|
Name |
Accession |
Description |
Interval |
E-value |
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
586-814 |
1.17e-161 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 486.63 E-value: 1.17e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLP 665
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGLQERTILRKNINPKRMYRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCRNRL 745
Cdd:cd18002 81 YWGNPKDRKVLRKFWDRKNLYTRDAPFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30694618 746 LLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHAEHGGTLNEHQLNRLHAILKPFMLRR 814
Cdd:cd18002 161 LLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGLNEHQLKRLHMILKPFMLRR 229
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
579-892 |
1.24e-92 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 315.63 E-value: 1.24e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 579 PELFKGTLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIwGPFLVVAPASVLNNWADEISRFC 658
Cdd:COG0553 235 PAGLKATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLA-RPVLIVAPTSLVGNWQRELAKFA 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 659 PDLKTLPYWGGLQErtilrkninpKRMYRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLS 738
Cdd:COG0553 314 PGLRVLVLDGTRER----------AKGANPFEDADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRA 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 739 FNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHaehggtlNEHQLNRLHAILKPFMLRRVKKD 818
Cdd:COG0553 384 LKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKG-------DEEALERLRRLLRPFLLRRTKED 456
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30694618 819 VVSELTTKTEVTVHCKLSSRQQAFYQAIknkisLAELFDSNRGQFTDKKVLNLMNIVIQLRKVCNHPELFERNE 892
Cdd:COG0553 457 VLKDLPEKTEETLYVELTPEQRALYEAV-----LEYLRRELEGAEGIRRRGLILAALTRLRQICSHPALLLEEG 525
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
589-888 |
1.49e-86 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 284.19 E-value: 1.49e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 589 YQMKGLQWLVNCYEQ-GLNGILADEMGLGKTIQAMAFLAHLAEEKNIWG-PFLVVAPASVLNNWADEISRFC--PDLKTL 664
Cdd:pfam00176 1 YQIEGVNWMLSLENNlGRGGILADEMGLGKTLQTISLLLYLKHVDKNWGgPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 665 PYWGGLQERTILRKninpKRMYRRDAGfhILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCRNR 744
Cdd:pfam00176 81 VLHGNKRPQERWKN----DPNFLADFD--VVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 745 LLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHAEHGGtlnehqLNRLHAILKPFMLRRVKKDVVSELT 824
Cdd:pfam00176 155 WILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKG------VSRLHKLLKPFLLRRTKKDVEKSLP 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30694618 825 TKTEVTVHCKLSSRQQAFYQAIKNKISLAELFDSNRGqftDKKVLNLMNIVIQLRKVCNHPELF 888
Cdd:pfam00176 229 PKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKTGEGG---REIKASLLNILMRLRKICNHPGLI 289
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
419-892 |
1.95e-84 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 300.18 E-value: 1.95e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 419 RYDKQMAEERKKQEKEAAEAFKREQEQR----ESKRQQQRLNFLIKQTELYSHFMQnktdsnpsealpigdenpidevlp 494
Cdd:PLN03142 59 KREKARLKELKKQKKQEIQKILEQQNAAidadMNNKGKGRLKYLLQQTEIFAHFAK------------------------ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 495 etsaaepseveDPEEAELKEKVLRAAQdavsKQKQITDAFDTEYMKlrqtSEMEGplndisVSGSSNIDLhnpstmpvts 574
Cdd:PLN03142 115 -----------GDQSASAKKAKGRGRH----ASKLTEEEEDEEYLK----EEEDG------LGGSGGTRL---------- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 575 TVQtPELFKGTLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEI 654
Cdd:PLN03142 160 LVQ-PSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRGITGPHMVVAPKSTLGNWMNEI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 655 SRFCPDLKTLPYWGGLQERTILRKNinpkrmYRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWK 734
Cdd:PLN03142 239 RRFCPVLRAVKFHGNPEERAHQREE------LLVAGKFDVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLSK 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 735 TLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHaehggtlNEHQLNRLHAILKPFMLRR 814
Cdd:PLN03142 313 TMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGEND-------QQEVVQQLHKVLRPFLLRR 385
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30694618 815 VKKDVVSELTTKTEVTVHCKLSSRQQAFYQAIKNKislaELFDSNRGqfTDKKvlNLMNIVIQLRKVCNHPELFERNE 892
Cdd:PLN03142 386 LKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQK----DLDVVNAG--GERK--RLLNIAMQLRKCCNHPYLFQGAE 455
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
1198-1330 |
4.48e-64 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 213.49 E-value: 4.48e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1198 PAKLLTD-SGKLQTLDILLKRLRAGNHRVLLFAQMTKMLNILEDYMNYRKYKYLRLDGSSTIMDRRDMVRDFQHRSDIFV 1276
Cdd:cd18793 2 PPKIEEVvSGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRV 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 30694618 1277 FLLSTRAGGLGINLTAADTVIFYESDWNPTLDLQAMDRAHRLGQTKDVTVYRLI 1330
Cdd:cd18793 82 FLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DBINO |
pfam13892 |
DNA-binding domain; DBINO is a DNA-binding domain found on global transcription activator ... |
345-476 |
8.08e-59 |
|
DNA-binding domain; DBINO is a DNA-binding domain found on global transcription activator SNF2L1 proteins and chromatin re-modelling proteins.
Pssm-ID: 464024 [Multi-domain] Cd Length: 134 Bit Score: 198.53 E-value: 8.08e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 345 DKIRKAWINIVRRDIAKHHRIFTTFHRKLSIDAKRFADGCQREVRMKVGRSYKIPRTAPIRTRKISRDMLLFWKRYDKQM 424
Cdd:pfam13892 3 EKRRKIWKNIAKKDIPKVYRAKQQNHQARLANCKKVAQLCAREARRKASRTQKTMKDPQLRAKRLMREMLLFWKKNEKEE 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 30694618 425 AEERKKQEKEAAEAFKREQEQRESKRQQQRLNFLIKQTELYSHFMQNKTDSN 476
Cdd:pfam13892 83 RELRKRAEKEALEQAKKEEELREAKRQQRKLNFLITQTELYSHFMGKKLKTD 134
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
1201-1459 |
3.41e-53 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 204.26 E-value: 3.41e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1201 LLTDSGKLQTLDILLKRLRAGNHRVLLFAQMTKMLNILEDYMNYRKYKYLRLDGSSTIMDRRDMVRDFQHR-SDIFVFLL 1279
Cdd:PLN03142 466 LVENSGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPgSEKFVFLL 545
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1280 STRAGGLGINLTAADTVIFYESDWNPTLDLQAMDRAHRLGQTKDVTVYRLICKETVEEKILHRASQKNTVQQLVMTGGH- 1358
Cdd:PLN03142 546 STRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRl 625
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1359 -----VQGDDFL-----GAADVVS---LLMDDAEAAQLEQKFRELPLQVKDRQKKKT-KRIRIDAEGDATLEELEDVDRQ 1424
Cdd:PLN03142 626 aeqktVNKDELLqmvryGAEMVFSskdSTITDEDIDRIIAKGEEATAELDAKMKKFTeDAIKFKMDDTAELYDFDDEDDK 705
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 30694618 1425 DNGQEPLEE------PEKPKSSNKKR-----------RAASNPKARAPQKAK 1459
Cdd:PLN03142 706 DENKLDFKKivsdnwIDPPKRERKRNyseseyfkqamRQGAPAKPKEPRIPR 757
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
1178-1346 |
2.08e-52 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 197.37 E-value: 2.08e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1178 PALQLtHRIFGSCPPMQSFDPAKLLTDSGKLQTLDILLKRLRAGNHRVLLFAQMTKMLNILEDYMNYRKYKYLRLDGSST 1257
Cdd:COG0553 506 AALTR-LRQICSHPALLLEEGAELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTS 584
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1258 IMDRRDMVRDFQHRSDIFVFLLSTRAGGLGINLTAADTVIFYESDWNPTLDLQAMDRAHRLGQTKDVTVYRLICKETVEE 1337
Cdd:COG0553 585 AEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEE 664
|
....*....
