSDTPASSSPPQGTSETPASNSPPQGTseTPGFSSPPQVTTATLVSSS 420
Cdd:pfam05539  176 KTTSWPTEVSHPTYPSQVTPQSQPATQGhqtaTANQRLSSTEPVGTQGTTTSSNPEPQT--EPPPSQRGPSGSPQHPPST 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   421 PPQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSdtpgfSSPTQVTTATLVSSSPPQVTSDTPASSSPP 500
Cdd:pfam05539  254 TSQDQSTTGDGQEHTQRRKTPPATSNRRSPHSTATPPPTTKRQET-----GRPTPRPTATTQSGSSPPHSSPPGVQANPT 328

                          170
                   ....*....|....
gi 557128996   501 QVTSDTPASSSPPQ 514
Cdd:pfam05539  329 TQNLVDCKELDPPK 342
Hamartin pfam04388
Hamartin protein; This family includes the hamartin protein which is thought to function as a ...
 417-661 1.61e-09

Hamartin protein; This family includes the hamartin protein which is thought to function as a tumour suppressor. The hamartin protein interacts with the tuberin protein pfam03542. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterized by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin pfam03542. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking.


Pssm-ID: 461287 [Multi-domain]  Cd Length: 730  Bit Score: 63.15  E-value: 1.61e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   417 VSSSPPqvTSETPASSSPTQVTSETP-ASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQV-TSDTP 494
Cdd:pfam04388  276 PTASPY--TDQQSSYGSSTSTPSSTPrLQLSSSSGTSPPYLSPPSIRLKTDSFPLWSPSSVCGMTTPPTSPGMVpTTPSE 353

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   495 ASSSPPQVTSDtpaSSSPPQVTSE-----TPASSSPPQVTSDTSASISPPQVISDTPASSSPPQvTSETPASSSP----- 564
Cdd:pfam04388  354 LSPSSSHLSSR---GSSPPEAAGEatpetTPAKDSPYLKQPPPLSDSHVHRALPASSQPSSPPR-KDGRSQSSFPplskq 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   565 --TNMTSDTPASSSPTNMTSDTpasSSPTNMTSDTpaSSSPPWPVITEVTRPESTipagRSLANITSKAQEdsplgviST 642
Cdd:pfam04388  430 apTNPNSRGLLEPPGDKSSVTL---SELPDFIKDL--ALSSEDSVEGAEEEAAIS----QELSEITTEKNE-------TD 493

                          250
                   ....*....|....*....
gi 557128996   643 HPQMSFQSSTSQALDETAG 661
Cdd:pfam04388  494 CSRGGLDMPFSRTMESLAG 512
PRK08581 PRK08581
amidase domain-containing protein;
360-596 2.19e-09

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 62.50  E-value: 2.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  360 TLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNsppqgTSETPgfssppQVTTATLVSSSPPQVTSETPASSSP-TQVT 438
Cdd:PRK08581   14 TLVLPTLTSPTAYADDPQKDSTAKTTSHDSKKSN-----DDETS------KDTSSKDTDKADNNNTSNQDNNDKKfSTID 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  439 SETPASS---SPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQvTSDTPASSSPPQVTSDTPASSSPPqv 515
Cdd:PRK08581   83 SSTSDSNniiDFIYKNLPQTNINQLLTKNKYDDNYSLTTLIQNLFNLNSDISD-YEQPRNSEKSTNDSNKNSDSSIKN-- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  516 tSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTS 595
Cdd:PRK08581  160 -DTDTQSSKQDKADNQKAPSSNNTKPSTSNKQPNSPKPTQPNQSNSQPASDDTANQKSSSKDNQSMSDSALDSILDQYSE 238


                  .
gi 557128996  596 D 596
Cdd:PRK08581  239 D 239
PRK10905 PRK10905
cell division protein DamX; Validated
 377-593 3.35e-09

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 60.72  E-value: 3.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  377 PASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQV-TSETPASSSPTQVTSDTP 455
Cdd:PRK10905   23 PSTSSSDQTASGEKSIDLAGNATDQANGVQPAPGTTSAEQTAGNTQQDVSLPPISSTPTQGqTPVATDGQQRVEVQGDLN 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  456 ASNSPPQGTSDTPGFSS----PTQVTT-----------ATLVSSSPPQVTSDTPA------SSSPPQVTSDTPASSSPPQ 514
Cdd:PRK10905  103 NALTQPQNQQQLNNVAVnstlPTEPATvapvrngnasrQTAKTQTAERPATTRPArkqaviEPKKPQATAKTEPKPVAQT 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  515 VTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPT--NMTSDTPASSSptNMTSDTPASSSPTN 592
Cdd:PRK10905  183 PKRTEPAAPVASTKAPAATSTPAPKETATTAPVQTASPAQTTATPAAGGKTagNVGSLKSAPSS--HYTLQLSSSSNYDN 260


                  .
gi 557128996  593 M 593
Cdd:PRK10905  261 L 261
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
414-665 3.39e-09

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 62.20  E-value: 3.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  414 ATLVSSSPPQVTSETPASSSPTQVTsETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSdT 493
Cdd:PRK12323  372 AGPATAAAAPVAQPAPAAAAPAAAA-PAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP-A 449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  494 PASSSPPqvtsdTPASSSPPQVTS-ETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTP 572
Cdd:PRK12323  450 PAPAPAA-----APAAAARPAAAGpRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAE 524

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  573 ASSSPTNMTSDTPASSSptnmtsdTPASSSPPWPVITEVTRPESTIPAGRSLANITSKAQEDSPLGVISTHP------QM 646
Cdd:PRK12323  525 SIPDPATADPDDAFETL-------APAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARLPvrglaqQL 597

                         250
                  ....*....|....*....
gi 557128996  647 SFQSSTSQALDETAGERVP 665
Cdd:PRK12323  598 ARQSELAGVEGDTVRLRVP 616
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 347-676 3.41e-09

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 62.32  E-value: 3.41e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   347 TSDTPASSSPPQGTLDTPSSSSPPQGTS------DTPassSPPQGTSE-TPAS----NSP-PQGT----SETPgfSSPPQ 410
Cdd:TIGR00927   76 SSDPPKSSSEMEGEMLAPQATVGRDEATpsiameNTP---SPPRRTAKiTPTTpknnYSPtAAGTervkEDTP--ATPSR 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   411 VTTATLVSSSPPQVTSETPA------SSSPTQVTSE----TPaSSSPTQVTSDTPAS-NSPPQGTSDTPGFSSPTQVTTA 479
Cdd:TIGR00927  151 ALNHYISTSGRQRVKSYTPKprgevkSSSPTQTREKvrkyTP-SPLGRMVNSYAPSTfMTMPRSHGITPRTTVKDSEITA 229

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   480 T---LVSSSPPQV---TSDTP----ASSSPPQVTSDTPAS--SSPPQVTsETPASSSPPQVTSDTSA---------SISP 538
Cdd:TIGR00927  230 TykmLETNPSKRTagkTTPTPlkgmTDNTPTFLTREVETDllTSPRSVV-EKNTLTTPRRVESNSSTnhwglvgknNLTT 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   539 PQ--VISDTPASSSPpQVTSETPASSSPTnmtsDTPASSSPTNMTSDTPASSSPTNMTsdtpaSSSPPWPVITEVTRPES 616
Cdd:TIGR00927  309 PQgtVLEHTPATSEG-QVTISIMTGSSPA----ETKASTAAWKIRNPLSRTSAPAVRI-----ASATFRGLEKNPSTAPS 378

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 557128996   617 TIPAGRSLANITSKAQE---DSPLGVISTHPQMSFQSST-SQALDETAGERVPTIPDFQAHSEF 676
Cdd:TIGR00927  379 TPATPRVRAVLTTQVHHcvvVKPAPAVPTTPSPSLTTALfPEAPSPSPSALPPGQPDLHPKAEY 442
PRK08581 PRK08581
amidase domain-containing protein;
402-704 5.10e-09

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 61.34  E-value: 5.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  402 TPGFSSPpQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSsptqvTSDTPASNSPPQGTSDTPgFSSPTQVTTAT- 480
Cdd:PRK08581   17 LPTLTSP-TAYADDPQKDSTAKTTSHDSKKSNDDETSKDTSSKD-----TDKADNNNTSNQDNNDKK-FSTIDSSTSDSn 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  481 ---------LVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTS-ETPASSS-PPQVTSDTSAS-ISPPQvisdTPAS 548
Cdd:PRK08581   90 niidfiyknLPQTNINQLLTKNKYDDNYSLTTLIQNLFNLNSDISDyEQPRNSEkSTNDSNKNSDSsIKNDT----DTQS 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  549 SSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSppwpvitevtrpESTIPAGRSLANIT 628
Cdd:PRK08581  166 SKQDKADNQKAPSSNNTKPSTSNKQPNSPKPTQPNQSNSQPASDDTANQKSSSK------------DNQSMSDSALDSIL 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557128996  629 SKAQEDsplgviSTHPQMSFQSSTSQALDETAGERVPTIPdfqAHSEFQKACAILQRLRDFLPTSPTSAQVSVANL 704
Cdd:PRK08581  234 DQYSED------AKKTQKDYASQSKKDKTETSNTKNPQLP---TQDELKHKSKPAQSFENDVNQSNTRSTSLFETG 300
PHA03255 PHA03255
BDLF3; Provisional
 464-622 9.14e-09

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 58.38  E-value: 9.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  464 TSDTPGFSSPTQVTTATlvsssppQVTSDTPASSSPPQVTSDTPASSSPPqVTSETPASSSPPQVTSdTSASISPPQVIS 543
Cdd:PHA03255   25 TSSGSSTASAGNVTGTT-------AVTTPSPSASGPSTNQSTTLTTTSAP-ITTTAILSTNTTTVTS-TGTTVTPVPTTS 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 557128996  544 DTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSPPWPVITEVTRPESTIPAGR 622
Cdd:PHA03255   96 NASTINVTTKVTAQNITATEAGTGTSTGVTSNVTTRSSSTTSATTRITNATTLAPTLSSKGTSNATKTTAELPTVPDER 174
PHA03377 PHA03377
EBNA-3C; Provisional
 203-654 9.87e-09

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 60.84  E-value: 9.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  203 PIDPASSAPPKATHRMTITSLTGRPQVTSDTLASSSPPQGTSDTPASSSPPQ---VTSATSASSSPPQGTSDTPASSSPP 279
Cdd:PHA03377  450 PERPGPSDQPSVPVEPAHLTPVEHTTVILHQPPQSPPTVAIKPAPPPSRRRRgacVVYDDDIIEVIDVETTEEEESVTQP 529

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  280 QVTSATSASSSPPQGTSD--------TPASSSPPQVTSATSASSSPPQGTSDTPASSspPQVTSATSASSSPPQGTSDTP 351
Cdd:PHA03377  530 AKPHRKVQDGFQRSGRRQkratppkvSPSDRGPPKASPPVMAPPSTGPRVMATPSTG--PRDMAPPSTGPRQQAKCKDGP 607

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  352 ASSSPPQgtlDTPSSSSP-----------------PQGTSDTPAS------SSPPQGTSETPASNSPPQGTSETPGFSSP 408
Cdd:PHA03377  608 PASGPHE---KQPPSSAPrdmapsvvrmflrerllEQSTGPKPKSfwemraGRDGSGIQQEPSSRRQPATQSTPPRPSWL 684

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  409 PQVTTATLVSSSPPQVTSETPASS-SPTQVTS--ETPASSSPTQVT--SDTPASNSPPQGTSDTPGFSSP--TQVTTATL 481
Cdd:PHA03377  685 PSVFVLPSVDAGRAQPSEESHLSSmSPTQPISheEQPRYEDPDDPLdlSLHPDQAPPPSHQAPYSGHEEPqaQQAPYPGY 764

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  482 VSSSPPQV--------------TSDTPASSSPPQVTSDTPASSSPPQVTSETPAsSSPPQVTSDTSASISPPQviSDTPA 547
Cdd:PHA03377  765 WEPRPPQApylgyqepqaqgvqVSSYPGYAGPWGLRAQHPRYRHSWAYWSQYPG-HGHPQGPWAPRPPHLPPQ--WDGSA 841

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  548 SSSPPQVTSETPASSSPTNMTSDTpaSSSPTNMTSDTPASSSPTNMTSDTPASSSPPWPvitevTR-PESTIPAGRSLAn 626
Cdd:PHA03377  842 GHGQDQVSQFPHLQSETGPPRLQL--SQVPQLPYSQTLVSSSAPSWSSPQPRAPIRPIP-----TRfPPPPMPLQDSMA- 913

                         490       500
                  ....*....|....*....|....*...
gi 557128996  627 itskAQEDSPLgviSTHPQMSFQSSTSQ 654
Cdd:PHA03377  914 ----VGCDSSG---TACPSMPFASDYSQ 934
PHA03255 PHA03255
BDLF3; Provisional
 425-588 1.12e-08

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 57.99  E-value: 1.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  425 TSETPASSSPTQVTSETpASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTS-DTPASSSPPQVT 503
Cdd:PHA03255   25 TSSGSSTASAGNVTGTT-AVTTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTVTSTGTTVTPvPTTSNASTINVT 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  504 SDTPASSSppqVTSETPASSSPPQVTSDTSasisppQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSD 583
Cdd:PHA03255  104 TKVTAQNI---TATEAGTGTSTGVTSNVTT------RSSSTTSATTRITNATTLAPTLSSKGTSNATKTTAELPTVPDER 174


                  ....*
gi 557128996  584 TPASS 588
Cdd:PHA03255  175 QPSLS 179
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 437-658 1.13e-08

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 58.72  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  437 VTSETPAS--SSPTQVTSDTPASNSPPQGTSDTPG----------FSSPTQVTTATLVSSSPPQVTSDTPASSSP-PQVT 503
Cdd:PHA02682   17 VLADTSSSlfTKCPQATIPAPAAPCPPDADVDPLDkysvkeagryYQSRLKANSACMQRPSGQSPLAPSPACAAPaPACP 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  504 SDTPASSSPpQVTSETPASSSPPQvtsdTSASISPPQVISDT--PASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMT 581
Cdd:PHA02682   97 ACAPAAPAP-AVTCPAPAPACPPA----TAPTCPPPAVCPAParPAPACPPSTRQCPPAPPLPTPKPAPAAKPIFLHNQL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  582 S--DTPASSSPTNMTSdtPASSsppwPVItEVTRPESTIPAGRS--------LANITSKAQEDSPLGVISTHPQMSFQSS 651
Cdd:PHA02682  172 PppDYPAASCPTIETA--PAAS----PVL-EPRIPDKIIDADNDdkdlikkeLADIADSVRDLNAESLSLTRDIENAKST 244


                  ....*..
gi 557128996  652 TSQALDE 658
Cdd:PHA02682  245 TQAAIDD 251
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
382-577 1.56e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 60.25  E-value: 1.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  382 PPQGTSETPASNSPPQGTSETPGfsSPPQVTTATLVSSSPPQvtseTPASSSPTQVTSETPASSSPTQVTSDTPASNSPP 461
Cdd:PRK07003  360 PAVTGGGAPGGGVPARVAGAVPA--PGARAAAAVGASAVPAV----TAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPP 433

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  462 Q-GTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSE-TPASSSPPQVTSDTSASISPP 539
Cdd:PRK07003  434 AtADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEpAPRAAAPSAATPAAVPDARAP 513

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 557128996  540 QVIS--DTPASSSPPqvtseTPASSSPTnmtsdtPASSSP 577
Cdd:PRK07003  514 AAASreDAPAAAAPP-----APEARPPT------PAAAAP 542
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1121-1225 1.57e-08

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 55.24  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996 1121 YLIQVYTGYRRRAATTAKVVITLYGSEGH-------SEPHHLCDPEKTVFERGALDVF------LLSTGSWLgdlhglRL 1187
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPglrianlEAWGGLMGAGHDYFERGNLDRFsgrgpcLPSPPCWM------NL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 557128996 1188 WHDNSGDSPSWYVSQVIVsdmtTRKKWHFQCNC-------WLAVD 1225
Cdd:cd01754    77 TSDGTGNHPGWYVNYVEV----TQAGQHAPCMQhlfaveqWLATD 117
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
269-487 1.74e-08

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 59.38  E-value: 1.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  269 TSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSasssppqGTS 348
Cdd:COG3469     1 SSSVSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTA-------ATS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  349 DTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPqgtseTPGFSSPPQVTTATLVSSSP-PQVTSE 427
Cdd:COG3469    74 STTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGS-----VTSTTSSTAGSTTTSGASATsSAGSTT 148

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557128996  428 TPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGF-----SSPTQVTTATLVSSSPP 487
Cdd:COG3469   149 TTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASgattpSATTTATTTGPPTPGLP 213
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 203-502 2.08e-08

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 59.20  E-value: 2.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   203 PIDPASSAPPKATHRMTITSLTGRPQVTSDTLASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVT 282
Cdd:pfam17823  153 NASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVG 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   283 SATSASssppqGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPpQVTSATSASSSPPQGTSDTPASSSPPQgtld 362
Cdd:pfam17823  233 NSSPAA-----GTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDP-HARRLSPAKHMPSDTMARNPAAPMGAQ---- 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   363 tpSSSSPPQGTSDTPASSSPPQGTSEtpasnspPQGTSETPGFSSPPQVTTATLVSSSPPQvTSETPASSSPTQVTSETP 442
Cdd:pfam17823  303 --AQGPIIQVSTDQPVHNTAGEPTPS-------PSNTTLEPNTPKSVASTNLAVVTTTKAQ-AKEPSASPVPVLHTSMIP 372

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 557128996   443 --ASSSPTQVTSDTPasnsPPQGTSDTPGFSSPTQVTT-ATLVSSSppqvTSDTPASSSPPQV 502
Cdd:pfam17823  373 evEATSPTTQPSPLL----PTQGAAGPGILLAPEQVATeATAGTAS----AGPTPRSSGDPKT 427
PHA03377 PHA03377
EBNA-3C; Provisional
 167-654 2.63e-08

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 59.30  E-value: 2.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  167 KRRGAETERHMIP-----GNGPPLAMCHQPAPPElfetlcfpIDPASSAPPKATHRMTITSLTGRPQVTSdtLASSSPPQ 241
Cdd:PHA03377  541 QRSGRRQKRATPPkvspsDRGPPKASPPVMAPPS--------TGPRVMATPSTGPRDMAPPSTGPRQQAK--CKDGPPAS 610

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  242 GTSD-TPASSSP----PQVTSATSASSSPPQGTSDTP-------ASSSPPQVTSATSASSSPPQgTSDTPASSSPPQVTS 309
Cdd:PHA03377  611 GPHEkQPPSSAPrdmaPSVVRMFLRERLLEQSTGPKPksfwemrAGRDGSGIQQEPSSRRQPAT-QSTPPRPSWLPSVFV 689

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  310 ATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLdtPSSSSPPQGTSDTPASSSPPQGTSET 389
Cdd:PHA03377  690 LPSVDAGRAQPSEESHLSSMSPTQPISHEEQPRYEDPDDPLDLSLHPDQAPP--PSHQAPYSGHEEPQAQQAPYPGYWEP 767

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  390 PASNSPPQGTSETPGfssppqvtTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPG 469
Cdd:PHA03377  768 RPPQAPYLGYQEPQA--------QGVQVSSYPGYAGPWGLRAQHPRYRHSWAYWSQYPGHGHPQGPWAPRPPHLPPQWDG 839

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  470 FSSPTQvttaTLVSSSPPqVTSDTpassSPPqvtsdTPASSSPPQVT-SETPASSSPPqvtsdtsasisppqvisdtPAS 548
Cdd:PHA03377  840 SAGHGQ----DQVSQFPH-LQSET----GPP-----RLQLSQVPQLPySQTLVSSSAP-------------------SWS 886

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  549 SSPPqvtsETPASSSPTNM-TSDTPASSSPTnMTSDTPASSSPtNMTSDTPASSSPPWPVITEVTRPESTIPAGRSLANI 627
Cdd:PHA03377  887 SPQP----RAPIRPIPTRFpPPPMPLQDSMA-VGCDSSGTACP-SMPFASDYSQGAFTPLDINAQTPKRPRVEESSHGPA 960

                         490       500
                  ....*....|....*....|....*...
gi 557128996  628 TSKAQEDSPLGVISTHPQMS-FQSSTSQ 654
Cdd:PHA03377  961 RCSQATTEAQEILSDNSEISvFPKDAKQ 988
Metaviral_G pfam09595
Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. ...
 443-595 4.51e-08

Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. It is high in serine and threonine suggesting it is highly glycosylated.


Pssm-ID: 462833 [Multi-domain]  Cd Length: 183  Bit Score: 55.35  E-value: 4.51e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   443 ASSSPTQVTSDTPASNSppqgtSDTPGFSSPTQVTTATLVSSSPPqvtsdTPASSSPPQVTSDTPASSSPPQVTSETPAS 522
Cdd:pfam09595   31 ASLILIGESNKEAALII-----TDIIDININKQHPEQEHHENPPL-----NEAAKEAPSESEDAPDIDPNNQHPSQDRSE 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   523 SSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSS----PTNMTSDTPAS----SSPTNMTSDTPASSSPTNMT 594
Cdd:pfam09595  101 APPLEPAAKTKPSEHEPANPPDASNRLSPPDASTAAIREARtfrkPSTGKRNNPSSaqsdQSPPRANHEAIGRANPFAMS 180


                   .
gi 557128996   595 S 595
Cdd:pfam09595  181 S 181
PHA03255 PHA03255
BDLF3; Provisional
 413-575 4.90e-08

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 56.07  E-value: 4.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  413 TATLVSSSPPQVTSETPASSSpTQVTSETPASSSPTQVTSDTPASNSPPQGTsdTPGFSSPTQVTTATLVSSSPPQVTSD 492
Cdd:PHA03255   20 TSLIWTSSGSSTASAGNVTGT-TAVTTPSPSASGPSTNQSTTLTTTSAPITT--TAILSTNTTTVTSTGTTVTPVPTTSN 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  493 TPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTP 572
Cdd:PHA03255   97 ASTINVTTKVTAQNITATEAGTGTSTGVTSNVTTRSSSTTSATTRITNATTLAPTLSSKGTSNATKTTAELPTVPDERQP 176


                  ...
gi 557128996  573 ASS 575
Cdd:PHA03255  177 SLS 179
Metaviral_G pfam09595
Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. ...
 406-569 4.91e-08

Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. It is high in serine and threonine suggesting it is highly glycosylated.


Pssm-ID: 462833 [Multi-domain]  Cd Length: 183  Bit Score: 54.96  E-value: 4.91e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   406 SSPPQVTT--ATLVSSSPPQVTsetPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVS 483
Cdd:pfam09595   33 LILIGESNkeAALIITDIIDIN---INKQHPEQEHHENPPLNEAAKEAPSESEDAPDIDPNNQHPSQDRSEAPPLEPAAK 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   484 SSPpqvTSDTPASssppqvTSDTPASSSPPQVTSETPASSsppqvTSDTSASISPPQVISDTPASSSPPQVTSETPASSS 563
Cdd:pfam09595  110 TKP---SEHEPAN------PPDASNRLSPPDASTAAIREA-----RTFRKPSTGKRNNPSSAQSDQSPPRANHEAIGRAN 175


                   ....*.
gi 557128996   564 PTNMTS 569
Cdd:pfam09595  176 PFAMSS 181
Metaviral_G pfam09595
Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. ...
 366-517 6.05e-08

Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. It is high in serine and threonine suggesting it is highly glycosylated.


Pssm-ID: 462833 [Multi-domain]  Cd Length: 183  Bit Score: 54.96  E-value: 6.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   366 SSSPPqGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASS 445
Cdd:pfam09595   32 SLILI-GESNKEAALIITDIIDININKQHPEQEHHENPPLNEAAKEAPSESEDAPDIDPNNQHPSQDRSEAPPLEPAAKT 110

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557128996   446 SPTQVT----SDTPASNSPPQGTSdtpgfSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTS 517
Cdd:pfam09595  111 KPSEHEpanpPDASNRLSPPDAST-----AAIREARTFRKPSTGKRNNPSSAQSDQSPPRANHEAIGRANPFAMSS 181
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 245-644 8.64e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 57.81  E-value: 8.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  245 DTPASSSPPQVTSATSA------SSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPP 318
Cdd:PRK14949  369 DDPAEISLPEGQTPSALaaavqaPHANEPQFVNAAPAEKKTALTEQTTAQQQVQAANAEAVAEADASAEPADTVEQALDD 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  319 QgTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPA---SSSPPQGTSETPASNSP 395
Cdd:PRK14949  449 E-SELLAALNAEQAVILSQAQSQGFEASSSLDADNSAVPEQIDSTAEQSVVNPSVTDTQVddtSASNNSAADNTVDDNYS 527

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  396 PQGTSETPG--------------------------FSSPPQVTTATLVSSSPPQVTSET-PASSSPTQVTSETPASSSP- 447
Cdd:PRK14949  528 AEDTLESNGldegdyaqdsapldayqddyvafsseSYNALSDDEQHSANVQSAQSAAEAqPSSQSLSPISAVTTAAASLa 607

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  448 ----------------TQVTSDTPASNSPPQGTSDTPGFSSPtqvttatlvsSSPPQVTSDTPASSSPPQVTSdtpASSS 511
Cdd:PRK14949  608 dddildavlaardsllSDLDALSPKEGDGKKSSADRKPKTPP----------SRAPPASLSKPASSPDASQTS---ASFD 674

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  512 PPQVTSETPASSSPPQVTSDTSASISPPQV-ISDTPASSSPPQVtseTPASSSPTNMTSDTPASSSPTNMTSDTPASSSP 590
Cdd:PRK14949  675 LDPDFELATHQSVPEAALASGSAPAPPPVPdPYDRPPWEEAPEV---ASANDGPNNAAEGNLSESVEDASNSELQAVEQQ 751

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 557128996  591 TNMTSDTPASSSPPwpviTEVTRPESTIPAGRSLANITSKaqedSPLGVISTHP 644
Cdd:PRK14949  752 ATHQPQVQAEAQSP----ASTTALTQTSSEVQDTELNLVL----LSSGSITGHP 797
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 349-662 1.08e-07

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 57.39  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  349 DTPASSSPPQGtldTPSSSSPPQGTSDTPASSS--PPQGTSETPASNSPPQGTSET-----PGFS---SPPQVTTATLVS 418
Cdd:PTZ00449  503 DSDKHDEPPEG---PEASGLPPKAPGDKEGEEGehEDSKESDEPKEGGKPGETKEGevgkkPGPAkehKPSKIPTLSKKP 579

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  419 SSP-----PQVTSETPASSSPtqVTSETPASssptqvtsdtPASNSPPQgTSDTPgfSSPTQVTTATLVSSSPPQVTSDT 493
Cdd:PTZ00449  580 EFPkdpkhPKDPEEPKKPKRP--RSAQRPTR----------PKSPKLPE-LLDIP--KSPKRPESPKSPKRPPPPQRPSS 644

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  494 PASSSPPQV--TSDTPASSSPPQVTS---------ETPASSSPPQVTS---DTSASISPPQVISDTPAS--SSPPQVTSE 557
Cdd:PTZ00449  645 PERPEGPKIikSPKPPKSPKPPFDPKfkekfyddyLDAAAKSKETKTTvvlDESFESILKETLPETPGTpfTTPRPLPPK 724

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  558 TPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMtSDTPASSSPPWPVITEVTRPESTIPAG---RSLANITSKAQ-E 633
Cdd:PTZ00449  725 LPRDEEFPFEPIGDPDAEQPDDIEFFTPPEEERTFF-HETPADTPLPDILAEEFKEEDIHAETGepdEAMKRPDSPSEhE 803

                         330       340
                  ....*....|....*....|....*....
gi 557128996  634 DSPLGvisTHPQMSFQSSTSQALDETAGE 662
Cdd:PTZ00449  804 DKPPG---DHPSLPKKRHRLDGLALSTTD 829
PHA03247 PHA03247
large tegument protein UL36; Provisional
 352-606 1.76e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 1.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  352 ASSSPPQGTLDTPSSssPPQGTSDTPASSSPPQGTSETPAsnsPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPAS 431
Cdd:PHA03247  243 VISHPLRGDIAAPAP--PPVVGEGADRAPETARGATGPPP---PPEAAAPNGAAAPPDGVWGAALAGAPLALPAPPDPPP 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  432 SSPTQVTSETPASSSPTQVTSDTPASNSP-PQGTSDT--PGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSD--- 505
Cdd:PHA03247  318 PAPAGDAEEEDDEDGAMEVVSPLPRPRQHyPLGFPKRrrPTWTPPSSLEDLSAGRHHPKRASLPTRKRRSARHAATPfar 397

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  506 TPASSSPPQVTSETPASSSPPqvtsdtsasiSPPQVISDTPASSSPPQVTSETPASSSPTNmtsdTPASSSPTNMTSDT- 584
Cdd:PHA03247  398 GPGGDDQTRPAAPVPASVPTP----------APTPVPASAPPPPATPLPSAEPGSDDGPAP----PPERQPPAPATEPAp 463

                         250       260
                  ....*....|....*....|..
gi 557128996  585 PASSSPTNMTSDTPASSSPPWP 606
Cdd:PHA03247  464 DDPDDATRKALDALRERRPPEP 485
rne PRK10811
ribonuclease E; Reviewed
 409-615 1.92e-07

