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Conserved domains on  [gi|15226754|ref|NP_180994|]
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urease accessory protein G [Arabidopsis thaliana]

Protein Classification

urease accessory protein UreG( domain architecture ID 12943093)

urease accessory protein UreG facilitates the functional incorporation of the urease nickel metallocenter

CATH:  3.40.50.300
Gene Ontology:  GO:0005525|GO:0003924|GO:0016151|GO:0043419
SCOP:  4003988

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UreG cd05540
urease accessory protein UreG; UreG is one of the four accessory proteins of urease. Urease is ...
 74-263 9.24e-141

urease accessory protein UreG; UreG is one of the four accessory proteins of urease. Urease is an enzyme which catalyzes the decomposition of urea to form ammonia and carbon dioxide. Bacterial urease is a trimer of three subunits which are encoded by genes ureA, ureB, and ureC. Up to four accessory proteins (ureD, ureE, ureF, and ureG) are required for urease catalytical function. UreG may play an important role in nickel incorporation of the urease metallocenter. UreG is a member of the Fer4_NifH superfamily which contains an ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.


:

Pssm-ID: 349776  Cd Length: 191  Bit Score: 393.55  E-value: 9.24e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754  74 FTVGIGGPVGTGKTALMLALCRFLRDKYSLAAVTNDIFTKEDGEFLVKNGALPEERIRAVETGGCPHAAIREDISINLGP 153
Cdd:cd05540   1 LTVGIGGPVGSGKTALVEALCRALRDKYSIAVVTNDIYTKEDAEFLIRNGALPEERIRGVETGGCPHTAIREDASMNLAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754 154 LEELSNLF-KADLLLCESGGDNLAANFSRELADYIIYIIDVSAGDKIPRKGGPGITQADLLVINKTDLAAAVGADLSVME 232
Cdd:cd05540  81 IEELTAKFpDLDLLLVESGGDNLAATFSPELADYIIYVIDVAGGDKIPRKGGPGITQSDLLVINKTDLAPYVGADLDVME 160

                       170       180       190
                ....*....|....*....|....*....|.
gi 15226754 233 RDSLRMRDGGPFVFAQVKHGLGVEEIVNHVM 263
Cdd:cd05540 161 RDAKKMRGGGPFVFTNLKTDVGLDEVIDWIL 191
 
Name Accession Description Interval E-value
UreG cd05540
urease accessory protein UreG; UreG is one of the four accessory proteins of urease. Urease is ...
 74-263 9.24e-141

urease accessory protein UreG; UreG is one of the four accessory proteins of urease. Urease is an enzyme which catalyzes the decomposition of urea to form ammonia and carbon dioxide. Bacterial urease is a trimer of three subunits which are encoded by genes ureA, ureB, and ureC. Up to four accessory proteins (ureD, ureE, ureF, and ureG) are required for urease catalytical function. UreG may play an important role in nickel incorporation of the urease metallocenter. UreG is a member of the Fer4_NifH superfamily which contains an ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.


Pssm-ID: 349776  Cd Length: 191  Bit Score: 393.55  E-value: 9.24e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754  74 FTVGIGGPVGTGKTALMLALCRFLRDKYSLAAVTNDIFTKEDGEFLVKNGALPEERIRAVETGGCPHAAIREDISINLGP 153
Cdd:cd05540   1 LTVGIGGPVGSGKTALVEALCRALRDKYSIAVVTNDIYTKEDAEFLIRNGALPEERIRGVETGGCPHTAIREDASMNLAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754 154 LEELSNLF-KADLLLCESGGDNLAANFSRELADYIIYIIDVSAGDKIPRKGGPGITQADLLVINKTDLAAAVGADLSVME 232
Cdd:cd05540  81 IEELTAKFpDLDLLLVESGGDNLAATFSPELADYIIYVIDVAGGDKIPRKGGPGITQSDLLVINKTDLAPYVGADLDVME 160