gi 30694618 1338 KILHRASQK 1346
Cdd:COG0553 665 KILELLEEK 673
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
578-775 |
2.39e-30 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 119.52 E-value: 2.39e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 578 TPELFKGTLKEYQMKGLQWLVNCYEqglNGILADEMGLGKTIQAMAFLAHLAEEKNiWGPFLVVAPASVL-NNWADEISR 656
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLR---DVILAAPTGSGKTLAALLPALEALKRGK-GGRVLVLVPTRELaEQWAEELKK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 657 FCPD--LKTLPYWGGLQERTILRKNINPKrmyrrdagFHILITSYQLLVTD--EKYFRRVKWQYMVLDEAQAIKSSSSIR 732
Cdd:smart00487 77 LGPSlgLKVVGLYGGDSKREQLRKLESGK--------TDILVTTPGRLLDLleNDKLSLSNVDLVILDEAHRLLDGGFGD 148
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 30694618 733 -WKTLLSF--NCRNRLLLTGTP---IQNNMAELWALLHFIMPMLFDNHD 775
Cdd:smart00487 149 qLEKLLKLlpKNVQLLLLSATPpeeIENLLELFLNDPVFIDVGFTPLEP 197
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
1206-1319 |
2.00e-25 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 102.29 E-value: 2.00e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1206 GKLQTLDILLKRLRagNHRVLLFAQMTKMLNIlEDYMNYRKYKYLRLDGSSTIMDRRDMVRDFqhRSDIFVFLLSTRAGG 1285
Cdd:pfam00271 1 EKLEALLELLKKER--GGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDF--RKGKIDVLVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 30694618 1286 LGINLTAADTVIFYESDWNPTLDLQAMDRAHRLG 1319
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1237-1319 |
7.70e-22 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 90.73 E-value: 7.70e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1237 ILEDYMNYRKYKYLRLDGSSTIMDRRDMVRDFqhRSDIFVFLLSTRAGGLGINLTAADTVIFYESDWNPTLDLQAMDRAH 1316
Cdd:smart00490 2 ELAELLKELGIKVARLHGGLSQEEREEILDKF--NNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAG 79
|
...
gi 30694618 1317 RLG 1319
Cdd:smart00490 80 RAG 82
|
|
| PRK07735 |
PRK07735 |
NADH-quinone oxidoreductase subunit C; |
1378-1480 |
4.83e-03 |
|
NADH-quinone oxidoreductase subunit C;
Pssm-ID: 236081 [Multi-domain] Cd Length: 430 Bit Score: 41.12 E-value: 4.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1378 AEAAQLEQKFRELPLQVKDRQKKKTKRiRIDAEGDATLEELEDVDRQDNGQEPLEEPEKPKS-SNKKRRAASNPKARAPQ 1456
Cdd:PRK07735 103 AKAAALAKQKREGTEEVTEEEKAAAKA-KAAAAAKAKAAALAKQKREGTEEVTEEEEETDKEkAKAKAAAAAKAKAAALA 181
|
90 100
....*....|....*....|....
gi 30694618 1457 KAKEEANGEDTPQRTKRVKRQTKS 1480
Cdd:PRK07735 182 KQKAAEAGEGTEEVTEEEKAKAKA 205
|
|
| PRK00247 |
PRK00247 |
putative inner membrane protein translocase component YidC; Validated |
385-506 |
8.05e-03 |
|
putative inner membrane protein translocase component YidC; Validated
Pssm-ID: 178945 [Multi-domain] Cd Length: 429 Bit Score: 40.60 E-value: 8.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 385 QREVRMKVGRSYKiprtapiRTRKISRDMLLF--WK--RYDKQMAEERK--KQEKEAAEAFKRE--QEQRESKRQQQRLN 456
Cdd:PRK00247 293 QYREKQKEKKAFL-------WTLRRNRLRMIItpWRapELHAENAEIKKtrTAEKNEAKARKKEiaQKRRAAEREINREA 365
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 30694618 457 FLIKQTELYSHFMQNKTDSNPSEALPIGDENPIDEVLPETSAAEPSEVED 506
Cdd:PRK00247 366 RQERAAAMARARARRAAVKAKKKGLIDASPNEDTPSENEESKGSPPQVEA 415
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
586-814 |
1.17e-161 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 486.63 E-value: 1.17e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLP 665
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGLQERTILRKNINPKRMYRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCRNRL 745
Cdd:cd18002 81 YWGNPKDRKVLRKFWDRKNLYTRDAPFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30694618 746 LLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHAEHGGTLNEHQLNRLHAILKPFMLRR 814
Cdd:cd18002 161 LLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGLNEHQLKRLHMILKPFMLRR 229
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
586-814 |
9.48e-101 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 321.61 E-value: 9.48e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLP 665
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGLQERTILRKNinpkrmYRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCRNRL 745
Cdd:cd18003 81 YYGSAKERKLKRQG------WMKPNSFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRL 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30694618 746 LLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHAEHGGTLNEHQLNRLHAILKPFMLRR 814
Cdd:cd18003 155 LLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPLTAMSEGSQEENEELVRRLHKVLRPFLLRR 223
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
579-892 |
1.24e-92 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 315.63 E-value: 1.24e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 579 PELFKGTLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIwGPFLVVAPASVLNNWADEISRFC 658
Cdd:COG0553 235 PAGLKATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLA-RPVLIVAPTSLVGNWQRELAKFA 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 659 PDLKTLPYWGGLQErtilrkninpKRMYRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLS 738
Cdd:COG0553 314 PGLRVLVLDGTRER----------AKGANPFEDADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRA 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 739 FNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHaehggtlNEHQLNRLHAILKPFMLRRVKKD 818
Cdd:COG0553 384 LKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKG-------DEEALERLRRLLRPFLLRRTKED 456
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30694618 819 VVSELTTKTEVTVHCKLSSRQQAFYQAIknkisLAELFDSNRGQFTDKKVLNLMNIVIQLRKVCNHPELFERNE 892
Cdd:COG0553 457 VLKDLPEKTEETLYVELTPEQRALYEAV-----LEYLRRELEGAEGIRRRGLILAALTRLRQICSHPALLLEEG 525
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
583-816 |
6.22e-87 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 283.12 E-value: 6.22e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 583 KGTLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKnIWGPFLVVAPASVLNNWADEISRFCPDLK 662
Cdd:cd18009 1 GGVMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRERG-VWGPFLVIAPLSTLPNWVNEFARFTPSVP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 663 TLPYWGGLQERTILRKNINPKRmyRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCR 742
Cdd:cd18009 80 VLLYHGTKEERERLRKKIMKRE--GTLQDFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSD 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30694618 743 NRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWF-----SKGIENHAEHGGTLNEHQLNRLHAILKPFMLRRVK 816
Cdd:cd18009 158 NRLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFdfsslSDNAADISNLSEEREQNIVHMLHAILKPFLLRRLK 236
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
589-888 |
1.49e-86 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 284.19 E-value: 1.49e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 589 YQMKGLQWLVNCYEQ-GLNGILADEMGLGKTIQAMAFLAHLAEEKNIWG-PFLVVAPASVLNNWADEISRFC--PDLKTL 664
Cdd:pfam00176 1 YQIEGVNWMLSLENNlGRGGILADEMGLGKTLQTISLLLYLKHVDKNWGgPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 665 PYWGGLQERTILRKninpKRMYRRDAGfhILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCRNR 744
Cdd:pfam00176 81 VLHGNKRPQERWKN----DPNFLADFD--VVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 745 LLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHAEHGGtlnehqLNRLHAILKPFMLRRVKKDVVSELT 824
Cdd:pfam00176 155 WILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKG------VSRLHKLLKPFLLRRTKKDVEKSLP 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30694618 825 TKTEVTVHCKLSSRQQAFYQAIKNKISLAELFDSNRGqftDKKVLNLMNIVIQLRKVCNHPELF 888
Cdd:pfam00176 229 PKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKTGEGG---REIKASLLNILMRLRKICNHPGLI 289
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