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 56.59  E-value: 1.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  409 PQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDT----PASNSPPQGTSDTPGFSSPTQVTTATLVSs 484
Cdd:PRK10811  848 VRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEvveePVVVAEPQPEEVVVVETTHPEVIAAPVTE- 926

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  485 sPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPP-QVISDTPASSSPPQVTSETPASSS 563
Cdd:PRK10811  927 -QPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAaPVVAEVAAEVETVTAVEPEVAPAQ 1005

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 557128996  564 PTNMTSDTPASSSPtnMTSdTPAsssptnmtsdtPASSSPPwPVITEVTRPE 615
Cdd:PRK10811 1006 VPEATVEHNHATAP--MTR-APA-----------PEYVPEA-PRHSDWQRPT 1042
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 352-578 2.01e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 56.26  E-value: 2.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  352 ASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETpgfSSPPQVTTATLVSSSPPQVTSETPAS 431
Cdd:PRK08691  363 AASCDANAVIENTELQSPSAQTAEKETAAKKPQPRPEAETAQTPVQTASAA---AMPSEGKTAGPVSNQENNDVPPWEDA 439

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  432 SSPTQvTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDtpasSSPPQVTSDTPASSS 511
Cdd:PRK08691  440 PDEAQ-TAAGTAQTSAKSIQTASEAETPPENQVSKNKAADNETDAPLSEVPSENPIQATPN----DEAVETETFAHEAPA 514

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 557128996  512 PPQVTSETPASSSPPQvtsdTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPT 578
Cdd:PRK08691  515 EPFYGYGFPDNDCPPE----DGAEIPPPDWEHAAPADTAGGGADEEAEAGGIGGNNTPSAPPPEFST 577
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 240-589 2.34e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.46  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  240 PQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQ 319
Cdd:NF033609  558 PEDSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSA 637

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  320 GTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGT 399
Cdd:NF033609  638 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 717

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  400 SETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDTPA-SNSPPQGTSDTPGFSSPTQVTT 478
Cdd:NF033609  718 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSD 797

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  479 ATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSET 558
Cdd:NF033609  798 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNS 877

                         330       340       350
                  ....*....|....*....|....*....|..
gi 557128996  559 PASSSPTNMTSDTPASSSPTNMT-SDTPASSS 589
Cdd:NF033609  878 PKNGTNASNKNEAKDSKEPLPDTgSEDEANTS 909
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 349-601 2.36e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.46  E-value: 2.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  349 DTPASSSPPqgtlDTPSSSSP-PQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSE 427
Cdd:NF033609  540 DKPVVPEQP----DEPGEIEPiPEDSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASD 615

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  428 TPASSSPTQVTSETPASSSPTQVTSDtpaSNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTP 507
Cdd:NF033609  616 SDSASDSDSASDSDSASDSDSASDSD---SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 692

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  508 ASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASS-SPTNMTSDTPA 586
Cdd:NF033609  693 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDS 772

                         250
                  ....*....|....*.
gi 557128996  587 -SSSPTNMTSDTPASS 601
Cdd:NF033609  773 dSDSDSDSDSDSDSDS 788
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 295-624 2.46e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 56.16  E-value: 2.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   295 TSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPssSSPPQGTS 374
Cdd:TIGR00927   76 SSDPPKSSSEMEGEMLAPQATVGRDEATPSIAMENTPSPPRRTAKITPTTPKNNYSPTAAGTERVKEDTP--ATPSRALN 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   375 DTPASSSPPQGTSETPA------SNSPPQGTSETPGFSSPPQvttATLVSSSPPQVTSETPASSSPTQVTS--------- 439
Cdd:TIGR00927  154 HYISTSGRQRVKSYTPKprgevkSSSPTQTREKVRKYTPSPL---GRMVNSYAPSTFMTMPRSHGITPRTTvkdseitat 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   440 ----ETPASSSPTQVTSDTP----ASNSPPQGTSD--TPGFSSPTQVTTATLVsSSPPQVTSDtpaSSSPPQVTSDTPAS 509
Cdd:TIGR00927  231 ykmlETNPSKRTAGKTTPTPlkgmTDNTPTFLTREveTDLLTSPRSVVEKNTL-TTPRRVESN---SSTNHWGLVGKNNL 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   510 SSPPQVTSETPASSSPPQVTSDTSASISPpqviSDTPASSSPPQVTSETPASSSPTNMTSDTP-----ASSSPTNMTSDT 584
Cdd:TIGR00927  307 TTPQGTVLEHTPATSEGQVTISIMTGSSP----AETKASTAAWKIRNPLSRTSAPAVRIASATfrgleKNPSTAPSTPAT 382

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 557128996   585 P-ASSSPTN------MTSDTPASSSPPWPVITEVTRPESTIPAGRSL 624
Cdd:TIGR00927  383 PrVRAVLTTqvhhcvVVKPAPAVPTTPSPSLTTALFPEAPSPSPSAL 429
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 439-631 3.04e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.07  E-value: 3.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  439 SETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQvtSDTPASSSPPQVTSE 518
Cdd:NF033609   33 SSKEADASENSVTQSDSASNESKSNDSSSVSAAPKTDDTNVSDTKTSSNTNNGETSVAQNPAQ--QETTQSASTNATTEE 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  519 TPASSsppQVTSDTSASISPPQVI--SDTPASSSPPQVTSETpaSSSPTNMTSDTpasSSPTN--------MTSDTPASS 588
Cdd:NF033609  111 TPVTG---EATTTATNQANTPATTqsSNTNAEELVNQTSNET--TSNDTNTVSSV---NSPQNstnaenvsTTQDTSTEA 182

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 557128996  589 SPTNMTSDTPASSSPPWPVITEVTRPESTIPAGRSLANITSKA 631
Cdd:NF033609  183 TPSNNESAPQSTDASNKDVVNQAVNTSAPRMRAFSLAAVAADA 225
Caprin-1_C pfam12287
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ...
 416-651 3.29e-07

Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.


Pssm-ID: 463522 [Multi-domain]  Cd Length: 320  Bit Score: 54.41  E-value: 3.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   416 LVSSSPPQVTSETPASSSPtqvtsetPASssptqvtsdtPASNSPPQgtSDTPGFSSPTQVttatlvssspPQVTSDTPA 495
Cdd:pfam12287   30 IVSAQPPSQSPDLSQMVCP-------PAS----------PEQRLSQQ--SDVLQQPEQTQV----------SPVSPSSNA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   496 SSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPpqvisdtpasSSPPQVTSETPASSSPTNMTSdTPASS 575
Cdd:pfam12287   81 CASSGSEYQFHTSEPPQPEAIDPIQSSMSLPSELAPPSPPLSP----------ASQPQVFQSKPASSSGINVNA-APFQS 149

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 557128996   576 SPT--NMTSDTP-ASSSPTNMTSDTPASSSPPWPVITEVTRPESTIPAGRSLANITSKAQEDSPLGVISTHpqMSFQSS 651
Cdd:pfam12287  150 MQTvfNVNAPVPpRNEQELKESSQYSSGYNQSFSSQSTQTVPQCQLPSEQLEQTVVGAYHPDGTIQVSNGH--LAFYPA 226
PHA03255 PHA03255
BDLF3; Provisional
 490-669 3.35e-07

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 53.75  E-value: 3.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  490 TSDTPASSSPPQVTSDTpasssppQVTSETPASSSPPQVTSDTSASISPPqvISDTPASSSPPQVTSETPASSSPTNMTS 569
Cdd:PHA03255   25 TSSGSSTASAGNVTGTT-------AVTTPSPSASGPSTNQSTTLTTTSAP--ITTTAILSTNTTTVTSTGTTVTPVPTTS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  570 DTPASSSPTNMTSDTPASSSptnmtsdTPASSSPpwPVITEV-TRPESTIPAGRSLANITSKAQEDSplgvisthpqmsf 648
Cdd:PHA03255   96 NASTINVTTKVTAQNITATE-------AGTGTST--GVTSNVtTRSSSTTSATTRITNATTLAPTLS------------- 153

                         170       180
                  ....*....|....*....|.
gi 557128996  649 qSSTSQALDETAGErVPTIPD 669
Cdd:PHA03255  154 -SKGTSNATKTTAE-LPTVPD 172
COG5099 COG5099
RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal ...
 361-656 3.40e-07

RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227430 [Multi-domain]  Cd Length: 777  Bit Score: 55.52  E-value: 3.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  361 LDTPSSSSPPQgtSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQvTTATLVSSSPPQVTSETPASSSPTQVTSE 440
Cdd:COG5099    69 KITSSSSSRRK--PSGSWSVAISSSTSGSQSLLMELPSSSFNPSTSSRNK-SNSALSSTQQGNANSSVTLSSSTASSMFN 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  441 TPASSSPTQVTSDTPASNSPP--QGTSDTPGFSSPTQvttaTLVSSSPPQVTSDTpaSSSPPQVTSDTPASSSPpqvTSE 518
Cdd:COG5099   146 SNKLPLPNPNHSNSATTNQSGssFINTPASSSSQPLT----NLVVSSIKRFPYLT--SLSPFFNYLIDPSSDSA---TAS 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  519 TPASSSPPQVTSDTSASISPPQVISDTPASSSPpQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTP 598
Cdd:COG5099   217 ADTSPSFNPPPNLSPNNLFSTSDLSPLPDTQSV-ENNIILNSSSSINELTSIYGSVPSIRNLRGLNSALVSFLNVSSSSL 295

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 557128996  599 ASSSPPwpvITEVtrPESTIPAGRSLANITSK------AQEDSPLGVISTHPQMS-----FQSSTSQAL 656
Cdd:COG5099   296 AFSALN---GKEV--SPTGSPSTRSFARVLPKsspnnlLTEILTTGVNPPQSLPSllnpvFLSTSTGFS 359
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
473-606 3.76e-07

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 55.05  E-value: 3.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   473 PTQVTTAtlvsssppQVTSDTPASSSPPQVTSDTPASSSPPQ----VTSETPASSSPPQVTSDTSASISPPQVISDTPAS 548
Cdd:pfam05539  169 KTAVTTS--------KTTSWPTEVSHPTYPSQVTPQSQPATQghqtATANQRLSSTEPVGTQGTTTSSNPEPQTEPPPSQ 240

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 557128996   549 SSPPQVTSETPASSSPtnmTSDTPASSSPTNMTSDTPASSSPTNmtsdTPASSSPPWP 606
Cdd:pfam05539  241 RGPSGSPQHPPSTTSQ---DQSTTGDGQEHTQRRKTPPATSNRR----SPHSTATPPP 291
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 270-604 4.02e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.69  E-value: 4.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  270 SDT-PASSSPPQVTSATSASSSPPQGTSDTPASSSppqvtsatsasssppqgtSDTPASSSPPQVTSATSASSSPPQGTS 348
Cdd:NF033609  561 SDSdPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSA------------------SDSDSASDSDSASDSDSASDSDSASDS 622

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  349 DTPASSSPPQGTldtpSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSET 428
Cdd:NF033609  623 DSASDSDSASDS----DSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 698

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  429 PASSSPTQVTSETPASSSPTQVTSDTpASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDtpaSSSPPQVTSDTPA 508
Cdd:NF033609  699 DSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD---SDSDSDSDSDSDS 774

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  509 SSSPPQVTSETPASSSPPQVTSDT-SASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPAS 587
Cdd:NF033609  775 DSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 854

                         330       340
                  ....*....|....*....|.
gi 557128996  588 SSPTNMTSDTPASSS----PP 604
Cdd:NF033609  855 DSESDSNSDSESGSNnnvvPP 875
PHA03255 PHA03255
BDLF3; Provisional
 363-532 4.06e-07

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 53.37  E-value: 4.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  363 TPSSSSPPQGTSDTPASSSppqgTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETP 442
Cdd:PHA03255   25 TSSGSSTASAGNVTGTTAV----TTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTVTSTGTTVTPVPTTSNASTI 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  443 ASSspTQVTSDTPASNSppQGTSDTPGFSSptQVTTATlvSSSPPQVTSDTPASSSPPQVTSDTpaSSSPPQVTSETPAS 522
Cdd:PHA03255  101 NVT--TKVTAQNITATE--AGTGTSTGVTS--NVTTRS--SSTTSATTRITNATTLAPTLSSKG--TSNATKTTAELPTV 170

                         170
                  ....*....|
gi 557128996  523 SSPPQVTSDT 532
Cdd:PHA03255  171 PDERQPSLSY 180
motB PRK12799
flagellar motor protein MotB; Reviewed
 347-465 5.04e-07

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 54.72  E-value: 5.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  347 TSDTPASSSPPQGTldTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVS--SSPPQV 424
Cdd:PRK12799  296 HGTVPVAAVTPSSA--VTQSSAITPSSAAIPSPAVIPSSVTTQSATTTQASAVALSSAGVLPSDVTLPGTVAlpAAEPVN 373

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 557128996  425 TSETPASSSPTQVTSE---TPASSSPTQVTSDTPASNSPPQGTS 465
Cdd:PRK12799  374 MQPQPMSTTETQQSSTgniTSTANGPTTSLPAAPASNIPVSPTS 417
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 423-582 5.57e-07

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 54.71  E-value: 5.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  423 QVTSETPASSSPTQVTSETPASSSPTQVTSDTPASN------SPPQGTSDTPG-FSSPTQVTTATLVSSSPPQVTSDTPA 495
Cdd:PLN02217  508 EVQNTGPGAAITKRVTWPGIKKLSDEEILKFTPAQYiqgdawIPGKGVPYIPGlFAGNPGSTNSTPTGSAASSNTTFSSD 587

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  496 SSSppqvTSDTPASSSPPQVTSETPASSSpPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNM-TSDTPAS 574
Cdd:PLN02217  588 SPS----TVVAPSTSPPAGHLGSPPATPS-KIVSPSTSPPASHLGSPSTTPSSPESSIKVASTETASPESSIkVASTESS 662


                  ....*...
gi 557128996  575 SSPTNMTS 582
Cdd:PLN02217  663 VSMVSMST 670
PRK13914 PRK13914
invasion associated endopeptidase;
417-602 5.93e-07

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 54.42  E-value: 5.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  417 VSSSPPQVTSETPASSSPTQVTsetPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATL--------------- 481
Cdd:PRK13914  143 VTSTPVAPTQEVKKETTTQQAA---PAAETKTEVKQTTQATTPAPKVAETKETPVVDQNATTHAVksgdtiwalsvkygv 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  482 ----------VSSSPPQVTSD----TPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPA 547
Cdd:PRK13914  220 svqdimswnnLSSSSIYVGQKlaikQTANTATPKAEVKTEAPAAEKQAAPVVKENTNTNTATTEKKETTTQQQTAPKAPT 299

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 557128996  548 SSS----PPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSS 602
Cdd:PRK13914  300 EAAkpapAPSTNTNANKTNTNTNTNTNNTNTSTPSKNTNTNTNSNTNTNSNTNANQGSS 358
PHA03255 PHA03255
BDLF3; Provisional
 347-511 7.33e-07

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 52.60  E-value: 7.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  347 TSDTPASSSppqgtldTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTseTPGFSSPPQVTTATLVSSSPPQVTS 426
Cdd:PHA03255   25 TSSGSSTAS-------AGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPITT--TAILSTNTTTVTSTGTTVTPVPTTS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  427 ETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTpgfSSPTQVTTATLVSSSPPQVTSD--TPASSSPPQVTS 504
Cdd:PHA03255   96 NASTINVTTKVTAQNITATEAGTGTSTGVTSNVTTRSSSTT---SATTRITNATTLAPTLSSKGTSnaTKTTAELPTVPD 172


                  ....*..
gi 557128996  505 DTPASSS 511
Cdd:PHA03255  173 ERQPSLS 179
motB PRK12799
flagellar motor protein MotB; Reviewed
 477-607 7.57e-07

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 53.95  E-value: 7.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  477 TTATLVSSSPPqvTSDTPASSSPPQVTSDTPASSSPPqvtseTPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTS 556
Cdd:PRK12799  296 HGTVPVAAVTP--SSAVTQSSAITPSSAAIPSPAVIP-----SSVTTQSATTTQASAVALSSAGVLPSDVTLPGTVALPA 368

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 557128996  557 ETPASSSPTNMTSDTPASSSPTNMtsdTPASSSPTNMTSDTPASSSPPWPV 607
Cdd:PRK12799  369 AEPVNMQPQPMSTTETQQSSTGNI---TSTANGPTTSLPAAPASNIPVSPT 416
PAP1 pfam08601
Transcription factor PAP1; The transcription factor Pap1 regulates antioxidant-gene ...
 346-536 8.13e-07

Transcription factor PAP1; The transcription factor Pap1 regulates antioxidant-gene transcription in response to H2O2. This region is cysteine rich. Alkylation of cysteine residues following treatment with a cysteine alkylating agent can mask the accessibility of the nuclear exporter Crm1, triggering nuclear accumulation and Pap1 dependent transcriptional expression.


Pssm-ID: 369990  Cd Length: 363  Bit Score: 53.71  E-value: 8.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   346 GTSDTPASSSPPQGTLDTPSSSSPPqgtSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVT 425
Cdd:pfam08601   31 QLSKAKQNTAKPGVRSDSRSPSPNA---STSTPDSQPPPSASSSTTPNQGSNGLNAFTGEDNNNYSNSAANPGATRGSTA 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   426 SETPASSSPTQVTSETPASS-SPTQvTSDTPASNSPPQGTSDTPGFSSPTQ--VTTATLVSSSPPQVTSDTPASSSPPQV 502
Cdd:pfam08601  108 SSARSQSSPYSFGSGTSTSSdSPSS-SSSSHQGQLSSCGTSPEPSTQSPGGqkSVETMIGEEQCAHGTIDGEKSFCAKLG 186

                          170       180       190
                   ....*....|....*....|....*....|....
gi 557128996   503 TSDTPASSSPPQVTSETPASSSPPQVTSDTSASI 536
Cdd:pfam08601  187 MACGNINNPIPAAMSKSNSLSNTPGHASNDSNGL 220
GPS pfam01825
GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for ...
 1010-1048 8.46e-07

GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for auto-proteolysis, so is thus named, GPS. The GPS motif is a conserved sequence of ~40 amino acids containing canonical cysteine and tryptophan residues, and is the most highly conserved part of the domain. In most, if not all, cell-adhesion GPCRs these undergo autoproteolysis in the GPS between a conserved aliphatic residue (usually a leucine) and a threonine, serine, or cysteine residue. In higher eukaryotes this motif is found embedded in the C-terminal beta-stranded part of a GAIN domain - GPCR-Autoproteolysis INducing (GAIN). The GAIN-GPS domain adopts a fold in which the GPS motif, at the C-terminus, forms five beta-strands that are tightly integrated into the overall GAIN domain. The GPS motif, evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations. The GAIN-GPS domain is both necessary and sufficient functionally for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment in the GPS to catalyze peptide bond hydrolysis. In the cell-adhesion GPCRs and PKD proteins, the GPS motif is always located at the end of their long N-terminal extracellular regions, immediately before the first transmembrane helix of the respective protein.


Pssm-ID: 460350  Cd Length: 44  Bit Score: 47.30  E-value: 8.46e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 557128996  1010 QCYFWDRYNRT---WKSDGCQVGPKSTiLKTQCLCDHLTFFS 1048
Cdd:pfam01825    2 QCVFWDFTNSTtgrWSTEGCTTVSLND-THTVCSCNHLTSFA 42
SP2_N cd22540
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ...
 351-619 9.22e-07

N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.


Pssm-ID: 411776 [Multi-domain]  Cd Length: 511  Bit Score: 53.78  E-value: 9.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  351 PASSSPPQGTLDTPSSSS------PPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSS---- 420
Cdd:cd22540    66 PLPLGPGKNSIGFLSAKGniiqlqGSQLSSSAPGGQQVFAIQNPTMIIKGSQTRSSTNQQYQISPQIQAAGQINNSgqiq 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  421 -----------PPQVTSETPASSSPTQVTsetPASSSPTQVTSDTPASN-------SPPQGTSDTP-----GFSSPTQVT 477
Cdd:cd22540   146 iipgtnqaiitPVQVLQQPQQAHKPVPIK---PAPLQTSNTNSASLQVPgnviklqSGGNVALTLPvnnlvGTQDGATQL 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  478 TATLVSSSPPQVTSDTPASSSPPQVTS--------------------------DTPASSSPPQV--------TSETPASS 523
Cdd:cd22540   223 QLAAAPSKPSKKIRKKSAQAAQPAVTVaeqvetvliettadniiqagnnllivQSPGTGQPAVLqqvqvlqpKQEQQVVQ 302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  524 SPP------QVTSDTSASI--SPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTS 595
Cdd:cd22540   303 IPQqalrvvQAASATLPTVpqKPLQNIQIQNSEPTPTQVYIKTPSGEVQTVLLQEAPAATATPSSSTSTVQQQVTANNGT 382

                         330       340
                  ....*....|....*....|....
gi 557128996  596 DTPASSSPpwpvitevTRPESTIP 619
Cdd:cd22540   383 GTSKPNYN--------VRKERTLP 398
CLECT cd00037
C-type lectin (CTL)/C-type lectin-like (CTLD) domain; CLECT: C-type lectin (CTL)/C-type ...
 37-142 9.29e-07

C-type lectin (CTL)/C-type lectin-like (CTLD) domain; CLECT: C-type lectin (CTL)/C-type lectin-like (CTLD) domain; protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. This group is chiefly comprised of eukaryotic CTLDs, but contains some, as yet functionally uncharacterized, bacterial CTLDs. Many CTLDs are calcium-dependent carbohydrate binding modules; other CTLDs bind protein ligands, lipids, and inorganic surfaces, including CaCO3 and ice. Animal C-type lectins are involved in such functions as extracellular matrix organization, endocytosis, complement activation, pathogen recognition, and cell-cell interactions. For example: mannose-binding lectin and lung surfactant proteins A and D bind carbohydrates on surfaces (e.g. pathogens, allergens, necrotic, and apoptotic cells) and mediate functions associated with killing and phagocytosis; P (platlet)-, E (endothelial)-, and L (leukocyte)- selectins (sels) mediate the initial attachment, tethering, and rolling of lymphocytes on inflamed vascular walls enabling subsequent lymphocyte adhesion and transmigration. CTLDs may bind a variety of carbohydrate ligands including mannose, N-acetylglucosamine, galactose, N-acetylgalactosamine, and fucose. Several CTLDs bind to protein ligands, and only some of these binding interactions are Ca2+-dependent; including the CTLDs of Coagulation Factors IX/X (IX/X) and Von Willebrand Factor (VWF) binding proteins, and natural killer cell receptors. C-type lectins, such as lithostathine, and some type II antifreeze glycoproteins function in a Ca2+-independent manner to bind inorganic surfaces. Many proteins in this group contain a single CTLD; these CTLDs associate with each other through several different surfaces to form dimers, trimers, or tetramers, from which ligand-binding sites project in different orientations. Various vertebrate type 1 transmembrane proteins including macrophage mannose receptor, endo180, phospholipase A2 receptor, and dendritic and epithelial cell receptor (DEC205) have extracellular domains containing 8 or more CTLDs; these CTLDs remain in the parent model. In some members (IX/X and VWF binding proteins), a loop extends to the adjoining domain to form a loop-swapped dimer. A similar conformation is seen in the macrophage mannose receptor CRD4's putative non-sugar bound form of the domain in the acid environment of the endosome. Lineage specific expansions of CTLDs have occurred in several animal lineages including Drosophila melanogaster and Caenorhabditis elegans; these CTLDs also remain in the parent model.


Pssm-ID: 153057 [Multi-domain]  Cd Length: 116  Bit Score: 49.54  E-value: 9.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   37 SCYQLNRLFCDFQEADNYCHAQRGRLAHTWNPKLRGFLKSFL---NEETVW-------------WVRGNLTLPGSHPGIN 100
Cdd:cd00037     1 SCYKFSTEKLTWEEAQEYCRSLGGHLASIHSEEENDFLASLLkksSSSDVWiglndlssegtwkWSDGSPLVDYTNWAPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 557128996  101 QTGGDDvlrnqkPGECpsvVTHSNAVFSRWN--LCIEKHHFICQ 142
Cdd:cd00037    81 EPNPGG------SEDC---VVLSSSSDGKWNdvSCSSKLPFICE 115
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 377-665 1.09e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 54.22  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  377 PASSSPPQGTS---ETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPtQVTSETPASSSPTQVTSD 453
Cdd:PRK07764  365 PSASDDERGLLarlERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAP-AAAPQPAPAPAPAPAPPS 443

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  454 TPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQ------------------- 514
Cdd:PRK07764  444 PAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAgaddaatlrerwpeilaav 523

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  515 ---VTSETPASSSPPQVTS----------DTSAS---ISPPQ---------------------VISDTPASSSPPQVTSE 557
Cdd:PRK07764  524 pkrSRKTWAILLPEATVLGvrgdtlvlgfSTGGLarrFASPGnaevlvtalaeelggdwqveaVVGPAPGAAGGEGPPAP 603

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  558 TPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSPPWPVITEVTRPESTIPAGRSLANITSKAQEDSPL 637
Cdd:PRK07764  604 ASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPP 683

                         330       340
                  ....*....|....*....|....*...
gi 557128996  638 GVISTHPQMSFQSSTSQALDETAGERVP 665
Cdd:PRK07764  684 APAPAAPAAPAGAAPAQPAPAPAATPPA 711
PHA03255 PHA03255
BDLF3; Provisional
 373-559 1.40e-06

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 51.83  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  373 TSDTPASSSPpQGTSETPASNSPpqgtseTPGFSSPPQVTTATLVSSSPPqVTSETPASSSPTQVTSeTPASSSPTQVTS 452
Cdd:PHA03255   25 TSSGSSTASA-GNVTGTTAVTTP------SPSASGPSTNQSTTLTTTSAP-ITTTAILSTNTTTVTS-TGTTVTPVPTTS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  453 DTpasnsppqgtsdtpgfSSPTQVTTATLVSSSppqvTSDTPASSSPPQVTSDTPASSSPPQVTSE-TPASSSPPQVTSD 531
Cdd:PHA03255   96 NA----------------STINVTTKVTAQNIT----ATEAGTGTSTGVTSNVTTRSSSTTSATTRiTNATTLAPTLSSK 155

                         170       180
                  ....*....|....*....|....*...
gi 557128996  532 TSASISPPQVISDTPASSSPPQVTSETP 559
Cdd:PHA03255  156 GTSNATKTTAELPTVPDERQPSLSYGLP 183
Caprin-1_C pfam12287
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ...
 362-498 1.53e-06

Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.


