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    relb v-rel avian reticuloendotheliosis viral oncogene homolog B [ Danio rerio (zebrafish) ]

    Gene ID: 795414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    relbprovided by ZNC
    Official Full Name
    v-rel avian reticuloendotheliosis viral oncogene homolog Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9531
    See related
    Ensembl:ENSDARG00000086173 AllianceGenome:ZFIN:ZDB-GENE-030131-9531
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj85b02; wu:fj85b02
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including innate immune response; intracellular signaling cassette; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in cytoplasm and nucleus. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in breast cancer and immunodeficiency 53. Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See relb in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (17100570..17125223)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (17164141..17188133)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene CLPTM1 regulator of GABA type A receptor forward trafficking Neighboring gene v-mos Moloney murine sarcoma viral oncogene homolog Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene transfer RNA opal suppressor (anticodon UCA)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Myocardial NF-κB activation is essential for zebrafish heart regeneration. Karra R, et al. Proc Natl Acad Sci U S A, 2015 Oct 27. PMID 26472034, Free PMC Article
    2. Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress. Zimmer TS, et al. Brain Pathol, 2021 Sep. PMID 33786950, Free PMC Article
    3. Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish. Marín-Juez R, et al. J Endocrinol, 2014 Aug. PMID 24904114
    4. mitfa deficiency promotes immune vigor and potentiates antitumor effects in zebrafish. Bian WP, et al. Fish Shellfish Immunol, 2023 Nov. PMID 37777099
    5. Deletion of mstna and mstnb impairs the immune system and affects growth performance in zebrafish. Wang C, et al. Fish Shellfish Immunol, 2018 Jan. PMID 29175471

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelium development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor RelB
    Names
    v-rel reticuloendotheliosis viral oncogene homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      17100570..17125223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213693.1 → XP_068069794.1  transcription factor RelB isoform X2

      UniProtKB/TrEMBL
      A0A8M9PC94

    2. XM_021466348.2 → XP_021322023.1  transcription factor RelB isoform X1

      UniProtKB/TrEMBL
      A0A8M9P750, A0A8M9PC94
      Related
      ENSDARP00000128656.1, ENSDART00000154418.3
      Conserved Domains (2) summary
      cl08275
      Location:134 → 306
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
      pfam16179
      Location:314 → 410
      RHD_dimer; Rel homology dimerisation domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394943.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      217441..242094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068218791.1 → XP_068074892.1  transcription factor RelB isoform X2

      UniProtKB/TrEMBL
      A0A8M9PC94

    2. XM_021472925.2 → XP_021328600.1  transcription factor RelB isoform X1

      UniProtKB/TrEMBL
      A0A8M9P750, A0A8M9PC94
      Conserved Domains (2) summary
      cl08275
      Location:134 → 306
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
      pfam16179
      Location:314 → 410
      RHD_dimer; Rel homology dimerisation domain

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395321.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      64602..87570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001335557.6 → XP_001335593.3  transcription factor RelB isoform X1

      UniProtKB/TrEMBL
      A0A8M1Q745, A0A8M9PC94
      Conserved Domains (2) summary
      cl08275
      Location:134 → 306
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
      pfam16179
      Location:314 → 410
      RHD_dimer; Rel homology dimerisation domain
    Nucleotide Protein Strain
    Heading Accession and Version

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