419-892 |
1.95e-84 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 300.18 E-value: 1.95e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 419 RYDKQMAEERKKQEKEAAEAFKREQEQR----ESKRQQQRLNFLIKQTELYSHFMQnktdsnpsealpigdenpidevlp 494
Cdd:PLN03142 59 KREKARLKELKKQKKQEIQKILEQQNAAidadMNNKGKGRLKYLLQQTEIFAHFAK------------------------ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 495 etsaaepseveDPEEAELKEKVLRAAQdavsKQKQITDAFDTEYMKlrqtSEMEGplndisVSGSSNIDLhnpstmpvts 574
Cdd:PLN03142 115 -----------GDQSASAKKAKGRGRH----ASKLTEEEEDEEYLK----EEEDG------LGGSGGTRL---------- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 575 TVQtPELFKGTLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEI 654
Cdd:PLN03142 160 LVQ-PSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRGITGPHMVVAPKSTLGNWMNEI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 655 SRFCPDLKTLPYWGGLQERTILRKNinpkrmYRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWK 734
Cdd:PLN03142 239 RRFCPVLRAVKFHGNPEERAHQREE------LLVAGKFDVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLSK 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 735 TLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHaehggtlNEHQLNRLHAILKPFMLRR 814
Cdd:PLN03142 313 TMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGEND-------QQEVVQQLHKVLRPFLLRR 385
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30694618 815 VKKDVVSELTTKTEVTVHCKLSSRQQAFYQAIKNKislaELFDSNRGqfTDKKvlNLMNIVIQLRKVCNHPELFERNE 892
Cdd:PLN03142 386 LKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQK----DLDVVNAG--GERK--RLLNIAMQLRKCCNHPYLFQGAE 455
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
586-768 |
1.97e-81 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 265.20 E-value: 1.97e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLP 665
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGLQERTILRKNINPKRmyrrdagFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCRNRL 745
Cdd:cd17919 81 YHGSQRERAQIRAKEKLDK-------FDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRL 153
|
170 180
....*....|....*....|...
gi 30694618 746 LLTGTPIQNNMAELWALLHFIMP 768
Cdd:cd17919 154 LLTGTPLQNNLEELWALLDFLDP 176
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
583-816 |
8.04e-81 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 265.34 E-value: 8.04e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 583 KGTLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLK 662
Cdd:cd17997 1 GGTMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHYKNINGPHLIIVPKSTLDNWMREFKRWCPSLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 663 TLPYWGGLQER-TILRKNINPKRmyrrdagFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNC 741
Cdd:cd17997 81 VVVLIGDKEERaDIIRDVLLPGK-------FDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNS 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30694618 742 RNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSkgienhAEHGGTLNEHQLNRLHAILKPFMLRRVK 816
Cdd:cd17997 154 RNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFN------VNNCDDDNQEVVQRLHKVLRPFLLRRIK 222
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
584-816 |
3.04e-78 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 258.07 E-value: 3.04e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 584 GTLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKT 663
Cdd:cd17996 2 GTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 664 LPYWGGLQERTILRKNInpkrmyrRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNC-R 742
Cdd:cd17996 82 IVYKGTPDVRKKLQSQI-------RAGKFNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTYYHaR 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30694618 743 NRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHAE-HGGTLNEHQ----LNRLHAILKPFMLRRVK 816
Cdd:cd17996 155 YRLLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANTGEqVKIELNEEEtlliIRRLHKVLRPFLLRRLK 233
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
582-816 |
1.22e-75 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 250.18 E-value: 1.22e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 582 FKGTLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIwGPFLVVAPASVLNNWADEISRFCPDL 661
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRK-GPSLVVAPTSLIYNWEEEAAKFAPEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 662 KTLPYWGglqertilrknINPKRMYRRDAGFH-ILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFN 740
Cdd:cd18012 80 KVLVIHG-----------TKRKREKLRALEDYdLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALK 148
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30694618 741 CRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHAehggtlNEHQLNRLHAILKPFMLRRVK 816
Cdd:cd18012 149 ADHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDG------DEEALEELKKLISPFILRRLK 218
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
585-814 |
3.28e-70 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 234.56 E-value: 3.28e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 585 TLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTL 664
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 665 PYWGGLQERTILRK----NINPKRMyrrdaGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFN 740
Cdd:cd17993 81 VYLGDIKSRDTIREyefyFSQTKKL-----KFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFK 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30694618 741 CRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGienhaehggtlNEHQLNRLHAILKPFMLRR 814
Cdd:cd17993 156 TNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEEHDEE-----------QEKGIADLHKELEPFILRR 218
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
586-814 |
9.86e-70 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 233.29 E-value: 9.86e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCpDLKTLP 665
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGIRGPFLVIAPLSTIPNWQREFETWT-DMNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGLQERTILRK---------NINPKRMYRrdagFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTL 736
Cdd:cd17995 80 YHGSGESRQIIQQyemyfkdaqGRKKKGVYK----FDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGL 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30694618 737 LSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEwfskgienhaEHGGTLNEHQLNRLHAILKPFMLRR 814
Cdd:cd17995 156 KKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLE----------EFGDLKTAEQVEKLQALLKPYMLRR 223
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
586-814 |
3.19e-69 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 231.56 E-value: 3.19e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLP 665
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGLQERTILRKNInpkrmyRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCRNRL 745
Cdd:cd18006 81 YMGDKEKRLDLQQDI------KSTNRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRL 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30694618 746 LLTGTPIQNNMAELWALLHFIMPMLF--DNHDQFNEWFSKgIENHAEhggTLNEhqlnrLHAILKPFMLRR 814
Cdd:cd18006 155 LLTGTPIQNSLQELYALLSFIEPNVFpkDKLDDFIKAYSE-TDDESE---TVEE-----LHLLLQPFLLRR 216
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
586-771 |
2.44e-65 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 219.56 E-value: 2.44e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLaEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLP 665
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYL-KEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGLQERTILRKNINPKRMyrrdaGFHILITSYQLLVT---DEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCR 742
Cdd:cd17998 80 YYGSQEERKHLRYDILKGLE-----DFDVIVTTYNLATSnpdDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINAN 154
|
170 180
....*....|....*....|....*....