Pssm-ID: 463522 [Multi-domain]  Cd Length: 320  Bit Score: 52.49  E-value: 1.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   362 DTPS-----SSSPPQGTSDTPASSSPPQgtsetpasnSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQ 436
Cdd:pfam12287   23 DKPSdsaivSAQPPSQSPDLSQMVCPPA---------SPEQRLSQQSDVLQQPEQTQVSPVSPSSNACASSGSEYQFHTS 93

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557128996   437 VTSETPASSSPtqvtsdtPASNSPPqgtsdtpgfSSPTQvTTATLVSSSPPQVTSDTPASSS 498
Cdd:pfam12287   94 EPPQPEAIDPI-------QSSMSLP---------SELAP-PSPPLSPASQPQVFQSKPASSS 138
PHA03378 PHA03378
EBNA-3B; Provisional
 410-632 1.69e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 53.53  E-value: 1.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  410 QVTTATLVSSSPPQVTSetpASSSPTQVTSETpasssptQVTSDTPASNSPPQGTS-DTPGfssPTQVTTATLVSSSPPQ 488
Cdd:PHA03378  518 QRVMATLLPPSPPQPRA---GRRAPCVYTEDL-------DIESDEPASTEPVHDQLlPAPG---LGPLQIQPLTSPTTSQ 584

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  489 VTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPP---QVIS-DTPASSSPPQVTSETPASSSP 564
Cdd:PHA03378  585 LASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPlrmQPITfNVLVFPTPHQPPQVEITPYKP 664

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 557128996  565 T-NMTSDTPASSSPTNMTSDTPASSSPTNMTSD--TPASSSPPWPVITEVTRPESTIPAGRSLANITSKAQ 632
Cdd:PHA03378  665 TwTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPprAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRAR 735
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 347-604 2.28e-06

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 52.33  E-value: 2.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  347 TSDTPASSSPPQGTLDTPSSSSpPQGTSDTPASSSPPQGTSETPASNSPPQGtsetpgfSSPPQVTTATLVSSSPPQVts 426
Cdd:COG5068   163 PSDSSEEPSSSASFSVDPNDNN-PMGSFQHNGSPQTNFIPLQNPQTQQYQQH-------SSRKDHPTVPHSNTNNGRP-- 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  427 etPASSSPTQVTSETPASSSPTQVTSDtpaSNSPPQG-TSDTPGFSSPTQVTTATLVsSSPPQVTSDTPASSSPPQVTSD 505
Cdd:COG5068   233 --PAKFMIPELHSSHSTLDLPSDFISD---SGFPNQSsTSIFPLDSAIIQITPPHLP-NNPPQENRHELYSNDSSMVSET 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  506 TPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTP 585
Cdd:COG5068   307 PPPKNLPNGSPNQSPLNNLSRGNPASPNSIIRENNQVEDESFNGRQGSAIWNALISTTQPNSGLHTEASTAPSSTIPADP 386

                         250
                  ....*....|....*....
gi 557128996  586 ASSSPTNMTSDTPASSSPP 604
Cdd:COG5068   387 LKNAAQTNSGTRNNNFSDN 405
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 353-499 2.63e-06

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 52.09  E-value: 2.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   353 SSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSS---PPQVTTATLVSSSPPQVT--SE 427
Cdd:pfam13254  210 RSPAPGGHSKSPSVSGISADSSPTKEEPSEEADTLSTDKEQSPAPTSASEPPPKTkelPKDSEEPAAPSKSAEASTekKE 289

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 557128996   428 TPASSSP--TQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSsppQVTSDTPASSSP 499
Cdd:pfam13254  290 PDTESSPetSSEKSAPSLLSPVSKASIDKPLSSPDRDPLSPKPKPQSPPKDFRANLRSR---EVPKDKSKKDEP 360
PRK10856 PRK10856
cytoskeleton protein RodZ;
496-577 2.90e-06

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 51.57  E-value: 2.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  496 SSSPPQVTSDTPASSSPPQVTSETPASSSP--PQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPA 573
Cdd:PRK10856  168 TTTDPATTPAPAAPVDTTPTNSQTPAVATApaPAVDPQQNAVVAPSQANVDTAATPAPAAPATPDGAAPLPTDQAGVSTP 247


                  ....
gi 557128996  574 SSSP 577
Cdd:PRK10856  248 AADP 251
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 211-586 3.23e-06

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 52.37  E-value: 3.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  211 PPKATHRMTITSLTgRPQVTSDTLASSSPPQGTSDT----PASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATS 286
Cdd:COG5180   187 EPRDALKDSPEKLD-RPKVEVKDEAQEEPPDLTGGAdhprPEAASSPKVDPPSTSEARSRPATVDAQPEMRPPADAKERR 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  287 ASSSPpqgtsDTPASSSPPQvtsatSASSSPPQGTSDTPASSSPPQvtsatsasssppqgTSDTPASSSPPQGTLDTPSS 366
Cdd:COG5180   266 RAAIG-----DTPAAEPPGL-----PVLEAGSEPQSDAPEAETARP--------------IDVKGVASAPPATRPVRPPG 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  367 SSPPQGTSDTPASSSPPQGTSETpASNSPPQGTSETPGFSSPPqvtTATLVSSSPpqvtsetPASSSPTQVTSETPASSS 446
Cdd:COG5180   322 GARDPGTPRPGQPTERPAGVPEA-ASDAGQPPSAYPPAEEAVP---GKPLEQGAP-------RPGSSGGDGAPFQPPNGA 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  447 PtQVTSDTPASNSPPQGTSDTPGFSSPTQVTTAtlVSSSPPQvtsdTPASSSPPQVTSDTPASS----SPPQVTSETPAS 522
Cdd:COG5180   391 P-QPGLGRRGAPGPPMGAGDLVQAALDGGGRET--ASLGGAA----GGAGQGPKADFVPGDAESvsgpAGLADQAGAAAS 463

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557128996  523 SSP-PQVTSDTSASISPPQVISDTPASSSPPqvTSETPASSSPtnmTSDTPASSSPTNMTSDTPA 586
Cdd:COG5180   464 TAMaDFVAPVTDATPVDVADVLGVRPDAILG--GNVAPASGLD---AETRIIEAEGAPATEDFVA 523
PHA03377 PHA03377
EBNA-3C; Provisional
 408-696 3.36e-06

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 52.36  E-value: 3.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  408 PPQVTTATLVSSSPPQVTSE----TPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVS 483
Cdd:PHA03377  399 PVQQRPVMFVSRVPWRKPRTlpwpTPKTHPVKRTLVKTSGRSDEAEQAQSTPERPGPSDQPSVPVEPAHLTPVEHTTVIL 478

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  484 SSPPQVTSDTPASSSPPQV---------------------TSDTPASSSPPQVTSETPASSSppQVTSDTSASISPPQVI 542
Cdd:PHA03377  479 HQPPQSPPTVAIKPAPPPSrrrrgacvvydddiievidveTTEEEESVTQPAKPHRKVQDGF--QRSGRRQKRATPPKVS 556

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  543 -SDT-PASSSPPQV---TSETPASSSPTNMTSDT-PASSSPTNMT--SDTPASSSPTNMtsdTPASSSPPW---PVITEV 611
Cdd:PHA03377  557 pSDRgPPKASPPVMappSTGPRVMATPSTGPRDMaPPSTGPRQQAkcKDGPPASGPHEK---QPPSSAPRDmapSVVRMF 633

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  612 TR----PESTIPAGRSLANItsKAQEDSPLgviSTHPQMSFQSSTSQALDETAgERVPTIPDFQAHSEFQKACAILQRLR 687
Cdd:PHA03377  634 LRerllEQSTGPKPKSFWEM--RAGRDGSG---IQQEPSSRRQPATQSTPPRP-SWLPSVFVLPSVDAGRAQPSEESHLS 707


                  ....*....
gi 557128996  688 DFLPTSPTS 696
Cdd:PHA03377  708 SMSPTQPIS 716
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 190-576 3.63e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 52.60  E-value: 3.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  190 QPAPPELFEtlcfPIDPASSAPPKathrmtitSLTGRPQVTSDTlASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGT 269
Cdd:NF033609  547 QPDEPGEIE----PIPEDSDSDPG--------SDSGSDSSNSDS-GSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSA 613

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  270 SDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSD 349
Cdd:NF033609  614 SDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 693

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  350 TPASSSPpqgtlDTPS-SSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSET 428
Cdd:NF033609  694 SDSDSDS-----DSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 768

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  429 PASSSPTQVTSETPASSSPTQVTSDTPA-SNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSppqvtSDTP 507
Cdd:NF033609  769 DSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-----SDSD 843

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  508 ASSSPPQVTSETPASSSPPQVTSDTSASISPPqvisDTPASSSPPQVTSETPASSSPTNMT-SDTPASSS 576
Cdd:NF033609  844 SDSDSDSDSDSDSESDSNSDSESGSNNNVVPP----NSPKNGTNASNKNEAKDSKEPLPDTgSEDEANTS 909
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
239-551 4.05e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 52.16  E-value: 4.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  239 PPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPqvtsatsassspp 318
Cdd:PRK07003  360 PAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAP------------- 426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  319 qgtsdtPASSSPPQvtsatsasssPPQGTSDTPASSSPPQGTLDTPSS-SSPPQGTSDTPASSSPPQGtseTPASNSPPQ 397
Cdd:PRK07003  427 ------PAAPAPPA----------TADRGDDAADGDAPVPAKANARASaDSRCDERDAQPPADSGSAS---APASDAPPD 487

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  398 GTSEtpgfSSPPqvttATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPqgtSDTPGFSSPTQV- 476
Cdd:PRK07003  488 AAFE----PAPR----AAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPA---ARAGGAAAALDVl 556

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557128996  477 TTATLVSSSPPQVTSDTPASSSPPQVTSDTPAsssPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSP 551
Cdd:PRK07003  557 RNAGMRVSSDRGARAAAAAKPAAAPAAAPKPA---APRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPPP 628
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
319-547 4.06e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 52.19  E-value: 4.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  319 QGTSDTPASSSPPQVTSATSASSSPPQGTSdTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQG 398
Cdd:PRK12323  368 SGGGAGPATAAAAPVAQPAPAAAAPAAAAP-APAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGG 446

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  399 TSETPgfSSPPQVTTATlvsSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPtqvTT 478
Cdd:PRK12323  447 APAPA--PAPAAAPAAA---ARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDA---AP 518

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 557128996  479 ATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPqvtsDTSASISPPQVISDTPA 547
Cdd:PRK12323  519 AGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPP----RASASGLPDMFDGDWPA 583
PPE COG5651
PPE-repeat protein [Function unknown];
363-587 4.20e-06

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 51.43  E-value: 4.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  363 TPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGtsetpGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETP 442
Cdd:COG5651   165 TPFTQPPPTITNPGGLLGAQNAGSGNTSSNPGFANL-----GLTGLNQVGIGGLNSGSGPIGLNSGPGNTGFAGTGAAAG 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  443 ASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPAS 522
Cdd:COG5651   240 AAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGAGGAAGAA 319

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557128996  523 SSPP-QVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPAS 587
Cdd:COG5651   320 GATGaGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAAA 385
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 485-636 4.85e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 52.02  E-value: 4.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  485 SPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSE---TPASSSPPQVTSDTSASISPPQvisDTPASSSPPQVTSETPAS 561
Cdd:PRK08691  379 SPSAQTAEKETAAKKPQPRPEAETAQTPVQTASAaamPSEGKTAGPVSNQENNDVPPWE---DAPDEAQTAAGTAQTSAK 455

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 557128996  562 SSPTNMTSDTPASSSPT-NMTSDTPASSSPTNMTSDTPASSSP-PWPVITEVTRPESTIPAgrslANITSKAQEDSP 636
Cdd:PRK08691  456 SIQTASEAETPPENQVSkNKAADNETDAPLSEVPSENPIQATPnDEAVETETFAHEAPAEP----FYGYGFPDNDCP 528
PHA03379 PHA03379
EBNA-3A; Provisional
 211-606 5.79e-06

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 51.60  E-value: 5.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  211 PP---KATHRMTITSLTGRPQVTSDTLASssPPQGTSDTPassSPPQVTSATSASSSPPQGTSDTPASS-SPPQVTSATS 286
Cdd:PHA03379  379 PPiflRRLHRLLLMRAGKLTERAREALEK--ASEPTYGTP---RPPVEKPRPEVPQSLETATSHGSAQVpEPPPVHDLEP 453

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  287 ASSSPPQGTSDTPASSSPPqvtsatsasssppqgtsdtpassSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSS 366
Cdd:PHA03379  454 GPLHDQHSMAPCPVAQLPP-----------------------GPLQDLEPGDQLPGVVQDGRPACAPVPAPAGPIVRPWE 510

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  367 SSPPQGTSDTPASSSP----------PQGTSETPASNSPP----QGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASS 432
Cdd:PHA03379  511 ASLSQVPGVAFAPVMPqpmpvepvpvPTVALERPVCPAPPliamQGPGETSGIVRVRERWRPAPWTPNPPRSPSQMSVRD 590

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  433 SPTQVTSET-----PASSSPTQVTSDTPAS-----NSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTS---DTPASSSP 499
Cdd:PHA03379  591 RLARLRAEAqpyqaSVEVQPPQLTQVSPQQpmeypLEPEQQMFPGSPFSQVADVMRAGGVPAMQPQYFDlplQQPISQGA 670

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  500 PQVTSDTPASSSPPqVTSETPASSSPPqVTSDTSASISPPQVISDTPAssSPPQVtseTPASSSPTNMTSDTPASSSPTN 579
Cdd:PHA03379  671 PLAPLRASMGPVPP-VPATQPQYFDIP-LTEPINQGASAAHFLPQQPM--EGPLV---PERWMFQGATLSQSVRPGVAQS 743

                         410       420
                  ....*....|....*....|....*..
gi 557128996  580 MTSDTPASSSPTNMTSDTPASSSPPWP 606
Cdd:PHA03379  744 QYFDLPLTQPINHGAPAAHFLHQPPME 770
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
455-625 6.29e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 51.39  E-value: 6.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  455 PASNSPPQGTSDTPGfssPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPqvtsETPASSSPPQVTSD--T 532
Cdd:PRK07003  368 PGGGVPARVAGAVPA---PGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRA----EAPPAAPAPPATADrgD 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  533 SASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTN-MTSDTPASSSPTNMTSDTPASSSPPW--PVIT 609
Cdd:PRK07003  441 DAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDaAFEPAPRAAAPSAATPAAVPDARAPAaaSRED 520

                         170
                  ....*....|....*.
gi 557128996  610 EVTRPESTIPAGRSLA 625
Cdd:PRK07003  521 APAAAAPPAPEARPPT 536
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
 1985-2140 6.69e-06

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 51.87  E-value: 6.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996 1985 LRGFLLLFATVRVWDLLRHHAQLQVINKTLSKAWDEVLGFILIIVVLLSSYAMTFNLLFGWSISDYQSFFRSIVTVVGLL 2064
Cdd:PLN03223 1294 LSGINIILLLGRILKLMDFQPRLGVITRTLWLAGADLMHFFVIFGMVFVGYAFIGHVIFGNASVHFSDMTDSINSLFENL 1373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996 2065 MG-----TSKHKEVIALYPILGSLLVLSSIILMGLVIINLFVSAILIAFGkERKACEKEAT-----LTDMLLQKLSSLLG 2134
Cdd:PLN03223 1374 LGdityfNEDLKNLTGLQFVVGMIYFYSYNIFVFMILFNFLLAIICDAFG-EVKANAAETVsvhteLFPMLRDKWRSMFK 1452


                  ....*.
gi 557128996 2135 IRLHQN 2140
Cdd:PLN03223 1453 GWFYKN 1458
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 371-484 7.26e-06

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 51.24  E-value: 7.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  371 QGTSDTPASSSP--PQGTSETPAS-NSPPQGTSeTPGFSSPPQVTTATLV--SSSPPQVTSETPASSSPTQVTSETPASS 445
Cdd:PLN02217  545 QGDAWIPGKGVPyiPGLFAGNPGStNSTPTGSA-ASSNTTFSSDSPSTVVapSTSPPAGHLGSPPATPSKIVSPSTSPPA 623

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 557128996  446 SPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSS 484
Cdd:PLN02217  624 SHLGSPSTTPSSPESSIKVASTETASPESSIKVASTESS 662
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
 1009-1048 9.44e-06

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


Pssm-ID: 197639  Cd Length: 49  Bit Score: 44.69  E-value: 9.44e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 557128996   1009 TQCYFWDRYNRTWKSDGCQVGPKS-TIlkTQCLCDHLTFFS 1048
Cdd:smart00303    3 PICVFWDESSGEWSTRGCELLETNgTH--TTCSCNHLTTFA 41
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 494-674 1.05e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.94  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  494 PASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQvisDTPASSSPPQVTSETPASSSPTNMTSDTPA 573
Cdd:PHA03307   22 PRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPP---TGPPPGPGTEAPANESRSTPTWSLSTLAPA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  574 SSSPTNmtSDTPASSSPTNMTSDTPASSSP---PWPVITEVTRPE-STIPAGRSLANITSKAQEDSPLGVISTHPQMSFQ 649
Cdd:PHA03307   99 SPAREG--SPTPPGPSSPDPPPPTPPPASPppsPAPDLSEMLRPVgSPGPPPAASPPAAGASPAAVASDAASSRQAALPL 176

                         170       180
                  ....*....|....*....|....*..
gi 557128996  650 SSTSQALD--ETAGERVPTIPDFQAHS 674
Cdd:PHA03307  177 SSPEETARapSSPPAEPPPSTPPAAAS 203
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 351-448 1.06e-05

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 50.34  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  351 PASSSPPQGTLDTPSSSSPPQ-GTSD--TPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSE 427
Cdd:PHA03291  176 PLGEGSADGSCDPALPLSAPRlGPADvfVPATPRPTPRTTASPETTPTPSTTTSPPSTTIPAPSTTIAAPQAGTTPEAEG 255

                          90       100
                  ....*....|....*....|.
gi 557128996  428 TPASSSPTqVTSETPASSSPT 448
Cdd:PHA03291  256 TPAPPTPG-GGEAPPANATPA 275
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
321-469 1.31e-05

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 50.05  E-value: 1.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   321 TSDTPASSSPPQ----VTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPqgTSDTPASSSPPQGTSETPASNSPP 396
Cdd:pfam05539  191 SQVTPQSQPATQghqtATANQRLSSTEPVGTQGTTTSSNPEPQTEPPPSQRGPS--GSPQHPPSTTSQDQSTTGDGQEHT 268

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557128996   397 QGTSETPGFSSPPQV-TTATLVSSSPPQVTSE-TPASSSPTQVTSeTPASSSPTQVTSDTPASNSPPQGTSDTPG 469
Cdd:pfam05539  269 QRRKTPPATSNRRSPhSTATPPPTTKRQETGRpTPRPTATTQSGS-SPPHSSPPGVQANPTTQNLVDCKELDPPK 342
SP4_N cd22536
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins ...
 345-722 1.32e-05

N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Human SP4 is a risk gene of multiple psychiatric disorders including schizophrenia, bipolar disorder, and major depression. SP4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP4.


Pssm-ID: 411773 [Multi-domain]  Cd Length: 623  Bit Score: 50.30  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  345 QGTSDTPASSSPPQGTldtpSSSSPPQGTSDTPASSSPPQGTSETPASNSP-PQGTSEtpgFSSPPQVTTatlVSSSPPQ 423
Cdd:cd22536    90 QGVSAATSSAAPSSSN----NGSTSPTKVKAGNSNASAPGQFQVIQVQNMQnPSGSVQ---YQVIPQIQT---VEGQQIQ 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  424 VTSETPASSSPTQVTSE-TPASS--SPTQVTSDTPASNSPPQGTSDT-------PGFSSPTQVTTatlVSSSPPQVTSDT 493
Cdd:cd22536   160 ISPANATALQDLQGQIQlIPAGNnqAILTTPNRTASGNIIAQNLANQtvpvqirPGVSIPLQLQT---IPGAQAQVVTTL 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  494 PASSSppQVTSDTPasssppqVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMT----- 568
Cdd:cd22536   237 PINIG--GVTLALP-------VINNVAAGGGSGQLVQPSDGGVSNGNQLVSTPITTASVSTMPESPSSSTTCTTTastsl 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  569 --SDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSPPWPVI-TEVTRPESTIPAGRSLANITSKAQE--------DSPL 637
Cdd:cd22536   308 tsSDTLVSSAETGQYASTAASSERTEEEPQTSAAESEAQSSSqLQSNGLQNVQDQSNSLQQVQIVGQPilqqiqiqQPQQ 387

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  638 GVISTHPQMSFQSSTSQALDETAGERVPTIpDFQAhseFQKACAILQRLRDFLPTSPTSAQ-VSVANL---------LID 707
Cdd:cd22536   388 QIIQAIQPQSFQLQSGQTIQTIQQQPLQNV-QLQA---VQSPTQVLIRAPTLTPSGQISWQtVQVQNIqslsnlqvqNAG 463

                         410
                  ....*....|....*
gi 557128996  708 LSEQLLVLPFQKNNS 722
Cdd:cd22536   464 LPQQLTLTPVSSSAG 478
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 395-532 1.39e-05

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 50.47  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  395 PPQGTSETPG-FSSPPQVTTATLVSSSPPQVTSETpaSSSPTqvTSETPASSSPTQVTSDTPASnsppqgtsdtpgfssP 473
Cdd:PLN02217  551 PGKGVPYIPGlFAGNPGSTNSTPTGSAASSNTTFS--SDSPS--TVVAPSTSPPAGHLGSPPAT---------------P 611

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 557128996  474 TQVTTAtlvSSSPPQ----VTSDTPASSSPPQVTSDTPaSSSPPQVTSETPASSSPPQVTSDT 532
Cdd:PLN02217  612 SKIVSP---STSPPAshlgSPSTTPSSPESSIKVASTE-TASPESSIKVASTESSVSMVSMST 670
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 403-558 1.48e-05

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 50.09  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  403 PGFSSPPQVTTATLVSSSPPQVTSETPASSspTQVTSETPASSSPTQ---VTSDTPASNSPPQGTSdTPGFSSPTQVTTA 479
Cdd:PLN02217  514 PGAAITKRVTWPGIKKLSDEEILKFTPAQY--IQGDAWIPGKGVPYIpglFAGNPGSTNSTPTGSA-ASSNTTFSSDSPS 590

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  480 TLV--SSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPqVTSDTSASISPPQVISDTPASSSPPQVTSE 557
Cdd:PLN02217  591 TVVapSTSPPAGHLGSPPATPSKIVSPSTSPPASHLGSPSTTPSSPESS-IKVASTETASPESSIKVASTESSVSMVSMS 669


                  .
gi 557128996  558 T 558
Cdd:PLN02217  670 T 670
motB PRK12799
flagellar motor protein MotB; Reviewed
 477-595 1.48e-05

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 49.71  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  477 TTATLVSSSPPQVTSDTPASSSPPqvtsdTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTS 556
Cdd:PRK12799  307 SSAVTQSSAITPSSAAIPSPAVIP-----SSVTTQSATTTQASAVALSSAGVLPSDVTLPGTVALPAAEPVNMQPQPMST 381

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 557128996  557 ETPASSSPTNMtsdTPASSSPTNMTSDTPASSSPTNMTS 595
Cdd:PRK12799  382 TETQQSSTGNI---TSTANGPTTSLPAAPASNIPVSPTS 417
PRK13914 PRK13914
invasion associated endopeptidase;
352-588 1.48e-05

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 50.19  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  352 ASSSPPQGTLDTPSSSSPPQGTsdtPASSSPPQGTSETPASNSPPQG--TSETPGFSSppQVTTATLVSSSPPQVTSeTP 429
Cdd:PRK13914  143 VTSTPVAPTQEVKKETTTQQAA---PAAETKTEVKQTTQATTPAPKVaeTKETPVVDQ--NATTHAVKSGDTIWALS-VK 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  430 ASSSPTQVTSETPASSSPTQVTSD----TPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSD 505
Cdd:PRK13914  217 YGVSVQDIMSWNNLSSSSIYVGQKlaikQTANTATPKAEVKTEAPAAEKQAAPVVKENTNTNTATTEKKETTTQQQTAPK 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  506 TPASSSPPqvtseTPAssspPQVTSDTSASISPPQVISDTPASSSPPQVTSETpaSSSPTNMTSDTPASSSPTNMTSDTP 585
Cdd:PRK13914  297 APTEAAKP-----APA----PSTNTNANKTNTNTNTNTNNTNTSTPSKNTNTN--TNSNTNTNSNTNANQGSSNNNSNSS 365


                  ...
gi 557128996  586 ASS 588
Cdd:PRK13914  366 ASA 368
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
224-422 1.51e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 50.14  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  224 TGRPQVTSDTLASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSS 303
Cdd:COG3469    12 AGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  304 PPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSS--SSPPQGTSDTPASSS 381
Cdd:COG3469    92 TSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSgtETATGGTTTTSTTTT 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 557128996  382 PPQGTSETPASNSPPQGTSETPGFSSPP-QVTTATLVSSSPP 422
Cdd:COG3469   172 TTSASTTPSATTTATATTASGATTPSATtTATTTGPPTPGLP 213
DUF612 pfam04747
Protein of unknown function, DUF612; This family includes several uncharacterized proteins ...
 228-575 1.65e-05

Protein of unknown function, DUF612; This family includes several uncharacterized proteins from Caenorhabditis elegans.


Pssm-ID: 282585 [Multi-domain]  Cd Length: 511  Bit Score: 50.06  E-value: 1.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   228 QVTSDTLASSSP-PQGTSDTPASSSPpQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSppqgTSDTPASSSPPQ 306
Cdd:pfam04747  181 KVANDRSAAPAPePKTPTNTPAEPAE-QVQEITGKKNKKNKKKSESEATAAPASVEQVVEQPKV----VTEEPHQQAAPQ 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   307 vtSATSASSSPPQGTSDTPASSSPPQvtsatsasssppqgtsdTPASSSPPqgtldtPSSSSPPQGTSDTPASSSppQGT 386
Cdd:pfam04747  256 --EKKNKKNKRKSESENVPAASETPV-----------------EPVVETTP------PASENQKKNKKDKKKSES--EKV 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   387 SETPASNSPPQgtSETPGFSSPPQVTTATLVSSSPPQVTSETPASssPTQVTSETPASSSPTQVTSdTPASNSPPQGTSD 466
Cdd:pfam04747  309 VEEPVQAEAPK--SKKPTADDNMDFLDFVTAKEEPKDEPAETPAA--PVEEVVENVVENVVEKSTT-PPATENKKKNKKD 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   467 TPGfSSPTQVTTATLVSS-SPPQVT----SDTPASSSPPQVTSDTPASSSPPQVtsETPASSSPPQVTSDTSASISPPQV 541
Cdd:pfam04747  384 KKK-SESEKVTEQPVESApAPPQVEqvveTTPPASENKKKNKKDKKKSESEKAV--EEPVQAAPSSKKPTADDNMDFLDF 460

                          330       340       350
                   ....*....|....*....|....*....|....
gi 557128996   542 ISDTPASSSPPQVTSETPASSSPTNMTSDTPASS 575
Cdd:pfam04747  461 VTAKPDKSESVEEHIAAPMIVEPAHADEETAAAA 494
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 468-628 1.67e-05

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 50.09  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  468 PGFSSPTQVTTATLVSSSPPQVTSDTPASssppQVTSDT--PASSSP--PQVTSETPASSsppqvTSDTSASISPpqviS 543
Cdd:PLN02217  514 PGAAITKRVTWPGIKKLSDEEILKFTPAQ----YIQGDAwiPGKGVPyiPGLFAGNPGST-----NSTPTGSAAS----S 580

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  544 DTPASSSPPQvTSETPASSSPTNMTSDTPASSSpTNMTSDTPASSSPTNMTSDTPAS-SSPPWPVITEVTRPESTIPAGR 622
Cdd:PLN02217  581 NTTFSSDSPS-TVVAPSTSPPAGHLGSPPATPS-KIVSPSTSPPASHLGSPSTTPSSpESSIKVASTETASPESSIKVAS 658


                  ....*.
gi 557128996  623 SLANIT 628
Cdd:PLN02217  659 TESSVS 664
rne PRK10811
ribonuclease E; Reviewed
 474-620 1.81e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 50.04  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  474 TQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSP----------PQVTSETPASSSPPQVTSDTSASIS-----P 538
Cdd:PRK10811  848 VRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPvveavaevveEPVVVAEPQPEEVVVVETTHPEVIAapvteQ 927

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  539 PQVISDTPASssppqVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSPPWPVITEVTRPESTI 618
Cdd:PRK10811  928 PQVITESDVA-----VAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVA 1002


                  ..
gi 557128996  619 PA 620
Cdd:PRK10811 1003 PA 1004
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 476-616 1.90e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 49.81  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  476 VTTATLVSSSPPQVTSDTPASSSPPQvtsDTPASSSPPQVTSETPASSSPPQvtsdtsASISPPQVISDTPASSSPPqvt 555
Cdd:PRK14950  355 VIEALLVPVPAPQPAKPTAAAPSPVR---PTPAPSTRPKAAAAANIPPKEPV------RETATPPPVPPRPVAPPVP--- 422

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557128996  556 seTPASSSPTNMTSDTPASSSPtnmTSDTPASSSPTNMTSDTPASS----SPPWPVITEVTRPES 616
Cdd:PRK14950  423 --HTPESAPKLTRAAIPVDEKP---KYTPPAPPKEEEKALIADGDVleqlEAIWKQILRDVPPRS 482
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 226-466 1.91e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.98  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  226 RPQVTSDTLASSSPPQGTSDTPASSSPPQVTSAtsasssppqGTSDTPASSSPPqvtsatsasssppqgtSDTPASSSPP 305
Cdd:PRK07764  583 QVEAVVGPAPGAAGGEGPPAPASSGPPEEAARP---------AAPAAPAAPAAP----------------APAGAAAAPA 637

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  306 QVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQgtlDTPSSSSPPQGTSDTPASSSPPQG 385
Cdd:PRK07764  638 EASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAP---AAPAGAAPAQPAPAPAATPPAGQA 714

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  386 TSETPASNSPPQGTSETPGFSS-----PPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSP 460
Cdd:PRK07764  715 DDPAAQPPQAAQGASAPSPAADdpvplPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMD 794


                  ....*.
gi 557128996  461 PQGTSD 466
Cdd:PRK07764  795 DEDRRD 800
Mating_C pfam12737
C-terminal domain of homeodomain 1; Mating in fungi is controlled by the loci that determine ...
 361-632 2.13e-05

C-terminal domain of homeodomain 1; Mating in fungi is controlled by the loci that determine the mating type of an individual, and only individuals with differing mating types can mate. Basidiomycete fungi have evolved a unique mating system, termed tetrapolar or bifactorial incompatibility, in which mating type is determined by two unlinked loci; compatibility at both loci is required for mating to occur. The multi-allelic tetrapolar mating system is considered to be a novel innovation that could have only evolved once, and is thus unique to the mushroom fungi. This domain is C-terminal to the homeodomain transcription factor region.


