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    OASC O-acetylserine (thiol) lyase isoform C [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825145, updated on 18-Sep-2024

    Summary

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    Official Symbol
    OASC
    Official Full Name
    O-acetylserine (thiol) lyase isoform C
    Primary source
    TAIR:AT3G59760
    Locus tag
    AT3G59760
    See related
    Araport:AT3G59760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA CYSTEINSYNTHASE-C; ATCS-C; CSASE C; O-acetylserine (thiol) lyase isoform C
    Summary
    Arabidopsis thaliana O-acetylserine (thiol) lyase (OAS-TL) isoform oasC. Required for pollen tube growth and/or fertilization.
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    Genomic context

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    See OASC in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (22071948..22075453, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Concanavalin A-like lectin protein kinase family protein Neighboring gene Concanavalin A-like lectin protein kinase family protein Neighboring gene ncRNA Neighboring gene sacI homology domain-containing protein / WW domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial sulfide detoxification requires a functional isoform O-acetylserine(thiol)lyase C in Arabidopsis thaliana. Álvarez C, et al. Mol Plant, 2012 Nov. PMID 22511607
    2. The cysteine synthase complex from plants. Mitochondrial serine acetyltransferase from Arabidopsis thaliana carries a bifunctional domain for catalysis and protein-protein interaction. Wirtz M, et al. Eur J Biochem, 2001 Feb. PMID 11168407
    3. Allosterically gated enzyme dynamics in the cysteine synthase complex regulate cysteine biosynthesis in Arabidopsis thaliana. Feldman-Salit A, et al. Structure, 2012 Feb 8. PMID 22325778
    4. Use of biomolecular interaction analysis to elucidate the regulatory mechanism of the cysteine synthase complex from Arabidopsis thaliana. Berkowitz O, et al. J Biol Chem, 2002 Aug 23. PMID 12063244
    5. Successful fertilization requires the presence of at least one major O-acetylserine(thiol)lyase for cysteine synthesis in pollen of Arabidopsis. Birke H, et al. Plant Physiol, 2013 Oct. PMID 24001608, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the significance of OAS-C is related to its role in the proper sulfide and cyanide detoxification in mitochondria
      Title: Mitochondrial sulfide detoxification requires a functional isoform O-acetylserine(thiol)lyase C in Arabidopsis thaliana.
    2. We describe the crystal structure of OAS-TLC from A. thaliana mitochondria and compare it with our previously modeled structure.
      Title: Allosterically gated enzyme dynamics in the cysteine synthase complex regulate cysteine biosynthesis in Arabidopsis thaliana.
    3. Null alleles of oastlA or oastlB alone showed that cytosolic OAS-TL A and plastid OAS-TL B were completely dispensable, although together they contributed 95% of total OAS-TL activity. oastlC plants also showed retarded growth.
      Title: Analysis of the Arabidopsis O-acetylserine(thiol)lyase gene family demonstrates compartment-specific differences in the regulation of cysteine synthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_115838.6
    NM_180691.1
    NM_180692.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables cysteine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cysteine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within double fertilization forming a zygote and endosperm IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    O-acetylserine (thiol) lyase isoform C
    NP_191535.2
    • O-acetylserine (thiol) lyase isoform C (OASC); FUNCTIONS IN: protein binding, cysteine synthase activity, zinc ion binding, ATP binding; INVOLVED IN: cysteine biosynthetic process, pollen tube development; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase B (TAIR:AT2G43750.2); Has 22643 Blast hits to 22626 proteins in 2678 species: Archae - 432; Bacteria - 15847; Metazoa - 414; Fungi - 670; Plants - 570; Viruses - 2; Other Eukaryotes - 4708 (source: NCBI BLink).
    NP_851022.1
    • O-acetylserine (thiol) lyase isoform C (OASC); FUNCTIONS IN: protein binding, cysteine synthase activity, zinc ion binding, ATP binding; INVOLVED IN: cysteine biosynthetic process, pollen tube development; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase B (TAIR:AT2G43750.2); Has 22520 Blast hits to 22503 proteins in 2668 species: Archae - 432; Bacteria - 15729; Metazoa - 413; Fungi - 668; Plants - 568; Viruses - 2; Other Eukaryotes - 4708 (source: NCBI BLink).
    NP_851023.1
    • O-acetylserine (thiol) lyase isoform C (OASC); FUNCTIONS IN: protein binding, cysteine synthase activity, zinc ion binding, ATP binding; INVOLVED IN: cysteine biosynthetic process, pollen tube development; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase B (TAIR:AT2G43750.2); Has 22651 Blast hits to 22634 proteins in 2657 species: Archae - 442; Bacteria - 15920; Metazoa - 415; Fungi - 665; Plants - 567; Viruses - 2; Other Eukaryotes - 4640 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      22071948..22075453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180691.1 → NP_851022.1  O-acetylserine (thiol) lyase isoform C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851022.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V9N8, A0A5S9XMB0, B9DFR6
      Conserved Domains (2) summary
      PLN02565
      Location:113 → 426
      PLN02565; cysteine synthase
      PLN03013
      Location:1 → 429
      PLN03013; cysteine synthase

    2. NM_115838.6 → NP_191535.2  O-acetylserine (thiol) lyase isoform C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191535.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q43725, Q8L4A2, Q9M1Z8, Q9M440
      UniProtKB/TrEMBL
      A0A178V9N8, A0A5S9XMB0, Q0WWQ5
      Conserved Domains (1) summary
      PLN03013
      Location:1 → 430
      PLN03013; cysteine synthase

    3. NM_180692.1 → NP_851023.1  O-acetylserine (thiol) lyase isoform C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851023.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V9N8, A0A5S9XMB0, F4J9F7
      Conserved Domains (2) summary
      PLN03013
      Location:1 → 418
      PLN03013; cysteine synthase
      pfam00291
      Location:117 → 379
      PALP; Pyridoxal-phosphate dependent enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q43725.3

    Gene LinkOut

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