gi 30694618 743 NRLLLTGTPIQNNMAELWALLHFIMPMLF 771
Cdd:cd17998 155 FRLLLTGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
1198-1330 |
4.48e-64 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 213.49 E-value: 4.48e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1198 PAKLLTD-SGKLQTLDILLKRLRAGNHRVLLFAQMTKMLNILEDYMNYRKYKYLRLDGSSTIMDRRDMVRDFQHRSDIFV 1276
Cdd:cd18793 2 PPKIEEVvSGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRV 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 30694618 1277 FLLSTRAGGLGINLTAADTVIFYESDWNPTLDLQAMDRAHRLGQTKDVTVYRLI 1330
Cdd:cd18793 82 FLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
586-814 |
7.44e-59 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 202.93 E-value: 7.44e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLP 665
Cdd:cd18054 21 LRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLLVVPLSTLTSWQREFEIWAPEINVVV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGLQERTILRK----NINPKRMyrrdaGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNC 741
Cdd:cd18054 101 YIGDLMSRNTIREyewiHSQTKRL-----KFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKS 175
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30694618 742 RNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHAEhggtlnehqlnRLHAILKPFMLRR 814
Cdd:cd18054 176 NHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENGYQ-----------SLHKVLEPFLLRR 237
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
584-826 |
7.55e-59 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 202.97 E-value: 7.55e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 584 GTLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKT 663
Cdd:cd18064 14 GKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 664 LPYWGGLQERTILRKNInpkrmyRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCRN 743
Cdd:cd18064 94 VCLIGDKDQRAAFVRDV------LLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 744 RLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFskgienhaEHGGTLNEHQL-NRLHAILKPFMLRRVKKDVVSE 822
Cdd:cd18064 168 RLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWF--------DTNNCLGDQKLvERLHMVLRPFLLRRIKADVEKS 239
|
....
gi 30694618 823 LTTK 826
Cdd:cd18064 240 LPPK 243
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
577-816 |
8.04e-59 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 202.55 E-value: 8.04e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 577 QTPELFKG-TLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEIS 655
Cdd:cd18065 6 ESPSYVKGgTLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 656 RFCPDLKTLPYWGGLQER-TILRKNINPKRmyrrdagFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWK 734
Cdd:cd18065 86 RWVPSLRAVCLIGDKDARaAFIRDVMMPGE-------WDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 735 TLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFskgienhaEHGGTLNEHQL-NRLHAILKPFMLR 813
Cdd:cd18065 159 IVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWF--------DTKNCLGDQKLvERLHAVLKPFLLR 230
|
...
gi 30694618 814 RVK 816
Cdd:cd18065 231 RIK 233
|
|
| DBINO |
pfam13892 |
DNA-binding domain; DBINO is a DNA-binding domain found on global transcription activator ... |
345-476 |
8.08e-59 |
|
DNA-binding domain; DBINO is a DNA-binding domain found on global transcription activator SNF2L1 proteins and chromatin re-modelling proteins.
Pssm-ID: 464024 [Multi-domain] Cd Length: 134 Bit Score: 198.53 E-value: 8.08e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 345 DKIRKAWINIVRRDIAKHHRIFTTFHRKLSIDAKRFADGCQREVRMKVGRSYKIPRTAPIRTRKISRDMLLFWKRYDKQM 424
Cdd:pfam13892 3 EKRRKIWKNIAKKDIPKVYRAKQQNHQARLANCKKVAQLCAREARRKASRTQKTMKDPQLRAKRLMREMLLFWKKNEKEE 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 30694618 425 AEERKKQEKEAAEAFKREQEQRESKRQQQRLNFLIKQTELYSHFMQNKTDSN 476
Cdd:pfam13892 83 RELRKRAEKEALEQAKKEEELREAKRQQRKLNFLITQTELYSHFMGKKLKTD 134
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
577-816 |
9.78e-55 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 191.43 E-value: 9.78e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 577 QTPELFKGTLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISR 656
Cdd:cd18063 15 QSSLLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDK 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 657 FCPDLKTLPYWGglqeRTILRKNINPKrmyRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTL 736
Cdd:cd18063 95 WAPSVVKISYKG----TPAMRRSLVPQ---LRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 737 LS-FNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHAEHgGTLNEHQ----LNRLHAILKPFM 811
Cdd:cd18063 168 NThYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGER-VDLNEEEtiliIRRLHKVLRPFL 246
|
....*
gi 30694618 812 LRRVK 816
Cdd:cd18063 247 LRRLK 251
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
577-816 |
1.56e-54 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 191.03 E-value: 1.56e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 577 QTPELFKGTLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISR 656
Cdd:cd18062 15 QSSLLVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWVYEFDK 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 657 FCPDLKTLPYWGGLQERTILRKNInpkrmyrRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTL 736
Cdd:cd18062 95 WAPSVVKVSYKGSPAARRAFVPQL-------RSGKFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQVL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 737 LS-FNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHAEHgGTLNEHQ----LNRLHAILKPFM 811
Cdd:cd18062 168 NThYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEK-VDLNEEEtiliIRRLHKVLRPFL 246
|
....*
gi 30694618 812 LRRVK 816
Cdd:cd18062 247 LRRLK 251
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
586-814 |
2.44e-53 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 186.79 E-value: 2.44e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLA----HLAEEKNIWG-PFLVVAPASVLNNWADEISRFCPD 660
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILAsdhhKRANSFNSENlPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 661 --LKTLPYWGGLQERTILRKNINPKRmyrrdagfhILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLS 738
Cdd:cd17999 81 afLKPLAYVGPPQERRRLREQGEKHN---------VIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 739 FNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGI--------ENHAEHGGTLnehQLNRLHAILKPF 810
Cdd:cd17999 152 LKANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPIlasrdskaSAKEQEAGAL---ALEALHKQVLPF 228
|
....
gi 30694618 811 MLRR 814
Cdd:cd17999 229 LLRR 232
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
1201-1459 |
3.41e-53 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 204.26 E-value: 3.41e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1201 LLTDSGKLQTLDILLKRLRAGNHRVLLFAQMTKMLNILEDYMNYRKYKYLRLDGSSTIMDRRDMVRDFQHR-SDIFVFLL 1279
Cdd:PLN03142 466 LVENSGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPgSEKFVFLL 545
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1280 STRAGGLGINLTAADTVIFYESDWNPTLDLQAMDRAHRLGQTKDVTVYRLICKETVEEKILHRASQKNTVQQLVMTGGH- 1358
Cdd:PLN03142 546 STRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRl 625
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1359 -----VQGDDFL-----GAADVVS---LLMDDAEAAQLEQKFRELPLQVKDRQKKKT-KRIRIDAEGDATLEELEDVDRQ 1424
Cdd:PLN03142 626 aeqktVNKDELLqmvryGAEMVFSskdSTITDEDIDRIIAKGEEATAELDAKMKKFTeDAIKFKMDDTAELYDFDDEDDK 705
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 30694618 1425 DNGQEPLEE------PEKPKSSNKKR-----------RAASNPKARAPQKAK 1459
Cdd:PLN03142 706 DENKLDFKKivsdnwIDPPKRERKRNyseseyfkqamRQGAPAKPKEPRIPR 757
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
1178-1346 |
2.08e-52 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 197.37 E-value: 2.08e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1178 PALQLtHRIFGSCPPMQSFDPAKLLTDSGKLQTLDILLKRLRAGNHRVLLFAQMTKMLNILEDYMNYRKYKYLRLDGSST 1257
Cdd:COG0553 506 AALTR-LRQICSHPALLLEEGAELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTS 584
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1258 IMDRRDMVRDFQHRSDIFVFLLSTRAGGLGINLTAADTVIFYESDWNPTLDLQAMDRAHRLGQTKDVTVYRLICKETVEE 1337
Cdd:COG0553 585 AEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEE 664
|
....*....