Pssm-ID: 372279 [Multi-domain]  Cd Length: 412  Bit Score: 49.22  E-value: 2.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   361 LDTPSSSSPPQGTSDTPASSSpPQGTSETPASNSPpqgtseTPGFSSPPQVTTATLVSSSPPQVTSEtpassspTQVTSE 440
Cdd:pfam12737  123 LDSPSSSSSPEKCLPSPAPSE-QEALSEISAACGP------TPSTLTPLNVAPSLTPSKKRKRCLSD-------GFDGPK 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   441 TPASSSPT---QVTSDT-PASNSPPQGTSDTPGFSSPtqvtTATLVSSSPPQVTSDTPASSSP-----------PQVTSD 505
Cdd:pfam12737  189 RPPNKRVQprpQTVSDPfPTSTSIPEWDEWLQNHMSP----SLTLHGDIPPPVSVEAPDSNTPldieifnfpyhPDLTPS 264

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   506 TPASSSPPQVTSETPASSSPP-------QVTSDTSASISPPQVISDTPAS----SSPPQVTSETPASSSPTNMTSDTPAS 574
Cdd:pfam12737  265 PAPSLSDSVIEVATPTTESDYmcngtlrQTFSWFEFDFPELIQPTNTPASnnelSLPFDPSTDIVVSRTILPLLDWRSQS 344

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 557128996   575 SSPTNMTSDTPA-----SSSPTnmTSDTPASSSPPWPVITEVTRPESTIPAGRSLANITSKAQ 632
Cdd:pfam12737  345 FLSQTFASPPHSilrsnSSSPD--VSAFALDLTPAFTPITYSLSESEKEAKRRELEELEARLQ 405
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 356-555 2.33e-05

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 49.54  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  356 PPQGTLDTPSSSSPPQG----------TSDTPASSSPPQGTSETPASNSPPQGTSetpgfsspPQVTTATLVSSSPPQVT 425
Cdd:PLN03209  382 PPTSPIPTPPSSSPASSksvdavakpaEPDVVPSPGSASNVPEVEPAQVEAKKTR--------PLSPYARYEDLKPPTSP 453

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  426 SETPASSSPTQVTSETPASSSPtqvtsDTPASNSPPQGTSDTPGFSSPtqvTTATLVSSSPPQVTSDTPASSSPPQVTSD 505
Cdd:PLN03209  454 SPTAPTGVSPSVSSTSSVPAVP-----DTAPATAATDAAAPPPANMRP---LSPYAVYDDLKPPTSPSPAAPVGKVAPSS 525

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 557128996  506 TPAssSPPQVTSETPASSSPPQVTSDTSAS-ISPPQVISDT--PASSSPPQVT 555
Cdd:PLN03209  526 TNE--VVKVGNSAPPTALADEQHHAQPKPRpLSPYTMYEDLkpPTSPTPSPVL 576
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
487-642 2.75e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.46  E-value: 2.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  487 PQVTSDT-PASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPT 565
Cdd:PRK07003  360 PAVTGGGaPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRG 439

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 557128996  566 N--MTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSPPWPVITEVTRPESTIPAGRSLANITSKAQEDSPLGVIST 642
Cdd:PRK07003  440 DdaADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASR 518
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
508-599 2.82e-05

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 49.47  E-value: 2.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  508 ASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDT-PASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPA 586
Cdd:PRK11907   18 LTASNPKLAQAEEIVTTTPATSTEAEQTTPVESDATEEaDNTETPVAATTAAEAPSSSETAETSDPTSEATDTTTSEART 97

                          90
                  ....*....|...
gi 557128996  587 SSSPTnmTSDTPA 599
Cdd:PRK11907   98 VTPAA--TETSKP 108
PRK13335 PRK13335
superantigen-like protein SSL3; Reviewed;
413-520 2.91e-05

superantigen-like protein SSL3; Reviewed;


Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 48.58  E-value: 2.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  413 TATLVSSSPPQVTSETPASSSPTQV--TSETPASSSPTQVTSDTPASNsppQGTSDTPGFSSPTQVTTATLVSSSPPQVT 490
Cdd:PRK13335   55 TAGANSATTQAANTRQERTPKLEKApnTNEEKTSASKIEKISQPKQEE---QKSLNISATPAPKQEQSQTTTESTTPKTK 131

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 557128996  491 SDTPASSSPPQ----VTSDTPASSSPPQVTSE-TP 520
Cdd:PRK13335  132 VTTPPSTNTPQpmqsTKSDTPQSPTIKQAQTDmTP 166
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 472-564 3.12e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 49.04  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  472 SPTQVTTATLVSSSPPQVTsDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSAsisPPQVISDTPASSSP 551
Cdd:PRK14950  362 PVPAPQPAKPTAAAPSPVR-PTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPH---TPESAPKLTRAAIP 437

                          90
                  ....*....|...
gi 557128996  552 PQVTSETPASSSP 564
Cdd:PRK14950  438 VDEKPKYTPPAPP 450
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
534-633 3.14e-05

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 49.47  E-value: 3.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  534 ASISPPQVISDTPASSSPPQvTSETPASSSPTnmtsDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSPPWPVITEVTR 613
Cdd:PRK11907   18 LTASNPKLAQAEEIVTTTPA-TSTEAEQTTPV----ESDATEEADNTETPVAATTAAEAPSSSETAETSDPTSEATDTTT 92

                          90       100
                  ....*....|....*....|
gi 557128996  614 PEStiPAGRSLANITSKAQE 633
Cdd:PRK11907   93 SEA--RTVTPAATETSKPVE 110
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 348-564 3.20e-05

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 47.93  E-value: 3.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  348 SDTPAS--SSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGT-------SETPASNSPPQGTSetPGFSSPPqvttatlVS 418
Cdd:PHA02682   19 ADTSSSlfTKCPQATIPAPAAPCPPDADVDPLDKYSVKEAGryyqsrlKANSACMQRPSGQS--PLAPSPA-------CA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  419 SSPPQVTSETPASSSPTqVTSETPASSSPTqvtsdTPASNSPPQGTSDTPGfssptqvttatlvsssppqvtsdTPASSS 498
Cdd:PHA02682   90 APAPACPACAPAAPAPA-VTCPAPAPACPP-----ATAPTCPPPAVCPAPA-----------------------RPAPAC 140

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557128996  499 PPQVTSDTPAsssPPQVTSEtPASSSPPQVTSDtsaSISPPQVisdtPASSSPpqvTSETPASSSP 564
Cdd:PHA02682  141 PPSTRQCPPA---PPLPTPK-PAPAAKPIFLHN---QLPPPDY----PAASCP---TIETAPAASP 192
KAR9 pfam08580
Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal ...
 414-621 3.30e-05

Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal protein required for karyogamy, correct positioning of the mitotic spindle and for orientation of cytoplasmic microtubules. KAR9 localizes at the shmoo tip in mating cells and at the tip of the growing bud in anaphase.


Pssm-ID: 430088 [Multi-domain]  Cd Length: 684  Bit Score: 49.06  E-value: 3.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   414 ATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQV-----TSDTPASNSP-----PQGTSDTPGFSSPTQVTTATLVS 483
Cdd:pfam08580  422 ATLVANKTPGSSPPSSVIMTPVNKGSKTPSSRRGSSFdfgssSERVINSKLRresklPQIASTLKQTKRPSKIPRASPNH 501

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   484 SSPPQVTSDTPASSSPpqvtsdTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSS 563
Cdd:pfam08580  502 SGFLSTPSNTATSETP------TPALRPPSRPQPPPPGNRPRWNASTNTNDLDVGHNFKPLTLTTPSPTPSRSSRSSSTL 575

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 557128996   564 PTNMTSDTPASSSPT-NMTSDTPASSSPTNMTSDTPASSSPPWPVITEVTRPESTIPAG 621
Cdd:pfam08580  576 PPVSPLSRDKSRSPApTCRSVSRASRRRASRKPTRIGSPNSRTSLLDEPPYPKLTLSKG 634
KAR9 pfam08580
Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal ...
 322-589 3.41e-05

Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal protein required for karyogamy, correct positioning of the mitotic spindle and for orientation of cytoplasmic microtubules. KAR9 localizes at the shmoo tip in mating cells and at the tip of the growing bud in anaphase.


Pssm-ID: 430088 [Multi-domain]  Cd Length: 684  Bit Score: 49.06  E-value: 3.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   322 SDTPASSSPPQvtsatsasssppqgTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQG-TS 400
Cdd:pfam08580  427 NKTPGSSPPSS--------------VIMTPVNKGSKTPSSRRGSSFDFGSSSERVINSKLRRESKLPQIASTLKQTKrPS 492

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   401 ETPGFSSPPQVTtatlVSSSPPQVTSETPA-SSSPTQVTSETPASSSPTQVTSDTPASNSPPQ-GTSDTPGFSSPTQVTT 478
Cdd:pfam08580  493 KIPRASPNHSGF----LSTPSNTATSETPTpALRPPSRPQPPPPGNRPRWNASTNTNDLDVGHnFKPLTLTTPSPTPSRS 568

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   479 ATLVSSSPPQVTSDTPASSSPpqVTSDTPASSSPPQVTSETPASSSPPQvtsdtsasiSPPQVISDTPASSSP-PQVTSE 557
Cdd:pfam08580  569 SRSSSTLPPVSPLSRDKSRSP--APTCRSVSRASRRRASRKPTRIGSPN---------SRTSLLDEPPYPKLTlSKGLPR 637

                          250       260       270
                   ....*....|....*....|....*....|..
gi 557128996   558 TPASSSPTNMTSDTPASSSPTNMTSDTPASSS 589
Cdd:pfam08580  638 TPRNRQSYAGTSPSRSVSVSSGLGPQTRPGTS 669
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 436-638 3.57e-05

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 48.77  E-value: 3.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  436 QVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQvtSDTPASsspPQVTSDTPASSSPPQV 515
Cdd:PLN03209  304 EVIAETTAPLTPMEELLAKIPSQRVPPKESDAADGPKPVPTKPVTPEAPSPPI--EEEPPQ---PKAVVPRPLSPYTAYE 378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  516 TSETPASSSPPQVTSDTSAS-----ISPPQVISDTPASSSPPQV------TSET-----------------PASSSPTNM 567
Cdd:PLN03209  379 DLKPPTSPIPTPPSSSPASSksvdaVAKPAEPDVVPSPGSASNVpevepaQVEAkktrplspyaryedlkpPTSPSPTAP 458

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557128996  568 TSDTPASSSPT--NMTSDTPASSSPTNMTSDTPASSSP--PWPVITEVTRPESTIPAGRSLANITSKAQEDSPLG 638
Cdd:PLN03209  459 TGVSPSVSSTSsvPAVPDTAPATAATDAAAPPPANMRPlsPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVG 533
PHA03377 PHA03377
EBNA-3C; Provisional
 235-668 3.90e-05

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 48.90  E-value: 3.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  235 ASSSPPQ-GTSDTPASSSPP----QVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQG--------TSDTPAS 301
Cdd:PHA03377  446 AQSTPERpGPSDQPSVPVEPahltPVEHTTVILHQPPQSPPTVAIKPAPPPSRRRRGACVVYDDDiievidveTTEEEES 525

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  302 SSPPQVTSATSASSSPPQGT------------SDT-PASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLD-TPSSS 367
Cdd:PHA03377  526 VTQPAKPHRKVQDGFQRSGRrqkratppkvspSDRgPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQqAKCKD 605

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  368 SPPQGTSD--TPASSSP-----------------PQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQvtset 428
Cdd:PHA03377  606 GPPASGPHekQPPSSAPrdmapsvvrmflrerllEQSTGPKPKSFWEMRAGRDGSGIQQEPSSRRQPATQSTPPR----- 680

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  429 PASSSPTQVTSETPASSS-PTQVTSDTPASNSPPQGTSDTPGFSSPtqvTTATLVSSSPPQVTSdtPASSSPPQVTSDTP 507
Cdd:PHA03377  681 PSWLPSVFVLPSVDAGRAqPSEESHLSSMSPTQPISHEEQPRYEDP---DDPLDLSLHPDQAPP--PSHQAPYSGHEEPQ 755

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  508 ASSSPPQVTSETPASSSPPQVTSDTSASISPpqvISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPAS 587
Cdd:PHA03377  756 AQQAPYPGYWEPRPPQAPYLGYQEPQAQGVQ---VSSYPGYAGPWGLRAQHPRYRHSWAYWSQYPGHGHPQGPWAPRPPH 832

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  588 SSPTNMTSDTPA------------SSSPPWPVITEVTRPESTIPAGRSLANITSKAQEDSPLGVISTH---PQMSFQSST 652
Cdd:PHA03377  833 LPPQWDGSAGHGqdqvsqfphlqsETGPPRLQLSQVPQLPYSQTLVSSSAPSWSSPQPRAPIRPIPTRfppPPMPLQDSM 912

                         490
                  ....*....|....*.
gi 557128996  653 SQALDeTAGERVPTIP 668
Cdd:PHA03377  913 AVGCD-SSGTACPSMP 927
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
225-461 4.05e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.08  E-value: 4.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  225 GRPQVTSDTLASSSPPQGTSDTPASSSP-PQVTSATSASSSPPQGTSDTPASSSppQVTSATSASSSPPQGTSDTPASSS 303
Cdd:PRK07003  383 PGARAAAAVGASAVPAVTAVTGAAGAALaPKAAAAAAATRAEAPPAAPAPPATA--DRGDDAADGDAPVPAKANARASAD 460

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  304 PPqvTSATSASSSPPQGTSDTPASSSPPQVTSATSasssppqgTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSPP 383
Cdd:PRK07003  461 SR--CDERDAQPPADSGSASAPASDAPPDAAFEPA--------PRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAP 530

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  384 QGTSETPASNSPP---------------------QGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETP 442
Cdd:PRK07003  531 EARPPTPAAAAPAaraggaaaaldvlrnagmrvsSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPP 610

                         250
                  ....*....|....*....
gi 557128996  443 ASSSPTQVTSDTPASnSPP 461
Cdd:PRK07003  611 NGAARAEQAAESRGA-PPP 628
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
358-566 4.09e-05

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 48.83  E-value: 4.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  358 QGTLDTPSSSSP--PQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPT 435
Cdd:PRK12727   52 QRALETARSDTPatAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDMIAAMALRQPVSVPRQAPAAAPVR 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  436 QVTSETPAssspTQVTSDTPASNSPPQGTSDTPgfSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQV 515
Cdd:PRK12727  132 AASIPSPA----AQALAHAAAVRTAPRQEHALS--AVPEQLFADFLTTAPVPRAPVQAPVVAAPAPVPAIAAALAAHAAY 205

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 557128996  516 TSETPASSSPPQVTSDTS--ASISPPQVISDTPASSSPPQVTSETPASSSPTN 566
Cdd:PRK12727  206 AQDDDEQLDDDGFDLDDAlpQILPPAALPPIVVAPAAPAALAAVAAAAPAPQN 258
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 411-549 4.17e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 48.65  E-value: 4.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  411 VTTATLVSSSPPQvtSETPASSSPTQVTsETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATlvsSSPPQVT 490
Cdd:PRK14950  355 VIEALLVPVPAPQ--PAKPTAAAPSPVR-PTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPV---PHTPESA 428

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 557128996  491 SDTPASSSPPQVtsdTPASSSPPQVTSETPASSSPPQVTSDTSASIspPQVISDTPASS 549
Cdd:PRK14950  429 PKLTRAAIPVDE---KPKYTPPAPPKEEEKALIADGDVLEQLEAIW--KQILRDVPPRS 482
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 426-565 4.37e-05

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 48.02  E-value: 4.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  426 SETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPG--FSSPTQVTTATLVSSSPPQVTSDTPA-SSSPPQV 502
Cdd:PTZ00436  208 AAAPSGKKSAKAAAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAkaAAPPAKAAAPPAKAAAPPAKAAAPPAkAAAPPAK 287

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 557128996  503 TSDTPASSSppqvTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPT 565
Cdd:PTZ00436  288 AAAPPAKAA----AAPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAA 346
PHA02732 PHA02732
hypothetical protein; Provisional
 355-609 4.67e-05

hypothetical protein; Provisional


Pssm-ID: 165099 [Multi-domain]  Cd Length: 1467  Bit Score: 48.98  E-value: 4.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  355 SPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSP-PQGTSETPGFS-SPPQVTTATLVSSSPPQ----VTSET 428
Cdd:PHA02732 1074 SPSYIFLNSWASSYVAPGFLGSPYALPYFMNQTSALVGNTAlPKGLNVFSGYMfGAGTVASAFLYMNSTPQspvlALLLA 1153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  429 PASSSPTQVTSETPASSSPTQVTSDTP------ASNSPPQG----TSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSS 498
Cdd:PHA02732 1154 PYISYKFNALSLGFSITADAAIFSLFGipapqlLSSYIPTGsvlyQDPIFTYIPPGIIGMSGTNTFTFKAAQLQLSAASS 1233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  499 PPQVTSDTPASSSPPQVTSETpASSSPP--QVTSDTSASISPPQVISdtPASSSPP--QVTSETPASSSPTNMTS-DTPA 573
Cdd:PHA02732 1234 PPAATTPTPPPSSSSSSSAQS-ISTSPGqiQIVLNGSTTIHINFLFF--PALSTPKigQILAMPIVNSSGAFISLyVNSA 1310

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 557128996  574 SSSPTNMTSDTPASSSPTNMTSDTPASSSPPWPVIT 609
Cdd:PHA02732 1311 ISANFNVTIEYVFSNGTVIKRFTDEPGQIFPLPLIN 1346
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
405-521 4.76e-05

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 48.70  E-value: 4.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  405 FSSPPQVTTATLVSSSPPQVTSETPASssptqvtseTPASSSPTQVTSDTPASNSppqGTSDTPGFSSPTQVTTATLVSS 484
Cdd:PRK11907    6 FSKSAVALTLALLTASNPKLAQAEEIV---------TTTPATSTEAEQTTPVESD---ATEEADNTETPVAATTAAEAPS 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 557128996  485 SPPQVTSDTPASSSPPQVTSDTPasSSPPQVTSETPA 521
Cdd:PRK11907   74 SSETAETSDPTSEATDTTTSEAR--TVTPAATETSKP 108
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
448-585 5.31e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 48.23  E-value: 5.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  448 TQVTSDTPASNSPPQGTSdtPGFS---SPTQVTTATLVSSSPPQvTSDTPASSSPPQVTsdtPASSSPPQVtSETPASSS 524
Cdd:PRK14971  363 TQKGDDASGGRGPKQHIK--PVFTqpaAAPQPSAAAAASPSPSQ-SSAAAQPSAPQSAT---QPAGTPPTV-SVDPPAAV 435

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 557128996  525 PPQVTSDTSASISPPQVISDTPASSSppQVTSETPASSSPTNMTSDTPASSSPTNMTSDTP 585
Cdd:PRK14971  436 PVNPPSTAPQAVRPAQFKEEKKIPVS--KVSSLGPSTLRPIQEKAEQATGNIKEAPTGTQK 494
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
470-573 5.36e-05

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 48.70  E-value: 5.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  470 FSSPTQVTTATLVSSSPPQVTSDTPASSSPPqvTSDTPASSSPPQVTSET---PASSSPPQVTSDTSASISPPQVISDTP 546
Cdd:PRK11907    6 FSKSAVALTLALLTASNPKLAQAEEIVTTTP--ATSTEAEQTTPVESDATeeaDNTETPVAATTAAEAPSSSETAETSDP 83

                          90       100
                  ....*....|....*....|....*..
gi 557128996  547 ASSSPPQVTSETPASSSPTnmTSDTPA 573
Cdd:PRK11907   84 TSEATDTTTSEARTVTPAA--TETSKP 108
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
293-521 5.69e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 48.33  E-value: 5.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  293 QGTSDTPASSSPPQVTSATSASSSPpqgTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQG 372
Cdd:PRK12323  368 SGGGAGPATAAAAPVAQPAPAAAAP---AAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  373 TSDTPASSSPPQgtseTPASNSPPQgtsetpgfSSPPQVTTATLVSSSPPQvtseTPASSSPTQVTSETPASSSPTQVTS 452
Cdd:PRK12323  445 GGAPAPAPAPAA----APAAAARPA--------AAGPRPVAAAAAAAPARA----APAAAPAPADDDPPPWEELPPEFAS 508

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557128996  453 DTPASNSPPQGTSDTPGFSSP-TQVTTATLVSSSPPQVTSDTPASSSP-----PQVTSDTPASSSPPQVTSETPA 521
Cdd:PRK12323  509 PAPAQPDAAPAGWVAESIPDPaTADPDDAFETLAPAPAAAPAPRAAAAtepvvAPRPPRASASGLPDMFDGDWPA 583
motB PRK12799
flagellar motor protein MotB; Reviewed
 373-504 6.10e-05

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 47.79  E-value: 6.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  373 TSDTPASSSPPqgTSETPASNSPPQGTSETPGfssppQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTS 452
Cdd:PRK12799  296 HGTVPVAAVTP--SSAVTQSSAITPSSAAIPS-----PAVIPSSVTTQSATTTQASAVALSSAGVLPSDVTLPGTVALPA 368

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 557128996  453 DTPASNSPPQGTSDTPGFSSPTQVTTATlvsSSPPQVTSDTPASSSPPQVTS 504
Cdd:PRK12799  369 AEPVNMQPQPMSTTETQQSSTGNITSTA---NGPTTSLPAAPASNIPVSPTS 417
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
513-713 6.14e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 48.23  E-value: 6.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  513 PQVTSETPASSSPPQVTSD-TSASISPPQVISDTPASSSPPQvTSETPASSSPTNMTsdTPASSSPTNMTSdtPASSSPT 591
Cdd:PRK14971  363 TQKGDDASGGRGPKQHIKPvFTQPAAAPQPSAAAAASPSPSQ-SSAAAQPSAPQSAT--QPAGTPPTVSVD--PPAAVPV 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  592 NMTSDTPASSSPPwpviteVTRPESTIPagrslaniTSKAqedSPLGVISTHPQmsfQSSTSQALDETAgeRVPTIPDFQ 671
Cdd:PRK14971  438 NPPSTAPQAVRPA------QFKEEKKIP--------VSKV---SSLGPSTLRPI---QEKAEQATGNIK--EAPTGTQKE 495

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 557128996  672 AHSEFQkacaiLQRL-RDFLPTSPtSAQVSVANLLIDLSEQLL 713
Cdd:PRK14971  496 IFTEED-----LQYYwQEFAGTRP-QEEKALKETMINCRPKLL 532
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 347-580 6.49e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.15  E-value: 6.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  347 TSDTPASSSPPQgTLDTPSSSSPPQgtsdTPASSSPPQGTsETPASNSPPQgtSETPGFSspPQVTTATLVSSSppqvts 426
Cdd:PTZ00449  617 LLDIPKSPKRPE-SPKSPKRPPPPQ----RPSSPERPEGP-KIIKSPKPPK--SPKPPFD--PKFKEKFYDDYL------ 680

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  427 eTPASSSPTQVTSETPASSSPTQVTSDTPASNSPPqgtSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASS---SPPQVT 503
Cdd:PTZ00449  681 -DAAAKSKETKTTVVLDESFESILKETLPETPGTP---FTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDIeffTPPEEE 756

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  504 S----DTPASSSPPQVTSETPASsspPQVTSDTSASISP------PQVISDTPASSSP--PQ--------VTSETPASSS 563
Cdd:PTZ00449  757 RtffhETPADTPLPDILAEEFKE---EDIHAETGEPDEAmkrpdsPSEHEDKPPGDHPslPKkrhrldglALSTTDLESD 833

                         250
                  ....*....|....*..
gi 557128996  564 PTNMTSDtpASSSPTNM 580
Cdd:PTZ00449  834 AGRIAKD--ASGKIVKL 848
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 471-591 7.25e-05

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 47.25  E-value: 7.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  471 SSPTQVTTATLVSSSPPQVTSDTPA-SSSPPQVTSDTPA-SSSPPQVTSETP--ASSSPPQVTSDTSASISPPQVISDTP 546
Cdd:PTZ00436  220 AAPAKAAAAPAKAAAPPAKAAAAPAkAAAAPAKAAAPPAkAAAPPAKAAAPPakAAAPPAKAAAPPAKAAAPPAKAAAAP 299

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 557128996  547 A-SSSPPQVTSETPA-SSSPTNMTSDTPASSSPTNMTSDTPASSSPT 591
Cdd:PTZ00436  300 AkAAAAPAKAAAAPAkAAAPPAKAAAPPAKAATPPAKAAAPPAKAAA 346
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
481-577 7.92e-05

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 46.93  E-value: 7.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  481 LVSSSPPQVTSDTPASSSPPQVTSDTPaSSSPPQVTSETPASSspPQVTSDTSASISPPQvisDTPASSSPPQVTSETPa 560
Cdd:PRK13042   15 LLTTGVITTTTQAANATTPSSTKVEAP-QSTPPSTKVEAPQSK--PNATTPPSTKVEAPQ---QTPNATTPSSTKVETP- 87

                          90
                  ....*....|....*..
gi 557128996  561 sSSPTnmTSDTPASSSP 577
Cdd:PRK13042   88 -QSPT--TKQVPTEINP 101
PHA03247 PHA03247
large tegument protein UL36; Provisional
 429-669 8.25e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 8.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  429 PASSSPTQVTSETPASSSPTQVTSDTPASNSPPqgtsdTPGFSSPTQVTTATLVSSSPP----------QVTSDTPASSS 498
Cdd:PHA03247 2478 PVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPP-----APSRLAPAILPDEPVGEPVHPrmltwirgleELASDDAGDPP 2552

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  499 PPqvtsdtpassSPPQVTSETPASSSPPqvtSDTSASISPPQVISDTPASSSPPQvtSETPasSSPTNMTSDTPASSSPt 578
Cdd:PHA03247 2553 PP----------LPPAAPPAAPDRSVPP---PRPAPRPSEPAVTSRARRPDAPPQ--SARP--RAPVDDRGDPRGPAPP- 2614

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  579 nmtsdtpaSSSPtnmtsdtPASSSPPWPVITEVTRPESTIPAGRSLANITSKAQEDSPLGVISTHPQMSFQSSTSQALDE 658
Cdd:PHA03247 2615 --------SPLP-------PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP 2679

                         250
                  ....*....|.
gi 557128996  659 TAGERVPTIPD 669
Cdd:PHA03247 2680 PQRPRRRAARP 2690
Metaviral_G pfam09595
Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. ...
 521-635 8.62e-05

Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. It is high in serine and threonine suggesting it is highly glycosylated.


Pssm-ID: 462833 [Multi-domain]  Cd Length: 183  Bit Score: 45.72  E-value: 8.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   521 ASSSPPQVTSDTSASISPpQVISDTPASSSPPQVTSETP-----ASSSPT--------NMTSDTPASSSPTNMTSDTPAS 587
Cdd:pfam09595   31 ASLILIGESNKEAALIIT-DIIDININKQHPEQEHHENPplneaAKEAPSesedapdiDPNNQHPSQDRSEAPPLEPAAK 109

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 557128996   588 SSPT----NMTSDTPASSSPPWPVITEVTRPESTIPAGRSLANITSKAQEDS 635
Cdd:pfam09595  110 TKPSehepANPPDASNRLSPPDASTAAIREARTFRKPSTGKRNNPSSAQSDQ 161
PRK10856 PRK10856
cytoskeleton protein RodZ;
457-551 8.96e-05

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 46.94  E-value: 8.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  457 SNSPPQGTSDTPgfSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASI 536
Cdd:PRK10856  159 GQSVPLDTSTTT--DPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPAAPATPDGAAP 236

                          90
                  ....*....|....*
gi 557128996  537 SPPQVISDTPASSSP 551
Cdd:PRK10856  237 LPTDQAGVSTPAADP 251
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
415-590 9.05e-05

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 47.24  E-value: 9.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   415 TLVSSSPPQVTSETPA-----SSSPTQVTSETPASSSPTQVT---SDTPASNSPPqgTSDTPGFSSPTQVTTATlVSSSP 486
Cdd:pfam16014    1 ALGSSPRPSILRKKPAtegakPKPDIHVAVAPPVTVAVEALPgqnSEQQTASASP--PSQHPAQAIPTILAPAA-PPSQP 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   487 PQVTSDTPASS--SPPQVTSDTPASSSPPQvtsetPASSSPPQ-VTSDTSASISPPQVISDTPASSSPPQVTSETPASSs 563
Cdd:pfam16014   78 SVVLSTLPAAMavTPPIPASMANVVAPPTQ-----PAASSTAAcAVSSVLPEIKIKQEAEPMDTSQSVPPLTPTSISPA- 151

                          170       180
                   ....*....|....*....|....*..
gi 557128996   564 ptnMTSDTPASSSPtnmTSDTPASSSP 590
Cdd:pfam16014  152 ---LTSLANNLSVP---AGDLLPGASP 172
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 321-609 9.15e-05

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 47.46  E-value: 9.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  321 TSDTPA-------SSSPPQVTSATSASSSPPQGTSDTPASSSPPQgtLDTPSSSSPPQgtSDTPASSSPPQgtSETPASN 393
Cdd:NF033839  280 TQDTPKepgnkkpSAPKPGMQPSPQPEKKEVKPEPETPKPEVKPQ--LEKPKPEVKPQ--PEKPKPEVKPQ--LETPKPE 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  394 SPPQGTSETPGFSSPPQvttaTLVSSSPPQVTSETPasssptQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFsSP 473
Cdd:NF033839  354 VKPQPEKPKPEVKPQPE----KPKPEVKPQPETPKP------EVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEV-KP 422

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  474 TQVTTATLVSSSPPqvtsdTPASSSPPQvtSDTPASSSPPQvtSETPASSSPPQVtsdtsasisppqvisDTPASSSPPQ 553
Cdd:NF033839  423 QPEKPKPEVKPQPE-----KPKPEVKPQ--PEKPKPEVKPQ--PETPKPEVKPQP---------------EKPKPEVKPQ 478

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 557128996  554 VTSETPASSSPtnmTSDTPASSSPTNMTSDTPAS--SSPTNMTSDTPASSSPPWPVIT 609
Cdd:NF033839  479 PEKPKPDNSKP---QADDKKPSTPNNLSKDKQPSnqASTNEKATNKPKKSLPSTGSIS 533
Metaviral_G pfam09595
Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. ...
 353-472 9.20e-05

Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. It is high in serine and threonine suggesting it is highly glycosylated.


