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    Pabp2 Pabp2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35788, updated on 17-Dec-2024

    Summary

    Official Symbol
    Pabp2provided by FlyBase
    Official Full Name
    Pabp2provided by FlyBase
    Primary source
    FLYBASE:FBgn0005648
    Locus tag
    Dmel_CG2163
    See related
    AllianceGenome:FB:FBgn0005648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2163; Dmel\CG2163; dpabII; pabp2; pAbp2; PABP2; PABPN1; rox2; Rox2; ROX2
    Summary
    Enables poly(A) binding activity. Involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway and nuclear-transcribed mRNA poly(A) tail shortening. Located in cytosol and nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head; follicle cell; germline cell; and ovary. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to human PABPN1 (poly(A) binding protein nuclear 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Pabp2 in Genome Data Viewer
    Location:
    44B3-44B3; 2-58 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8131431..8134374)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4018936..4021879)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Nucleoporin 50kD Neighboring gene coilin Neighboring gene Suppressor of Cytokine Signaling at 44A Neighboring gene uncharacterized protein Neighboring gene PSEA-binding protein 49kD Neighboring gene Odorant-binding protein 44a Neighboring gene Lipin Neighboring gene kermit Neighboring gene long non-coding RNA:CR44068 Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables RNA binding  
    enables poly(A) binding  
    enables poly(A) binding PubMed 
    enables poly(A) binding PubMed 
    enables protein binding PubMed 

    General protein information

    Preferred Names
    Pabp2
    Names
    CG2163-PA
    CG2163-PB
    Pabp2-PA
    Pabp2-PB
    nuclear poly(A)-binding protein
    poly-A binding protein 2
    polyA-binding protein II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8131431..8134374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057554.4 → NP_476902.1  Pabp2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476902.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7B1, Q27926, Q7JQ60, Q7KNF2
      UniProtKB/TrEMBL
      E2QC83
      Related
      FBpp0087863
      Conserved Domains (2) summary
      COG0724
      Location:43 → 172
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12550
      Location:97 → 172
      RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins
    2. NM_165589.3 → NP_724648.1  Pabp2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724648.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7B1, Q27926, Q7JQ60, Q7KNF2
      UniProtKB/TrEMBL
      E2QC83
      Related
      FBpp0087864
      Conserved Domains (2) summary
      COG0724
      Location:43 → 172
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12550
      Location:97 → 172
      RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins
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