gi 30694618 1338 KILHRASQK 1346
Cdd:COG0553 665 KILELLEEK 673
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
586-814 |
2.36e-51 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 181.40 E-value: 2.36e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLP 665
Cdd:cd18053 21 LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWAPQMNAVV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGLQERTILRKN--INPKRmyrRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCRN 743
Cdd:cd18053 101 YLGDINSRNMIRTHewMHPQT---KRLKFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNH 177
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30694618 744 RLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGienhaehggtlNEHQLNRLHAILKPFMLRR 814
Cdd:cd18053 178 RLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKG-----------REYGYASLHKELEPFLLRR 237
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
586-814 |
7.83e-51 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 178.02 E-value: 7.83e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLP 665
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YwgglqertilrkninpkrmyrrdAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCRNRL 745
Cdd:cd17994 81 Y-----------------------VGDHVLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKL 137
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30694618 746 LLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKgienhaehggTLNEHQLNRLHAILKPFMLRR 814
Cdd:cd17994 138 LLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFAD----------ISKEDQIKKLHDLLGPHMLRR 196
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
586-814 |
8.42e-47 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 167.88 E-value: 8.42e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLP 665
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGLQERTILRKN---------INPKRMY--RRDA--GFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIR 732
Cdd:cd18055 81 YTGDKDSRAIIRENefsfddnavKGGKKAFkmKREAqvKFHVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 733 WKTLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKgienhaehggTLNEHQLNRLHAILKPFML 812
Cdd:cd18055 161 FRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFAD----------ISKEDQIKKLHDLLGPHML 230
|
..
gi 30694618 813 RR 814
Cdd:cd18055 231 RR 232
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
586-814 |
1.08e-46 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 167.55 E-value: 1.08e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIwGPFLVVAPASVLNNWADEISRFCPDLKTLP 665
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLI-KSVLVVMPTSLIPHWVKEFAKWTPGLRVKV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGlqERTILRKNINpkRMYRrdaGFHILITSYQLLVTDEKYF-----RRVKWQYMVLDEAQAIKSSSSIRWKTLLSFN 740
Cdd:cd18001 80 FHGT--SKKERERNLE--RIQR---GGGVLLTTYGMVLSNTEQLsaddhDEFKWDYVILDEGHKIKNSKTKSAKSLREIP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 741 CRNRLLLTGTPIQNNMAELWALLHFIMP-MLFDNHDQFNEWFSKGIENHAEHGGTLNEHQLNR-----LHAILKPFMLRR 814
Cdd:cd18001 153 AKNRIILTGTPIQNNLKELWALFDFACNgSLLGTRKTFKMEFENPITRGRDKDATQGEKALGSevaenLRQIIKPYFLRR 232
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
586-814 |
1.92e-46 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 167.56 E-value: 1.92e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHL-------AEEKNI-------------WGPFLVVAPAS 645
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVlgktgtrRDRENNrprfkkkppassaKKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 646 VLNNWADEISRFcPDLKTLPYWGGLQERtilrkninpKRMYRRDAG-FHILITSYQLLVTDEKYFRRVKWQYMVLDEAQA 724
Cdd:cd18005 81 VLYNWKDELDTW-GHFEVGVYHGSRKDD---------ELEGRLKAGrLEVVVTTYDTLRRCIDSLNSINWSAVIADEAHR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 725 IKSSSSIRWKTLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHAEHGGTLNEHQLNR-- 802
Cdd:cd18005 151 IKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRkr 230
|
250
....*....|....*
gi 30694618 803 ---LHAILKPFMLRR 814
Cdd:cd18005 231 kqeLAVKLSKFFLRR 245
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
586-814 |
3.32e-46 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 166.39 E-value: 3.32e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLP 665
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGLQERTILRKN---------INPKRMYRRDA----GFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIR 732
Cdd:cd18057 81 YTGDKESRSVIRENefsfednaiRSGKKVFRMKKeaqiKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 733 WKTLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKgienhaehggTLNEHQLNRLHAILKPFML 812
Cdd:cd18057 161 FRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFAD----------ISKEDQIKKLHDLLGPHML 230
|
..
gi 30694618 813 RR 814
Cdd:cd18057 231 RR 232
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
586-768 |
1.45e-45 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 162.88 E-value: 1.45e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLP 665
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YW----GGLQERTILRKNINPKRMYRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIK---SSSSIRWKtllS 738
Cdd:cd18000 81 LHssgsGTGSEEKLGSIERKSQLIRKVVGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRnpdAEITLACK---Q 157
|
170 180 190
....*....|....*....|....*....|
gi 30694618 739 FNCRNRLLLTGTPIQNNMAELWALLHFIMP 768
Cdd:cd18000 158 LRTPHRLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
586-814 |
1.63e-45 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 164.47 E-value: 1.63e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLP 665
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGLQERTILRKN------------INPKRMYRR-DAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIR 732
Cdd:cd18056 81 YVGDKDSRAIIRENefsfednairggKKASRMKKEaSVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 733 WKTLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKgienhaehggTLNEHQLNRLHAILKPFML 812
Cdd:cd18056 161 FRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFAD----------IAKEDQIKKLHDMLGPHML 230
|
..
gi 30694618 813 RR 814
Cdd:cd18056 231 RR 232
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
586-814 |
5.51e-44 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 160.15 E-value: 5.51e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCyeqGlnGILADEMGLGKTIQAMAF-LAHLAEEKNI----------------WGPFLVVAPASVLN 648
Cdd:cd18008 1 LLPYQKQGLAWMLPR---G--GILADEMGLGKTIQALALiLATRPQDPKIpeeleenssdpkklylSKTTLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 649 NWADEISRFC--PDLKTLPYWGGlqertilRKNINPKRMYRRDagfhILITSYQLLVTDEKYF----------------R 710
Cdd:cd18008 76 QWKDEIEKHTkpGSLKVYVYHGS-------KRIKSIEELSDYD----IVITTYGTLASEFPKNkkgggrdskekeasplH 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 711 RVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHae 790
Cdd:cd18008 145 RIRWYRVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFSKN-- 222
|
250 260
....*....|....*....|....
