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    LSD1 LSD1 zinc finger family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827786, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LSD1
    Official Full Name
    LSD1 zinc finger family protein
    Primary source
    TAIR:AT4G20380
    Locus tag
    AT4G20380
    See related
    Araport:AT4G20380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F9F13.30; F9F13_30; LESION SIMULATING DISEASE; LESION SIMULATING DISEASE 1
    Summary
    LSD1 monitors a superoxide-dependent signal and negatively regulates a plant cell death pathway. contains zinc-finger motifs. LSD1 negatively regulates a basal defense pathway that can act upstream or independently of both NIM1/NPR1 function and SA accumulation following avirulent or virulent pathogen challenge
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    Genomic context

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    See LSD1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (11004503..11006968)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene PEBP (phosphatidylethanolamine-binding protein) family protein Neighboring gene Uncharacterized protein family (UPF0497) Neighboring gene JUMONJI 14 Neighboring gene gamma-soluble NSF attachment protein Neighboring gene Subtilase family protein Neighboring gene Tapetum specific protein TAP35/TAP44

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Initiation of runaway cell death in an Arabidopsis mutant by extracellular superoxide. Jabs T, et al. Science, 1996 Sep 27. PMID 8791589
    2. Salicylic Acid Accumulation Controlled by LSD1 Is Essential in Triggering Cell Death in Response to Abiotic Stress. Bernacki MJ, et al. Cells, 2021 Apr 20. PMID 33924244, Free PMC Article
    3. Runaway cell death, but not basal disease resistance, in lsd1 is SA- and NIM1/NPR1-dependent. Aviv DH, et al. Plant J, 2002 Feb. PMID 11844114
    4. LESION SIMULATING DISEASE 1 is required for acclimation to conditions that promote excess excitation energy. Mateo A, et al. Plant Physiol, 2004 Sep. PMID 15347794, Free PMC Article
    5. The Arabidopsis LSD1 gene plays an important role in the regulation of low temperature-dependent cell death. Huang X, et al. New Phytol, 2010 Jul. PMID 20456049

