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    LysoPL2 lysophospholipase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841709, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LysoPL2
    Official Full Name
    lysophospholipase 2
    Primary source
    TAIR:AT1G52760
    Locus tag
    AT1G52760
    See related
    Araport:AT1G52760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Caffeoyl Shikimate Esterase; CSE; F14G24.3; F14G24_3; lysophospholipase 2
    Summary
    Encodes a lysophospholipase 2 (LysoPL2). Involved in tolerance to cadmium-induced oxidative stress. Binds Acyl-CoA-binding protein 2 (ACBP2).
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    Genomic context

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    See LysoPL2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (19651172..19652825)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene histone H2A protein 9 Neighboring gene Phototropic-responsive NPH3 family protein Neighboring gene PII, uridylyltransferase (DUF2921)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caffeoyl shikimate esterase (CSE) is an enzyme in the lignin biosynthetic pathway in Arabidopsis. Vanholme R, et al. Science, 2013 Sep 6. PMID 23950498
    2. Thermodynamic insights into an interaction between ACYL-CoA-BINDING PROTEIN2 and LYSOPHOSPHOLIPASE2 in Arabidopsis. Miao R, et al. J Biol Chem, 2019 Apr 19. PMID 30782848, Free PMC Article
    3. A bifunctional enzyme that has both monoacylglycerol acyltransferase and acyl hydrolase activities. Vijayaraj P, et al. Plant Physiol, 2012 Oct. PMID 22915575, Free PMC Article
    4. Acyl-CoA-binding protein 2 binds lysophospholipase 2 and lysoPC to promote tolerance to cadmium-induced oxidative stress in transgenic Arabidopsis. Gao W, et al. Plant J, 2010 Jun 1. PMID 20345607
    5. Protein interactors of acyl-CoA-binding protein ACBP2 mediate cadmium tolerance in Arabidopsis. Gao W, et al. Plant Signal Behav, 2010 Aug. PMID 20657176, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that AtACBP270-354 probably binds to lysoPC through a hydrophobic interface that enhances a hydrotropic interaction of AtACBP270-354 with AtLYSOPL2 and thereby facilitates AtLYSOPL2's lysophospholipase function.
      Title: Thermodynamic insights into an interaction between ACYL-CoA-BINDING PROTEIN2 and LYSOPHOSPHOLIPASE2 in Arabidopsis.
    2. Caffeoyl shikimate esterase (CSE) is an enzyme central to the lignin biosynthetic pathway that, together with 4-coumarate:CoA ligase (4CL), bypasses the second HCT reaction. [CSE]
      Title: Caffeoyl shikimate esterase (CSE) is an enzyme in the lignin biosynthetic pathway in Arabidopsis.
    3. ACBP2 can mediate tolerance to Cd(II)-induced oxidative stress by interacting with two protein partners, AtFP6 and lysoPL2.
      Title: Protein interactors of acyl-CoA-binding protein ACBP2 mediate cadmium tolerance in Arabidopsis.
    4. ACBP2 can bind lysoPL2 to promote the degradation of lysophosphatidylcholine in response to Cd-induced oxidative stress.
      Title: Acyl-CoA-binding protein 2 binds lysophospholipase 2 and lysoPC to promote tolerance to cadmium-induced oxidative stress in transgenic Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_104154.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 2-acylglycerol O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables caffeoyl-CoA: alcohol caffeoyl transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophospholipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    lysophospholipase 2
    NP_175685.1
    • lysophospholipase 2 (LysoPL2); BEST Arabidopsis thaliana protein match is: alpha/beta-Hydrolases superfamily protein (TAIR:AT1G11090.1); Has 2373 Blast hits to 2373 proteins in 808 species: Archae - 32; Bacteria - 1418; Metazoa - 106; Fungi - 99; Plants - 433; Viruses - 39; Other Eukaryotes - 246 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19651172..19652825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104154.4 → NP_175685.1  lysophospholipase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175685.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C942
      UniProtKB/TrEMBL
      A0A5S9WP41, A0A654ETM6
      Conserved Domains (1) summary
      cl21494
      Location:21 → 325
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C942.1

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