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    BIO2 Radical SAM superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818937, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BIO2
    Official Full Name
    Radical SAM superfamily protein
    Primary source
    TAIR:AT2G43360
    Locus tag
    AT2G43360
    See related
    Araport:AT2G43360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BIOB; BIOTIN AUXOTROPH 2; BIOTIN AUXOTROPH B; BIOTIN SYNTHASE; T1O24.10
    Summary
    Catalyzes the conversion of dethiobiotin to biotin.
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    Genomic context

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    See BIO2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (18010676..18013252, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene hypothetical protein (DUF1685) Neighboring gene ncRNA Neighboring gene glutathione peroxidase 3 Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis Bio2 protein requires mitochondrial targeting for activity. Arnal N, et al. Plant Mol Biol, 2006 Oct. PMID 16897469
    2. Biotin synthesis in higher plants: isolation of a cDNA encoding Arabidopsis thaliana bioB-gene product equivalent by functional complementation of a biotin auxotroph mutant bioB105 of Escherichia coli K12. Baldet P, et al. C R Acad Sci III, 1996 Feb. PMID 8680961
    3. Characterization of the cDNA and gene coding for the biotin synthase of Arabidopsis thaliana. Weaver LM, et al. Plant Physiol, 1996 Mar. PMID 8819873, Free PMC Article
    4. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article
    5. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129897.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables biotin synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables biotin synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables zinc ion binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in biotin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within biotin biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Radical SAM superfamily protein
    NP_181864.1
    • BIOTIN AUXOTROPH 2 (BIO2); CONTAINS InterPro DOMAIN/s: Biotin/thiamin synthesis-associated protein (InterPro:IPR010722), Aldolase-type TIM barrel (InterPro:IPR013785), Elongator protein 3/MiaB/NifB (InterPro:IPR006638), Radical SAM (InterPro:IPR007197), Biotin synthase (InterPro:IPR002684); Has 5366 Blast hits to 5366 proteins in 2012 species: Archae - 191; Bacteria - 4453; Metazoa - 6; Fungi - 120; Plants - 75; Viruses - 0; Other Eukaryotes - 521 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18010676..18013252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129897.4 → NP_181864.1  Radical SAM superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181864.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54967
      UniProtKB/TrEMBL
      A0A178VTJ8, A0A384KLW7, Q24JJ0, Q84WG4
      Conserved Domains (1) summary
      PLN02389
      Location:1 → 377
      PLN02389; biotin synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54967.1

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