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    CIAPIN1 Cytokine induced apoptosis inhibitor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49424, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CIAPIN1provided by FlyBase
    Official Full Name
    Cytokine induced apoptosis inhibitor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0001977
    Locus tag
    Dmel_CG4180
    See related
    AllianceGenome:FB:FBgn0001977
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-35Ba; B; BG:DS00929.9; br26; CG4180; D-CIAPIN1; D1; Dmel\CG4180; l(2)35Bg; l(2)br26
    Summary
    Predicted to enable iron-sulfur cluster binding activity. Involved in follicle cell of egg chamber development. Predicted to be active in cytoplasm. Orthologous to human CIAPIN1 (cytokine induced apoptosis inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CIAPIN1 in Genome Data Viewer
    Location:
    35B8-35B8; 2-50 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15036293..15038861, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15036293..15038861, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene metabotropic GABA-B receptor subtype 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene yellow-c Neighboring gene Suppressor of Hairless Neighboring gene crinkled

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila CIAPIN1 homologue is required for follicle cell proliferation and survival. Marzuk O, et al. Dev Dyn, 2013 Jun. PMID 23444317
    2. Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates. Schweisguth F, et al. Cell, 1992 Jun 26. PMID 1617730
    3. Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo. Morel V, et al. Genes Dev, 2000 Feb 1. PMID 10673509, Free PMC Article
    4. Topological constraints on transvection between white genes within the transposing element TE35B in Drosophila melanogaster. Gubb D, et al. Genetics, 1997 Jul. PMID 9215897, Free PMC Article
    5. Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals. de Wit E, et al. Genome Res, 2005 Sep. PMID 16109969, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. D-CIAPIN1 is essential for egg chamber development and is required for follicle cell proliferation and survival
      Title: Drosophila CIAPIN1 homologue is required for follicle cell proliferation and survival.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytokine induced apoptosis inhibitor 1
    Names
    CG4180-PA
    CIAPIN1 ortholog
    CIAPIN1-PA
    lethal (2) 35Bg
    lethal 26 in the black-reduced region
    lethal group D1
    transcription unit B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15036293..15038861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080199.3 → NP_524938.1  cytokine induced apoptosis inhibitor 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524938.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3Y2
      Related
      FBpp0080284
      Conserved Domains (1) summary
      pfam05093
      Location:172 → 239
      CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3Y2.1 Q9V3Y2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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