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METACASPASE8 (MC8) Is a Crucial Protein in the LSD1-Dependent Cell Death Pathway in Response to Ultraviolet Stress.
      Title: METACASPASE8 (MC8) Is a Crucial Protein in the LSD1-Dependent Cell Death Pathway in Response to Ultraviolet Stress.
    2. Antagonistic modules regulate photosynthesis-associated nuclear genes via GOLDEN2-LIKE transcription factors.
      Title: Antagonistic modules regulate photosynthesis-associated nuclear genes via GOLDEN2-LIKE transcription factors.
    3. Salicylic Acid Accumulation Controlled by LSD1 Is Essential in Triggering Cell Death in Response to Abiotic Stress.
      Title: Salicylic Acid Accumulation Controlled by LSD1 Is Essential in Triggering Cell Death in Response to Abiotic Stress.
    4. Salicylic acid and hydrogen peroxide are conditionally regulated by LSD1/EDS/PAD4 to govern water use efficiency, biomass accumulation and seed yield.
      Title: LSD1-, EDS1- and PAD4-dependent conditional correlation among salicylic acid, hydrogen peroxide, water use efficiency and seed yield in Arabidopsis thaliana.
    5. LSD1 plays a dual role within the cell by acting as a condition-dependent scaffold protein and as a transcription regulator.
      Title: The dual role of LESION SIMULATING DISEASE 1 as a condition-dependent scaffold protein and transcription regulator.
    6. Data indicate that Arabidopsis proteins PAD4, LSD1 and EDS1 constitute a molecular hub, which integrates plant responses to water stress, vegetative biomass production and generative development.
      Title: PAD4, LSD1 and EDS1 regulate drought tolerance, plant biomass production, and cell wall properties.
    7. LSD1 and EDS1 regulate processes extinguishing excessive energy, reactive oxygen species formation and subsequent programmed cell death in response to different stresses related to impaired electron transport.
      Title: Lesion simulating disease 1 and enhanced disease susceptibility 1 differentially regulate UV-C-induced photooxidative stress signalling and programmed cell death in Arabidopsis thaliana.
    8. lsd1-catalase interaction plays an important role in regulating programmed cell death (PCD) in Arabidopsis.
      Title: LESION SIMULATING DISEASE1 interacts with catalases to regulate hypersensitive cell death in Arabidopsis.
    9. These findings reveal a role of LSD1 in regulating cell death trigged by cold stress and a link between cold stress responses and ROS-associated signaling.
      Title: The Arabidopsis LSD1 gene plays an important role in the regulation of low temperature-dependent cell death.
    10. Data suggest that the balanced activities of LSD1, EDS1, PAD4, and EIN2 regulate signaling of programmed cell death, light acclimation, and holistic defense responses that are initiated, at least in part, by redox changes of the plastoquinone pool.
      Title: Chloroplast signaling and LESION SIMULATING DISEASE1 regulate crosstalk between light acclimation and immunity in Arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036601.1
    NM_001036602.2
    NM_001036603.2
    NM_001084944.2
    NM_001160785.1
    NM_118157.5
    NM_179217.4
    NM_179218.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within aerenchyma formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of 1-aminocyclopropane-1-carboxylate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of ethylene-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of hydrogen peroxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to molecule of oomycetes origin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to superoxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within systemic acquired resistance, salicylic acid mediated signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    LSD1 zinc finger family protein
    NP_001031678.1
    • LESION SIMULATING DISEASE (LSD1); CONTAINS InterPro DOMAIN/s: Zinc finger, LSD1-type (InterPro:IPR005735); BEST Arabidopsis thaliana protein match is: lsd one like 1 (TAIR:AT1G32540.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001031679.1
    • LESION SIMULATING DISEASE (LSD1); CONTAINS InterPro DOMAIN/s: Zinc finger, LSD1-type (InterPro:IPR005735); BEST Arabidopsis thaliana protein match is: lsd one like 1 (TAIR:AT1G32540.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001031680.2
    • LESION SIMULATING DISEASE (LSD1); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 11 processes; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, LSD1-type (InterPro:IPR005735); BEST Arabidopsis thaliana protein match is: lsd one like 1 (TAIR:AT1G32540.1); Has 361 Blast hits to 293 proteins in 54 species: Archae - 0; Bacteria - 0; Metazoa - 49; Fungi - 0; Plants - 249; Viruses - 0; Other Eukaryotes - 63 (source: NCBI BLink).
    NP_001078413.1
    • LESION SIMULATING DISEASE (LSD1); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 11 processes; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, LSD1-type (InterPro:IPR005735); BEST Arabidopsis thaliana protein match is: lsd one like 1 (TAIR:AT1G32540.1); Has 362 Blast hits to 294 proteins in 54 species: Archae - 0; Bacteria - 0; Metazoa - 49; Fungi - 0; Plants - 250; Viruses - 0; Other Eukaryotes - 63 (source: NCBI BLink).
    NP_001154257.1
    • LSD1 zinc finger family protein; FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 11 processes; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, LSD1-type (InterPro:IPR005735); BEST Arabidopsis thaliana protein match is: lsd one like 1 (TAIR:AT1G32540.1); Has 317 Blast hits to 247 proteins in 38 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 273; Viruses - 0; Other Eukaryotes - 44 (source: NCBI BLink).
    NP_567599.3
    • LESION SIMULATING DISEASE (LSD1); CONTAINS InterPro DOMAIN/s: Zinc finger, LSD1-type (InterPro:IPR005735); BEST Arabidopsis thaliana protein match is: lsd one like 1 (TAIR:AT1G32540.1); Has 361 Blast hits to 293 proteins in 54 species: Archae - 0; Bacteria - 0; Metazoa - 49; Fungi - 0; Plants - 249; Viruses - 0; Other Eukaryotes - 63 (source: NCBI BLink).
    NP_849548.1
    • LESION SIMULATING DISEASE (LSD1); CONTAINS InterPro DOMAIN/s: Zinc finger, LSD1-type (InterPro:IPR005735); BEST Arabidopsis thaliana protein match is: lsd one like 1 (TAIR:AT1G32540.1); Has 361 Blast hits to 293 proteins in 54 species: Archae - 0; Bacteria - 0; Metazoa - 49; Fungi - 0; Plants - 249; Viruses - 0; Other Eukaryotes - 63 (source: NCBI BLink).
    NP_849549.1
    • LESION SIMULATING DISEASE (LSD1); CONTAINS InterPro DOMAIN/s: Zinc finger, LSD1-type (InterPro:IPR005735); BEST Arabidopsis thaliana protein match is: lsd one like 1 (TAIR:AT1G32540.1); Has 362 Blast hits to 294 proteins in 54 species: Archae - 0; Bacteria - 0; Metazoa - 49; Fungi - 0; Plants - 250; Viruses - 0; Other Eukaryotes - 63 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11004503..11006968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341436.1 → NP_001328264.1  LSD1 zinc finger family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B450

