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    UREG urease accessory protein G [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818010, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UREG
    Official Full Name
    urease accessory protein G
    Primary source
    TAIR:AT2G34470
    Locus tag
    AT2G34470
    See related
    Araport:AT2G34470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    PSKF109; T31E10.19; T31E10_19; urease accessory protein G; UREASE ACCESSORY PROTEIN UREG
    Summary
    Encodes a urease accessory protein which is essential for the activation of plant urease.
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    Genomic context

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    See UREG in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (14530735..14532505, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene light-harvesting chlorophyll-protein complex II subunit B1 Neighboring gene HMG-box (high mobility group) DNA-binding family protein Neighboring gene AGAMOUS-like 29 Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene Ribosomal protein L18ae/LX family protein Neighboring gene cytochrome P450, family 710, subfamily A, polypeptide 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The assembly of the plant urease activation complex and the essential role of the urease accessory protein G (UreG) in delivery of nickel to urease. Myrach T, et al. J Biol Chem, 2017 Sep 1. PMID 28710280, Free PMC Article
    2. Identification of three urease accessory proteins that are required for urease activation in Arabidopsis. Witte CP, et al. Plant Physiol, 2005 Nov. PMID 16244137, Free PMC Article
    3. Glutaredoxin GRXS17 Associates with the Cytosolic Iron-Sulfur Cluster Assembly Pathway. Iñigo S, et al. Plant Physiol, 2016 Oct. PMID 27503603, Free PMC Article
    4. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data (including data from studies using transgenic plants or cells from transgenic plants) suggest crucial role for UreG in nickel delivery for urease multimerization/activation. These studies were conducted using recombinant Arabidopsis thaliana proteins expressed in transgenic Nicotiana benthamiana cloned cells or hydroponic plants. (UreG = urease accessory protein UreG)
      Title: The assembly of the plant urease activation complex and the essential role of the urease accessory protein G (UreG) in delivery of nickel to urease.
    2. Plants bearing T-DNA or Ds element insertions in either the structural gene for urease or in any of the three putative urease accessory genes AtureD, AtureF, and AtureG lacked the corresponding mRNAs and were defective in urease activity
      Title: Identification of three urease accessory proteins that are required for urease activation in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036404.1
    NM_128999.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nickel cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables urease activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    urease accessory protein G
    NP_001031481.1
    • urease accessory protein G (UREG); FUNCTIONS IN: nickel ion binding, nucleotide binding, metal ion binding, ATP binding; INVOLVED IN: nitrogen compound metabolic process, positive regulation of metalloenzyme activity; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Urease accessory protein UreG (InterPro:IPR004400), [NiFe]-hydrogenase/urease maturation factor, Ni(2+)-binding GTPase (InterPro:IPR012202), Cobalamin (vitamin B12) biosynthesis CobW-like (InterPro:IPR003495); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_180994.1
    • urease accessory protein G (UREG); FUNCTIONS IN: nickel ion binding, nucleotide binding, metal ion binding, ATP binding; INVOLVED IN: nitrogen compound metabolic process, positive regulation of metalloenzyme activity; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Urease accessory protein UreG (InterPro:IPR004400), [NiFe]-hydrogenase/urease maturation factor, Ni(2+)-binding GTPase (InterPro:IPR012202), Cobalamin (vitamin B12) biosynthesis CobW-like (InterPro:IPR003495); Has 3841 Blast hits to 3838 proteins in 1211 species: Archae - 152; Bacteria - 2767; Metazoa - 198; Fungi - 88; Plants - 54; Viruses - 3; Other Eukaryotes - 579 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14530735..14532505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128999.3 → NP_180994.1  urease accessory protein G [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180994.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64700, Q9SYT8
      UniProtKB/TrEMBL
      A0A178VVU4, A0A5S9X3W3
      Conserved Domains (1) summary
      cd05540
      Location:74 → 263
      UreG; urease accessory protein UreG

    2. NM_001036404.1 → NP_001031481.1  urease accessory protein G [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031481.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4IHW4
      Conserved Domains (1) summary
      cl21455
      Location:77 → 265
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64700.1

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