gi 30694618 791 hggtlNEHQLNRLHAILKPFMLRR 814
Cdd:cd18008 223 -----DRKALERLQALLKPILLRR 241
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
586-814 |
5.09e-43 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 156.75 E-value: 5.09e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEeKNIWGPFLVVAPASVLNNWADEISRFCpDLKTLP 665
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYN-VGIHGPFLVIAPLSTITNWEREFNTWT-EMNTIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGLQERTILRKninpKRMYRRDAGFHI---------LITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTL 736
Cdd:cd18060 79 YHGSLASRQMIQQ----YEMYCKDSRGRLipgaykfdaLITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSL 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30694618 737 LSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFskgienhaehGGTLNEHQLNRLHAILKPFMLRR 814
Cdd:cd18060 155 KHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDF----------GDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
586-814 |
1.06e-42 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 155.97 E-value: 1.06e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEeKNIWGPFLVVAPASVLNNWADEIsRFCPDLKTLP 665
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFL-MGIRGPFLIIAPLSTITNWEREF-RTWTEMNAIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGlqerTILRKNINPKRMYRRDA---------GFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTL 736
Cdd:cd18058 79 YHGS----QISRQMIQQYEMYYRDEqgnplsgifKFQVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGL 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30694618 737 LSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEwfskgienhaEHGGTLNEHQLNRLHAILKPFMLRR 814
Cdd:cd18058 155 KLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLE----------EFGDLKTEEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
586-814 |
1.05e-40 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 150.18 E-value: 1.05e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEeKNIWGPFLVVAPASVLNNWADEIsRFCPDLKTLP 665
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYL-KGIHGPFLVIAPLSTIPNWEREF-RTWTELNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGLQERtilrKNINPKRMYRRDA---------GFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTL 736
Cdd:cd18059 79 YHGSQASR----RTIQLYEMYFKDPqgrvikgsyKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGL 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30694618 737 LSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEwfskgienhaEHGGTLNEHQLNRLHAILKPFMLRR 814
Cdd:cd18059 155 KMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQ----------EFGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
586-814 |
3.32e-40 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 149.36 E-value: 3.32e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCY--EQGLNG---ILADEMGLGKTIQAMAFLAHLAEEKNIWGP----FLVVAPASVLNNWADEISR 656
Cdd:cd18004 1 LRPHQREGVQFLYDCLtgRRGYGGggaILADEMGLGKTLQAIALVWTLLKQGPYGKPtakkALIVCPSSLVGNWKAEFDK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 657 FCPDLKTLPYwgGLQERTILRKNINPKRMYRRDagFHILITSYQLLVT-DEKYFRRVKWQYMVLDEAQAIKSSSSIRWKT 735
Cdd:cd18004 81 WLGLRRIKVV--TADGNAKDVKASLDFFSSAST--YPVLIISYETLRRhAEKLSKKISIDLLICDEGHRLKNSESKTTKA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 736 LLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHAEHGGTLNEHQLNRLHA-----ILKPF 810
Cdd:cd18004 157 LNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSqelseLTSRF 236
|
....
gi 30694618 811 MLRR 814
Cdd:cd18004 237 ILRR 240
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
586-814 |
9.82e-38 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 141.68 E-value: 9.82e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEeKNIWGPFLVVAPASVLNNWADEIsRFCPDLKTLP 665
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILL-TGIRGPFLIIAPLSTIANWEREF-RTWTDLNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 YWGGLQERTILRKninpKRMYRRDAG---------FHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTL 736
Cdd:cd18061 79 YHGSLISRQMIQQ----YEMYFRDSQgriirgayrFQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGL 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30694618 737 LSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEwfskgienhaEHGGTLNEHQLNRLHAILKPFMLRR 814
Cdd:cd18061 155 KLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQ----------EFGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
586-814 |
9.33e-36 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 135.41 E-value: 9.33e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVncyEQGLNGILADEMGLGKTIQAMAFLAHLAEEkniWgPFLVVAPASVLNNWADEISRFCPDLKTLP 665
Cdd:cd18010 1 LLPFQREGVCFAL---RRGGRVLIADEMGLGKTVQAIAIAAYYREE---W-PLLIVCPSSLRLTWADEIERWLPSLPPDD 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 666 ywgglqertILRknINPKRMYRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSF--NCRN 743
Cdd:cd18010 74 ---------IQV--IVKSKDGLRDGDAKVVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLlkRAKR 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 744 RLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNE-----------WFSKGIENHAEhggtlnehqlnrLHAIL-KPFM 811
Cdd:cd18010 143 VILLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRrycaakqggfgWDYSGSSNLEE------------LHLLLlATIM 210
|
...
gi 30694618 812 LRR 814
Cdd:cd18010 211 IRR 213
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
586-787 |
3.85e-33 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 128.95 E-value: 3.85e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWL-VNCYEQGLNG------ILADEMGLGKTIQAMAFL-AHLAEEKNIWGPfLVVAPASVLNNWADEISRF 657
Cdd:cd18007 1 LKPHQVEGVRFLwSNLVGTDVGSdegggcILAHTMGLGKTLQVITFLhTYLAAAPRRSRP-LVLCPASTLYNWEDEFKKW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 658 CPDlKTLPYWGGLQERTILRKNINPKRMYR--RDAGfhILITSYQLLV-------TDEKYFRRV-KWQYM------VLDE 721
Cdd:cd18007 80 LPP-DLRPLLVLVSLSASKRADARLRKINKwhKEGG--VLLIGYELFRnlasnatTDPRLKQEFiAALLDpgpdllVLDE 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30694618 722 AQAIKSSSSIRWKTLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIEN 787
Cdd:cd18007 157 GHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEA 222
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
578-775 |
2.39e-30 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 119.52 E-value: 2.39e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 578 TPELFKGTLKEYQMKGLQWLVNCYEqglNGILADEMGLGKTIQAMAFLAHLAEEKNiWGPFLVVAPASVL-NNWADEISR 656
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLR---DVILAAPTGSGKTLAALLPALEALKRGK-GGRVLVLVPTRELaEQWAEELKK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 657 FCPD--LKTLPYWGGLQERTILRKNINPKrmyrrdagFHILITSYQLLVTD--EKYFRRVKWQYMVLDEAQAIKSSSSIR 732
Cdd:smart00487 77 LGPSlgLKVVGLYGGDSKREQLRKLESGK--------TDILVTTPGRLLDLleNDKLSLSNVDLVILDEAHRLLDGGFGD 148
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 30694618 733 -WKTLLSF--NCRNRLLLTGTP---IQNNMAELWALLHFIMPMLFDNHD 775
Cdd:smart00487 149 qLEKLLKLlpKNVQLLLLSATPpeeIENLLELFLNDPVFIDVGFTPLEP 197
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
586-814 |
1.82e-29 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 118.34 E-value: 1.82e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCYE----QGLNG-ILADEMGLGKTIQAMAFLAHLAEEKNIWGPFL----VVAPASVLNNWADEISR 656
Cdd:cd18067 1 LRPHQREGVKFLYRCVTgrriRGSHGcIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIdkaiVVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 657 FC-PDLKTLPYWGGlQERTILRKNINPKRMYRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKT 735
Cdd:cd18067 81 WLgGRLQPLAIDGG-SKKEIDRKLVQWASQQGRRVSTPVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTYQA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 736 LLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGI-----ENHAEHGGTLNEHQLNRLHAILKPF 810
Cdd:cd18067 160 LDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPIlkgrdADASEKERQLGEEKLQELISIVNRC 239
|
....
