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Conserved domains on  [gi|1958644648|ref|XP_038964770|]
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hsp90 co-chaperone Cdc37-like 1 isoform X5 [Rattus norvegicus]

Protein Classification

CDC37_M domain-containing protein( domain architecture ID 10660755)

CDC37_M domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 44-183 1.05e-63

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


:

Pssm-ID: 215010  Cd Length: 155  Bit Score: 194.52  E-value: 1.05e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644648   44 QSFINQDKRKTE--DEDKSQSFMQKYEQKIRHFGMLS--RWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEQKGALME 119
Cdd:smart01070   4 TSSKNPPSAPSEeeDEIDDKDFVLKLEPATKKFGMIPagDYDDSQKFLSEHPHIVSEETADALVMWAFDLELEGKEALME 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958644648  120 QIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAE----EEGYFEAFKNELEAFKARVRLYAQSQS 183
Cdd:smart01070  84 QVAHQAILMQYILELAKSLKVDPRNCVRLFFQKIKTPshpaKEGFLEDVQSEFEHIKTRVRIIAQEQA 151
 
Name Accession Description Interval E-value
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 44-183 1.05e-63

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


Pssm-ID: 215010  Cd Length: 155  Bit Score: 194.52  E-value: 1.05e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644648   44 QSFINQDKRKTE--DEDKSQSFMQKYEQKIRHFGMLS--RWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEQKGALME 119
Cdd:smart01070   4 TSSKNPPSAPSEeeDEIDDKDFVLKLEPATKKFGMIPagDYDDSQKFLSEHPHIVSEETADALVMWAFDLELEGKEALME 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958644648  120 QIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAE----EEGYFEAFKNELEAFKARVRLYAQSQS 183
Cdd:smart01070  84 QVAHQAILMQYILELAKSLKVDPRNCVRLFFQKIKTPshpaKEGFLEDVQSEFEHIKTRVRIIAQEQA 151
CDC37_M pfam08565
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 74-176 4.93e-19

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain pfam03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 pfam08564 whose function is unclear.


Pssm-ID: 430078  Cd Length: 113  Bit Score: 78.77  E-value: 4.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644648  74 FGMLSR--WDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEQKGALMEQIAHQAVVMQFIMEMAkncnvDPRGCFRLFFQ 151
Cdd:pfam08565   2 FAKIPSgdYKASEQFLLKHPEILSEQQKDALLMEAFDAQLEGKTKYARQCVHQSLLLQYCRQLD-----GRINGVKLFFK 76

                          90       100
                  ....*....|....*....|....*
gi 1958644648 152 KAKAEEEGYFEAFKNELEAFKARVR 176
Cdd:pfam08565  77 RITTKDHQAKKLFLDDVQSTYNHIK 101
 
Name Accession Description Interval E-value
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 44-183 1.05e-63

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


Pssm-ID: 215010  Cd Length: 155  Bit Score: 194.52  E-value: 1.05e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644648   44 QSFINQDKRKTE--DEDKSQSFMQKYEQKIRHFGMLS--RWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEQKGALME 119
Cdd:smart01070   4 TSSKNPPSAPSEeeDEIDDKDFVLKLEPATKKFGMIPagDYDDSQKFLSEHPHIVSEETADALVMWAFDLELEGKEALME 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958644648  120 QIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAE----EEGYFEAFKNELEAFKARVRLYAQSQS 183
Cdd:smart01070  84 QVAHQAILMQYILELAKSLKVDPRNCVRLFFQKIKTPshpaKEGFLEDVQSEFEHIKTRVRIIAQEQA 151
CDC37_M pfam08565
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 74-176 4.93e-19

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain pfam03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 pfam08564 whose function is unclear.


Pssm-ID: 430078  Cd Length: 113  Bit Score: 78.77  E-value: 4.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644648  74 FGMLSR--WDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEQKGALMEQIAHQAVVMQFIMEMAkncnvDPRGCFRLFFQ 151
Cdd:pfam08565   2 FAKIPSgdYKASEQFLLKHPEILSEQQKDALLMEAFDAQLEGKTKYARQCVHQSLLLQYCRQLD-----GRINGVKLFFK 76

                          90       100
                  ....*....|....*....|....*
gi 1958644648 152 KAKAEEEGYFEAFKNELEAFKARVR 176
Cdd:pfam08565  77 RITTKDHQAKKLFLDDVQSTYNHIK 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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