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Conserved domains on  [gi|17933742|ref|NP_524938|]
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cytokine induced apoptosis inhibitor 1 [Drosophila melanogaster]

Protein Classification

CIAPIN1 domain-containing protein( domain architecture ID 10523887)

CIAPIN1 (cytokine-induced apoptosis inhibitor 1) domain-containing protein similar to anamorsin that is a component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins

Gene Ontology:  GO:0051536|GO:0016226|GO:0009055|GO:0046872

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 173-239 6.10e-34

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


:

Pssm-ID: 398662  Cd Length: 99  Bit Score: 117.76  E-value: 6.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17933742   173 STTGKRKACKNCSCGLAEELETEKQSQKA----------------------TENAKSSCGNCYLGDAFRCSTCPYLGMPA 230
Cdd:pfam05093  11 NGKKRRKACKDCTCGLKELEEAEDAAQRAlqdkalgkvkfteddlteidftVQGKTGSCGSCALGDAFRCSGCPYLGLPA 90


                  ....*....
gi 17933742   231 FKPGEKVQL 239
Cdd:pfam05093  91 FKPGEEVTI 99
 
Name Accession Description Interval E-value
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 173-239 6.10e-34

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


Pssm-ID: 398662  Cd Length: 99  Bit Score: 117.76  E-value: 6.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17933742   173 STTGKRKACKNCSCGLAEELETEKQSQKA----------------------TENAKSSCGNCYLGDAFRCSTCPYLGMPA 230
Cdd:pfam05093  11 NGKKRRKACKDCTCGLKELEEAEDAAQRAlqdkalgkvkfteddlteidftVQGKTGSCGSCALGDAFRCSGCPYLGLPA 90


                  ....*....
gi 17933742   231 FKPGEKVQL 239
Cdd:pfam05093  91 FKPGEEVTI 99
COG5636 COG5636
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
173-248 1.18e-24

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 99.07  E-value: 1.18e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17933742 173 STTGKRKACKNCSCGLAEELETEKQSQKATENAK------------------SSCGNCYLGDAFRCSTCPYLGMPAFKPG 234
Cdd:COG5636 187 SKTKKKRACKDCTCGLKEEEENEIVRTRQDKVVKftedelteidftidgkkvSACGNCYLGDAFRCSGCPYLGLPAFEPG 266

                        90
                ....*....|....
gi 17933742 235 EKVQLADNLLKSDI 248
Cdd:COG5636 267 DVVSFSMNLDNEFQ 280
 
Name Accession Description Interval E-value
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 173-239 6.10e-34

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


Pssm-ID: 398662  Cd Length: 99  Bit Score: 117.76  E-value: 6.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17933742   173 STTGKRKACKNCSCGLAEELETEKQSQKA----------------------TENAKSSCGNCYLGDAFRCSTCPYLGMPA 230
Cdd:pfam05093  11 NGKKRRKACKDCTCGLKELEEAEDAAQRAlqdkalgkvkfteddlteidftVQGKTGSCGSCALGDAFRCSGCPYLGLPA 90


                  ....*....
gi 17933742   231 FKPGEKVQL 239
Cdd:pfam05093  91 FKPGEEVTI 99
COG5636 COG5636
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
173-248 1.18e-24

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 99.07  E-value: 1.18e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17933742 173 STTGKRKACKNCSCGLAEELETEKQSQKATENAK------------------SSCGNCYLGDAFRCSTCPYLGMPAFKPG 234
Cdd:COG5636 187 SKTKKKRACKDCTCGLKEEEENEIVRTRQDKVVKftedelteidftidgkkvSACGNCYLGDAFRCSGCPYLGLPAFEPG 266

                        90
                ....*....|....
gi 17933742 235 EKVQLADNLLKSDI 248
Cdd:COG5636 267 DVVSFSMNLDNEFQ 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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