gi 30694618 811 MLRR 814
Cdd:cd18067 240 IIRR 243
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
602-814 |
4.69e-27 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 111.41 E-value: 4.69e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 602 EQGLNGILADEMGLGKTIQAMAFLAHlaeekniwGPFLVVAPASVLNNWADEISRFCPD--LKTLPYWGGlqertilRKN 679
Cdd:cd18071 46 ELVRGGILADDMGLGKTLTTISLILA--------NFTLIVCPLSVLSNWETQFEEHVKPgqLKVYTYHGG-------ERN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 680 INPKRMYRRDagfhILITSYQLLVTDEKY-----FRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCRNRLLLTGTPIQN 754
Cdd:cd18071 111 RDPKLLSKYD----IVLTTYNTLASDFGAkgdspLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQN 186
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 755 NMAELWALLHFIMPMLFDNhdqfNEWFSKGIENHAEHGgtlNEHQLNRLHAILKPFMLRR 814
Cdd:cd18071 187 SPKDLGSLLSFLHLKPFSN----PEYWRRLIQRPLTMG---DPTGLKRLQVLMKQITLRR 239
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
1206-1319 |
2.00e-25 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 102.29 E-value: 2.00e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1206 GKLQTLDILLKRLRagNHRVLLFAQMTKMLNIlEDYMNYRKYKYLRLDGSSTIMDRRDMVRDFqhRSDIFVFLLSTRAGG 1285
Cdd:pfam00271 1 EKLEALLELLKKER--GGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDF--RKGKIDVLVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 30694618 1286 LGINLTAADTVIFYESDWNPTLDLQAMDRAHRLG 1319
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
608-814 |
1.60e-24 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 103.14 E-value: 1.60e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 608 ILADEMGLGKTIQA-MAFLAHLAEekNIWGPFLVVAPASVLNNWADEISRFCPDLKTLPYWGGLqeRTILRKNINPKRMy 686
Cdd:cd18011 21 LLADEVGLGKTIEAgLIIKELLLR--GDAKRVLILCPASLVEQWQDELQDKFGLPFLILDRETA--AQLRRLIGNPFEE- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 687 rrdagFHILITSYQLLVTDEKY---FRRVKWQYMVLDEAQAIKSSSSIRWKTLLSF------NCRNRLLLTGTPIQNNMA 757
Cdd:cd18011 96 -----FPIVIVSLDLLKRSEERrglLLSEEWDLVVVDEAHKLRNSGGGKETKRYKLgrllakRARHVLLLTATPHNGKEE 170
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 30694618 758 ELWALLHFIMPmlfdnhDQFNEWFSkgienhaehggtlnEHQLNRLHAILKPFMLRR 814
Cdd:cd18011 171 DFRALLSLLDP------GRFAVLGR--------------FLRLDGLREVLAKVLLRR 207
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
586-813 |
5.70e-24 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 102.81 E-value: 5.70e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNcyeqgLNGILADEMGLGKTIQAMAF-LAH----LAEEKNIW--------------------GPFLV 640
Cdd:cd18070 1 LLPYQRRAVNWMLV-----PGGILADEMGLGKTVEVLALiLLHprpdNDLDAADDdsdemvccpdclvaetpvssKATLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 641 VAPASVLNNWADEISRFCPD-LKTLPYWGglQERTILRKNINPKRMYRRDagfhILITSYQLLvTDEKYFR--------- 710
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPSsLKVLTYQG--VKKDGALASPAPEILAEYD----IVVTTYDVL-RTELHYAeanrsnrrr 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 711 --------------RVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMpmlFDNHDQ 776
Cdd:cd18070 149 rrqkryeappsplvLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLG---VEPFCD 225
|
250 260 270
....*....|....*....|....*....|....*..
gi 30694618 777 FNEWFSKGIENHAEHGGTLnehqlnRLHAILKPFMLR 813
Cdd:cd18070 226 SDWWARVLIRPQGRNKARE------PLAALLKELLWR 256
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
586-814 |
3.26e-23 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 99.92 E-value: 3.26e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNC-----YEQGLNGILADEMGLGKTIQAMAFLAHLAEE-----KNIWGPFLVVAPASVLNNWADEIS 655
Cdd:cd18066 1 LRPHQREGIEFLYECvmgmrVNERFGAILADEMGLGKTLQCISLIWTLLRQgpyggKPVIKRALIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 656 RfcpdlktlpyWGGLQE-RTILRKNINPKRMYRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWK 734
Cdd:cd18066 81 K----------WLGSERiKVFTVDQDHKVEEFIASPLYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 735 TLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHAEHGGTLNEHQLNRLHA-----ILKP 809
Cdd:cd18066 151 ALTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGEARAaeltrLTGL 230
|
....*
gi 30694618 810 FMLRR 814
Cdd:cd18066 231 FILRR 235
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
591-814 |
1.54e-22 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 98.32 E-value: 1.54e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 591 MKGLQWLVNCYEQGlnGILADEMGLGKTIQAMAF----------------------LAHLAEEKNIWGPFLVVAPASVLN 648
Cdd:cd18072 9 LAWLLWRERQKPRG--GILADDMGLGKTLTMIALilaqkntqnrkeeekekaltewESKKDSTLVPSAGTLVVCPASLVH 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 649 NWADEISRFCPD--LKTLPYWGGLQER--TILRKninpkrmyrrdagFHILITSYQLLVTDEKYFR---------RVKWQ 715
Cdd:cd18072 87 QWKNEVESRVASnkLRVCLYHGPNRERigEVLRD-------------YDIVITTYSLVAKEIPTYKeesrssplfRIAWA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 716 YMVLDEAQAIKSSSSIRWKTLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFdnhDQFNEWfSKGIENHAEHGGtl 795
Cdd:cd18072 154 RIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPF---DDLKVW-KKQVDNKSRKGG-- 227
|
250
....*....|....*....
gi 30694618 796 nehqlNRLHAILKPFMLRR 814
Cdd:cd18072 228 -----ERLNILTKSLLLRR 241
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1237-1319 |
7.70e-22 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 90.73 E-value: 7.70e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1237 ILEDYMNYRKYKYLRLDGSSTIMDRRDMVRDFqhRSDIFVFLLSTRAGGLGINLTAADTVIFYESDWNPTLDLQAMDRAH 1316
Cdd:smart00490 2 ELAELLKELGIKVARLHGGLSQEEREEILDKF--NNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAG 79
|
...
gi 30694618 1317 RLG 1319
Cdd:smart00490 80 RAG 82
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
586-787 |
1.84e-18 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 86.02 E-value: 1.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLV-NCYE--------QGLNGILADEMGLGKTIQAMAF----LAHLAEEKniwgpFLVVAPASVLNNWAD 652
Cdd:cd18069 1 LKPHQIGGIRFLYdNIIEslerykgsSGFGCILAHSMGLGKTLQVISFldvlLRHTGAKT-----VLAIVPVNTLQNWLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 653 EISRFCPDLKTLPYWGGLQERTILRKNINPKRMYRRDagfhiLITSYQ-----LLVTDEKYFRRVKWQYMVLDEAQAIKS 727
Cdd:cd18069 76 EFNKWLPPPEALPNVRPRPFKVFILNDEHKTTAARAK-----VIEDWVkdggvLLMGYEMFRLRPGPDVVICDEGHRIKN 150
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 728 SSSIRWKTLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIEN 787
Cdd:cd18069 151 CHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILN 210
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
586-787 |
2.24e-17 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 83.40 E-value: 2.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVNCY---------EQGLNGILADEMGLGKTIQAMAFLaH---LAEEKNIWGPFLVVAPASVLNNWADE 653
Cdd:cd18068 1 LKPHQVDGVQFMWDCCceslkktkkSPGSGCILAHCMGLGKTLQVVTFL-HtvlLCEKLENFSRVLVVCPLNTVLNWLNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 654 ISRFCPDLKTlpyWGGLQERTILRKNINPKRMYR-----RDAGFHIL-ITSYQLLVT--DEKYFRRVKWQYM-------- 717
Cdd:cd18068 80 FEKWQEGLKD---EEKIEVNELATYKRPQERSYKlqrwqEEGGVMIIgYDMYRILAQerNVKSREKLKEIFNkalvdpgp 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30694618 718 ---VLDEAQAIKSSSSIRWKTLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIEN 787
Cdd:cd18068 157 dfvVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQN 229
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
586-766 |
6.35e-15 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 75.46 E-value: 6.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQWLVncyEQGLNGILADeMGLGKTIQAMAFLAHLAEEKNIwGPFLVVAPASVL-NNWADEISRfcpdlktl 664
Cdd:cd18013 1 PHPYQKVAINFII---EHPYCGLFLD-MGLGKTVTTLTALSDLQLDDFT-RRVLVIAPLRVArSTWPDEVEK-------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 665 pyWGGLQERTILRKNINPK-RMYRRDAGFHILITSYQLLV-TDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCR 742
Cdd:cd18013 68 --WNHLRNLTVSVAVGTERqRSKAANTPADLYVINRENLKwLVNKSGDPWPFDMVVIDELSSFKSPRSKRFKALRKVRPV 145
|
170 180
....*....|....*....|....*.
