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    Muc18B Mucin 18B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32913, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Muc18Bprovided by FlyBase
    Official Full Name
    Mucin 18Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031000
    Locus tag
    Dmel_CG7876
    See related
    AllianceGenome:FB:FBgn0031000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7876; Dmel\CG7876
    Summary
    Predicted to be an extracellular matrix structural constituent. Predicted to be involved in extracellular matrix organization. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including embryonic/larval gut; embryonic/larval posterior spiracle; embryonic/larval salivary gland; epithelial tube; and gut section. Orthologous to human HCG22 (HLA complex group 22 (non-protein coding)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Muc18B in Genome Data Viewer
    Location:
    18B1-18B1; 1-62 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19215515..19216660)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19109548..19110693)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Mucin related 18B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential splicing of the lectin domain of an O-glycosyltransferase modulates both peptide and glycopeptide preferences. May C, et al. J Biol Chem, 2020 Aug 28. PMID 32669364, Free PMC Article
    2. Molecular evolution under increasing transposable element burden in Drosophila: a speed limit on the evolutionary arms race. Castillo DM, et al. BMC Evol Biol, 2011 Sep 14. PMID 21917173, Free PMC Article
    3. A potential role for Drosophila mucins in development and physiology. Syed ZA, et al. PLoS One, 2008 Aug 22. PMID 18725942, Free PMC Article
    4. Drosophila soluble guanylyl cyclase mutants exhibit increased foraging locomotion: behavioral and genomic investigations. Riedl CA, et al. Behav Genet, 2005 May. PMID 15864439
    5. p120 catenin is required for the stress response in Drosophila. Stefanatos RK, et al. PLoS One, 2013. PMID 24349561, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular matrix structural constituent ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mucin 18B
    Names
    CG7876-PA
    CG7876-PB
    Muc18B-PA
    Muc18B-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19215515..19216660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298502.1 → NP_001285431.1  mucin 18B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285431.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWK2
      Conserved Domains (2) summary
      pfam01607
      Location:26 → 72
      CBM_14; Chitin binding Peritrophin-A domain
      pfam05934
      Location:77 → 177
      MCLC; Mid-1-related chloride channel (MCLC)

    2. NM_133137.3 → NP_573365.1  mucin 18B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573365.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWK2
      Related
      FBpp0074444
      Conserved Domains (2) summary
      pfam01607
      Location:26 → 72
      CBM_14; Chitin binding Peritrophin-A domain
      pfam05934
      Location:77 → 177
      MCLC; Mid-1-related chloride channel (MCLC)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWK2 Q9VWK2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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