                       170       180       190
                ....*....|....*....|....*....|.
gi 15226754 233 RDSLRMRDGGPFVFAQVKHGLGVEEIVNHVM 263
Cdd:cd05540 161 RDAKKMRGGGPFVFTNLKTDVGLDEVIDWIL 191
ureG TIGR00101
urease accessory protein UreG; This model represents UreG, a GTP hydrolase that acts in the ...
 76-264 2.12e-90

urease accessory protein UreG; This model represents UreG, a GTP hydrolase that acts in the assembly of the nickel metallocenter of urease. It is found only in urease-positive species, although some urease-positive species (e.g. Bacillus subtilis) lack this protein. A similar protein, hypB, is an accessory protein for expression of hydrogenase, which also uses nickel. [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 129208  Cd Length: 199  Bit Score: 266.35  E-value: 2.12e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754    76 VGIGGPVGTGKTALMLALCRFLRDKYSLAAVTNDIFTKEDGEFLVKNGALPEERIRAVETGGCPHAAIREDISINLGPLE 155
Cdd:TIGR00101   4 IGVAGPVGSGKTALIEALTRHMSKKYDMAVITNDIYTQEDAEFLCKNSVLPPERIIGVETGGCPHTAIREDASMNLEAVE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754   156 ELSNLF-KADLLLCESGGDNLAANFSRELADYIIYIIDVSAGDKIPRKGGPGITQADLLVINKTDLAAAVGADLSVMERD 234
Cdd:TIGR00101  84 EMHGRFpNLELVFIESGGDNLSATFSPELADFTIFVIDVAEGDKIPRKGGPGITRSDLLVINKIDLAPYVGADLKVMERD 163

                         170       180       190
                  ....*....|....*....|....*....|
gi 15226754   235 SLRMRDGGPFVFAQVKHGLGVEEIVNHVMH 264
Cdd:TIGR00101 164 AKKMRGEKPFIFTNLRAKEGLDDVIAWIER 193
HypB COG0378
Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase [Posttranslational modification, ...
 61-269 7.18e-76

Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440147 [Multi-domain]  Cd Length: 200  Bit Score: 229.18  E-value: 7.18e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754  61 APPLHDRNFSERAFTVGIGGPVGTGKTALMLALCRFLRDKYSLAAVTNDIFTKEDGEFLVKNGAlpeeRIRAVETGGCPH 140
Cdd:COG0378   1 AAENRALFAEKGVLAVNLMGSPGSGKTTLLEKTIRALKDRLRIAVIEGDIYTTEDAERLRAAGV----PVVQINTGGCCH 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754 141 AaireDISINLGPLEELsNLFKADLLLCESGGDNLAANFSRELADYIIYIIDVSAGDKIPRKGGPGITQADLLVINKTDL 220
Cdd:COG0378  77 L----DASMVLEALEEL-DLPDLDLLFIENVGNLVCPAFFPLGEDLKVVVLSVTEGDDKPRKYPPMFTAADLLVINKIDL 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 15226754 221 AAAVGADLSVMERDSLRMRDGGPFVFAQVKHGLGVEEIVNHVMHSWEHA 269
Cdd:COG0378 152 APYVGFDLEVMEEDARRVNPGAPIFEVSAKTGEGLDEWADWLREQLRAK 200
cobW pfam02492
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase ...
 75-246 5.94e-51

CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.


Pssm-ID: 396860  Cd Length: 179  Bit Score: 165.12  E-value: 5.94e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754    75 TVGIGGPVGTGKTALMLALCRFLRDKYSLAAVTNDIF-TKEDGEFLVKNGALpeerIRAVETGGCPHaAIREDISINLGP 153
Cdd:pfam02492   2 VTVITGFLGSGKTTLLNHLLKQNRAGLRIAVIVNEFGeTGIDAELLSETGVL----IVELSNGCICC-TIREDLSMALEA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754   154 LEELSNLFkaDLLLCESGGdNLAANFS-----------RELADYIIYIIDVSA---GDKIPRKGGPGITQADLLVINKTD 219
Cdd:pfam02492  77 LLEREGRL--DVIFIETTG-LAEPAPVaqtflspelrsPVLLDGVITVVDAANeadGEKIPRKAGDQIAFADLIVLNKTD 153

                         170       180
                  ....*....|....*....|....*..
gi 15226754   220 LAAAVgADLSVMERDSLRMRDGGPFVF 246
Cdd:pfam02492 154 LAPEV-ALLEVLEEDLRRLNPGAPVVP 179
 
Name Accession Description Interval E-value
UreG cd05540
urease accessory protein UreG; UreG is one of the four accessory proteins of urease. Urease is ...
 74-263 9.24e-141

urease accessory protein UreG; UreG is one of the four accessory proteins of urease. Urease is an enzyme which catalyzes the decomposition of urea to form ammonia and carbon dioxide. Bacterial urease is a trimer of three subunits which are encoded by genes ureA, ureB, and ureC. Up to four accessory proteins (ureD, ureE, ureF, and ureG) are required for urease catalytical function. UreG may play an important role in nickel incorporation of the urease metallocenter. UreG is a member of the Fer4_NifH superfamily which contains an ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.