Pssm-ID: 462833 [Multi-domain]  Cd Length: 183  Bit Score: 45.33  E-value: 9.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   353 SSSPPQGTLDTPSSSSPPQGTSDtPASSSPPQGTSETPASNSppqGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASS 432
Cdd:pfam09595   66 ENPPLNEAAKEAPSESEDAPDID-PNNQHPSQDRSEAPPLEP---AAKTKPSEHEPANPPDASNRLSPPDASTAAIREAR 141

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 557128996   433 SPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSS 472
Cdd:pfam09595  142 TFRKPSTGKRNNPSSAQSDQSPPRANHEAIGRANPFAMSS 181
KLF12_N cd21441
N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as ...
 555-603 9.78e-05

N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as Krueppel-like transcription factor 12, KLF12) regulates, by transcriptionally repressing Nur77 expression, endometrial decidualization, which is a prerequisite for successful implantation and the establishment of pregnancy. It is involved in the maturation processes of kidney collecting ducts after birth, and is able to increase the promoter activity of the UT-A1 urea transporter promoter by binding to the CACCC motif. KLF12 has also been found to promote colorectal cancer growth is also involved in the invasion and apoptosis of basal-like breast carcinoma. KLF12 belongs to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Although these factors bind to similar elements in vitro, they have distinct activities in vivo depending on their expression profile and the sequence of the N-terminal activation/repression domain, which differ between members. KLF12 contains an N-terminal domain that is related to the N-terminal repression domain of KLF8.


Pssm-ID: 410608 [Multi-domain]  Cd Length: 197  Bit Score: 45.77  E-value: 9.78e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 557128996  555 TSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSP 603
Cdd:cd21441    65 TSPTAVSSSPVSMTASASPSSSSSSSSSSSRPASSPTVITSVSSASSVP 113
PRK08581 PRK08581
amidase domain-containing protein;
353-550 1.01e-04

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 47.48  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  353 SSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETpgfSSPPQVTTATLVSSSPPQVTSETPASS 432
Cdd:PRK08581  129 LNSDISDYEQPRNSEKSTNDSNKNSDSSIKNDTDTQSSKQDKADNQKAPS---SNNTKPSTSNKQPNSPKPTQPNQSNSQ 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  433 SPTQVTSETPASSSPTQVTSDTPASNSPPQgtsdtpgFSSPTQVTTATLVSSSPPQVTSdTPASSSPPQVTSDTPASSSP 512
Cdd:PRK08581  206 PASDDTANQKSSSKDNQSMSDSALDSILDQ-------YSEDAKKTQKDYASQSKKDKTE-TSNTKNPQLPTQDELKHKSK 277

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 557128996  513 PQVTSETPAssspPQVTSDTSASISPPQVISDTPASSS 550
Cdd:PRK08581  278 PAQSFENDV----NQSNTRSTSLFETGPSLSNNDDSGS 311
PRK10856 PRK10856
cytoskeleton protein RodZ;
451-538 1.01e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 46.94  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  451 TSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTS 530
Cdd:PRK10856  164 LDTSTTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPAAPATPDGAAPLPTDQAG 243


                  ....*...
gi 557128996  531 DTSASISP 538
Cdd:PRK10856  244 VSTPAADP 251
PRK10856 PRK10856
cytoskeleton protein RodZ;
361-450 1.03e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 46.94  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  361 LDTPSSSSP-PQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTS 439
Cdd:PRK10856  164 LDTSTTTDPaTTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPAAPATPDGAAPLPTDQAG 243

                          90
                  ....*....|.
gi 557128996  440 ETPASSSPTQV 450
Cdd:PRK10856  244 VSTPAADPNAL 254
Hamartin pfam04388
Hamartin protein; This family includes the hamartin protein which is thought to function as a ...
 205-585 1.03e-04

Hamartin protein; This family includes the hamartin protein which is thought to function as a tumour suppressor. The hamartin protein interacts with the tuberin protein pfam03542. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterized by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin pfam03542. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking.


Pssm-ID: 461287 [Multi-domain]  Cd Length: 730  Bit Score: 47.36  E-value: 1.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   205 DPASSAPPKATHRMTITSLTGrpqvTSDTLASSSPPQGTSDTPASSSPPQVTsatsasssppqGTSDTPASS-----SPP 279
Cdd:pfam04388  288 YGSSTSTPSSTPRLQLSSSSG----TSPPYLSPPSIRLKTDSFPLWSPSSVC-----------GMTTPPTSPgmvptTPS 352

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   280 QVTSATSASSSPPQGTSD---------TPASSSPPQvtsatsasssppqgTSDTPASSSPPQVTSatsasssppqgtsdt 350
Cdd:pfam04388  353 ELSPSSSHLSSRGSSPPEaageatpetTPAKDSPYL--------------KQPPPLSDSHVHRAL--------------- 403

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   351 PASSSPpqgtldtpssSSPPQgTSDTPASSSPPQgTSETPASNSppqgtseTPGFSSPP-QVTTATLvsSSPPQVTSETP 429
Cdd:pfam04388  404 PASSQP----------SSPPR-KDGRSQSSFPPL-SKQAPTNPN-------SRGLLEPPgDKSSVTL--SELPDFIKDLA 462

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   430 ASSSPTQVTSETPAS-----SSPTQVTSDTPASNsppqgtsdtPGFSSPTQVTTATLVSSsppQVTSDTPASSSPPQVTS 504
Cdd:pfam04388  463 LSSEDSVEGAEEEAAisqelSEITTEKNETDCSR---------GGLDMPFSRTMESLAGS---QRSRNRIASYCSSTSQS 530

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   505 DTPASSSPPQVTSETPASSSPPQVTSDTSASISPP--QVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTS 582
Cdd:pfam04388  531 DSHGPATTPESKPSALAEDGLRRTKSCSFKQSFTPieQPIESSDDCPTDEQDGENGLETSILTPSPCKIPSRQKVSTQSG 610


                   ...
gi 557128996   583 DTP 585
Cdd:pfam04388  611 QPL 613
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 482-620 1.06e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 47.55  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  482 VSSSPPQVTSDTPASssppQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPAS 561
Cdd:PRK07994  367 EPEVPPQSAAPAASA----QATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSE 442

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 557128996  562 SSPTNMTsdTPASSSPTNMTSDTPASSSPTNMTSDTPA----SSSPPWPVITEVTRPESTIPA 620
Cdd:PRK07994  443 PAAASRA--RPVNSALERLASVRPAPSALEKAPAKKEAyrwkATNPVEVKKEPVATPKALKKA 503
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 365-554 1.06e-04

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 46.37  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  365 SSSSPpqgtsdTPASSSPPQGTSETPASNSppQGTSETPGFSSPPQVTTATLVSSSPPQVTS-ETPASSSPTQVTSETPA 443
Cdd:PLN02983    3 SLSVP------CAKTAAAAANVGSRLSRSS--FRLQPKPNISFPSKGPNPKRSAVPKVKAQLnEVAVDGSSNSAKSDDPK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  444 SSSPTQVTSDTPASNSPPQGTSDTPGFSSP--TQVTT------------------------------------ATLVSSS 485
Cdd:PLN02983   75 SEVAPSEPKDEPPSNSSSKPNLPDEESISEfmTQVSSlvklvdsrdivelqlkqldcelvirkkealpqppppAPVVMMQ 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 557128996  486 PPQVTSDTPASSSPPQVTSDTPASSSPPqvtseTPASSSPPQVTSDTSASISPPQ--VISDTPASSSPPQV 554
Cdd:PLN02983  155 PPPPHAMPPASPPAAQPAPSAPASSPPP-----TPASPPPAKAPKSSHPPLKSPMagTFYRSPAPGEPPFV 220
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 427-588 1.10e-04

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 47.28  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  427 ETPASSSPTQVTSETPASSSPTQVTS---DTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSppqvtsDTPASSSPPQVT 503
Cdd:PRK13108  280 EAPGALRGSEYVVDEALEREPAELAAaavASAASAVGPVGPGEPNQPDDVAEAVKAEVAEVT------DEVAAESVVQVA 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  504 SDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSS--PTNMT 581
Cdd:PRK13108  354 DRDGESTPAVEETSEADIEREQPGDLAGQAPAAHQVDAEAASAAPEEPAALASEAHDETEPEVPEKAAPIPDPakPDELA 433


                  ....*..
gi 557128996  582 SDTPASS 588
Cdd:PRK13108  434 VAGPGDD 440
Metaviral_G pfam09595
Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. ...
 483-604 1.14e-04

Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. It is high in serine and threonine suggesting it is highly glycosylated.


Pssm-ID: 462833 [Multi-domain]  Cd Length: 183  Bit Score: 45.33  E-value: 1.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   483 SSSPPQVTSDTpASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASS 562
Cdd:pfam09595   32 SLILIGESNKE-AALIITDIIDININKQHPEQEHHENPPLNEAAKEAPSESEDAPDIDPNNQHPSQDRSEAPPLEPAAKT 110

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 557128996   563 SPT----NMTSDTPASSSPTNMTSDTPASSS----PTNMTSDTPAS----SSPP 604
Cdd:pfam09595  111 KPSehepANPPDASNRLSPPDASTAAIREARtfrkPSTGKRNNPSSaqsdQSPP 164
PLN03131 PLN03131
hypothetical protein; Provisional
 353-609 1.21e-04

hypothetical protein; Provisional


Pssm-ID: 178677 [Multi-domain]  Cd Length: 705  Bit Score: 47.46  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  353 SSSPPQGTLDTPSSSSPPQGTSdtpaSSSPPQGTSETPA-SNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPAS 431
Cdd:PLN03131  335 AGSGSHASLDHFKAPVAPEAAA----PMAPPIDLFQLPAtSPAPPVDLFEIPPLDPAPAINAYQPPQTSLPSSIDLFGGI 410

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  432 SSPTQVTS---ETPASSSPTqvtSDTPASNSPPQGTSDTPGFS--SPTQVTTATLVSSSPPQVTSDTPASSSPP-QVTSD 505
Cdd:PLN03131  411 TQQQSINSldeKSPELSIPK---NEGWATFDGIQPIASTPGNEnlTPFSIGPSMAGSANFDQVPSLDKGMQWPPfQNSSD 487

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  506 TPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPT-NMTSDTPASSSPT------ 578
Cdd:PLN03131  488 EESASGPAPWLGDLHNVEAPDNTSAQNWNAFEFDDSVAGIPLEGIKQSSEPQTAANMPPTaDQLIGCKALEDFNkdgikr 567

                         250       260       270
                  ....*....|....*....|....*....|....
gi 557128996  579 ---NMTSDTPASSSPTNMTSDtPASSSPPWPVIT 609
Cdd:PLN03131  568 tapHGQGELPGLDEPSDILAE-PSYTPPAHPIME 600
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 239-599 1.31e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.38  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  239 PPQGTSDTPASSSPPQvtsatsasssppqGtsdtPASSSPPQVTSATSASSSPPQGTSDtpaSSSPPQVTSATSASSSPP 318
Cdd:PTZ00449  497 APIEEEDSDKHDEPPE-------------G----PEASGLPPKAPGDKEGEEGEHEDSK---ESDEPKEGGKPGETKEGE 556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  319 QGTSDTPASSSPPqvtsatsasssppqgtSDTPASSSPPQGTLDTPSSSSPpqgtsDTPASSSPPQGTSETPASNSP--P 396
Cdd:PTZ00449  557 VGKKPGPAKEHKP----------------SKIPTLSKKPEFPKDPKHPKDP-----EEPKKPKRPRSAQRPTRPKSPklP 615

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  397 QgTSETPGFSSPPQVTTAtlvSSSPPqvtsetpassSPTQVTSETPASSSPTQVTSDTPASNSPP----------QGTSD 466
Cdd:PTZ00449  616 E-LLDIPKSPKRPESPKS---PKRPP----------PPQRPSSPERPEGPKIIKSPKPPKSPKPPfdpkfkekfyDDYLD 681

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  467 TPGFSSPTqVTTATLVSSSPPQVTSDTPASSSPPQVTSDT--PASSSPPQVTSETPASSSPPQvtSDTSASISPPQ---- 540
Cdd:PTZ00449  682 AAAKSKET-KTTVVLDESFESILKETLPETPGTPFTTPRPlpPKLPRDEEFPFEPIGDPDAEQ--PDDIEFFTPPEeert 758

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 557128996  541 VISDTPASSSPPQVTSETPASSsptNMTSDTPASSSPTNmTSDTPASSSPTNmTSDTPA 599
Cdd:PTZ00449  759 FFHETPADTPLPDILAEEFKEE---DIHAETGEPDEAMK-RPDSPSEHEDKP-PGDHPS 812
PPE COG5651
PPE-repeat protein [Function unknown];
322-539 1.34e-04

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 46.81  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  322 SDTPASSSPPQVTSATSASSSPPQGTSDTPAS--------SSPPQGTLDTPSSSSPPQGTsdtpASSSPPQGTSETPASN 393
Cdd:COG5651   163 ALTPFTQPPPTITNPGGLLGAQNAGSGNTSSNpgfanlglTGLNQVGIGGLNSGSGPIGL----NSGPGNTGFAGTGAAA 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  394 SPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSP 473
Cdd:COG5651   239 GAAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGAGGAAGA 318

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557128996  474 TQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPP 539
Cdd:COG5651   319 AGATGAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAA 384
PRK10856 PRK10856
cytoskeleton protein RodZ;
522-603 1.34e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 46.56  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  522 SSSPPQVTSDTSASISPPQVISDTPASSSP--PQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPA 599
Cdd:PRK10856  168 TTTDPATTPAPAAPVDTTPTNSQTPAVATApaPAVDPQQNAVVAPSQANVDTAATPAPAAPATPDGAAPLPTDQAGVSTP 247


                  ....
gi 557128996  600 SSSP 603
Cdd:PRK10856  248 AADP 251
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
460-636 1.35e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.15  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  460 PPQGTSDTPGFSSPTQVTTAtlVSSSPPQVTSDTPASSSPPQvtsdTPASSSPPQVTSETPASSSPPQVTSDTSASISPP 539
Cdd:PRK07003  360 PAVTGGGAPGGGVPARVAGA--VPAPGARAAAAVGASAVPAV----TAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPP 433

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  540 Q---VISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTnmTSDTPASSSPTNMTSDtPASSSPPWPVITEVTRPES 616
Cdd:PRK07003  434 AtadRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSG--SASAPASDAPPDAAFE-PAPRAAAPSAATPAAVPDA 510

                         170       180
                  ....*....|....*....|
gi 557128996  617 TIPAGRSLANITSKAQEDSP 636
Cdd:PRK07003  511 RAPAAASREDAPAAAAPPAP 530
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1179-1231 1.40e-04

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 43.30  E-value: 1.40e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996 1179 LGDLHGLRLWHDNSGDSPSWYVSQVIVSDMTTRKKWHFQCNCWL-------AVDLGNCER 1231
Cdd:cd01757    52 LGKLTTVQIGHDNSGLLAKWLVEYVMVRNEITGHTYKFPCGRWLgegvddgNGEDGSLER 111
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 468-591 1.41e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 47.02  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  468 PGFSSPTQVT--TATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTsdtsASISPPQVISDT 545
Cdd:PRK14951  366 PAAAAEAAAPaeKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAP----AAAAPAAAPAAA 441

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 557128996  546 PASSSPPQVTSETPAS--SSPTNMTSDTPASSSPTNMTSDTPASSSPT 591
Cdd:PRK14951  442 PAAVALAPAPPAQAAPetVAIPVRVAPEPAVASAAPAPAAAPAAARLT 489
PPE COG5651
PPE-repeat protein [Function unknown];
267-500 1.44e-04

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 46.42  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  267 QGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPqvtsATSASSSPPQG 346
Cdd:COG5651   155 AAASAAAVALTPFTQPPPTITNPGGLLGAQNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGP----IGLNSGPGNTG 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  347 TSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTS 426
Cdd:COG5651   231 FAGTGAAAGAAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGL 310

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 557128996  427 ETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPP 500
Cdd:COG5651   311 GAGGAAGAAGATGAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAA 384
PRK10856 PRK10856
cytoskeleton protein RodZ;
362-476 1.44e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 46.17  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  362 DTPSSSSPPQGTSDTP--ASSSPPQGTSETPASNSPPQGTSetpgfSSPPQVTTATlvsssPPQVTSETPASSSPTQVTS 439
Cdd:PRK10856  148 DQSSAELSQNSGQSVPldTSTTTDPATTPAPAAPVDTTPTN-----SQTPAVATAP-----APAVDPQQNAVVAPSQANV 217

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 557128996  440 ETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQV 476
Cdd:PRK10856  218 DTAATPAPAAPATPDGAAPLPTDQAGVSTPAADPNAL 254
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1121-1222 1.45e-04

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 43.07  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996 1121 YLIQVYTGYRRRAATTAKVVITLYGSEGHSEPhHLCDPEKTVFERGALDVFLLSTGSWLGDLHGLRLWHDNSGDSPSWYV 1200
Cdd:cd01753     3 YKVTVATGSSLFAGTDDYIYLTLVGTAGESEK-QLLDRPGYDFERGAVDEYKVKVPEDLGELLLVRLRKRKYLLFDAWFC 81

                          90       100
                  ....*....|....*....|..
gi 557128996 1201 SQVIVSDmTTRKKWHFQCNCWL 1222
Cdd:cd01753    82 NYITVTG-PGGDEYHFPCYRWI 102
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 430-603 1.60e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 46.91  E-value: 1.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   430 ASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPgfssptQVTTAtlVSSSPPQVT-SDTPasSSPPQVTSDTPA 508
Cdd:TIGR00927   55 SSQQPIKLASRDLSNDEMMMVSSDPPKSSSEMEGEMLAP------QATVG--RDEATPSIAmENTP--SPPRRTAKITPT 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   509 SSSppqvTSETPASSSPPQVTSDTSAsiSPPQVISDTPASSSPPQVTSETPA------SSSPTNMTSDTPA-SSSPTNMT 581
Cdd:TIGR00927  125 TPK----NNYSPTAAGTERVKEDTPA--TPSRALNHYISTSGRQRVKSYTPKprgevkSSSPTQTREKVRKyTPSPLGRM 198

                          170       180
                   ....*....|....*....|..
gi 557128996   582 SDTPASSspTNMTSDTPASSSP 603
Cdd:TIGR00927  199 VNSYAPS--TFMTMPRSHGITP 218
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 208-572 1.60e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 46.91  E-value: 1.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   208 SSAPPKATHRMTITSLTGRPQVTSDtlaSSSPPQGTSDTPassSPPQVTSATSASSSPpqgTSDTPASSSPPQVtsatsa 287
Cdd:TIGR00927   76 SSDPPKSSSEMEGEMLAPQATVGRD---EATPSIAMENTP---SPPRRTAKITPTTPK---NNYSPTAAGTERV------ 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   288 sssppqgTSDTPASssPPQVTSATSASSSPPQGTSDTPA------SSSPPQVTSatsasssppQGTSDTPASSSPPQGTL 361
Cdd:TIGR00927  141 -------KEDTPAT--PSRALNHYISTSGRQRVKSYTPKprgevkSSSPTQTRE---------KVRKYTPSPLGRMVNSY 202

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   362 DTPSSSSPPQGTSDTPASSsppQGTSETPASNS--PPQGTSETPGFSSPpqVTTATLVSSSPPQVTS--ETPASSSPTQV 437
Cdd:TIGR00927  203 APSTFMTMPRSHGITPRTT---VKDSEITATYKmlETNPSKRTAGKTTP--TPLKGMTDNTPTFLTRevETDLLTSPRSV 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   438 TsETPASSSPTQVTSDTPAS-------NSP--PQGT--SDTPGfSSPTQVTTATLVSSSPPQVTSDTPA-SSSPPQVTSD 505
Cdd:TIGR00927  278 V-EKNTLTTPRRVESNSSTNhwglvgkNNLttPQGTvlEHTPA-TSEGQVTISIMTGSSPAETKASTAAwKIRNPLSRTS 355

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   506 TPA-------------SSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPaSSSPTNMTSDTP 572
Cdd:TIGR00927  356 APAvriasatfrglekNPSTAPSTPATPRVRAVLTTQVHHCVVVKPAPAVPTTPSPSLTTALFPEAP-SPSPSALPPGQP 434
PRK12495 PRK12495
hypothetical protein; Provisional
 447-565 1.62e-04

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 45.24  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  447 PT---QVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQV-TSDTPASSSPPQVTSETPAS 522
Cdd:PRK12495   62 PTcqqPVTEDGAAGDDAGDGAEATAPSDAGSQASPDDDAQPAAEAEAADQSAPPEASSTsATDEAATDPPATAAARDGPT 141

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 557128996  523 SSPPQVTSDTSASISPPQvisDTPASSSPPQvTSETPASSSPT 565
Cdd:PRK12495  142 PDPTAQPATPDERRSPRQ---RPPVSGEPPT-PSTPDAHVAGT 180
PRK11901 PRK11901
hypothetical protein; Reviewed
 345-530 1.63e-04

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 46.21  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  345 QGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQgtsetPASNSPPQGTS--ETPGFssppqvttatlVSSSPP 422
Cdd:PRK11901   91 NQSSPSAANNTSDGHDASGVKNTAPPQDISAPPISPTPTQ-----AAPPQTPNGQQriELPGN-----------ISDALS 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  423 QVTSETPASSSPTQvtseTPASSSPTqvtsdTPASNSPPQGTSdtPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQV 502
Cdd:PRK11901  155 QQQGQVNAASQNAQ----GNTSTLPT-----APATVAPSKGAK--VPATAETHPTPPQKPATKKPAVNHHKTATVAVPPA 223

                         170       180
                  ....*....|....*....|....*....
gi 557128996  503 TSDTPASSSPPQ-VTSETPASSSPPQVTS 530
Cdd:PRK11901  224 TSGKPKSGAASArALSSAPASHYTLQLSS 252
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 427-578 1.67e-04

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 46.10  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  427 ETPASSSPTQVTSETPASSSPTQVTSdtpASNSPPQGTSDTPGFSS--PTQVTTATLVSSSPPQVTSDTPA-SSSPPQVT 503
Cdd:PTZ00436  191 EDAAAAAAAKQKAAAKKAAAPSGKKS---AKAAAPAKAAAAPAKAAapPAKAAAAPAKAAAAPAKAAAPPAkAAAPPAKA 267

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 557128996  504 SDTPA-SSSPPQVTSETP--ASSSPPQVTSDTSASISPPQVISDTPA-SSSPPQVTSETPASSSPTNMTSDTPASSSPT 578
Cdd:PTZ00436  268 AAPPAkAAAPPAKAAAPPakAAAPPAKAAAAPAKAAAAPAKAAAAPAkAAAPPAKAAAPPAKAATPPAKAAAPPAKAAA 346
PRK10856 PRK10856
cytoskeleton protein RodZ;
483-564 2.01e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 45.79  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  483 SSSPPQVTSDTPASSSPPQVTSDTPASSSP--PQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPA 560
Cdd:PRK10856  168 TTTDPATTPAPAAPVDTTPTNSQTPAVATApaPAVDPQQNAVVAPSQANVDTAATPAPAAPATPDGAAPLPTDQAGVSTP 247


                  ....
gi 557128996  561 SSSP 564
Cdd:PRK10856  248 AADP 251
PHA03255 PHA03255
BDLF3; Provisional
 295-461 2.13e-04

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 45.28  E-value: 2.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  295 TSDTPASSSppqvtsatsassspPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSppqGTS 374
Cdd:PHA03255   25 TSSGSSTAS--------------AGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTVTST---GTT 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  375 DTPASSSpPQGTSETPASNSPPQGTSET-PGFSSPPQVTtatlvSSSPPQVTSETPASSSPTQVTSETPASSS-----PT 448
Cdd:PHA03255   88 VTPVPTT-SNASTINVTTKVTAQNITATeAGTGTSTGVT-----SNVTTRSSSTTSATTRITNATTLAPTLSSkgtsnAT 161

                         170
                  ....*....|...
gi 557128996  449 QVTSDTPasnSPP 461
Cdd:PHA03255  162 KTTAELP---TVP 171
KLF12_N cd21441
N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as ...
 542-603 2.13e-04

N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as Krueppel-like transcription factor 12, KLF12) regulates, by transcriptionally repressing Nur77 expression, endometrial decidualization, which is a prerequisite for successful implantation and the establishment of pregnancy. It is involved in the maturation processes of kidney collecting ducts after birth, and is able to increase the promoter activity of the UT-A1 urea transporter promoter by binding to the CACCC motif. KLF12 has also been found to promote colorectal cancer growth is also involved in the invasion and apoptosis of basal-like breast carcinoma. KLF12 belongs to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Although these factors bind to similar elements in vitro, they have distinct activities in vivo depending on their expression profile and the sequence of the N-terminal activation/repression domain, which differ between members. KLF12 contains an N-terminal domain that is related to the N-terminal repression domain of KLF8.


Pssm-ID: 410608 [Multi-domain]  Cd Length: 197  Bit Score: 44.61  E-value: 2.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557128996  542 ISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSP 603
Cdd:cd21441    65 TSPTAVSSSPVSMTASASPSSSSSSSSSSSRPASSPTVITSVSSASSVPTVLTPGPLVASAS 126
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 147-433 2.16e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.68  E-value: 2.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   147 PPQGASIWRNEF-GPGPLLPmkRRGAETERHMIPGNGPPLAMCHQPAPPElfETlcfPIDPASSAPPKATHRMTiTSLTG 225
Cdd:pfam03154  294 PPQPFPLTPQSSqSQVPPGP--SPAAPGQSQQRIHTPPSQSQLQSQQPPR--EQ---PLPPAPLSMPHIKPPPT-TPIPQ 365

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   226 RPQVTSDT----LASSSPPQGTSDTPAsssPPQVTSATSAsssppqgTSDTPASSSPPQVTSATsasssppQGTSDTPAS 301
Cdd:pfam03154  366 LPNPQSHKhpphLSGPSPFQMNSNLPP---PPALKPLSSL-------STHHPPSAHPPPLQLMP-------QSQQLPPPP 428

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   302 SSPPQVTsatsasssppQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSS 381
Cdd:pfam03154  429 AQPPVLT----------QSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSA 498

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 557128996   382 PPQGTSETPASNS---PP-QGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSS 433
Cdd:pfam03154  499 SVSSSGPVPAAVScplPPvQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTPSHAS 554
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
507-619 2.23e-04

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 46.19  E-value: 2.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   507 PASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPA----SSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTS 582
Cdd:pfam05539  169 KTAVTTSKTTSWPTEVSHPTYPSQVTPQSQPATQGHQTATAnqrlSSTEPVGTQGTTTSSNPEPQTEPPPSQRGPSGSPQ 248

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 557128996   583 DTPASSSP-TNMTSD----TPASSSPPWPVITEVTRPESTIP 619
Cdd:pfam05539  249 HPPSTTSQdQSTTGDgqehTQRRKTPPATSNRRSPHSTATPP 290
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 375-554 2.37e-04

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 45.71  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  375 DTPASSSPPQGTSETPASnsPPQGTSETPGfSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTqvtsdT 454
Cdd:PTZ00436  192 DAAAAAAAKQKAAAKKAA--APSGKKSAKA-AAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAA-----P 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  455 PASNSPPQGTSDTPgfssPTQVTTATLVSSSPPQVTSDTPA-SSSPPQVTSDTPA-SSSPPQVTSETPASSSppqvtsdt 532
Cdd:PTZ00436  264 PAKAAAPPAKAAAP----PAKAAAPPAKAAAPPAKAAAAPAkAAAAPAKAAAAPAkAAAPPAKAAAPPAKAA-------- 331

                         170       180
                  ....*....|....*....|..
gi 557128996  533 sasiSPPQVISDTPASSSPPQV 554
Cdd:PTZ00436  332 ----TPPAKAAAPPAKAAAAPV 349
motB PRK12799
flagellar motor protein MotB; Reviewed
 425-556 2.55e-04

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 45.86  E-value: 2.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  425 TSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDtpgfSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVts 504
Cdd:PRK12799  296 HGTVPVAAVTPSSAVTQSSAITPSSAAIPSPAVIPSSVTTQS----ATTTQASAVALSSAGVLPSDVTLPGTVALPAA-- 369

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 557128996  505 dTPASSSPPQVTSETPASSSPPQVTSDTSasiSPPQVISDTPASSSPPQVTS 556
Cdd:PRK12799  370 -EPVNMQPQPMSTTETQQSSTGNITSTAN---GPTTSLPAAPASNIPVSPTS 417
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 364-499 2.61e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 46.21  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  364 PSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPqvTSETPASSSPTQVTSETPa 443
Cdd:PRK14959  367 PVESLRPSGGGASAPSGSAAEGPASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPATPA--PSAAPSPRVPWDDAPPAP- 443

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 557128996  444 sssptqvtsdtPASNSPPQGTSDTPGFSSPT--QVTTATLVSSSPPQVTSDTPASSSP 499
Cdd:PRK14959  444 -----------PRSGIPPRPAPRMPEASPVPgaPDSVASASDAPPTLGDPSDTAEHTP 490
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 429-561 2.64e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 46.25  E-value: 2.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  429 PASSSPTQVTSEtpaSSSPTQVTSDTPASNSPPQgtsdtpgfSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPA 508
Cdd:PRK14951  366 PAAAAEAAAPAE---KKTPARPEAAAPAAAPVAQ--------AAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAP 434

