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    SK2 shikimate kinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830108, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SK2
    Official Full Name
    shikimate kinase 2
    Primary source
    TAIR:AT4G39540
    Locus tag
    AT4G39540
    See related
    Araport:AT4G39540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSK2; F23K16.170; F23K16_170; shikimate kinase 2
    Summary
    Encodes a shikimate kinase. Its transcripts appear to be expressed in vegetative tissues and developing embryos. SK2 transcript levels rise in response to Phytophthora infestans spores. SK2 is believed to be localized to the chloroplast.
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    Genomic context

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    See SK2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    11
    Sequence:
    Chromosome: 4; NC_003075.7 (18378225..18380417)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene GTP-binding protein-like protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene Galactose oxidase/kelch repeat superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and biochemical investigation of two Arabidopsis shikimate kinases: the heat-inducible isoform is thermostable. Fucile G, et al. Protein Sci, 2011 Jul. PMID 21520319, Free PMC Article
    2. The in-vitro synthesized tomato shikimate kinase precursor is enzymatically active and is imported and processed to the mature enzyme by chloroplasts. Schmid J, et al. Plant J, 1992 May. PMID 1338949
    3. Evolutionary diversification of plant shikimate kinase gene duplicates. Fucile G, et al. PLoS Genet, 2008 Dec. PMID 19057671, Free PMC Article
    4. Differential binding of calmodulin-related proteins to their targets revealed through high-density Arabidopsis protein microarrays. Popescu SC, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360592, Free PMC Article
    5. MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays. Popescu SC, et al. Genes Dev, 2009 Jan 1. PMID 19095804, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001204040.1
    NM_120114.2
    NM_202986.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables shikimate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within aromatic amino acid family biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in chorismate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within shikimate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in shikimate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    shikimate kinase 2
    NP_001190969.1
    • shikimate kinase 2 (SK2); FUNCTIONS IN: shikimate kinase activity, ATP binding; INVOLVED IN: aromatic amino acid family biosynthetic process; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Shikimate kinase (InterPro:IPR000623); BEST Arabidopsis thaliana protein match is: shikimate kinase 1 (TAIR:AT2G21940.5).
    NP_195664.2
    • shikimate kinase 2 (SK2); FUNCTIONS IN: shikimate kinase activity, ATP binding; INVOLVED IN: aromatic amino acid family biosynthetic process; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Shikimate kinase (InterPro:IPR000623); BEST Arabidopsis thaliana protein match is: shikimate kinase 1 (TAIR:AT2G21940.5); Has 7816 Blast hits to 7816 proteins in 2412 species: Archae - 26; Bacteria - 5492; Metazoa - 45; Fungi - 121; Plants - 162; Viruses - 0; Other Eukaryotes - 1970 (source: NCBI BLink).
    NP_974715.1
    • shikimate kinase 2 (SK2); FUNCTIONS IN: shikimate kinase activity, ATP binding; INVOLVED IN: aromatic amino acid family biosynthetic process; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Shikimate kinase (InterPro:IPR000623); BEST Arabidopsis thaliana protein match is: shikimate kinase 1 (TAIR:AT2G21940.5); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      18378225..18380417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001204040.1 → NP_001190969.1  shikimate kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190969.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JW33
      Conserved Domains (2) summary
      PLN02199
      Location:1 → 307
      PLN02199; shikimate kinase
      cd00464
      Location:107 → 271
      SK; Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis ...

    2. NM_202986.2 → NP_974715.1  shikimate kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974715.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GY88, Q9SVA4
      UniProtKB/TrEMBL
      A0A178UTT0, A0A5S9Y0D0
      Conserved Domains (1) summary
      PLN02199
      Location:1 → 299
      PLN02199; shikimate kinase

    3. NM_120114.2 → NP_195664.2  shikimate kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195664.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GY88, Q9SVA4
      UniProtKB/TrEMBL
      A0A178UTT0, A0A5S9Y0D0
      Conserved Domains (1) summary
      PLN02199
      Location:1 → 299
      PLN02199; shikimate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GY88.1

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