Pssm-ID: 349776  Cd Length: 191  Bit Score: 393.55  E-value: 9.24e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754  74 FTVGIGGPVGTGKTALMLALCRFLRDKYSLAAVTNDIFTKEDGEFLVKNGALPEERIRAVETGGCPHAAIREDISINLGP 153
Cdd:cd05540   1 LTVGIGGPVGSGKTALVEALCRALRDKYSIAVVTNDIYTKEDAEFLIRNGALPEERIRGVETGGCPHTAIREDASMNLAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754 154 LEELSNLF-KADLLLCESGGDNLAANFSRELADYIIYIIDVSAGDKIPRKGGPGITQADLLVINKTDLAAAVGADLSVME 232
Cdd:cd05540  81 IEELTAKFpDLDLLLVESGGDNLAATFSPELADYIIYVIDVAGGDKIPRKGGPGITQSDLLVINKTDLAPYVGADLDVME 160

                       170       180       190
                ....*....|....*....|....*....|.
gi 15226754 233 RDSLRMRDGGPFVFAQVKHGLGVEEIVNHVM 263
Cdd:cd05540 161 RDAKKMRGGGPFVFTNLKTDVGLDEVIDWIL 191
ureG TIGR00101
urease accessory protein UreG; This model represents UreG, a GTP hydrolase that acts in the ...
 76-264 2.12e-90

urease accessory protein UreG; This model represents UreG, a GTP hydrolase that acts in the assembly of the nickel metallocenter of urease. It is found only in urease-positive species, although some urease-positive species (e.g. Bacillus subtilis) lack this protein. A similar protein, hypB, is an accessory protein for expression of hydrogenase, which also uses nickel. [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 129208  Cd Length: 199  Bit Score: 266.35  E-value: 2.12e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754    76 VGIGGPVGTGKTALMLALCRFLRDKYSLAAVTNDIFTKEDGEFLVKNGALPEERIRAVETGGCPHAAIREDISINLGPLE 155
Cdd:TIGR00101   4 IGVAGPVGSGKTALIEALTRHMSKKYDMAVITNDIYTQEDAEFLCKNSVLPPERIIGVETGGCPHTAIREDASMNLEAVE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754   156 ELSNLF-KADLLLCESGGDNLAANFSRELADYIIYIIDVSAGDKIPRKGGPGITQADLLVINKTDLAAAVGADLSVMERD 234
Cdd:TIGR00101  84 EMHGRFpNLELVFIESGGDNLSATFSPELADFTIFVIDVAEGDKIPRKGGPGITRSDLLVINKIDLAPYVGADLKVMERD 163

                         170       180       190
                  ....*....|....*....|....*....|
gi 15226754   235 SLRMRDGGPFVFAQVKHGLGVEEIVNHVMH 264
Cdd:TIGR00101 164 AKKMRGEKPFIFTNLRAKEGLDDVIAWIER 193
HypB COG0378
Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase [Posttranslational modification, ...
 61-269 7.18e-76

Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440147 [Multi-domain]  Cd Length: 200  Bit Score: 229.18  E-value: 7.18e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754  61 APPLHDRNFSERAFTVGIGGPVGTGKTALMLALCRFLRDKYSLAAVTNDIFTKEDGEFLVKNGAlpeeRIRAVETGGCPH 140
Cdd:COG0378   1 AAENRALFAEKGVLAVNLMGSPGSGKTTLLEKTIRALKDRLRIAVIEGDIYTTEDAERLRAAGV----PVVQINTGGCCH 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754 141 AaireDISINLGPLEELsNLFKADLLLCESGGDNLAANFSRELADYIIYIIDVSAGDKIPRKGGPGITQADLLVINKTDL 220
Cdd:COG0378  77 L----DASMVLEALEEL-DLPDLDLLFIENVGNLVCPAFFPLGEDLKVVVLSVTEGDDKPRKYPPMFTAADLLVINKIDL 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 15226754 221 AAAVGADLSVMERDSLRMRDGGPFVFAQVKHGLGVEEIVNHVMHSWEHA 269
Cdd:COG0378 152 APYVGFDLEVMEEDARRVNPGAPIFEVSAKTGEGLDEWADWLREQLRAK 200
cobW pfam02492
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase ...
 75-246 5.94e-51

CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.


