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    Pten phosphatase and tensin homolog [ Mus musculus (house mouse) ]

    Gene ID: 19211, updated on 14-Jan-2025

    Summary

    Official Symbol
    Ptenprovided by MGI
    Official Full Name
    phosphatase and tensin homologprovided by MGI
    Primary source
    MGI:MGI:109583
    See related
    Ensembl:ENSMUSG00000013663 AllianceGenome:MGI:109583
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TEP1; MMAC1; PTENbeta; 2310035O07Rik; A130070J02Rik; B430203M17Rik
    Summary
    This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 14.6), cortex adult (RPKM 12.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pten in Genome Data Viewer
    Location:
    19 C1; 19 28.14 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (32734977..32803560)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (32757577..32826160)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ATPase family, AAA domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr19:32786522-32786822 Neighboring gene STARR-positive B cell enhancer mm9_chr19:32787156-32787457 Neighboring gene STARR-seq mESC enhancer starr_45951 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:32828923-32829124 Neighboring gene STARR-positive B cell enhancer ABC_E7646 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:32830866-32830975 Neighboring gene killin, p53-regulated DNA replication inhibitor pseudogene Neighboring gene STARR-seq mESC enhancer starr_45956 Neighboring gene predicted gene, 36774 Neighboring gene STARR-seq mESC enhancer starr_45960 Neighboring gene predicted gene, 36914 Neighboring gene predicted gene, 36860

