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    kpnb3 karyopherin (importin) beta 3 [ Danio rerio (zebrafish) ]

    Gene ID: 569455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kpnb3provided by ZNC
    Official Full Name
    karyopherin (importin) beta 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030424-2
    See related
    Ensembl:ENSDARG00000040245 AllianceGenome:ZFIN:ZDB-GENE-030424-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb273; fc38a10; wu:fc38a10
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and ventral mesoderm. Orthologous to several human genes including IPO5 (importin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kpnb3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (2260414..2299553)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (2112653..2151759)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene RAP2A, member of RAS oncogene family b Neighboring gene uncharacterized LOC137495389 Neighboring gene small nucleolar RNA SNORA84 Neighboring gene si:ch211-235f1.3 Neighboring gene FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) Neighboring gene gamma-glutamylamine cyclotransferase, tandem duplicate 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    importin-5
    Names
    importin 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145604.1 → NP_001139076.1  importin-5

      Status: PROVISIONAL

      Source sequence(s)
      CR352215, CR847928
      UniProtKB/TrEMBL
      A0A8N7UZ95
      Conserved Domains (3) summary
      pfam13513
      Location:368 → 422
      HEAT_EZ; HEAT-like repeat
      pfam13646
      Location:355 → 463
      HEAT_2; HEAT repeats
      sd00044
      Location:319 → 341
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      2260414..2299553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009305394.3 → XP_009303669.1  importin-5 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AWW3, B8JHR9
      Related
      ENSDARP00000058875.7, ENSDART00000058876.9
      Conserved Domains (3) summary
      pfam13513
      Location:368 → 422
      HEAT_EZ; HEAT-like repeat
      pfam13646
      Location:355 → 463
      HEAT_2; HEAT repeats
      sd00044
      Location:319 → 341
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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