Pssm-ID: 396860  Cd Length: 179  Bit Score: 165.12  E-value: 5.94e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754    75 TVGIGGPVGTGKTALMLALCRFLRDKYSLAAVTNDIF-TKEDGEFLVKNGALpeerIRAVETGGCPHaAIREDISINLGP 153
Cdd:pfam02492   2 VTVITGFLGSGKTTLLNHLLKQNRAGLRIAVIVNEFGeTGIDAELLSETGVL----IVELSNGCICC-TIREDLSMALEA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754   154 LEELSNLFkaDLLLCESGGdNLAANFS-----------RELADYIIYIIDVSA---GDKIPRKGGPGITQADLLVINKTD 219
Cdd:pfam02492  77 LLEREGRL--DVIFIETTG-LAEPAPVaqtflspelrsPVLLDGVITVVDAANeadGEKIPRKAGDQIAFADLIVLNKTD 153

                         170       180
                  ....*....|....*....|....*..
gi 15226754   220 LAAAVgADLSVMERDSLRMRDGGPFVF 246
Cdd:pfam02492 154 LAPEV-ALLEVLEEDLRRLNPGAPVVP 179
HypB cd05390
nickel incorporation protein HypB; HypB is one of numerous accessory proteins required for the ...
 83-263 3.78e-15

nickel incorporation protein HypB; HypB is one of numerous accessory proteins required for the maturation of nickel-dependent hydrogenases, like carbon monoxide dehydrogenase or urease. HypB is a GTP-binding protein and has GTP hyrolase activity. It forms homodimer and is capable of binding two nickel ions and two zinc ions. The active site is located on the dimer interface. Energy from hydrolysis of GTP is used to insert nickels into hydrogenases.


Pssm-ID: 349775  Cd Length: 203  Bit Score: 72.24  E-value: 3.78e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754  83 GTGKTALMLALCRFLRDKYSLAAVTNDIFTKEDGEFLVKNGAlpeeRIRAVETGGCPH--AAIREDIsinlgpLEELsNL 160
Cdd:cd05390  31 GSGKTTLLERTIDALKDELKIAVIEGDLETDNDAERIRATGV----PAIQINTGGACHldADMVARA------LHDL-DL 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754 161 FKADLLLCESGGdNLAANFSREL-ADYIIYIIDVSAGDKIPRKGgPGITQ-ADLLVINKTDLAAAVGADLSVMERDSLRM 238
Cdd:cd05390 100 DELDLLFIENVG-NLVCPAEFDLgEHKNVVLLSVTEGDDKPLKY-PLMFQvADVVLINKIDLLPYFDFDVEKAKEDIKKL 177

                       170       180
                ....*....|....*....|....*
gi 15226754 239 RDGGPFVFAQVKHGLGVEEIVNHVM 263
Cdd:cd05390 178 NPNAPIIEVSAKTGEGMEAWIDWLR 202
MMAA-like cd03114
methylmalonic aciduria associated protein; Methylmalonyl Co-A mutase-associated GTPase MeaB ...
 72-268 2.37e-06

methylmalonic aciduria associated protein; Methylmalonyl Co-A mutase-associated GTPase MeaB and its human homolog, methylmalonic aciduria associated protein (MMAA) are metallochaperones that function as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) and reactivation of the enzyme during catalysis. A member of the family, Escherichia coli ArgK, was previously thought to be a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and ornithine (AO system) and lysine, arginine and ornithine (LAO) transport systems.


Pssm-ID: 349768  Cd Length: 252  Bit Score: 47.57  E-value: 2.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754  72 RAFTVGIGGPVGTGKTALMLALCRFLR-DKYSLAAVTNDIFTKEDGeflvknGALPEERIRAVETGGCPHAAIREdiSIN 150
Cdd:cd03114  45 RAFRVGITGPPGAGKSTLIEALGRLLReQGHRVAVLAVDPSSPRSG------GSILGDKTRMQRLARDPNAFIRP--SPS 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754 151 LGPLEELSNLFKADLLLCEsggdnlAANFS----------------RELADYIIYIIDVSAGD-----KIprkggpGITQ 209
Cdd:cd03114 117 RGTLGGVARATREAILLCE------AAGYDvvlvetvgvgqsevavADMVDTFVLLLPPGGGDelqgiKA------GIME 184

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15226754 210 -ADLLVINKTDLAAAVGADLSVMERDS----LRMRDGG--PFVFA-QVKHGLGVEEIVNHVMHSWEH 268
Cdd:cd03114 185 iADLVVVNKADGDLKTGARRAQRELTSalklLRPRSDGwrPPVLRtSALTGEGIDELWEAIEEHRAA 251
GTP_translation_factor cd00881
GTP translation factor family primarily contains translation initiation, elongation and ...
 75-264 3.48e-04

GTP translation factor family primarily contains translation initiation, elongation and release factors; The GTP translation factor family consists primarily of translation initiation, elongation, and release factors, which play specific roles in protein translation. In addition, the family includes Snu114p, a component of the U5 small nuclear riboprotein particle which is a component of the spliceosome and is involved in excision of introns, TetM, a tetracycline resistance gene that protects the ribosome from tetracycline binding, and the unusual subfamily CysN/ATPS, which has an unrelated function (ATP sulfurylase) acquired through lateral transfer of the EF1-alpha gene and development of a new function.