gi 30694618 743 -NRLL-LTGTPIQNNMAELWALLHFI 766
Cdd:cd18013 146 iKRLIgLTGTPSPNGLMDLWAQIALL 171
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
582-751 |
3.95e-10 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 64.28 E-value: 3.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 582 FKGTLKEYQMKGL-QWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIwgpfLVVAPASVLNN-WADEISRFCP 659
Cdd:COG1061 77 TSFELRPYQQEALeALLAALERGGGRGLVVAPTGTGKTVLALALAAELLRGKRV----LVLVPRRELLEqWAEELRRFLG 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 660 DlktlPYWGGLqertilrkninpkrmyRRDAGFHILITSYQLLVTDE--KYFRRvKWQYMVLDEAQAIkSSSSIRwKTLL 737
Cdd:COG1061 153 D----PLAGGG----------------KKDSDAPITVATYQSLARRAhlDELGD-RFGLVIIDEAHHA-GAPSYR-RILE 209
|
170
....*....|....
gi 30694618 738 SFNCRNRLLLTGTP 751
Cdd:COG1061 210 AFPAAYRLGLTATP 223
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
586-751 |
4.92e-08 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 53.46 E-value: 4.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 586 LKEYQMKGLQ-WLVNCYEQGlnGILADEMGLGKTIQAMAFLAHLAEEKniwgpFLVVAP-ASVLNNWADEISRFCPDlKT 663
Cdd:cd17926 1 LRPYQEEALEaWLAHKNNRR--GILVLPTGSGKTLTALALIAYLKELR-----TLIVVPtDALLDQWKERFEDFLGD-SS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 664 LPYWGGlqERTILRKNINpkrmyrrdagfhILITSYQLLVTDEKYFRRVKWQY--MVLDEAQAIkSSSSIRwKTLLSFNC 741
Cdd:cd17926 73 IGLIGG--GKKKDFDDAN------------VVVATYQSLSNLAEEEKDLFDQFglLIVDEAHHL-PAKTFS-EILKELNA 136
|
170
....*....|
gi 30694618 742 RNRLLLTGTP 751
Cdd:cd17926 137 KYRLGLTATP 146
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
606-750 |
4.61e-07 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 50.86 E-value: 4.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 606 NGILADEMGLGKTIQAMAFLAHLAEEKNiwGPFLVVAPASVL-NNWADEI-SRFCPDLKTLPYWGGlqertilrKNINPK 683
Cdd:cd00046 3 NVLITAPTGSGKTLAALLAALLLLLKKG--KKVLVLVPTKALaLQTAERLrELFGPGIRVAVLVGG--------SSAEER 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30694618 684 RMY-RRDAgfHILITSYQLLVTD---EKYFRRVKWQYMVLDEAQAIKSSS--------SIRWktLLSFNCRnRLLLTGT 750
Cdd:cd00046 73 EKNkLGDA--DIIIATPDMLLNLllrEDRLFLKDLKLIIVDEAHALLIDSrgalildlAVRK--AGLKNAQ-VILLSAT 146
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
583-752 |
3.52e-06 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 48.44 E-value: 3.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 583 KGTLKEYQMKGLQWLVNCYEQGLNGILAdEM--GLGKTIQAMAFLAHLAEeKNIWGPFLVVAP-ASVLNNWADEISRFCP 659
Cdd:pfam04851 1 KLELRPYQIEAIENLLESIKNGQKRGLI-VMatGSGKTLTAAKLIARLFK-KGPIKKVLFLVPrKDLLEQALEEFKKFLP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 660 DLKTLPywgglqertilrKNINPKRMYRRDAGFHILITSYQ----LLVTDEKYFRRVKWQYMVLDEAQaikSSSSIRWKT 735
Cdd:pfam04851 79 NYVEIG------------EIISGDKKDESVDDNKIVVTTIQslykALELASLELLPDFFDVIIIDEAH---RSGASSYRN 143
|
170
....*....|....*...
gi 30694618 736 LLSFNCRNRLL-LTGTPI 752
Cdd:pfam04851 144 ILEYFKPAFLLgLTATPE 161
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
1272-1327 |
1.16e-05 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 44.62 E-value: 1.16e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 30694618 1272 SDIFVFLLSTRAGGLGINLTAADTVIFYESDWNPTLDLQAMDRAHRLGQTKDVTVY 1327
Cdd:cd18785 20 ASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVIL 75
|
|
| PRK07735 |
PRK07735 |
NADH-quinone oxidoreductase subunit C; |
1378-1480 |
4.83e-03 |
|
NADH-quinone oxidoreductase subunit C;
Pssm-ID: 236081 [Multi-domain] Cd Length: 430 Bit Score: 41.12 E-value: 4.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 1378 AEAAQLEQKFRELPLQVKDRQKKKTKRiRIDAEGDATLEELEDVDRQDNGQEPLEEPEKPKS-SNKKRRAASNPKARAPQ 1456
Cdd:PRK07735 103 AKAAALAKQKREGTEEVTEEEKAAAKA-KAAAAAKAKAAALAKQKREGTEEVTEEEEETDKEkAKAKAAAAAKAKAAALA 181
|
90 100
....*....|....*....|....
gi 30694618 1457 KAKEEANGEDTPQRTKRVKRQTKS 1480
Cdd:PRK07735 182 KQKAAEAGEGTEEVTEEEKAKAKA 205
|
|
| PRK00247 |
PRK00247 |
putative inner membrane protein translocase component YidC; Validated |
385-506 |
8.05e-03 |
|
putative inner membrane protein translocase component YidC; Validated
Pssm-ID: 178945 [Multi-domain] Cd Length: 429 Bit Score: 40.60 E-value: 8.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694618 385 QREVRMKVGRSYKiprtapiRTRKISRDMLLF--WK--RYDKQMAEERK--KQEKEAAEAFKRE--QEQRESKRQQQRLN 456
Cdd:PRK00247 293 QYREKQKEKKAFL-------WTLRRNRLRMIItpWRapELHAENAEIKKtrTAEKNEAKARKKEiaQKRRAAEREINREA 365
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 30694618 457 FLIKQTELYSHFMQNKTDSNPSEALPIGDENPIDEVLPETSAAEPSEVED 506
Cdd:PRK00247 366 RQERAAAMARARARRAAVKAKKKGLIDASPNEDTPSENEESKGSPPQVEA 415
|
|
| |
