INO80 DNA helicase INO80-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: INO80
Official Full Name: DNA helicase INO80-like protein
Primary source: TAIR:AT3G57300
Locus tag: AT3G57300
See related: Araport:AT3G57300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATINO80; INO80 ortholog; INO80 ORTHOLOG
Summary: Encodes the Arabidopsis INO80 ortholog of the SWI/SNF ATPase family. Functions as a positive regulator of DNA homologous recombination (HR). In INO80 mutants, the HR frequency is reduced to 15% of that in the wild-type. Mutation in INO80 does not affect sensitivity to genotoxic agents and efficiency of T-DNA integration. INO80 was also shown to regulate a subset of the Arabidopsis transcriptome.
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Genomic context

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See INO80 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 25

Sequence:: Chromosome: 3; NC_003074.8 (21199150..21207893)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Complexes and complexities: INO80 takes center stage.
Title: Complexes and complexities: INO80 takes center stage.
The INO80 chromatin remodeling complex promotes thermomorphogenesis by connecting H2A.Z eviction and active transcription in Arabidopsis.
Title: The INO80 chromatin remodeling complex promotes thermomorphogenesis by connecting H2A.Z eviction and active transcription in Arabidopsis.
COMPASS functions as a module of the INO80 chromatin remodeling complex to mediate histone H3K4 methylation in Arabidopsis.
Title: COMPASS functions as a module of the INO80 chromatin remodeling complex to mediate histone H3K4 methylation in Arabidopsis.
AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes.
Title: AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes.
These findings provide insights into the common and distinct roles of AtINO80 and AtARP5 in diverse aspects of plant development.
Title: AtINO80 and AtARP5 physically interact and play common as well as distinct roles in regulating plant growth and development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001203188.1

Supported by ESTs:

NM_001339850.1

Supported by ESTs:

NM_001339851.1

Supported by ESTs:

NM_115590.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of double-strand break repair via homologous recombination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic cell DNA recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: DNA helicase INO80-like protein

NP_001190117.1

INO80 ortholog (INO80); FUNCTIONS IN: helicase activity, DNA binding, nucleic acid binding, ATP binding; INVOLVED IN: somatic cell DNA recombination, positive regulation of DNA repair, regulation of transcription; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA binding domain, INO80 (InterPro:IPR020838), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), SNF2-related (InterPro:IPR000330); BEST Arabidopsis thaliana protein match is: SNF2 domain-containing protein / helicase domain-containing protein (TAIR:AT3G12810.1).

NP_001319776.1

INO80 ortholog (INO80); FUNCTIONS IN: helicase activity, DNA binding, ATP binding, nucleic acid binding; INVOLVED IN: somatic cell DNA recombination, positive regulation of DNA repair, regulation of transcription; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA binding domain, INO80 (InterPro:IPR020838), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), SNF2-related (InterPro:IPR000330); BEST Arabidopsis thaliana protein match is: SNF2 domain-containing protein / helicase domain-containing protein (TAIR:AT3G12810.1); Has 26461 Blast hits to 15529 proteins in 1767 species: Archae - 159; Bacteria - 7863; Metazoa - 5872; Fungi - 5586; Plants - 2348; Viruses - 196; Other Eukaryotes - 4437 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

21199150..21207893

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001339850.1 → NP_001319776.1 DNA helicase INO80-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8RXS6, Q9M2L7

UniProtKB/TrEMBL

A0A178VA10, A0A5S9XLL0, A0A654FIL5
NM_001339851.1 → NP_001327678.1 DNA helicase INO80-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VA10, A0A1I9LT22, A0A5S9XLL0, A0A654FIL5
NM_115590.4 → NP_191289.2 DNA helicase INO80-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191289.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8RXS6, Q9M2L7

UniProtKB/TrEMBL

A0A178VA10, A0A5S9XLL0, A0A654FIL5

Conserved Domains (6) summary

cd00046
Location:606 → 751

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:589 → 888

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1205 → 1319

Helicase_C; Helicase conserved C-terminal domain

pfam11221
Location:452 → 530

Med21; Subunit 21 of Mediator complex

pfam13892
Location:345 → 476

DBINO; DNA-binding domain

cl15354
Location:840 → 889

CBS_pair; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_001203188.1 → NP_001190117.1 DNA helicase INO80-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190117.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VA10, A0A5S9XLL0, A0A654FIL5, F4J277

Conserved Domains (6) summary

cd00046
Location:606 → 784

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:589 → 921

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1238 → 1352

Helicase_C; Helicase conserved C-terminal domain

pfam11221
Location:452 → 530

Med21; Subunit 21 of Mediator complex

pfam13892
Location:345 → 476

DBINO; DNA-binding domain

cl15354
Location:873 → 922

CBS_pair; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...