Pssm-ID: 206647 [Multi-domain]  Cd Length: 183  Bit Score: 40.36  E-value: 3.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754  75 TVGIGGPVGTGKTALMLALCRFLRDKYSLAAVTNDIFTKedgeflvkngaLPEERIRAvetggcphaairedISINLGPL 154
Cdd:cd00881   1 NVGVIGHVDHGKTTLTGSLLYQTGAIDRRGTRKETFLDT-----------LKEERERG--------------ITIKTGVV 55

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754 155 EELSNLFKADLLLCEsgGDnlaANFSRE------LADYIIYIIDVSAGDK--------IPRKGGPGItqadLLVINKTDL 220
Cdd:cd00881  56 EFEWPKRRINFIDTP--GH---EDFSKEtvrglaQADGALLVVDANEGVEpqtrehlnIALAGGLPI----IVAVNKIDR 126

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 15226754 221 AAAVGADLSVME-RDSLRMR-------DGGPFVFAQVKHGLGVEEIVNHVMH 264
Cdd:cd00881 127 VGEEDFDEVLREiKELLKLIgftflkgKDVPIIPISALTGEGIEELLDAIVE 178
MeaB pfam03308
Methylmalonyl Co-A mutase-associated GTPase MeaB; Family members were previously thought to be ...
 72-275 2.16e-03

Methylmalonyl Co-A mutase-associated GTPase MeaB; Family members were previously thought to be ArgK proteins acting as ATPase enzymes and kinases. They are now believed to be methylmalonyl Co-A mutase-associated GTPase MeaB. Structural studies of MeaB and the human ortholog (methylmalonyl associated protein A) MMAA, reveal alpha-helical domains at the N- and C-termini as well as a Ras-like GTPase domain. Mutational analysis of MeaB, show prohibited growth in Methylobacterium due to the inability to convert methylmalonyl-CoA to succinyl-CoA caused by an inactive form of methylmalonyl-CoA mutatase (mcm). In humans, mutations in (MMAA) are associated with the fatal disease methylmalonyl aciduria.


Pssm-ID: 281323 [Multi-domain]  Cd Length: 272  Bit Score: 38.96  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754    72 RAFTVGIGGPVGTGKTALMLALCRFLRDK-YSLAAVTNDIFTKEDGeflvknGALPEERIRAVETGGCPHAAIREdiSIN 150
Cdd:pfam03308  32 RAHRVGVTGVPGAGKSTLIEALGMELRRRgHRVAVLAVDPSSPRTG------GSILGDKTRMDRLAVDPGAFIRP--SPS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754   151 LGPLEELSNLFKADLLLCESGG------DNLAANFSR----ELADYIIYIIDVSAGDKIP--RKGGPGItqADLLVINKT 218
Cdd:pfam03308 104 RGALGGLSRKTREVVLLLEAAGfdviiiETVGVGQSEvdvaNMVDTFVLLTMPGGGDELQgiKAGIMEI--ADIYVVNKA 181

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15226754   219 DL----AAAVGADLSVMERDSLRMRDG--GPFVFAQVKHGLGVEEIVNHVMHSWEHATGKKRQ 275
Cdd:pfam03308 182 DGnlpgAERAARELRAALHLLTPFEAGwrPPVLTTSAVRGEGIDELWDAIEEHREVLTATGLI 244
MnmE COG0486
tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal ...
 184-262 8.47e-03

tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal structure and biogenesis]; tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440253 [Multi-domain]  Cd Length: 448  Bit Score: 37.35  E-value: 8.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226754 184 ADYIIYIIDVSAG---------DKIPRKGgpgitqaDLLVINKTDLAAAVGADlsvmerdsLRMRDGGPFVFAQVKHGLG 254
Cdd:COG0486 293 ADLVLLLLDASEPlteedeeilEKLKDKP-------VIVVLNKIDLPSEADGE--------LKSLPGEPVIAISAKTGEG 357


                ....*...
gi 15226754 255 VEEIVNHV 262
Cdd:COG0486 358 IDELKEAI 365
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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