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 557128996  509 SSSPPQVTSETPASSSPPQVTSDTSASI-----SPPQVISDTPASSSPPQVTSETPAS 561
Cdd:PRK14951  435 AAAPAAAPAAVALAPAPPAQAAPETVAIpvrvaPEPAVASAAPAPAAAPAAARLTPTE 492
PHA03255 PHA03255
BDLF3; Provisional
 321-497 2.74e-04

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 44.89  E-value: 2.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  321 TSDTPASSSPPQVTSATSASSSPPQGtSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSppqGTSETPASnsppqgts 400
Cdd:PHA03255   25 TSSGSSTASAGNVTGTTAVTTPSPSA-SGPSTNQSTTLTTTSAPITTTAILSTNTTTVTST---GTTVTPVP-------- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  401 eTPGFSSPPQVTTatlvsssppQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTAT 480
Cdd:PHA03255   93 -TTSNASTINVTT---------KVTAQNITATEAGTGTSTGVTSNVTTRSSSTTSATTRITNATTLAPTLSSKGTSNATK 162

                         170
                  ....*....|....*..
gi 557128996  481 LVSSSPPQVTSDTPASS 497
Cdd:PHA03255  163 TTAELPTVPDERQPSLS 179
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 178-606 2.75e-04

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 45.89  E-value: 2.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   178 IPGNGPPLAMCHQPAPPelfetlCFPIDPASSAPPKATHrmtitsltgrpqvtsdtlaSSSPPQGTsdtPASSSPPqvts 257
Cdd:pfam05110   75 IPKNSVPQTPQEKPDQP------FFPDKTSGLPPSFHTS-------------------SHSQPMGP---PSSSSPS---- 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   258 atsasSSPPQGTSDTPASSSPPQvtsatsasssPPQGTSDTPASSSPPQvtsatSASSSPPQGTSDTPASSSPPQVTSAT 337
Cdd:pfam05110  123 -----VSSSQSQKKSQARTEPAH----------GGHSSSGSQSSQRSQG-----QSRSKGGQESHSSSHHKRQERREDLF 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   338 SASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSPpqGTSETPASNSPPQGTSETPGFSSPpqVTTATLV 417
Cdd:pfam05110  183 SCASLSHSLEELSPLLSSLSSPVKPLSPSHSRQHTGSKAQNSSDH--HGKEYSHSKSPRDSEAGSHGPESP--STSLLAS 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   418 SSSPPQVTSETPASSSPTQVTSETPASSSP----TQVTSDTPASNSPPQG----------------TSDTPGFSSPTQVT 477
Cdd:pfam05110  259 SSQLSSQTFPPSLPSKTSAMQQKPTAYVRPmdgqDQAPSESPELKPSPEDyhgqsygklsdlkanaKAKLSKLKIPSQPL 338

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   478 TATLVS--------------SSPPQVTS-DTPASSSP---PQVTSDTPASSSPPQ------VTSETPASSSPPQVT---- 529
Cdd:pfam05110  339 EQSLSNdvhcveeilkemthSWPPPLTAiHTPSTAEPskfPFPTKESQHVTSGYQnqkqydAPSKTLPTSQQGTSMledd 418

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   530 ---------SDTSASISPPQviSDTPASSSPPQVTSETPASSSPTNMTSdtpASSSPTNMTSDTPASSSPTNMTSDTPAS 600
Cdd:pfam05110  419 lklsssedsDDDQAPEKPPP--SSAPPSAPQSQPNSVASAHSSSGESGS---SSDSESSSESDSESESSSSDSEANEPPR 493


                   ....*.
gi 557128996   601 SSPPWP 606
Cdd:pfam05110  494 SATPEP 499
PHA03193 PHA03193
tegument protein VP11/12; Provisional
 375-511 2.76e-04

tegument protein VP11/12; Provisional


Pssm-ID: 177555  Cd Length: 594  Bit Score: 45.86  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  375 DTPASSS---PPQG--TSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPAS------SSPTQVTSETPA 443
Cdd:PHA03193  440 DSPFQRKramPEDGgeIHEALANNGQAIFPECFSGDLPPIAQALLSADELPNDTTASTSNEMkgdaecPAAQDAAAILPA 519

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 557128996  444 SSsptQVTSDTPASNSPPQGTSDTpgfSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSS 511
Cdd:PHA03193  520 SF---QIENGGAADGSGLAIPAAM---CDATAVESPSTVAETPPERLLAAESGPRCKATAKHKGGSSK 581
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
487-594 2.89e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 45.92  E-value: 2.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  487 PQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVisdTPASSSPPQVtSETPASSSPTN 566
Cdd:PRK14971  363 TQKGDDASGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSA---TQPAGTPPTV-SVDPPAAVPVN 438

                          90       100
                  ....*....|....*....|....*...
gi 557128996  567 MTSDTPASSSPTNMTSDTPASSSPTNMT 594
Cdd:PRK14971  439 PPSTAPQAVRPAQFKEEKKIPVSKVSSL 466
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 350-435 2.97e-04

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 45.72  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  350 TPASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASnspPQGTSETPGFSSPPqvttatlvsssPPQVTSETP 429
Cdd:PHA03291  204 VPATPRPTPRTTASPETTPTPSTTTSPPSTTIPAPSTTIAAPQ---AGTTPEAEGTPAPP-----------TPGGGEAPP 269


                  ....*.
gi 557128996  430 ASSSPT 435
Cdd:PHA03291  270 ANATPA 275
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
435-572 3.04e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 45.92  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  435 TQVTSETPASSSPTQVTSDT---PASNSPPQGTSDtpgfssPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSS 511
Cdd:PRK14971  363 TQKGDDASGGRGPKQHIKPVftqPAAAPQPSAAAA------ASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVP 436

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 557128996  512 PPqvtsetPASSSPPQVTSDTSAS---ISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTP 572
Cdd:PRK14971  437 VN------PPSTAPQAVRPAQFKEekkIPVSKVSSLGPSTLRPIQEKAEQATGNIKEAPTGTQK 494
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
366-456 3.23e-04

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 46.00  E-value: 3.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  366 SSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSET-PGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPAS 444
Cdd:PRK11907   19 TASNPKLAQAEEIVTTTPATSTEAEQTTPVESDATEEaDNTETPVAATTAAEAPSSSETAETSDPTSEATDTTTSEARTV 98

                          90
                  ....*....|..
gi 557128996  445 SSPTqvTSDTPA 456
Cdd:PRK11907   99 TPAA--TETSKP 108
PRK10856 PRK10856
cytoskeleton protein RodZ;
431-525 3.25e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 45.40  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  431 SSSPTQVTSETPASSSPTQVTSDTPASNSPPQGtsdtpgfSSPTQVTTATlvssSPPQVTSDTPASSSPPQVTSDTPASS 510
Cdd:PRK10856  168 TTTDPATTPAPAAPVDTTPTNSQTPAVATAPAP-------AVDPQQNAVV----APSQANVDTAATPAPAAPATPDGAAP 236

                          90
                  ....*....|....*
gi 557128996  511 SPPQVTSETPASSSP 525
Cdd:PRK10856  237 LPTDQAGVSTPAADP 251
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 377-513 3.52e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.86  E-value: 3.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  377 PASSSPPQGTSETPASNSPPQGTsetPGFSSPPQVTTATLVSSSPPQVTSET---PASSSPTQVTSETPASSSPTQVTSD 453
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEAAA---PAAAPVAQAAAAPAPAAAPAAAASAPaapPAAAPPAPVAAPAAAAPAAAPAAAP 442

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  454 TPASNSPPQGTSDTPGFSSPtqvttatlvsssPPQVTSDTPASSSPPQVTSDTPASSSPP 513
Cdd:PRK14951  443 AAVALAPAPPAQAAPETVAI------------PVRVAPEPAVASAAPAPAAAPAAARLTP 490
motB PRK12799
flagellar motor protein MotB; Reviewed
 399-530 4.10e-04

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 45.09  E-value: 4.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  399 TSETPGFSSPPqvTTATLVSSSPPQVTSETPASS---SPTQVTSETPASSSPTQVTSDTPASnsppqgtSDTPGFSSPTQ 475
Cdd:PRK12799  296 HGTVPVAAVTP--SSAVTQSSAITPSSAAIPSPAvipSSVTTQSATTTQASAVALSSAGVLP-------SDVTLPGTVAL 366

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 557128996  476 VTTATLVSSSPPQVTSDTPASSSppqvTSDTPASSSPPQVTSETPASSSPPQVTS 530
Cdd:PRK12799  367 PAAEPVNMQPQPMSTTETQQSST----GNITSTANGPTTSLPAAPASNIPVSPTS 417
PHA03132 PHA03132
thymidine kinase; Provisional
 354-473 4.10e-04

thymidine kinase; Provisional


Pssm-ID: 222997 [Multi-domain]  Cd Length: 580  Bit Score: 45.52  E-value: 4.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  354 SSPPQGTLDTPSSSSPPQGTSDTPasSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSS 433
Cdd:PHA03132   65 GVATSTIYTVPRPPRGPEQTLDKP--DSLPASRELPPGPTPVPPGGFRGASSPRLGADSTSPRFLYQVNFPVILAPIGES 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 557128996  434 PTqvTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSP 473
Cdd:PHA03132  143 NS--SSEELSEEEEHSRPPPSESLKVKNGGKVYPKGFSKH 180
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 455-573 4.11e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 45.63  E-value: 4.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  455 PASNSPPQGTSDTPGfsspTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSdtSA 534
Cdd:PRK07994  366 PEPEVPPQSAAPAAS----AQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATK--AK 439

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 557128996  535 SISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPA 573
Cdd:PRK07994  440 KSEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEA 478
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
469-647 4.48e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.25  E-value: 4.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  469 GFSSPTQVTTATLVSSSPPQV--TSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPP--------QVTSDTSASIS- 537
Cdd:PRK12323  370 GGAGPATAAAAPVAQPAPAAAapAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPApealaaarQASARGPGGAPa 449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  538 PPQVISDTPASSSPPQVTS-ETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSPPWP--VITEVTRP 614
Cdd:PRK12323  450 PAPAPAAAPAAAARPAAAGpRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAgwVAESIPDP 529

                         170       180       190
                  ....*....|....*....|....*....|...
gi 557128996  615 ESTIPAGRSLANITSKAQEDSPLGVISTHPQMS 647
Cdd:PRK12323  530 ATADPDDAFETLAPAPAAAPAPRAAAATEPVVA 562
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 204-410 4.69e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 4.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  204 IDPASSAPPKATHRMTITSLTGRPQVTSDTLASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQvts 283
Cdd:PRK07764  588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD--- 664

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  284 atSASSSPPQGTSDTPASSSPPQVtsatsasssppQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDT 363
Cdd:PRK07764  665 --GGDGWPAKAGGAAPAAPPPAPA-----------PAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAP 731

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 557128996  364 PSSSS---PPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQ 410
Cdd:PRK07764  732 SPAADdpvPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSE 781
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 460-577 4.85e-04

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 44.95  E-value: 4.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  460 PPQGT-SDTPGFSSPTQvttatlvSSSPPQVTSDTPaSSSPPQVTsdTPASSSPPQVTSETPASSSPPQVTSDTSASISP 538
Cdd:PHA03291  167 PAEGTlAAPPLGEGSAD-------GSCDPALPLSAP-RLGPADVF--VPATPRPTPRTTASPETTPTPSTTTSPPSTTIP 236

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 557128996  539 PQVISDTPASSSPPQVTSETPASSSP-TNMTSDTPASSSP 577
Cdd:PHA03291  237 APSTTIAAPQAGTTPEAEGTPAPPTPgGGEAPPANATPAP 276
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
378-468 4.97e-04

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 45.23  E-value: 4.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  378 ASSSPPQGTSETPASNSPPQGTSETPgfSSPPQVTTAT---LVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDT 454
Cdd:PRK11907   18 LTASNPKLAQAEEIVTTTPATSTEAE--QTTPVESDATeeaDNTETPVAATTAAEAPSSSETAETSDPTSEATDTTTSEA 95

                          90
                  ....*....|....
gi 557128996  455 PAsnSPPQGTSDTP 468
Cdd:PRK11907   96 RT--VTPAATETSK 107
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
428-518 5.00e-04

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 44.62  E-value: 5.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  428 TPASSSPTQVTSETPASSSPTQVTSDTPASNSPpqgtsdtpgfSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTP 507
Cdd:PRK13042   18 TGVITTTTQAANATTPSSTKVEAPQSTPPSTKV----------EAPQSKPNATTPPSTKVEAPQQTPNATTPSSTKVETP 87

                          90
                  ....*....|.
gi 557128996  508 ASSSPPQVTSE 518
Cdd:PRK13042   88 QSPTTKQVPTE 98
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 442-578 5.12e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.09  E-value: 5.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  442 PASSSPTQVTSDTPASNSPPQGTsdtPGFSSPTQVTTATLVSSSPPQVTSdtpASSSPPqvtsdTPASSSPPQVTSETPA 521
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEAAA---PAAAPVAQAAAAPAPAAAPAAAAS---APAAPP-----AAAPPAPVAAPAAAAP 434

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 557128996  522 SSSPPQVTSdtSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPT 578
Cdd:PRK14951  435 AAAPAAAPA--AVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLT 489
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 390-530 5.26e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 45.24  E-value: 5.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  390 PASNSPPQGTSetpgfSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPG 469
Cdd:PRK07994  366 PEPEVPPQSAA-----PAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKK 440

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 557128996  470 fSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASS--SPPQVTSETPASSSPPQVTS 530
Cdd:PRK07994  441 -SEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYRwkATNPVEVKKEPVATPKALKK 502
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
357-501 5.52e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 45.15  E-value: 5.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  357 PQGTLDTPSSSSPPQGTSDT---PASSSPPQgtseTPASNSPPQGTSETPgfSSPPQVTTATLVSSSPPQVtSETPASSS 433
Cdd:PRK14971  363 TQKGDDASGGRGPKQHIKPVftqPAAAPQPS----AAAAASPSPSQSSAA--AQPSAPQSATQPAGTPPTV-SVDPPAAV 435

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 557128996  434 PTQVTSETPASSSPTQVTSDTPasNSPPQGTSDTPGFSSPTQVTTAtlvsssppQVTSDTPASSSPPQ 501
Cdd:PRK14971  436 PVNPPSTAPQAVRPAQFKEEKK--IPVSKVSSLGPSTLRPIQEKAE--------QATGNIKEAPTGTQ 493
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
396-540 5.61e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 45.15  E-value: 5.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  396 PQGTSETPGFSSPPQVTT-ATLVSSSPPQVTSETPASSSPTQvTSETPASSSPTQVtsdTPASNSPPQGTSDTPgfsSPT 474
Cdd:PRK14971  363 TQKGDDASGGRGPKQHIKpVFTQPAAAPQPSAAAAASPSPSQ-SSAAAQPSAPQSA---TQPAGTPPTVSVDPP---AAV 435

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557128996  475 QVTTAtlvSSSPPQVtsdTPASSSPPQVTSDTPASSSPPQVTSetPASSSPPQVTSDTSASISPPQ 540
Cdd:PRK14971  436 PVNPP---STAPQAV---RPAQFKEEKKIPVSKVSSLGPSTLR--PIQEKAEQATGNIKEAPTGTQ 493
CytochromB561_N pfam09786
Cytochrome B561, N terminal; Members of this family are found in the N terminal region of ...
 350-558 5.81e-04

Cytochrome B561, N terminal; Members of this family are found in the N terminal region of cytochrome B561, as well as in various other putative uncharacterized proteins.


Pssm-ID: 462899  Cd Length: 579  Bit Score: 44.82  E-value: 5.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   350 TPASSSPPQGTLDTPSssspPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFS--SPPQVTTATLVSSSPPQVTSE 427
Cdd:pfam09786  129 PPKSKSSPQSPSPVLV----PLHQSVSPSSSESRKGGDKSPAGSGKKLRSFSTSSKSpaSPSVYLRGSPVPLNSSPLPSD 204

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   428 TPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSpPQVTSDTP 507
Cdd:pfam09786  205 RNYENSVQSSPEIDSAVSTPWSRKRATIGKEIRTEKMLERFLAEVDEKITESAFGKASPSNVSGSANRSGS-TRSTPLRS 283

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 557128996   508 ASSSPPQVTSETPASSSPpqvtSDTSASISPPQVISDTPASSSPPQVTSET 558
Cdd:pfam09786  284 VRMSPGSQKFTTPPKKGE----GDLPSPMSMEENIEAFENLGIYPQIEQWR 330
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 346-460 6.83e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 44.67  E-value: 6.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  346 GTSDTPASSSPPQGTLDTPSSSSPpQGTSdtPASS-SPPQGTSETPASNSPPqgTSETPGFSSPPQVTTATLVSSSPPQV 424
Cdd:PRK14959  382 SGSAAEGPASGGAATIPTPGTQGP-QGTA--PAAGmTPSSAAPATPAPSAAP--SPRVPWDDAPPAPPRSGIPPRPAPRM 456

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 557128996  425 TSETPASSSPTQVTSEtpASSSPTQVTSDTPASNSP 460
Cdd:PRK14959  457 PEASPVPGAPDSVASA--SDAPPTLGDPSDTAEHTP 490
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
383-514 7.62e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 44.77  E-value: 7.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  383 PQGTSETPASNSPPQGTSetPGFS---SPPQVTTATLVSSSPPQvTSETPASSSPTQVtseTPASSSPTQVTSDTP-ASN 458
Cdd:PRK14971  363 TQKGDDASGGRGPKQHIK--PVFTqpaAAPQPSAAAAASPSPSQ-SSAAAQPSAPQSA---TQPAGTPPTVSVDPPaAVP 436

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 557128996  459 SPPQGT---SDTPGFSSPTQVTTATLVSSSPPQVTSdtPASSSPPQVTSDTPASSSPPQ 514
Cdd:PRK14971  437 VNPPSTapqAVRPAQFKEEKKIPVSKVSSLGPSTLR--PIQEKAEQATGNIKEAPTGTQ 493
PPE COG5651
PPE-repeat protein [Function unknown];
295-526 7.63e-04

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 44.11  E-value: 7.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  295 TSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSppqvtSATSASSSPPQGTSDTPASSSPPQGTldtpSSSSPPQGTS 374
Cdd:COG5651   162 VALTPFTQPPPTITNPGGLLGAQNAGSGNTSSNPG-----FANLGLTGLNQVGIGGLNSGSGPIGL----NSGPGNTGFA 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  375 DTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDT 454
Cdd:COG5651   233 GTGAAAGAAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGA 312

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557128996  455 PASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSdTPASSSPPQVTSDTPASSSPPQVTSETPASSSPP 526
Cdd:COG5651   313 GGAAGAAGATGAGAALGAGAAAAAAGAAAGAGAAAAA-AAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGA 383
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 354-502 7.92e-04

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 44.17  E-value: 7.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  354 SSPPQGTlDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPgfssPPQVTTATLVSSSPPQVTSETPASSS 433
Cdd:PTZ00436  208 AAAPSGK-KSAKAAAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAP----PAKAAAPPAKAAAPPAKAAAPPAKAA 282

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 557128996  434 ptqvTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSS--PTQVTTATLVSSSPPQVTSDTPASSSPPQV 502
Cdd:PTZ00436  283 ----APPAKAAAPPAKAAAAPAKAAAAPAKAAAAPAKAAapPAKAAAPPAKAATPPAKAAAPPAKAAAAPV 349
PHA03255 PHA03255
BDLF3; Provisional
 269-454 8.52e-04

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 43.35  E-value: 8.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  269 TSDTPASSSppqvtsatsassspPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSppqVTSATSASSSPPQGTS 348
Cdd:PHA03255   25 TSSGSSTAS--------------AGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPITTT---AILSTNTTTVTSTGTT 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  349 DTPASSSPPQGTLDTPSSSsppqgTSDTPASSSPPQGTSETPASNSPPQGTSETpgfSSPPQVTTATLVSSSPPQVTset 428
Cdd:PHA03255   88 VTPVPTTSNASTINVTTKV-----TAQNITATEAGTGTSTGVTSNVTTRSSSTT---SATTRITNATTLAPTLSSKG--- 156

                         170       180
                  ....*....|....*....|....*.
gi 557128996  429 paSSSPTQVTSETPASSSPTQVTSDT 454
Cdd:PHA03255  157 --TSNATKTTAELPTVPDERQPSLSY 180
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
443-552 8.76e-04

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 44.46  E-value: 8.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  443 ASSSPTQVTSDTPASNSPPqgtsdtpgfSSPTQVTTATLVSSSppqVTSDTPASSSPPQVTSDTPASSSPpqvtsETPAS 522
Cdd:PRK11907   18 LTASNPKLAQAEEIVTTTP---------ATSTEAEQTTPVESD---ATEEADNTETPVAATTAAEAPSSS-----ETAET 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 557128996  523 SSPPQVTSDTSASISPPQVISDTpaSSSPP 552
Cdd:PRK11907   81 SDPTSEATDTTTSEARTVTPAAT--ETSKP 108
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 404-526 1.00e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 44.32  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  404 GFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVS 483
Cdd:PRK14951  369 AAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALA 448

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 557128996  484 SSPPQVTSDTPAsSSPPQVTSDTPASSSPPQVTSETPASSSPP 526
Cdd:PRK14951  449 PAPPAQAAPETV-AIPVRVAPEPAVASAAPAPAAAPAAARLTP 490
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 434-560 1.05e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 44.09  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  434 PTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTS----DTPAS 509
Cdd:PRK07994  361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRaqgaTKAKK 440

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 557128996  510 SSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQ-------VTSETPA 560
Cdd:PRK07994  441 SEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYRWKATnpvevkkEPVATPK 498
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 487-620 1.06e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 44.09  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  487 PQVTSDTPASssPPQVTSDTPASssppQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTN 566
Cdd:PRK07994  361 PAAPLPEPEV--PPQSAAPAASA----QATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQG 434

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 557128996  567 mtSDTPASSSPTNMTSDTPASSSPTNMTSDTP-ASSSPPWPVITEVTRPESTIPA 620
Cdd:PRK07994  435 --ATKAKKSEPAAASRARPVNSALERLASVRPaPSALEKAPAKKEAYRWKATNPV 487
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
206-449 1.11e-03

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 43.91  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   206 PASSAPPKATHRMTitsltgRPQvtsdtlASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSP------- 278
Cdd:pfam03546  246 PAAATPAQAKPALK------TPQ------TKASPRKGTPITPTSAKVPPVRVGTPAPWKAGTVTSPACASSPAvargaqr 313

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   279 PQVTSATSASSSPPQGTSDTPASSSPPQV-------TSATSASSSPPQGTSDTPASSSPP---QVTSATSASSSPPQGTS 348
Cdd:pfam03546  314 PEEDSSSSEESESEEETAPAAAVGQAKSVgkglqgkAASAPTKGPSGQGTAPVPPGKTGPavaQVKAEAQEDSESSEEES 393

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   349 D------TPASSSPPQGTLDTPSSSSPPQGTSDTPASSSP-------PQGTSETPASNSPPQGTSETPGFSSPPQ----- 410
Cdd:pfam03546  394 DseeaaaTPAQVKASGKTPQAKANPAPTKASSAKGAASAPgkvvaaaAQAKQGSPAKVKPPARTPQNSAISVRGQasvpa 473

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 557128996   411 ----VTTATLVSSSPPQVTSETPASSS----------PTQV-----TSETPASSSPTQ 449
Cdd:pfam03546  474 vgkaVATAAQAQKGPVGGPQEEDSESSeeesdseeeaPAQAkpsgkTPQVRAASAPAK 531
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 375-512 1.11e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 43.79  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  375 DTPASSSPPQGTSETPASNSPpqgtSETPGFSSPPQvttatlvSSSPPQVTSETPaSSSPTQVTseTPASSSPTQVTSDT 454
Cdd:PHA03291  152 GATNASLFPLGLAAFPAEGTL----AAPPLGEGSAD-------GSCDPALPLSAP-RLGPADVF--VPATPRPTPRTTAS 217

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 557128996  455 PASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPAsSSPPQVTSDTPASSSP 512
Cdd:PHA03291  218 PETTPTPSTTTSPPSTTIPAPSTTIAAPQAGTTPEAEGTPA-PPTPGGGEAPPANATP 274
PHA03193 PHA03193
tegument protein VP11/12; Provisional
 347-476 1.12e-03

tegument protein VP11/12; Provisional


Pssm-ID: 177555  Cd Length: 594  Bit Score: 43.94  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  347 TSDTPASSsppQGTLDTPSSSsppqGTSDTPASSSPPQGTSETPASNSPPQGTsETPGFSSPPQVTTATLVSSSppQVTS 426
Cdd:PHA03193  456 IHEALANN---GQAIFPECFS----GDLPPIAQALLSADELPNDTTASTSNEM-KGDAECPAAQDAAAILPASF--QIEN 525

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 557128996  427 ETPASSSPTQVTSetpASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQV 476
Cdd:PHA03193  526 GGAADGSGLAIPA---AMCDATAVESPSTVAETPPERLLAAESGPRCKAT 572
PHA03193 PHA03193
tegument protein VP11/12; Provisional
 433-583 1.13e-03

tegument protein VP11/12; Provisional


Pssm-ID: 177555  Cd Length: 594  Bit Score: 43.94  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  433 SPTQVTSETPASSSPTqvtSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSD-----TPASSSPPQ-VTSDT 506
Cdd:PHA03193  441 SPFQRKRAMPEDGGEI---HEALANNGQAIFPECFSGDLPPIAQALLSADELPNDTTASTsnemkGDAECPAAQdAAAIL 517

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  507 PASSsppQVTSETPASSSPPQVTSDtsaSISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPT------NM 580
Cdd:PHA03193  518 PASF---QIENGGAADGSGLAIPAA---MCDATAVESPSTVAETPPERLLAAESGPRCKATAKHKGGSSKVEeilrrlRM 591


                  ...
gi 557128996  581 TSD 583
Cdd:PHA03193  592 ASD 594
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 485-609 1.17e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.93  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  485 SPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSAsiSPPQVISDTPASSSPPQVTSETPASSSP 564
Cdd:PRK14951  372 AAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAA--PPAPVAAPAAAAPAAAPAAAPAAVALAP 449

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 557128996  565 TNMTSDTPASSSPTNMTSDTPASSSPtnmtSDTPASSSPPWPVIT 609
Cdd:PRK14951  450 APPAQAAPETVAIPVRVAPEPAVASA----APAPAAAPAAARLTP 490
dnaA PRK14086
chromosomal replication initiator protein DnaA;
363-565 1.18e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 44.05  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  363 TPSSSSPPQGTSDTPASSSP--PQGTSETPASNSPPQGTSETPGFSSPPQVTTAtlVSSSPPQVTSETPASSSPTqvtse 440
Cdd:PRK14086   89 DPSAGEPAPPPPHARRTSEPelPRPGRRPYEGYGGPRADDRPPGLPRQDQLPTA--RPAYPAYQQRPEPGAWPRA----- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  441 tPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPpqvtsetP 520
Cdd:PRK14086  162 -ADDYGWQQQRLGFPPRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDRPRRDRTDRPEPP-------P 233

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 557128996  521 ASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPT 565
Cdd:PRK14086  234 GAGHVHRGGPGPPERDDAPVVPIRPSAPGPLAAQPAPAPGPGEPT 278
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 345-444 1.20e-03

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 43.92  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  345 QGTSDTPASSSP---------PQGTLDTPSSSSPPQ---GTSDTPASSSPPQGTSETPASNSPPQGTSE--TPGFSSP-- 408
Cdd:PLN02217  545 QGDAWIPGKGVPyipglfagnPGSTNSTPTGSAASSnttFSSDSPSTVVAPSTSPPAGHLGSPPATPSKivSPSTSPPas 624

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 557128996  409 ----PQVTTATLVSSSPPQVTSETPASSSPTQVTSETPAS 444
Cdd:PLN02217  625 hlgsPSTTPSSPESSIKVASTETASPESSIKVASTESSVS 664
NupH_GANP pfam16768
Nucleoporin homology of Germinal-centre associated nuclear protein; NupH_GANP is the ...
 371-589 1.27e-03

Nucleoporin homology of Germinal-centre associated nuclear protein; NupH_GANP is the nucleoporin-homology domain at the N-terminus of human GANP or germinal-centre associated nuclear proteins. GANP is part of the TREX-2 complex that links transcription with nuclear messenger RNA export, and it associates with the mRNP particle through the interaction of the NupH_GANP with NXF1, the export factor. This attachment mediates efficient delivery of mRNPs to nuclear pore complexes.


