Map1a microtubule-associated protein 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Map1aprovided by RGD
Official Full Name: microtubule-associated protein 1Aprovided by RGD
Primary source: RGD:3042
See related: EnsemblRapid:ENSRNOG00000014230 AllianceGenome:RGD:3042
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mtap1a
Summary: Enables actin binding activity; collagen binding activity; and microtubule binding activity. A structural constituent of presynapse. Involved in negative regulation of microtubule depolymerization. Located in several cellular components, including axon; dendrite; and neuronal cell body. Part of microtubule associated complex. Is active in glutamatergic synapse; postsynaptic density; and presynaptic active zone. Biomarker of hypothyroidism. Orthologous to human MAP1A (microtubule associated protein 1A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 361.7), Heart (RPKM 92.4) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (128716907..128736638)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (108263217..108283936)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (113251918..113272193)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of MAP 1A regulates hyperphosphorylation of Tau in Alzheimer's disease model.
Title: Phosphorylation of MAP 1A regulates hyperphosphorylation of Tau in Alzheimer's disease model.
Intracellular Accumulation of alpha-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines.
Title: Intracellular Accumulation of α-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines.
Disruption of MAP1A could be a very early manifestation of amyloid-beta-mediated synaptic dysfunction--one that presages the clinical onset of Alzheimer's disease by years.
Title: The microtubule-associated protein 1A (MAP1A) is an early molecular target of soluble Aβ-peptide.
Presynaptic surface localization of Ca(v)2.2 is mediated through its interaction with light chain 2 (LC2) of microtubule-associated protein MAP1A.
Title: The role of MAP1A light chain 2 in synaptic surface retention of Cav2.2 channels in hippocampal neurons.
Microtubule-associated protein-1 light chain-3 (LC3) protein and mRNA levels were significantly increased exclusively in denervated muscles from chloroquine-treated rats.
Title: Expression of autophagy-associated genes in skeletal muscle: an experimental model of chloroquine-induced myopathy.
After brain ischemia, MAP1A immunoreactivity was significantly decreased in the cerebral cortex and the hippocampus.
Title: Transcortical alterations in Na(+)-K+ ATPase and microtubule-associated proteins immunoreactivity in the rat cortical atrophy model induced by hypoxic ischemia.
there is a novel interaction between the C-terminal tail of the BKCa channel and the light chain of MAP1A, which enables channel association with and modulation by the cytoskeleton
Title: Direct interaction between BKCa potassium channel and microtubule-associated protein 1A.
The consensus GK-binding sequence in MAP1a and demonstrate that PSD-95 can use a similar interaction mode to bind diverse protein partners is determined.
Title: The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a.
Data show that microtubule associated protein 1A gene expression is upregulated by exposure to conditions of increased gravity.
Title: Microtubule associated protein (MAP1A) mRNA was up-regulated by hypergravity in the rat inner ear.
MAP1A expression is required for activity-dependent growth, branching, and stabilization of the dendritic arbor.
Title: Activity-driven dendritic remodeling requires microtubule-associated protein 1A.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE118757 (e-PCR)
- UniSTS:248882

ECD00556 (e-PCR)
- UniSTS:281666

stSG627752 (e-PCR)
- UniSTS:457801

MDB0962 (e-PCR)
- UniSTS:125041

ksks17 (e-PCR)
- UniSTS:514197

AI711500 (e-PCR)
- UniSTS:243922

D15S801 (e-PCR)
- UniSTS:151797

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytoskeletal anchor activity	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of presynapse	IDA Inferred from Direct Assay more info	PubMed
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde axonal protein transport	ISO Inferred from Sequence Orthology more info
involved_in associative learning	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite development	IBA Inferred from Biological aspect of Ancestor more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to microtubule	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in neuron projection maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within photoreceptor cell maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in presynapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in retrograde axonal protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in voluntary musculoskeletal movement	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in axon initial segment	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic branch	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic microtubule	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
part_of microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
located_in primary dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: microtubule-associated protein 1A

Names: MAP-1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030995.2 → NP_112257.2 microtubule-associated protein 1A

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P34926

UniProtKB/TrEMBL

A6HPN2, G3V7U2

Conserved Domains (3) summary

PTZ00121
Location:1370 → 1607

PTZ00121; MAEBL; Provisional

PHA03247
Location:1986 → 2445

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1743 → 2112

PHA03307; transcriptional regulator ICP4; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

128716907..128736638

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234826.5 → XP_006234888.1 microtubule-associated protein 1A isoform X1

UniProtKB/TrEMBL

A0A0G2K5C6, A6HPN1

Related

ENSRNOP00000073375.1, ENSRNOT00000083005.3

Conserved Domains (1) summary

cl23716
Location:284 → 387

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
XM_039104338.2 → XP_038960266.1 microtubule-associated protein 1A isoform X2

UniProtKB/TrEMBL

A6HPN1

Conserved Domains (3) summary

PTZ00121
Location:1608 → 1845

PTZ00121; MAEBL; Provisional

PHA03247
Location:2224 → 2683

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1981 → 2350

PHA03307; transcriptional regulator ICP4; Provisional
XM_008762145.3 → XP_008760367.1 microtubule-associated protein 1A isoform X3

See identical proteins and their annotated locations for XP_008760367.1

UniProtKB/Swiss-Prot

P34926

UniProtKB/TrEMBL

A6HPN2, G3V7U2

Conserved Domains (3) summary

PTZ00121
Location:1370 → 1607

PTZ00121; MAEBL; Provisional

PHA03247
Location:1986 → 2445

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1743 → 2112

PHA03307; transcriptional regulator ICP4; Provisional
XM_006234828.5 → XP_006234890.1 microtubule-associated protein 1A isoform X3

See identical proteins and their annotated locations for XP_006234890.1

UniProtKB/Swiss-Prot

P34926

UniProtKB/TrEMBL

A6HPN2, G3V7U2

Conserved Domains (3) summary

PTZ00121
Location:1370 → 1607

PTZ00121; MAEBL; Provisional

PHA03247
Location:1986 → 2445

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1743 → 2112

PHA03307; transcriptional regulator ICP4; Provisional