    2. NM_179217.4 → NP_849548.1  LSD1 zinc finger family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849548.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V3Z8
      Conserved Domains (2) summary
      pfam06943
      Location:95 → 119
      zf-LSD1; LSD1 zinc finger
      cl26935
      Location:45 → 75
      zf-LSD1; LSD1 zinc finger

    3. NM_001036603.2 → NP_001031680.2  LSD1 zinc finger family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031680.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V3Z8
      Conserved Domains (2) summary
      pfam06943
      Location:95 → 119
      zf-LSD1; LSD1 zinc finger
      cl26935
      Location:45 → 75
      zf-LSD1; LSD1 zinc finger

    4. NM_001160785.1 → NP_001154257.1  LSD1 zinc finger family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154257.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JUW0
      Conserved Domains (2) summary
      TIGR01053
      Location:45 → 75
      LSD1; zinc finger domain, LSD1 subclass
      pfam06943
      Location:121 → 145
      zf-LSD1; LSD1 zinc finger

    5. NM_179218.4 → NP_849549.1  LSD1 zinc finger family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849549.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z316, P94077, Q8RXL2
      UniProtKB/TrEMBL
      A0A178V4C0
      Conserved Domains (2) summary
      TIGR01053
      Location:50 → 80
      LSD1; zinc finger domain, LSD1 subclass
      pfam06943
      Location:100 → 124
      zf-LSD1; LSD1 zinc finger

    6. NM_118157.5 → NP_567599.3  LSD1 zinc finger family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567599.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V3Z8
      Conserved Domains (2) summary
      pfam06943
      Location:95 → 119
      zf-LSD1; LSD1 zinc finger
      cl26935
      Location:45 → 75
      zf-LSD1; LSD1 zinc finger

    7. NM_001084944.2 → NP_001078413.1  LSD1 zinc finger family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078413.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z316, P94077, Q8RXL2
      UniProtKB/TrEMBL
      A0A178V4C0
      Conserved Domains (2) summary
      TIGR01053
      Location:50 → 80
      LSD1; zinc finger domain, LSD1 subclass
      pfam06943
      Location:100 → 124
      zf-LSD1; LSD1 zinc finger

    8. NM_001036602.2 → NP_001031679.1  LSD1 zinc finger family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031679.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V3Z8
      Conserved Domains (2) summary
      pfam06943
      Location:95 → 119
      zf-LSD1; LSD1 zinc finger
      cl26935
      Location:45 → 75
      zf-LSD1; LSD1 zinc finger

    9. NM_001036601.1 → NP_001031678.1  LSD1 zinc finger family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031678.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V3Z8
      Conserved Domains (2) summary
      pfam06943
      Location:95 → 119
      zf-LSD1; LSD1 zinc finger
      cl26935
      Location:45 → 75
      zf-LSD1; LSD1 zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P94077.1

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