Pssm-ID: 435572 [Multi-domain]  Cd Length: 292  Bit Score: 43.36  E-value: 1.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   371 QGTSDTPASSSPPQGTSETPAS---NSPP------QGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSptqVTSET 441
Cdd:pfam16768    9 QQPSAFSTSSSPSTGTFQAKPPfrfGQPSlfgqnnTLSGKNSGFSQVSSFPTTSGVSHSSSGQTLGFTQTSG---VGLFS 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   442 PASSSPTQVTSDTPASNSPPQgtsdTPGFS--SPTQV----------TTATLVSSS----------PPQVTSDTP---AS 496
Cdd:pfam16768   86 GLEHTPSFVATSGPSSSSVPS----NPGFSfkSPTNLgafpststfgPESGEVASSgfgktefsfkPPENAVFRPifgAE 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   497 SSP----PQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASispPQVISDTPASSSPPQvTSETPASSSPT---NMTS 569
Cdd:pfam16768  162 SEPektqSQITSGFFTFSHPVSSGPGGLAPFSFSQVTSSSATS---SNFTFSKPVSSNNSS-SAFAPALSSQNveeEKRG 237

                          250       260
                   ....*....|....*....|
gi 557128996   570 DTPASSSPTNMTSDTPASSS 589
Cdd:pfam16768  238 PKSFFGSSNSSFTSFPNSSS 257
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 471-600 1.29e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 43.95  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  471 SSPTQVTTATLVSS-----SPPQVTSDTPASSSP-PQVTSDTPASSSPPQVTSETPASSSP--PQVTSDTSASISPPQVI 542
Cdd:PHA03269   21 NLNTNIPIPELHTSaatqkPDPAPAPHQAASRAPdPAVAPTSAASRKPDLAQAPTPAASEKfdPAPAPHQAASRAPDPAV 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 557128996  543 SDTPASSSPPQvtsetpASSSPTNMTSDTPASS-SPTNMTSDTPassSPTNMTSDTPAS 600
Cdd:PHA03269  101 APQLAAAPKPD------AAEAFTSAAQAHEAPAdAGTSAASKKP---DPAAHTQHSPPP 150
PRK10856 PRK10856
cytoskeleton protein RodZ;
419-512 1.33e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 43.48  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  419 SSPPQVTSETPASSSPTQVtseTPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSS 498
Cdd:PRK10856  161 SVPLDTSTTTDPATTPAPA---APVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPAAPATPDGAAPL 237

                          90
                  ....*....|....
gi 557128996  499 PPQVTSDTPASSSP 512
Cdd:PRK10856  238 PTDQAGVSTPAADP 251
PHA03193 PHA03193
tegument protein VP11/12; Provisional
 409-570 1.39e-03

tegument protein VP11/12; Provisional


Pssm-ID: 177555  Cd Length: 594  Bit Score: 43.94  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  409 PQVTTATLVSSSPPqvTSETPASSSPTQVTSETPASSSPtqvtsdtPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQ 488
Cdd:PHA03193  442 PFQRKRAMPEDGGE--IHEALANNGQAIFPECFSGDLPP-------IAQALLSADELPNDTTASTSNEMKGDAECPAAQD 512

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  489 VTSDTPASSsppQVTSDTPASSSPPQVTSetpASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPT--- 565
Cdd:PHA03193  513 AAAILPASF---QIENGGAADGSGLAIPA---AMCDATAVESPSTVAETPPERLLAAESGPRCKATAKHKGGSSKVEeil 586


                  ....*...
gi 557128996  566 ---NMTSD 570
Cdd:PHA03193  587 rrlRMASD 594
KLF12_N cd21441
N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as ...
 425-486 1.41e-03

N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as Krueppel-like transcription factor 12, KLF12) regulates, by transcriptionally repressing Nur77 expression, endometrial decidualization, which is a prerequisite for successful implantation and the establishment of pregnancy. It is involved in the maturation processes of kidney collecting ducts after birth, and is able to increase the promoter activity of the UT-A1 urea transporter promoter by binding to the CACCC motif. KLF12 has also been found to promote colorectal cancer growth is also involved in the invasion and apoptosis of basal-like breast carcinoma. KLF12 belongs to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Although these factors bind to similar elements in vitro, they have distinct activities in vivo depending on their expression profile and the sequence of the N-terminal activation/repression domain, which differ between members. KLF12 contains an N-terminal domain that is related to the N-terminal repression domain of KLF8.


Pssm-ID: 410608 [Multi-domain]  Cd Length: 197  Bit Score: 42.30  E-value: 1.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557128996  425 TSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSP 486
Cdd:cd21441    65 TSPTAVSSSPVSMTASASPSSSSSSSSSSSRPASSPTVITSVSSASSVPTVLTPGPLVASAS 126
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 476-627 1.49e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 43.56  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  476 VTTATLVSSSppqvTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQV-ISDTPASSSP--P 552
Cdd:PHA03269    9 IITIACINLI----IANLNTNIPIPELHTSAATQKPDPAPAPHQAASRAPDPAVAPTSAASRKPDLaQAPTPAASEKfdP 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 557128996  553 QVTSETPASSSPTNMTSDTPAsSSPTNMTSDTPASSS---PTNMTSDTPASSSPPWPVITEVTRPESTIpAGRSLANI 627
Cdd:PHA03269   85 APAPHQAASRAPDPAVAPQLA-AAPKPDAAEAFTSAAqahEAPADAGTSAASKKPDPAAHTQHSPPPFA-YTRSMEHI 160
PRK11901 PRK11901
hypothetical protein; Reviewed
 484-655 1.58e-03

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 43.13  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  484 SSPPQVTSDTPASSSPPQVTS----DTPASSSPPQVTSETPASSSPPQVTSD--TSASISPPQVISDTPASSSPPQVTSE 557
Cdd:PRK11901   55 GSALKSPTEHESQQSSNNAGAekniDLSGSSSLSSGNQSSPSAANNTSDGHDasGVKNTAPPQDISAPPISPTPTQAAPP 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  558 TPASSS-----PTNMTS----------------DTPASSSPTnmtsdTPASSSPTNMTSDTPASSSPPWPVITE-----V 611
Cdd:PRK11901  135 QTPNGQqrielPGNISDalsqqqgqvnaasqnaQGNTSTLPT-----APATVAPSKGAKVPATAETHPTPPQKPatkkpA 209

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 557128996  612 TRPESTIPAGRSLANITSKAQEDSPLGVISTHPQMSFQ---SSTSQA 655
Cdd:PRK11901  210 VNHHKTATVAVPPATSGKPKSGAASARALSSAPASHYTlqlSSASRS 256
PRK10856 PRK10856
cytoskeleton protein RodZ;
418-499 1.62e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 43.09  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  418 SSSPPQVTSETPA--SSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPA 495
Cdd:PRK10856  168 TTTDPATTPAPAApvDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPAAPATPDGAAPLPTDQAGVSTP 247


                  ....
gi 557128996  496 SSSP 499
Cdd:PRK10856  248 AADP 251
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 397-662 1.80e-03

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 43.46  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  397 QGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASS---SPTQVTSET-PASSSPTQVTSDTPA-SNSPPQGTSDTPGFS 471
Cdd:NF033849  247 VGHSTSQGQSHSVGTSESHSVGTSQSQSHTTGHGSTrgwSHTQSTSESeSTGQSSSVGTSESQShGTTEGTSTTDSSSHS 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  472 SPTQVTTATLVSSSpPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDT-------SASISPPQVISD 544
Cdd:NF033849  327 QSSSYNVSSGTGVS-SSHSDGTSQSTSISHSESSSESTGTSVGHSTSSSVSSSESSSRSSSsgvsggfSGGIAGGGVTSE 405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  545 TPASSsppQVTSET-PASSSPTNMTSDTPASSSPTNMTSDTPASS-SPTNMTSDTpASSSPPWPVITEVTRPESTipaGR 622
Cdd:NF033849  406 GLGAS---QGGSEGwGSGDSVQSVSQSYGSSSSTGTSSGHSDSSShSTSSGQADS-VSQGTSWSEGTGTSQGQSV---GT 478

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 557128996  623 SLANITSKAQEDSPLGVISTHPQMSFQSSTSQALDETAGE 662
Cdd:NF033849  479 SESWSTSQSETDSVGDSTGTSESVSQGDGRSTGRSESQGT 518
Caprin-1_C pfam12287
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ...
 322-553 1.81e-03

Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.


Pssm-ID: 463522 [Multi-domain]  Cd Length: 320  Bit Score: 42.86  E-value: 1.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   322 SDTPASSSP--PQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSS---SSPPQGTSDTPASSSPPQGTSETPASNSPP 396
Cdd:pfam12287   32 SAQPPSQSPdlSQMVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPSSnacASSGSEYQFHTSEPPQPEAIDPIQSSMSLP 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   397 qgtsetpgfSSPPQvTTATLVSSSPPQVTSETPASSSPTQVtsetpaSSSPTQVTSDTPASNSP-PQGTSDTPGFSSPTQ 475
Cdd:pfam12287  112 ---------SELAP-PSPPLSPASQPQVFQSKPASSSGINV------NAAPFQSMQTVFNVNAPvPPRNEQELKESSQYS 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   476 VTTATLVSSSPPQvtsdtpassSPPQvtSDTPASssppQVTSETPASSSPPQVTSDTSASIS--PPQvisdTPASSSPPQ 553
Cdd:pfam12287  176 SGYNQSFSSQSTQ---------TVPQ--CQLPSE----QLEQTVVGAYHPDGTIQVSNGHLAfyPAQ----TNGFPRPPQ 236
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 414-552 1.93e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 43.32  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  414 ATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTsdtPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSdt 493
Cdd:PRK07994  363 APLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVP---PPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATK-- 437

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  494 PASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSAS-ISPPQVISDTPASSSPP 552
Cdd:PRK07994  438 AKKSEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYrWKATNPVEVKKEPVATP 497
PRK10856 PRK10856
cytoskeleton protein RodZ;
391-485 1.95e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 42.71  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  391 ASNSPPQGTSE--TPGFSSPPQVTTATLVSSSPPQVTSETPASSSPT--QVTSETPASSSPTQVTSDTPASNSPPQGTSD 466
Cdd:PRK10856  152 AELSQNSGQSVplDTSTTTDPATTPAPAAPVDTTPTNSQTPAVATAPapAVDPQQNAVVAPSQANVDTAATPAPAAPATP 231

                          90       100
                  ....*....|....*....|
gi 557128996  467 TPGFSSPT-QVTTATLVSSS 485
Cdd:PRK10856  232 DGAAPLPTdQAGVSTPAADP 251
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 494-650 2.03e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.16  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  494 PASSSPPQVTSdtpASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDT---PASSSPPQVTSETPASSSPTNMTSD 570
Cdd:PRK14951  366 PAAAAEAAAPA---EKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPaapPAAAPPAPVAAPAAAAPAAAPAAAP 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  571 TPASSSPTNMTSDTPASSSPTNMTSDTPASSSPPWPVIT--EVTRPESTIPAGRSLANITSKAQEDSPLGVISthpQMSF 648
Cdd:PRK14951  443 AAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAapAAARLTPTEEGDVWHATVQQLAAAEAITALAR---ELAL 519


                  ..
gi 557128996  649 QS 650
Cdd:PRK14951  520 QS 521
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
325-532 2.11e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 43.03  E-value: 2.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  325 PASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPG 404
Cdd:PRK14948  364 FISEIANASAPANPTPAPNPSPPPAPIQPSAPKTKQAATTPSPPPAKASPPIPVPAEPTEPSPTPPANAANAPPSLNLEE 443

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  405 -----FSSPPQVTT-------ATLVSSSPPQVT------------SETP--------ASSSPTQVTSETPASSSPTQVTS 452
Cdd:PRK14948  444 lwqqiLAKLELPSTrmllsqqAELVSLDSNRAViavspnwlgmvqSRKPlleqafakVLGRSIKLNLESQSGSASNTAKT 523

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  453 DTPASNSPPQGTSdTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPqvtsdtPASSSPPQVTSETPASSSPPQVTSDT 532
Cdd:PRK14948  524 PPPPQKSPPPPAP-TPPLPQPTATAPPPTPPPPPPTATQASSNAPAQI------PADSSPPPPIPEEPTPSPTKDSSPEE 596
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 489-623 2.16e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 43.02  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  489 VTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSS-PPQVTSdTSASISPPQVIsdTPASSSPPQVTSETPASSSPTNM 567
Cdd:PHA03291  150 VEGATNASLFPLGLAAFPAEGTLAAPPLGEGSADGScDPALPL-SAPRLGPADVF--VPATPRPTPRTTASPETTPTPST 226

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 557128996  568 TSDTPASSSPTNMTSDTPASSSPTNMTSDTPAsssPPWPVITEvTRPESTIPAGRS 623
Cdd:PHA03291  227 TTSPPSTTIPAPSTTIAAPQAGTTPEAEGTPA---PPTPGGGE-APPANATPAPEA 278
CTD smart01104
Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription ...
 426-535 2.16e-03

Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe. The repeat has a characteristic TPA motif.


Pssm-ID: 215026 [Multi-domain]  Cd Length: 121  Bit Score: 40.20  E-value: 2.16e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996    426 SETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSdTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSD 505
Cdd:smart01104   12 SKTPAWGSRTPGTAAGGAPTARGGSGSRTPAWGGAGSRTP-AWGGAGPTGSRTPAWGGASAWGNKSSEGSASSWAAGPGG 90

                            90       100       110
                    ....*....|....*....|....*....|..
gi 557128996    506 TPASSSP--PQVTSeTPASSSPPQVTSDTSAS 535
Cdd:smart01104   91 AYGAPTPgyGGTPS-AYGPATPGGGAMAGSAS 121
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 430-604 2.23e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 42.13  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  430 ASSSPTQVTSETPASSSPTQvTSDTPASNSPPQgtsdtPGFSSPTQ----------VTTATL----VSSSPPQVTSDTPA 495
Cdd:PLN02983    1 MASLSVPCAKTAAAAANVGS-RLSRSSFRLQPK-----PNISFPSKgpnpkrsavpKVKAQLnevaVDGSSNSAKSDDPK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  496 SSSPPQVTSDTPA--SSSPPQVTSETPASSSPPQVTS-----DtSASISPPQ--------VISDTPASSSPPqvtseTPA 560
Cdd:PLN02983   75 SEVAPSEPKDEPPsnSSSKPNLPDEESISEFMTQVSSlvklvD-SRDIVELQlkqldcelVIRKKEALPQPP-----PPA 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 557128996  561 S---SSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPA----SSSPP 604
Cdd:PLN02983  149 PvvmMQPPPPHAMPPASPPAAQPAPSAPASSPPPTPASPPPAkapkSSHPP 199
CytochromB561_N pfam09786
Cytochrome B561, N terminal; Members of this family are found in the N terminal region of ...
 417-577 2.41e-03

Cytochrome B561, N terminal; Members of this family are found in the N terminal region of cytochrome B561, as well as in various other putative uncharacterized proteins.


Pssm-ID: 462899  Cd Length: 579  Bit Score: 42.89  E-value: 2.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   417 VSSSPPQVTSETPASSSPTQVTS---ETPASSSPTQVTSDTPASNSPPQGTSDTPGfssptqvttatlvssspPQVTSDT 493
Cdd:pfam09786   89 VQSKSPSKGTKTPSRLTNQQLGLlglKPNDSSFVTTHRKKPPKSKSSPQSPSPVLV-----------------PLHQSVS 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   494 PASSSPPQVTSDTPASSSPPQVTSETPASSSppqvtsdtsasISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPA 573
Cdd:pfam09786  152 PSSSESRKGGDKSPAGSGKKLRSFSTSSKSP-----------ASPSVYLRGSPVPLNSSPLPSDRNYENSVQSSPEIDSA 220


                   ....
gi 557128996   574 SSSP 577
Cdd:pfam09786  221 VSTP 224
KLF12_N cd21441
N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as ...
 529-590 2.43e-03

N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as Krueppel-like transcription factor 12, KLF12) regulates, by transcriptionally repressing Nur77 expression, endometrial decidualization, which is a prerequisite for successful implantation and the establishment of pregnancy. It is involved in the maturation processes of kidney collecting ducts after birth, and is able to increase the promoter activity of the UT-A1 urea transporter promoter by binding to the CACCC motif. KLF12 has also been found to promote colorectal cancer growth is also involved in the invasion and apoptosis of basal-like breast carcinoma. KLF12 belongs to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Although these factors bind to similar elements in vitro, they have distinct activities in vivo depending on their expression profile and the sequence of the N-terminal activation/repression domain, which differ between members. KLF12 contains an N-terminal domain that is related to the N-terminal repression domain of KLF8.


Pssm-ID: 410608 [Multi-domain]  Cd Length: 197  Bit Score: 41.53  E-value: 2.43e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557128996  529 TSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSP 590
Cdd:cd21441    65 TSPTAVSSSPVSMTASASPSSSSSSSSSSSRPASSPTVITSVSSASSVPTVLTPGPLVASAS 126
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 443-712 2.52e-03

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 42.70  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  443 ASSSPTQVTSdTPASNSPPQGTSDTPGF-SSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQvtsetpa 521
Cdd:COG5068   116 SVLTGTEVLL-LVISENGLVHTFTTPKLeSVVKSLEGKSLIQSPCSNAPSDSSEEPSSSASFSVDPNDNNPMG------- 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  522 ssSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETPASSSPTN------MTSDTPASSSPTNMTSDTPASSSPTNMTS 595
Cdd:COG5068   188 --SFQHNGSPQTNFIPLQNPQTQQYQQHSSRKDHPTVPHSNTNNGrppakfMIPELHSSHSTLDLPSDFISDSGFPNQSS 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  596 dtpASSSPPWPVITEVTRPES-----TIPAGRSLANITSKAQE-----DSPLGVISTHP-------------QMSFQSST 652
Cdd:COG5068   266 ---TSIFPLDSAIIQITPPHLpnnppQENRHELYSNDSSMVSEtpppkNLPNGSPNQSPlnnlsrgnpaspnSIIRENNQ 342

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 557128996  653 SQAlDETAGERVPTIPDFQA---------HSEFQKACAILQRLRDFLPTSPTSAQVSVANLLIDLSEQL 712
Cdd:COG5068   343 VED-ESFNGRQGSAIWNALIsttqpnsglHTEASTAPSSTIPADPLKNAAQTNSGTRNNNFSDNLYGQL 410
PAP1 pfam08601
Transcription factor PAP1; The transcription factor Pap1 regulates antioxidant-gene ...
 272-470 2.63e-03

Transcription factor PAP1; The transcription factor Pap1 regulates antioxidant-gene transcription in response to H2O2. This region is cysteine rich. Alkylation of cysteine residues following treatment with a cysteine alkylating agent can mask the accessibility of the nuclear exporter Crm1, triggering nuclear accumulation and Pap1 dependent transcriptional expression.


Pssm-ID: 369990  Cd Length: 363  Bit Score: 42.54  E-value: 2.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   272 TPASSSPPqvtsatsasssPPQGTSDTPASSSPPQVTSATSASSsppqGTSDTPASSSPPQVTSATSASSSPPQGTSDTP 351
Cdd:pfam08601   53 PNASTSTP-----------DSQPPPSASSSTTPNQGSNGLNAFT----GEDNNNYSNSAANPGATRGSTASSARSQSSPY 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   352 ASSSPPQGTLDTPSSSSPPQGTsdtPASSSppqGTSETPASNSPPQGTSetpgfssppqvTTATLVSSSPPQVTSETPAS 431
Cdd:pfam08601  118 SFGSGTSTSSDSPSSSSSSHQG---QLSSC---GTSPEPSTQSPGGQKS-----------VETMIGEEQCAHGTIDGEKS 180

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 557128996   432 S-SPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGF 470
Cdd:pfam08601  181 FcAKLGMACGNINNPIPAAMSKSNSLSNTPGHASNDSNGL 220
KLF12_N cd21441
N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as ...
 438-499 2.81e-03

N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as Krueppel-like transcription factor 12, KLF12) regulates, by transcriptionally repressing Nur77 expression, endometrial decidualization, which is a prerequisite for successful implantation and the establishment of pregnancy. It is involved in the maturation processes of kidney collecting ducts after birth, and is able to increase the promoter activity of the UT-A1 urea transporter promoter by binding to the CACCC motif. KLF12 has also been found to promote colorectal cancer growth is also involved in the invasion and apoptosis of basal-like breast carcinoma. KLF12 belongs to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Although these factors bind to similar elements in vitro, they have distinct activities in vivo depending on their expression profile and the sequence of the N-terminal activation/repression domain, which differ between members. KLF12 contains an N-terminal domain that is related to the N-terminal repression domain of KLF8.


Pssm-ID: 410608 [Multi-domain]  Cd Length: 197  Bit Score: 41.15  E-value: 2.81e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557128996  438 TSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSP 499
Cdd:cd21441    65 TSPTAVSSSPVSMTASASPSSSSSSSSSSSRPASSPTVITSVSSASSVPTVLTPGPLVASAS 126
PHA03249 PHA03249
DNA packaging tegument protein UL25; Provisional
 429-561 3.01e-03

DNA packaging tegument protein UL25; Provisional


Pssm-ID: 223023  Cd Length: 653  Bit Score: 42.69  E-value: 3.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  429 PASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTsDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSS--PPQVTSDT 506
Cdd:PHA03249   33 PRPRAPTEDLDRMEAGLSSYSSSSDNKSSFEVVSET-DSGSEAEAERGRRAGMGGRNKATKPSRRNKTTQcrPTSLALAT 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557128996  507 PASSSPPQVTSETPASSSPPQVTSDTS-------ASISPPQVISDTPASSSPPQVTSETPAS 561
Cdd:PHA03249  112 AATMPATPSSGKSPKVSSPPSIPSLSEedegaerNSGGDDSSHTDNESTQSQPEADDEPDLA 173
COG5099 COG5099
RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal ...
 155-601 3.05e-03

RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227430 [Multi-domain]  Cd Length: 777  Bit Score: 42.81  E-value: 3.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  155 RNEFGPGPLLPMKRRGAETERHMIPGNGPPLAMCHQPAPPELFetlcFPIDPASSAPPKATHRMTITSLTGRpQVTSDTL 234
Cdd:COG5099     1 PNSDTMNNLLPSIKSQLHHSKKSPPSSTTSQELMNGNSTPNSF----SPIPSKASSSATFTLNLPINNSVNH-KITSSSS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  235 ASSSPPqgtsdTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSppqvtsatsas 314
Cdd:COG5099    76 SRRKPS-----GSWSVAISSSTSGSQSLLMELPSSSFNPSTSSRNKSNSALSSTQQGNANSSVTLSSST----------- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  315 sspPQGTSDTPASSSPPQVT--SATSASSSPPQGTSDTPASSSPPQGtldtPSSSSPPQGTSDTpaSSSPPQGTSETPAS 392
Cdd:COG5099   140 ---ASSMFNSNKLPLPNPNHsnSATTNQSGSSFINTPASSSSQPLTN----LVVSSIKRFPYLT--SLSPFFNYLIDPSS 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  393 NSPpqgTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSpTQVTSETPASSSPTQVTSDTPASNSP---PQGTSDTPG 469
Cdd:COG5099   211 DSA---TASADTSPSFNPPPNLSPNNLFSTSDLSPLPDTQS-VENNIILNSSSSINELTSIYGSVPSIrnlRGLNSALVS 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  470 FSSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDtpaSSSPPQVTSETPASSSPPQVTSdtsaSISPPQVISdtPASS 549
Cdd:COG5099   287 FLNVSSSSLAFSALNGKEVSPTGSPSTRSFARVLPK---SSPNNLLTEILTTGVNPPQSLP----SLLNPVFLS--TSTG 357

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 557128996  550 SPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASS 601
Cdd:COG5099   358 FSLTNLSGYLNPNKNLKKNTLSSLSNLGYSSNVPSPSSSESTRNILGNISPN 409
NupH_GANP pfam16768
Nucleoporin homology of Germinal-centre associated nuclear protein; NupH_GANP is the ...
 354-524 3.06e-03

Nucleoporin homology of Germinal-centre associated nuclear protein; NupH_GANP is the nucleoporin-homology domain at the N-terminus of human GANP or germinal-centre associated nuclear proteins. GANP is part of the TREX-2 complex that links transcription with nuclear messenger RNA export, and it associates with the mRNP particle through the interaction of the NupH_GANP with NXF1, the export factor. This attachment mediates efficient delivery of mRNPs to nuclear pore complexes.


Pssm-ID: 435572 [Multi-domain]  Cd Length: 292  Bit Score: 41.82  E-value: 3.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   354 SSPPQGTLDTPSSSSPPQGTSDTPA---SSSPPQGTSETPASNSPPQGTSETPGFSSPPqvTTATLVSSSPPQVTSETPA 430
Cdd:pfam16768   56 SSFPTTSGVSHSSSGQTLGFTQTSGvglFSGLEHTPSFVATSGPSSSSVPSNPGFSFKS--PTNLGAFPSTSTFGPESGE 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   431 SSSPTQVTSETPASSSPTQVTSDTPASNSPP-----QGTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSppqVTSD 505
Cdd:pfam16768  134 VASSGFGKTEFSFKPPENAVFRPIFGAESEPektqsQITSGFFTFSHPVSSGPGGLAPFSFSQVTSSSATSSN---FTFS 210

                          170
                   ....*....|....*....
gi 557128996   506 TPASSSPPQvTSETPASSS 524
Cdd:pfam16768  211 KPVSSNNSS-SAFAPALSS 228
KLF12_N cd21441
N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as ...
 482-596 3.14e-03

N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as Krueppel-like transcription factor 12, KLF12) regulates, by transcriptionally repressing Nur77 expression, endometrial decidualization, which is a prerequisite for successful implantation and the establishment of pregnancy. It is involved in the maturation processes of kidney collecting ducts after birth, and is able to increase the promoter activity of the UT-A1 urea transporter promoter by binding to the CACCC motif. KLF12 has also been found to promote colorectal cancer growth is also involved in the invasion and apoptosis of basal-like breast carcinoma. KLF12 belongs to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Although these factors bind to similar elements in vitro, they have distinct activities in vivo depending on their expression profile and the sequence of the N-terminal activation/repression domain, which differ between members. KLF12 contains an N-terminal domain that is related to the N-terminal repression domain of KLF8.


Pssm-ID: 410608 [Multi-domain]  Cd Length: 197  Bit Score: 41.15  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  482 VSSSPPQ--VTSDTPASSSPPQVTSDTPASSSPpqvtseTPASSSPPQVTSDTSASISPPQVISDTPASSSPPQVTSETP 559
Cdd:cd21441    35 VKAEPPEdsLSTDHFQTQTEPVDLSINKARTSP------TAVSSSPVSMTASASPSSSSSSSSSSSRPASSPTVITSVSS 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 557128996  560 ASSSPTNMTSDTPASSSPT-------NMTSDTPaSSSPTNMTSD 596
Cdd:cd21441   109 ASSVPTVLTPGPLVASASGvggqqflHIIHPVP-PSSPMNLQSN 151
PRK10856 PRK10856
cytoskeleton protein RodZ;
346-437 3.64e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 41.94  E-value: 3.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  346 GTSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSSPPQGTSETPASnsppQGTSETPGFSSPPQVTTATLVSSSPPQVT 425
Cdd:PRK10856  167 STTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPS----QANVDTAATPAPAAPATPDGAAPLPTDQA 242

                          90
                  ....*....|..
gi 557128996  426 SETPASSSPTQV 437
Cdd:PRK10856  243 GVSTPAADPNAL 254
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
480-665 4.03e-03

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 41.84  E-value: 4.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   480 TLVSSSPPQVTSDTPAS-----------SSPPQVTSDT---PASSSPPQVTSETPASSSPPQVTSDTSASISPPqvisdt 545
Cdd:pfam16014    1 ALGSSPRPSILRKKPATegakpkpdihvAVAPPVTVAVealPGQNSEQQTASASPPSQHPAQAIPTILAPAAPP------ 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   546 pasSSPPQVTSETPASSSptnMTSDTPASSSPTNMTSDTPASSSPTNMtsdtPASSSPPWPVITEVTRPESTipagrsla 625
Cdd:pfam16014   75 ---SQPSVVLSTLPAAMA---VTPPIPASMANVVAPPTQPAASSTAAC----AVSSVLPEIKIKQEAEPMDT-------- 136

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 557128996   626 nitskAQEDSPLGVISTHPQMSFQSSTsqaLDETAGERVP 665
Cdd:pfam16014  137 -----SQSVPPLTPTSISPALTSLANN---LSVPAGDLLP 168
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 347-501 4.08e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 42.16  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  347 TSDTPASSSPPQG----TLDTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTAtlVSSSPP 422
Cdd:PRK07994  367 EPEVPPQSAAPAAsaqaTAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKA--KKSEPA 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  423 QVTSETPASSSPTQVTSETPASSSPTQVTSDTPASN---SPPQGTSDTPGfSSPTQVTTATLVSSSPPQVTSDTPASSSP 499
Cdd:PRK07994  445 AASRARPVNSALERLASVRPAPSALEKAPAKKEAYRwkaTNPVEVKKEPV-ATPKALKKALEHEKTPELAAKLAAEAIER 523


                  ..
gi 557128996  500 PQ 501
Cdd:PRK07994  524 DP 525
Mating_C pfam12737
C-terminal domain of homeodomain 1; Mating in fungi is controlled by the loci that determine ...
 167-534 4.13e-03

C-terminal domain of homeodomain 1; Mating in fungi is controlled by the loci that determine the mating type of an individual, and only individuals with differing mating types can mate. Basidiomycete fungi have evolved a unique mating system, termed tetrapolar or bifactorial incompatibility, in which mating type is determined by two unlinked loci; compatibility at both loci is required for mating to occur. The multi-allelic tetrapolar mating system is considered to be a novel innovation that could have only evolved once, and is thus unique to the mushroom fungi. This domain is C-terminal to the homeodomain transcription factor region.


