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    EMB2773 PHD finger family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831407, updated on 14-Nov-2024

    Summary

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    Official Symbol
    EMB2773
    Official Full Name
    PHD finger family protein
    Primary source
    TAIR:AT5G15540
    Locus tag
    AT5G15540
    See related
    Araport:AT5G15540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA SISTER-CHROMATID COHESION 2; ATSCC2; EMBRYO DEFECTIVE 2773; SCC2; SISTER-CHROMATID COHESION 2; T20K14.150; T20K14_150
    Summary
    Encodes Adherin SCC2. Essential for viability. Required for normal seed development. Plays a role in the establishment of sister-chromatid cohesion and chromosome organization during meiosis.
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    Genomic context

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    See EMB2773 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    28
    Sequence:
    Chromosome: 5; NC_003076.8 (5047515..5057666, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene Transducin/WD40 repeat-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The plant adherin AtSCC2 is required for embryogenesis and sister-chromatid cohesion during meiosis in Arabidopsis. Sebastian J, et al. Plant J, 2009 Jul. PMID 19228337
    2. The Arabidopsis homolog of Scc4/MAU2 is essential for embryogenesis. Minina EA, et al. J Cell Sci, 2017 Mar 15. PMID 28137757
    3. Cohesin gene defects may impair sister chromatid alignment and genome stability in Arabidopsis thaliana. Schubert V, et al. Chromosoma, 2009 Oct. PMID 19533160
    4. Identification of genes required for embryo development in Arabidopsis. Tzafrir I, et al. Plant Physiol, 2004 Jul. PMID 15266054, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtSCC2 is required during meiosis for the establishment of homologous pairing, sister-chromatid cohesion and for the normal distribution of cohesin along chromosomes.
      Title: The plant adherin AtSCC2 is required for embryogenesis and sister-chromatid cohesion during meiosis in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001203388.1
    NM_121558.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within centromere complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    PHD finger family protein
    NP_001190317.1
    • EMBRYO DEFECTIVE 2773 (EMB2773); FUNCTIONS IN: binding, zinc ion binding; INVOLVED IN: centromere complex assembly, sister chromatid cohesion, embryo development ending in seed dormancy, meiotic sister chromatid cohesion; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, PHD-type (InterPro:IPR001965), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Armadillo-type fold (InterPro:IPR016024), Zinc finger, PHD-finger (InterPro:IPR019787).
    NP_197058.2
    • EMBRYO DEFECTIVE 2773 (EMB2773); FUNCTIONS IN: binding, zinc ion binding; INVOLVED IN: centromere complex assembly, sister chromatid cohesion, embryo development ending in seed dormancy, meiotic sister chromatid cohesion; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, RING-type (InterPro:IPR001841), Armadillo-like helical (InterPro:IPR011989), Zinc finger, PHD-type (InterPro:IPR001965), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Armadillo-type fold (InterPro:IPR016024), Zinc finger, PHD-finger (InterPro:IPR019787); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5047515..5057666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121558.4 → NP_197058.2  PHD finger family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197058.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5HEI1, A7UDC4, F4K9U3, Q9LF28
      UniProtKB/TrEMBL
      A0A654G1Q7
      Conserved Domains (4) summary
      pfam00628
      Location:702 → 748
      PHD; PHD-finger
      sd00044
      Location:874 → 902
      HEAT; HEAT repeat [structural motif]
      pfam12765
      Location:895 → 936
      Cohesin_HEAT; HEAT repeat associated with sister chromatid cohesion
      pfam12830
      Location:1389 → 1585
      Nipped-B_C; Sister chromatid cohesion C-terminus

    2. NM_001203388.1 → NP_001190317.1  PHD finger family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190317.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654G1Q7
      Conserved Domains (4) summary
      pfam00628
      Location:700 → 746
      PHD; PHD-finger
      pfam12765
      Location:893 → 934
      Cohesin_HEAT; HEAT repeat associated with sister chromatid cohesion
      pfam12830
      Location:1387 → 1583
      Nipped-B_C; Sister chromatid cohesion C-terminus
      sd00044
      Location:872 → 900
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A5HEI1.1

    Gene LinkOut

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