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    Con Connectin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38590, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Conprovided by FlyBase
    Official Full Name
    Connectinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005775
    Locus tag
    Dmel_CG7503
    See related
    AllianceGenome:FB:FBgn0005775
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-64C; CG7503; con; CON; conn; CT1840; Dmel\CG7503; Ubx-t35
    Summary
    Involved in homophilic cell adhesion via plasma membrane adhesion molecules. Located in axonal growth cone; cell surface; and neuromuscular junction. Is expressed in several structures, including SN innervated muscle cell of A1-7; anterior-posterior subdivision of organism; embryonic VNC neuromere; glial cell; and supraesophageal ganglion. Orthologous to human LRG1 (leucine rich alpha-2-glycoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Con in Genome Data Viewer
    Location:
    64C2-64C5; 3-13 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4936758..5079033, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4936758..5079033, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43627 Neighboring gene Rh50 Neighboring gene long non-coding RNA:CR45685 Neighboring gene uncharacterized protein Neighboring gene testis-specific gamma-tubulin ring protein 128 Neighboring gene ATP synthase, coupling factor 6-like Neighboring gene long non-coding RNA:CR43884 Neighboring gene long non-coding RNA:CR46198 Neighboring gene long non-coding RNA:CR34047

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cell adhesion molecule, connectin, and the development of the Drosophila neuromuscular system. Meadows LA, et al. J Cell Sci, 1994 Jan. PMID 8175919
    2. Bacillus thuringiensis toxins divert progenitor cells toward enteroendocrine fate by decreasing cell adhesion with intestinal stem cells in Drosophila. Jneid R, et al. Elife, 2023 Feb 27. PMID 36847614, Free PMC Article
    3. Targets of homeotic gene regulation in Drosophila. White RA, et al. J Cell Sci Suppl, 1992. PMID 1363662
    4. Connectin: a homophilic cell adhesion molecule expressed on a subset of muscles and the motoneurons that innervate them in Drosophila. Nose A, et al. Cell, 1992 Aug 21. PMID 1505024
    5. Semaphorin-1a acts in concert with the cell adhesion molecules fasciclin II and connectin to regulate axon fasciculation in Drosophila. Yu HH, et al. Genetics, 2000 Oct. PMID 11014819, Free PMC Article

    See all (151) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c5043307-5034214 mobile_element_type = transposon:roo{}927

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axonal fasciculation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic target attraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    connectin
    Names
    CG7503-PA
    CG7503-PB
    Con-PA
    Con-PB
    transcript-35

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4936758..5079033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259706.2 → NP_001246635.1  connectin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246635.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G7H845, Q6AWM0
      Conserved Domains (4) summary
      smart00082
      Location:414 → 450
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:225 → 416
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:185 → 208
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:232 → 291
      LRR_8; Leucine rich repeat

    2. NM_079206.5 → NP_523930.3  connectin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523930.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G7H845, Q6AWM0
      Related
      FBpp0073231
      Conserved Domains (4) summary
      smart00082
      Location:414 → 450
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:225 → 416
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:185 → 208
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:232 → 291
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01819.2 Q01819
    Q6AWM0 Q6AWM0

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