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC183880

    Gene Ontology Provided by MGI

    Items 1 - 25 of 44
    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity  
    enables PDZ domain binding  
    enables PDZ domain binding  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
    enables anaphase-promoting complex binding  
    enables calmodulin-dependent protein phosphatase activity  
    enables enzyme binding  
    enables histone H2AXS140 phosphatase activity  
    enables histone H2AXY142 phosphatase activity  
    enables identical protein binding  
    enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity  
    enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity  
    enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity  
    enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity  
    enables ionotropic glutamate receptor binding  
    enables molecular function inhibitor activity  
    enables myosin phosphatase activity  
    enables non-membrane spanning protein tyrosine phosphatase activity  
    enables phosphatidylinositol phosphate phosphatase activity  
    enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  
    enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity PubMed 
    enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  
    enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  
    enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity  
    enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity  
    enables phosphatidylinositol-3-phosphate phosphatase activity  
    enables phosphatidylinositol-3-phosphate phosphatase activity  
    enables phosphoprotein phosphatase activity  
    enables platelet-derived growth factor receptor binding  
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    enables protein serine/threonine phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    enables protein tyrosine kinase binding  
    enables protein tyrosine phosphatase activity  
    enables protein tyrosine phosphatase activity  
    enables protein tyrosine phosphatase activity  
    enables protein tyrosine phosphatase activity, metal-dependent  
    enables ubiquitin ligase activator activity PubMed 
    enables ubiquitin-specific protease binding PubMed 
    Items 1 - 25 of 44
    Items 1 - 25 of 132
    Process Evidence Code Pubs
    acts_upstream_of B cell proliferation PubMed 
    acts_upstream_of T cell proliferation PubMed 
    involved_in adult behavior PubMed 
    acts_upstream_of_or_within angiogenesis PubMed 
    acts_upstream_of_or_within apoptotic process PubMed 
    involved_in brain morphogenesis PubMed 
    involved_in canonical Wnt signaling pathway  
    acts_upstream_of_or_within cardiac muscle tissue development PubMed 
    acts_upstream_of_or_within cell migration PubMed 
    involved_in cell motility  
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of_or_within cellular response to decreased oxygen levels PubMed 
    involved_in cellular response to electrical stimulus  
    involved_in cellular response to ethanol  
    acts_upstream_of_or_within cellular response to hypoxia PubMed 
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to insulin-like growth factor stimulus  
    involved_in cellular response to leptin stimulus  
    acts_upstream_of_or_within central nervous system development PubMed 
    involved_in central nervous system myelin maintenance PubMed 
    involved_in central nervous system neuron axonogenesis PubMed 
    involved_in chromatin remodeling  
    involved_in dendritic spine morphogenesis PubMed 
    involved_in dentate gyrus development PubMed 
    acts_upstream_of_or_within endothelial cell migration PubMed 
    involved_in forebrain morphogenesis PubMed 
    acts_upstream_of_or_within gene expression PubMed 
    acts_upstream_of_or_within heart development PubMed 
    involved_in inositol phosphate catabolic process  
    involved_in learning or memory PubMed 
    involved_in locomotor rhythm PubMed 
    involved_in locomotory behavior PubMed 
    involved_in long-term synaptic depression  
    involved_in long-term synaptic potentiation PubMed 
    involved_in male mating behavior PubMed 
    involved_in maternal behavior PubMed 
    involved_in memory  
    involved_in multicellular organismal response to stress PubMed 
    acts_upstream_of myelination PubMed 
    acts_upstream_of_or_within negative regulation of B cell proliferation PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle  
    acts_upstream_of_or_within negative regulation of T cell proliferation PubMed 
    acts_upstream_of_or_within negative regulation of TORC1 signaling PubMed 
    acts_upstream_of_or_within negative regulation of androgen receptor signaling pathway PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of axon regeneration PubMed 
    involved_in negative regulation of axonogenesis PubMed 
    involved_in negative regulation of cardiac muscle cell proliferation PubMed 
    involved_in negative regulation of cardiac muscle cell proliferation  
    involved_in negative regulation of cell cycle  
    involved_in negative regulation of cell cycle G1/S phase transition  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of cell migration  
    acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell size PubMed 
    involved_in negative regulation of cellular senescence PubMed 
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity  
    involved_in negative regulation of defense response to bacterium  
    involved_in negative regulation of dendrite extension  
    involved_in negative regulation of dendritic spine morphogenesis PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation PubMed 
    involved_in negative regulation of epithelial to mesenchymal transition  
    involved_in negative regulation of excitatory postsynaptic potential PubMed 
    involved_in negative regulation of focal adhesion assembly  
    involved_in negative regulation of focal adhesion assembly  
    involved_in negative regulation of keratinocyte migration  
    acts_upstream_of_or_within negative regulation of myelination PubMed 
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of organ growth PubMed 
    involved_in negative regulation of peptidyl-serine phosphorylation  
    involved_in negative regulation of phagocytosis  
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within negative regulation of protein kinase activity by regulation of protein phosphorylation PubMed 
    involved_in negative regulation of protein phosphorylation PubMed 
    involved_in negative regulation of protein phosphorylation  
    involved_in negative regulation of ribosome biogenesis PubMed 
    involved_in negative regulation of synaptic vesicle clustering PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell proliferation  
    involved_in negative regulation of wound healing, spreading of epidermal cells  
    involved_in neuron projection development  
    involved_in neuron-neuron synaptic transmission PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in phosphatidylinositol dephosphorylation  
    involved_in phosphatidylinositol dephosphorylation  
    involved_in phosphatidylinositol dephosphorylation  
    involved_in platelet-derived growth factor receptor signaling pathway  
    involved_in positive regulation of DNA-binding transcription factor activity  
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of apoptotic process  
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway PubMed 
    involved_in positive regulation of cardiac muscle cell apoptotic process  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of excitatory postsynaptic potential PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of ubiquitin protein ligase activity  
    involved_in positive regulation of ubiquitin-dependent protein catabolic process  
    involved_in postsynaptic density assembly PubMed 
    involved_in prepulse inhibition PubMed 
    involved_in presynaptic membrane assembly PubMed 
    acts_upstream_of_or_within prostate gland growth PubMed 
    involved_in protein dephosphorylation  
    involved_in protein dephosphorylation  
    involved_in protein stabilization  
    acts_upstream_of_or_within regulation of B cell apoptotic process PubMed 
    involved_in regulation of Fc receptor mediated stimulatory signaling pathway  
    acts_upstream_of_or_within regulation of axon regeneration PubMed 
    acts_upstream_of_or_within regulation of cell cycle PubMed 
    involved_in regulation of cellular component size PubMed 
    involved_in regulation of cellular localization PubMed 
    acts_upstream_of_or_within regulation of macrophage apoptotic process PubMed 
    involved_in regulation of neuron projection development PubMed 
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in regulation of protein stability  
    involved_in regulation of protein stability  
    acts_upstream_of_or_within regulation of synaptic transmission, GABAergic PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in rhythmic synaptic transmission PubMed 
    involved_in social behavior PubMed 
    involved_in spindle assembly involved in female meiosis  
    involved_in synapse assembly PubMed 
    involved_in synapse maturation PubMed 
    Items 1 - 25 of 132
    Items 1 - 20 of 25
    Component Evidence Code Pubs
    located_in PML body  
    located_in Schmidt-Lanterman incisure PubMed 
    located_in apical plasma membrane  
    is_active_in cell projection  
    located_in cell projection  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic side of plasma membrane  
    is_active_in cytosol  
    located_in cytosol  
    located_in dendritic spine  
    located_in dendritic spine  
    located_in myelin sheath adaxonal region PubMed 
    is_active_in neuron projection PubMed 
    located_in neuron projection PubMed 
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic cytosol  
    located_in postsynaptic density  
    located_in postsynaptic membrane  
    Items 1 - 20 of 25

    General protein information

    Preferred Names
    phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Names
    PTENepsilon
    inositol polyphosphate 3-phosphatase
    mitochondrial PTENalpha
    mutated in multiple advanced cancers 1
    NP_032986.1
    XP_006526832.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008960.2NP_032986.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

      See identical proteins and their annotated locations for NP_032986.1

      Status: REVIEWED

      Source sequence(s)
      AK138025, BU701098, CK616227, U92437
      Consensus CDS
      CCDS29753.1
      UniProtKB/Swiss-Prot
      O08586, Q3UFB0, Q542G1
      UniProtKB/TrEMBL
      A0A6G7SEK5, A0A6G7SF19
      Related
      ENSMUSP00000013807.8, ENSMUST00000013807.8
      Conserved Domains (2) summary
      cd14509
      Location:24181
      PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog
      pfam10409
      Location:188349
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      32734977..32803560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526769.3XP_006526832.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1

      UniProtKB/TrEMBL
      Q8BSR7
      Conserved Domains (2) summary
      pfam10409
      Location:55216
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:148
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

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