Pssm-ID: 372279 [Multi-domain]  Cd Length: 412  Bit Score: 41.90  E-value: 4.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   167 KRRGAETERHMIPGNGPPLAMChqpAPPELFETLCFPIDPASSAP-----PKATHRMTITSLT---------GRPQVTSD 232
Cdd:pfam12737   50 KKRKRQAERSMRDALAYPSPER---SPASSPERNLSPQVDVCQLTirqnnLNLKRRSSSSSDVdssnaerchKRPRLDSP 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   233 tlASSSPPQGTSDTPASSSPPQVTSATSAsssppqgTSDTPASSSPPQVTSATSASSSPPQGTSD-TPASSSPPQvtsat 311
Cdd:pfam12737  127 --SSSSSPEKCLPSPAPSEQEALSEISAA-------CGPTPSTLTPLNVAPSLTPSKKRKRCLSDgFDGPKRPPN----- 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   312 SASSSPPQGTSDT-PASSSPPQVtsatsasssppqgtSDTPASSSPPQGTLdtpSSSSPPQGTSDTPASSSPpqgtSETP 390
Cdd:pfam12737  193 KRVQPRPQTVSDPfPTSTSIPEW--------------DEWLQNHMSPSLTL---HGDIPPPVSVEAPDSNTP----LDIE 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   391 ASNSPPQgtsetpgfsspPQVTTATLVSSSPPQVTSETPASSSPtqVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGF 470
Cdd:pfam12737  252 IFNFPYH-----------PDLTPSPAPSLSDSVIEVATPTTESD--YMCNGTLRQTFSWFEFDFPELIQPTNTPASNNEL 318

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   471 SSPTQVTTATLVSSSPPQV------TSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSPPQVTSDTSA 534
Cdd:pfam12737  319 SLPFDPSTDIVVSRTILPLldwrsqSFLSQTFASPPHSILRSNSSSPDVSAFALDLTPAFTPITYSLSES 388
TYA pfam01021
Ty transposon capsid protein; Ty are yeast transposons. A 5.7kb transcript codes for p3 a ...
 423-543 4.58e-03

Ty transposon capsid protein; Ty are yeast transposons. A 5.7kb transcript codes for p3 a fusion protein of TYA and TYB. The TYA protein is analogous to the gag protein of retroviruses. TYA a is cleaved to form 46kd protein which can form mature virion like particles. This entry corresponds to the capsid protein from Ty1 and Ty2 transposons.


Pssm-ID: 425992  Cd Length: 384  Bit Score: 41.87  E-value: 4.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   423 QVTSETPASSSPTQVtSETPASSSPTqvtsdtPASNSPPQ-GTSDTPGFSSPTQVTTATLVSSSPPQVTSDTPASSSP-- 499
Cdd:pfam01021   33 KANSQQTTTPGSSAV-PENHHHASPQ------PASVPPPQnGPYSQQCMMTPNQANPSGWPFYGHPSMMPYTPYQMSPmy 105

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 557128996   500 ---------PQVTSD--TPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVIS 543
Cdd:pfam01021  106 fppgpqsqfPQYPSSvgTPLSTPSPESGNTFTDSSSAKSDMTSTNKYVRPPPILT 160
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 345-510 4.59e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 42.16  E-value: 4.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  345 QGTSDTPAssSPPQGTLDTPSSssppQGTSDTPASSSPPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQV 424
Cdd:PRK07994  362 AAPLPEPE--VPPQSAAPAASA----QATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGA 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  425 TSetPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFS-SPTQVTTATLVSSSPPQVTSDTPASSSPPQVT 503
Cdd:PRK07994  436 TK--AKKSEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYRwKATNPVEVKKEPVATPKALKKALEHEKTPELA 513


                  ....*..
gi 557128996  504 SDTPASS 510
Cdd:PRK07994  514 AKLAAEA 520
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 363-528 4.99e-03

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 40.69  E-value: 4.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  363 TPSSSSPpqgtSDTPASSSPPQGTSETPASNSPPQgtsetpgfsSPPQV-TTATLVSSSPPQVTSETPASSSPTQVTSET 441
Cdd:cd21974    32 TPSSDSS----DEDDAPESPKDFHSLSSLCMTPPY---------SPPFFeASHSPSVASLHPPSAASSQPPPEPESSEPP 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  442 PASSSPTQVTSdtpasnsppqgtsdtpgfssptqVT--TATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSET 519
Cdd:cd21974    99 AASPQRAQATS-----------------------VIrhTADPVPVSPPPVLCQMLPVSSSSGVIVAFLKAPQQPSPQPQK 155


                  ....*....
gi 557128996  520 PASSSPPQV 528
Cdd:cd21974   156 PALPQPQVV 164
KLF12_N cd21441
N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as ...
 460-525 5.02e-03

N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as Krueppel-like transcription factor 12, KLF12) regulates, by transcriptionally repressing Nur77 expression, endometrial decidualization, which is a prerequisite for successful implantation and the establishment of pregnancy. It is involved in the maturation processes of kidney collecting ducts after birth, and is able to increase the promoter activity of the UT-A1 urea transporter promoter by binding to the CACCC motif. KLF12 has also been found to promote colorectal cancer growth is also involved in the invasion and apoptosis of basal-like breast carcinoma. KLF12 belongs to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Although these factors bind to similar elements in vitro, they have distinct activities in vivo depending on their expression profile and the sequence of the N-terminal activation/repression domain, which differ between members. KLF12 contains an N-terminal domain that is related to the N-terminal repression domain of KLF8.


Pssm-ID: 410608 [Multi-domain]  Cd Length: 197  Bit Score: 40.38  E-value: 5.02e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557128996  460 PPQGTSDTPGFSSPTQV---------TTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSSP 525
Cdd:cd21441    39 PPEDSLSTDHFQTQTEPvdlsinkarTSPTAVSSSPVSMTASASPSSSSSSSSSSSRPASSPTVITSVSSASSVP 113
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 321-419 5.11e-03

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 42.00  E-value: 5.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  321 TSDTPASSSPPqvtsatsassSPPQGTSDTPA-----SSSPPQGTLDTPSSSSPPQGTSDTpassSPPQGT----SETPA 391
Cdd:PLN02217  569 TNSTPTGSAAS----------SNTTFSSDSPStvvapSTSPPAGHLGSPPATPSKIVSPST----SPPASHlgspSTTPS 634

                          90       100
                  ....*....|....*....|....*...
gi 557128996  392 SNSPPQGTSETPGFSSPPQVTTATLVSS 419
Cdd:PLN02217  635 SPESSIKVASTETASPESSIKVASTESS 662
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 351-459 5.16e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 41.47  E-value: 5.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  351 PA-SSSPPQGTLDTPS-SSSPPQGTSDTPA-SSSPPQGTSETPA-SNSPPQGTSETP--GFSSPPQVTTATLVSSSPPQV 424
Cdd:PTZ00436  229 PAkAAAPPAKAAAAPAkAAAAPAKAAAPPAkAAAPPAKAAAPPAkAAAPPAKAAAPPakAAAPPAKAAAAPAKAAAAPAK 308

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 557128996  425 TSETPA-SSSPTQVTSETPASSSPTQVTSDTPASNS 459
Cdd:PTZ00436  309 AAAAPAkAAAPPAKAAAPPAKAATPPAKAAAPPAKA 344
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 162-451 5.30e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 41.84  E-value: 5.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  162 PLLPMKRRGAETERHMIPGNGPPLAMCHQPAPPELFETLCfPIDPASSAPPKATHRMTitsltgRPQVTSDTLASSSPPQ 241
Cdd:PLN03209  312 PLTPMEELLAKIPSQRVPPKESDAADGPKPVPTKPVTPEA-PSPPIEEEPPQPKAVVP------RPLSPYTAYEDLKPPT 384

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  242 GTSDTPASSSPPQVTSATSASSSPPQGTSdtPASSSPPQVTSATSASSSPPQGTSDTPASS----SPPQvtsatsasssp 317
Cdd:PLN03209  385 SPIPTPPSSSPASSKSVDAVAKPAEPDVV--PSPGSASNVPEVEPAQVEAKKTRPLSPYARyedlKPPT----------- 451

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  318 pqGTSDTPASSSPPQVTSATSASssppqGTSDTPASSSPPQGTLDTPSSSSPpqgTSDTPASSSPPQGTSETPASNSPPQ 397
Cdd:PLN03209  452 --SPSPTAPTGVSPSVSSTSSVP-----AVPDTAPATAATDAAAPPPANMRP---LSPYAVYDDLKPPTSPSPAAPVGKV 521

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 557128996  398 GTSETPgfSSPPQVTTATLVSSSPPQVTSE---TPASSSPTQVTSETPASSSPTQVT 451
Cdd:PLN03209  522 APSSTN--EVVKVGNSAPPTALADEQHHAQpkpRPLSPYTMYEDLKPPTSPTPSPVL 576
PRK10672 PRK10672
endolytic peptidoglycan transglycosylase RlpA;
359-448 5.56e-03

endolytic peptidoglycan transglycosylase RlpA;


Pssm-ID: 236733 [Multi-domain]  Cd Length: 361  Bit Score: 41.59  E-value: 5.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  359 GTLDTPSSSSPPQGTSDT-PASSSPPQGTSETPAsnspPQGTSetpGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQV 437
Cdd:PRK10672  202 GGMGTPSVQPAPAPQGDVlPVSNSTLKSEDPTGA----PVTSS---GFLGAPTTLAPGVLEGSEPTPTAPSSAPATAPAA 274

                          90
                  ....*....|.
gi 557128996  438 TSETPASSSPT 448
Cdd:PRK10672  275 AAPQAAATSSS 285
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 455-552 5.57e-03

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 41.42  E-value: 5.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  455 PASNSPPQGTSDTPGFSSPTQVTTATLVSSSPpqvTSDTPASSSPPQVTSDTPASSSPPQvtsetpasSSPPQVTSDTSA 534
Cdd:PHA03201    4 ARSRSPSPPRRPSPPRPTPPRSPDASPEETPP---SPPGPGAEPPPGRAAGPAAPRRRPR--------GCPAGVTFSSSA 72

                          90
                  ....*....|....*...
gi 557128996  535 SISPPQVISDTPASSSPP 552
Cdd:PHA03201   73 PPRPPLGLDDAPAATPPP 90
PHA03193 PHA03193
tegument protein VP11/12; Provisional
 492-604 5.67e-03

tegument protein VP11/12; Provisional


Pssm-ID: 177555  Cd Length: 594  Bit Score: 41.63  E-value: 5.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  492 DTPASSSPPQV-----TSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISD-----TPASSSPPQ-VTSETPA 560
Cdd:PHA03193  440 DSPFQRKRAMPedggeIHEALANNGQAIFPECFSGDLPPIAQALLSADELPNDTTASTsnemkGDAECPAAQdAAAILPA 519

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 557128996  561 SSSPTNmtsDTPASSSPTNMTSDtpaSSSPTNMTSDTPASSSPP 604
Cdd:PHA03193  520 SFQIEN---GGAADGSGLAIPAA---MCDATAVESPSTVAETPP 557
PRK13335 PRK13335
superantigen-like protein SSL3; Reviewed;
347-425 6.32e-03

superantigen-like protein SSL3; Reviewed;


Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 41.27  E-value: 6.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 557128996  347 TSDTPASSSPPQGTLDTPSSSSPPQGTSDTPASSspPQGTSETPASNSPPQGTSETPGFSSPPQVTTATLVSSSPPQVT 425
Cdd:PRK13335   89 ASKIEKISQPKQEEQKSLNISATPAPKQEQSQTT--TESTTPKTKVTTPPSTNTPQPMQSTKSDTPQSPTIKQAQTDMT 165
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
149-447 6.34e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.76  E-value: 6.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  149 QGASIWRNEFGPGP---------LLPM-KRRGAETERHMIPGNGPPLAMCHQPAPPELFetlcfPIDPASSAPPKATHRM 218
Cdd:PRK07003  329 QIATVGRGELGLAPdeyagftmtLLRMlAFEPAVTGGGAPGGGVPARVAGAVPAPGARA-----AAAVGASAVPAVTAVT 403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  219 TITSLTGRPQVtsdtlASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGT-SDTPASSSPPQVTSATSASSSPPQGTSD 297
Cdd:PRK07003  404 GAAGAALAPKA-----AAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVpAKANARASADSRCDERDAQPPADSGSAS 478

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  298 TPASSSPPQVTSATSasssppqgTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQGTSDTP 377
Cdd:PRK07003  479 APASDAPPDAAFEPA--------PRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAA 550

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  378 AS-----------SSPPQGTSETPASNSPPQGTSETPgfsSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSS 446
Cdd:PRK07003  551 AAldvlrnagmrvSSDRGARAAAAAKPAAAPAAAPKP---AAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPP 627


                  .
gi 557128996  447 P 447
Cdd:PRK07003  628 P 628
PHA03132 PHA03132
thymidine kinase; Provisional
 357-606 6.37e-03

thymidine kinase; Provisional


Pssm-ID: 222997 [Multi-domain]  Cd Length: 580  Bit Score: 41.67  E-value: 6.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  357 PQGTLDTPSSSSPPQGTSDTPASSSPpqgTSETPASNSPPqgtSETPGFSSPPQVTTATLvsSSPPQVTSETPASSSPTQ 436
Cdd:PHA03132   21 PEGSRDENFDAERDDFLTPLGSTSEA---TSEDDDDLYPP---RETGSGGGVATSTIYTV--PRPPRGPEQTLDKPDSLP 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  437 VTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPtqvttatlvsssPPQVTSDTPASSSPPqvtSDTPASSSPPqvt 516
Cdd:PHA03132   93 ASRELPPGPTPVPPGGFRGASSPRLGADSTSPRFLYQ------------VNFPVILAPIGESNS---SSEELSEEEE--- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  517 SETPASSSPPQVTSDTSasisppqvISDTPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSdtpASSSPTN-MTS 595
Cdd:PHA03132  155 HSRPPPSESLKVKNGGK--------VYPKGFSKHKTHKRSEFSGLTKKAARKRKGSFVFKPSQLKE---LSGSLKNlLHL 223

                         250
                  ....*....|.
gi 557128996  596 DTPASSSPPWP 606
Cdd:PHA03132  224 DDSAETDPATR 234
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 225-395 6.41e-03

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 41.31  E-value: 6.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   225 GRP----QVTSDTLASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPqvtsaTSASSSPPQGTSDTPA 300
Cdd:pfam13254  195 GRPnsfkEVTPVGLMRSPAPGGHSKSPSVSGISADSSPTKEEPSEEADTLSTDKEQSPA-----PTSASEPPPKTKELPK 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   301 SSSPPQVTSATSASSSPPQgTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQGTLDTPSSSSPPQgtsDTPASS 380
Cdd:pfam13254  270 DSEEPAAPSKSAEASTEKK-EPDTESSPETSSEKSAPSLLSPVSKASIDKPLSSPDRDPLSPKPKPQSPPK---DFRANL 345

                          170
                   ....*....|....*
gi 557128996   381 SPPQGTSETPASNSP 395
Cdd:pfam13254  346 RSREVPKDKSKKDEP 360
PRK11901 PRK11901
hypothetical protein; Reviewed
 456-635 6.67e-03

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 41.21  E-value: 6.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  456 ASNSPPQGTSDTpgfsSPTQVTTATLV----SSSPPQVTSDTPASSSPPQVTSD--TPASSSPPQVTSETPASSSP---- 525
Cdd:PRK11901   57 ALKSPTEHESQQ----SSNNAGAEKNIdlsgSSSLSSGNQSSPSAANNTSDGHDasGVKNTAPPQDISAPPISPTPtqaa 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  526 PQVTSDTSASISPPQVISD-----------------TPASSSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPASS 588
Cdd:PRK11901  133 PPQTPNGQQRIELPGNISDalsqqqgqvnaasqnaqGNTSTLPTAPATVAPSKGAKVPATAETHPTPPQKPATKKPAVNH 212

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 557128996  589 SPTNMTSDTPASSSPPWPVITEVTRPESTiPAGRSLANITSKAQEDS 635
Cdd:PRK11901  213 HKTATVAVPPATSGKPKSGAASARALSSA-PASHYTLQLSSASRSDT 258
PRK10905 PRK10905
cell division protein DamX; Validated
 247-497 6.73e-03

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 41.08  E-value: 6.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  247 PASSSPPQVTSATSASSSPPQGTSDTPASSSPPQVTSATSASSSPPQGTSDTPASSSPPQ---VTSATSASSSPPQGtsD 323
Cdd:PRK10905   23 PSTSSSDQTASGEKSIDLAGNATDQANGVQPAPGTTSAEQTAGNTQQDVSLPPISSTPTQgqtPVATDGQQRVEVQG--D 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  324 TPASSSPPQvtsatsassspPQGTSDTPASSSppqgTLDT-PSSSSPPQG---TSDTPASSSPPQGTSETPASNsppQGT 399
Cdd:PRK10905  101 LNNALTQPQ-----------NQQQLNNVAVNS----TLPTePATVAPVRNgnaSRQTAKTQTAERPATTRPARK---QAV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  400 SEtpgfSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVTSDTPASNSPPQGTSDTPGFSSPTQVTTA 479
Cdd:PRK10905  163 IE----PKKPQATAKTEPKPVAQTPKRTEPAAPVASTKAPAATSTPAPKETATTAPVQTASPAQTTATPAAGGKTAGNVG 238

                         250
                  ....*....|....*...
gi 557128996  480 TLVSSSPPQVTSDTPASS 497
Cdd:PRK10905  239 SLKSAPSSHYTLQLSSSS 256
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 490-613 6.98e-03

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 40.30  E-value: 6.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  490 TSDTPASSSPPQVTSDTPASS--------SPPQVtsETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQ------V- 554
Cdd:cd21974    34 SSDSSDEDDAPESPKDFHSLSslcmtppySPPFF--EASHSPSVASLHPPSAASSQPPPEPESSEPPAASPQraqatsVi 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 557128996  555 --TSETPASSSPTNMTSDTPASSSPTNMTSDTPASSSPTNMTSDTPASSSPPWPVITEVTR 613
Cdd:cd21974   112 rhTADPVPVSPPPVLCQMLPVSSSSGVIVAFLKAPQQPSPQPQKPALPQPQVVLVGGQVPQ 172
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 390-513 7.76e-03

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 40.65  E-value: 7.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  390 PASNSPPQGTSETPGFSSPPQVTTATlvssspPQVTSETPASssptqvtsetPASSSPTQVTSDTPASNSPPQGtsdtpg 469
Cdd:PHA03201    4 ARSRSPSPPRRPSPPRPTPPRSPDAS------PEETPPSPPG----------PGAEPPPGRAAGPAAPRRRPRG------ 61

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 557128996  470 fssptqvttatlvssSPPQVTSDTPASSSPPQVTSDTPASSSPP 513
Cdd:PHA03201   62 ---------------CPAGVTFSSSAPPRPPLGLDDAPAATPPP 90
CTD smart01104
Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription ...
 348-465 7.94e-03

Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe. The repeat has a characteristic TPA motif.


Pssm-ID: 215026 [Multi-domain]  Cd Length: 121  Bit Score: 38.66  E-value: 7.94e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996    348 SDTPA-SSSPPQgtldTPSSSSPPQGTSDTPASSSPPQGTSETPASNSPPQGTSeTPGFSSPPQVTTATLVSSSPPQVTS 426
Cdd:smart01104    2 GRTPAwGASGSK----TPAWGSRTPGTAAGGAPTARGGSGSRTPAWGGAGSRTP-AWGGAGPTGSRTPAWGGASAWGNKS 76

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 557128996    427 ETPASSSPTQVTSETPASSSP------TQVTSDTPASNSPPQGTS 465
Cdd:smart01104   77 SEGSASSWAAGPGGAYGAPTPgyggtpSAYGPATPGGGAMAGSAS 121
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 502-629 7.97e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 41.25  E-value: 7.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  502 VTSDTPASSSPPQVTSETPASSSPPQVTSDTSASISPPQVISDTPASSSPPQV-TSETPASSSPTNmtsdtPASSSPTNM 580
Cdd:PHA03269   18 IIANLNTNIPIPELHTSAATQKPDPAPAPHQAASRAPDPAVAPTSAASRKPDLaQAPTPAASEKFD-----PAPAPHQAA 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 557128996  581 TSDTPASSSPTNMTSDTPASSSPPwpvITEVTRPESTIPAGRSLANITS 629
Cdd:PHA03269   93 SRAPDPAVAPQLAAAPKPDAAEAF---TSAAQAHEAPADAGTSAASKKP 138
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 507-606 8.32e-03

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 40.65  E-value: 8.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  507 PASSSPPQVTSETPASSSPPQvTSDTSASISPPqvisdtpassSPPQVTSETPASSSPTNMTSDTPASSSPTNMTSDTPA 586
Cdd:PHA03201    4 ARSRSPSPPRRPSPPRPTPPR-SPDASPEETPP----------SPPGPGAEPPPGRAAGPAAPRRRPRGCPAGVTFSSSA 72

                          90       100
                  ....*....|....*....|..
gi 557128996  587 SSSPTNMTSDTPASSSPP--WP 606
Cdd:PHA03201   73 PPRPPLGLDDAPAATPPPldWT 94
CLECT smart00034
C-type lectin (CTL) or carbohydrate-recognition domain (CRD); Many of these domains function ...
 35-142 8.52e-03

C-type lectin (CTL) or carbohydrate-recognition domain (CRD); Many of these domains function as calcium-dependent carbohydrate binding modules.


Pssm-ID: 214480 [Multi-domain]  Cd Length: 124  Bit Score: 38.35  E-value: 8.52e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996     35 GNSCYQLNRLFCDFQEADNYCHAQRGRLA-------HTWnpkLRGFLKSFLNEETVW-------------WVRGNLTLPG 94
Cdd:smart00034    9 GGKCYKFSTEKKTWEDAQAFCQSLGGHLAsihseaeNDF---VASLLKNSGSSDYYWiglsdpdsngswqWSDGSGPVSY 85

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|
gi 557128996     95 SHPGINQTggddvlrNQKPGECPSVVTHSNavfsRWNL--CIEKHHFICQ 142
Cdd:smart00034   86 SNWAPGEP-------NNSSGDCVVLSTSGG----KWNDvsCTSKLPFVCE 124
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 147-456 8.65e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.21  E-value: 8.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  147 PPQGASiwrnEFGPGPLLPMKRRGAETER-----------HMIPGNGPPLAMCHQPAP---------PELFETLCFPIDP 206
Cdd:PTZ00449  510 PPEGPE----ASGLPPKAPGDKEGEEGEHedskesdepkeGGKPGETKEGEVGKKPGPakehkpskiPTLSKKPEFPKDP 585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  207 ASSAPPKATHRmtitslTGRPQVTSDTLASSSP--PQgTSDTPASSSPPQvTSATSASSSPPQgtsdTPASSSPPQVTSA 284
Cdd:PTZ00449  586 KHPKDPEEPKK------PKRPRSAQRPTRPKSPklPE-LLDIPKSPKRPE-SPKSPKRPPPPQ----RPSSPERPEGPKI 653

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  285 TSasssppqgTSDTPASSSPP-------QVTSATSASSSPPQGTSDTPASSSPPQvtSATSASSSPPQGTSDTPASSSPP 357
Cdd:PTZ00449  654 IK--------SPKPPKSPKPPfdpkfkeKFYDDYLDAAAKSKETKTTVVLDESFE--SILKETLPETPGTPFTTPRPLPP 723

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  358 QGTLDtPSSSSPPQGTSDTPaSSSPPQgtsetpaSNSPPQGTS----ETPGFSSPPQVTTATLvssSPPQVTSETPASSS 433
Cdd:PTZ00449  724 KLPRD-EEFPFEPIGDPDAE-QPDDIE-------FFTPPEEERtffhETPADTPLPDILAEEF---KEEDIHAETGEPDE 791

                         330       340
                  ....*....|....*....|...
gi 557128996  434 PTQvTSETPASSSPTQvTSDTPA 456
Cdd:PTZ00449  792 AMK-RPDSPSEHEDKP-PGDHPS 812
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 370-521 9.14e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.00  E-value: 9.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996  370 PQGTSDTPASssPPQGTSETPASnsppQGTSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSetpASSSPTQ 449
Cdd:PRK07994  361 PAAPLPEPEV--PPQSAAPAASA----QATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLA---ARQQLQR 431

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 557128996  450 VTSDTPASNSPPQGTSDTPgfssPTQVTTATLVSSSP-PQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPA 521
Cdd:PRK07994  432 AQGATKAKKSEPAAASRAR----PVNSALERLASVRPaPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKAL 500
KLF12_N cd21441
N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as ...
 399-451 9.38e-03

N-terminal domain of Kruppel-like factor 12; Kruppel-like factor 12 (also known as Krueppel-like transcription factor 12, KLF12) regulates, by transcriptionally repressing Nur77 expression, endometrial decidualization, which is a prerequisite for successful implantation and the establishment of pregnancy. It is involved in the maturation processes of kidney collecting ducts after birth, and is able to increase the promoter activity of the UT-A1 urea transporter promoter by binding to the CACCC motif. KLF12 has also been found to promote colorectal cancer growth is also involved in the invasion and apoptosis of basal-like breast carcinoma. KLF12 belongs to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Although these factors bind to similar elements in vitro, they have distinct activities in vivo depending on their expression profile and the sequence of the N-terminal activation/repression domain, which differ between members. KLF12 contains an N-terminal domain that is related to the N-terminal repression domain of KLF8.


Pssm-ID: 410608 [Multi-domain]  Cd Length: 197  Bit Score: 39.61  E-value: 9.38e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 557128996  399 TSETPGFSSPPQVTTATLVSSSPPQVTSETPASSSPTQVTSETPASSSPTQVT 451
Cdd:cd21441    65 TSPTAVSSSPVSMTASASPSSSSSSSSSSSRPASSPTVITSVSSASSVPTVLT 117
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 377-609 9.58e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.17  E-value: 9.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   377 PASSSPPQGTSETPASNSPPQGTSETPGFSSPPqVTTATLVSSSPPQVtSETPASSSPTQVTSETPASSSPTQVTSDTPA 456
Cdd:pfam09770  107 PAARAAQSSAQPPASSLPQYQYASQQSQQPSKP-VRTGYEKYKEPEPI-PDLQVDASLWGVAPKKAAAPAPAPQPAAQPA 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   457 SNSPP------------QGTSDTPGfsSPTQVTTATLVSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETPASSS 524
Cdd:pfam09770  185 SLPAPsrkmmsleeveaAMRAQAKK--PAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHP 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   525 PPQVTSDTSASISPPQVISDTPASSSPPQVtseTPASSSPT------NMTSDTPAsSSPTNMTSdtPASSSPTNMTSDTP 598
Cdd:pfam09770  263 VTILQRPQSPQPDPAQPSIQPQAQQFHQQP---PPVPVQPTqilqnpNRLSAARV-GYPQNPQP--GVQPAPAHQAHRQQ 336

                          250
                   ....*....|.
gi 557128996   599 ASSSPPWPVIT 609
Cdd:pfam09770  337 GSFGRQAPIIT 347
Mating_C pfam12737
C-terminal domain of homeodomain 1; Mating in fungi is controlled by the loci that determine ...
 441-756 9.60e-03

C-terminal domain of homeodomain 1; Mating in fungi is controlled by the loci that determine the mating type of an individual, and only individuals with differing mating types can mate. Basidiomycete fungi have evolved a unique mating system, termed tetrapolar or bifactorial incompatibility, in which mating type is determined by two unlinked loci; compatibility at both loci is required for mating to occur. The multi-allelic tetrapolar mating system is considered to be a novel innovation that could have only evolved once, and is thus unique to the mushroom fungi. This domain is C-terminal to the homeodomain transcription factor region.


Pssm-ID: 372279 [Multi-domain]  Cd Length: 412  Bit Score: 40.74  E-value: 9.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   441 TPASSSPTQVTSDTPASNSPpqGTSDTPGFSSptqvttatlvSSSPPQVTSDTPASSSPPQVTSDTPASSSPPQVTSETP 520
Cdd:pfam12737   72 SPASSPERNLSPQVDVCQLT--IRQNNLNLKR----------RSSSSSDVDSSNAERCHKRPRLDSPSSSSSPEKCLPSP 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   521 ASSSPPQVtSDTSASISPpqvisdTPASSSPPQVTSETPASSSPTNMTSD-TPASSSPTN--------MTSDT-PASSSP 590
Cdd:pfam12737  140 APSEQEAL-SEISAACGP------TPSTLTPLNVAPSLTPSKKRKRCLSDgFDGPKRPPNkrvqprpqTVSDPfPTSTSI 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   591 TN--------MTSDTPASSSPPWPVitEVTRPESTIPAGRSLANITSKAQED-SPLGVISTHPQMSFQSSTSQALDETAG 661
Cdd:pfam12737  213 PEwdewlqnhMSPSLTLHGDIPPPV--SVEAPDSNTPLDIEIFNFPYHPDLTpSPAPSLSDSVIEVATPTTESDYMCNGT 290

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557128996   662 ERvPTIPDFQAH--SEFQKACAILQRLRDFLPTSP-TSAQVSVANL-LIDLSEQ-----LLVLPFQKNNSWSSQTPAVSC 732
Cdd:pfam12737  291 LR-QTFSWFEFDfpELIQPTNTPASNNELSLPFDPsTDIVVSRTILpLLDWRSQsflsqTFASPPHSILRSNSSSPDVSA 369

                          330       340       350
                   ....*....|....*....|....*....|..
gi 557128996   733 -------PFQP-LGRLTTTEKSSHQMAQQDME 756
Cdd:pfam12737  370 faldltpAFTPiTYSLSESEKEAKRRELEELE 401
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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