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    Cdc37l1 cell division cycle 37-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293886, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdc37l1provided by RGD
    Official Full Name
    cell division cycle 37-like 1provided by RGD
    Primary source
    RGD:1309295
    See related
    EnsemblRapid:ENSRNOG00000010967 AllianceGenome:RGD:1309295
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cdc37l
    Summary
    Predicted to enable heat shock protein binding activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in protein folding and protein stabilization. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human CDC37L1 (cell division cycle 37 like 1, HSP90 cochaperone). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 170.2), Muscle (RPKM 164.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdc37l1 in Genome Data Viewer
    Location:
    1q52
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (236118630..236147527)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (226705019..226733994)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (247110147..247139113)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 6-like Neighboring gene phospholipid phosphatase 6 Neighboring gene phytanoyl-CoA 2-hydroxylase, pseudogene 1 Neighboring gene tektin 5 like 1 Neighboring gene adenylate kinase 3 Neighboring gene uncharacterized LOC120100015

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37. Scholz GM, et al. J Biol Chem, 2001 Aug 17. PMID 11413142
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hsp90 co-chaperone Cdc37-like 1
    Names
    cell division cycle 37 homolog-like 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011941.1 → NP_001011941.1  hsp90 co-chaperone Cdc37-like 1

      See identical proteins and their annotated locations for NP_001011941.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083761
      UniProtKB/Swiss-Prot
      Q5XIC3
      UniProtKB/TrEMBL
      A0A8I5YCE5, A6I0U9
      Related
      ENSRNOP00000016000.4, ENSRNOT00000016000.7
      Conserved Domains (2) summary
      smart01070
      Location:145 → 277
      CDC37_M; Cdc37 Hsp90 binding domain
      cl03951
      Location:71 → 139
      CDC37_N; Cdc37 N terminal kinase binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      236118630..236147527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589033.3 → XP_017444522.1  hsp90 co-chaperone Cdc37-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYM6, A0A8I5YCE5, A6I0V0
      Related
      ENSRNOP00000070715.1, ENSRNOT00000082290.3

    2. XM_017589034.3 → XP_017444523.1  hsp90 co-chaperone Cdc37-like 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5YCE5, A0A8I6G803
      Related
      ENSRNOP00000101867.1, ENSRNOT00000133305.1
      Conserved Domains (2) summary
      smart01070
      Location:145 → 277
      CDC37_M; Cdc37 Hsp90 binding domain
      cl03951
      Location:71 → 139
      CDC37_N; Cdc37 N terminal kinase binding

    3. XM_039108842.2 → XP_038964770.1  hsp90 co-chaperone Cdc37-like 1 isoform X5

      Conserved Domains (1) summary
      smart01070
      Location:44 → 183
      CDC37_M; Cdc37 Hsp90 binding domain

    4. XM_039108840.2 → XP_038964768.1  hsp90 co-chaperone Cdc37-like 1 isoform X3

      Conserved Domains (1) summary
      smart01070
      Location:44 → 183
      CDC37_M; Cdc37 Hsp90 binding domain

    5. XM_063287021.1 → XP_063143091.1  hsp90 co-chaperone Cdc37-like 1 isoform X4

    RNA

    1. XR_005503952.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIC3.1 GenPept UniProtKB/Swiss-Prot:Q5XIC3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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