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    ift81 intraflagellar transport 81 homolog [ Danio rerio (zebrafish) ]

    Gene ID: 432390, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ift81provided by ZNC
    Official Full Name
    intraflagellar transport 81 homologprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040714-3
    See related
    Ensembl:ENSDARG00000007444 AllianceGenome:ZFIN:ZDB-GENE-040714-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cdv1
    Summary
    Predicted to enable tubulin binding activity. Acts upstream of or within pronephros development and regulation of TOR signaling. Predicted to be located in cilium. Predicted to be part of intraciliary transport particle B. Predicted to be active in ciliary basal body. Is expressed in notochord; otic vesicle; pronephric duct; and ventricular system. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 19 with or without polydactyly. Orthologous to human IFT81 (intraflagellar transport 81). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ift81 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (11642070..11681060)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (11604365..11643355)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene piercer of microtubule wall 1 Neighboring gene microRNA 126a Neighboring gene formin binding protein 1a Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a Neighboring gene anaphase promoting complex subunit 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of Ift74 Leads to Slow Photoreceptor Degeneration and Ciliogenesis Defects in Zebrafish. Zhu P, et al. Int J Mol Sci, 2021 Aug 28. PMID 34502236, Free PMC Article
    2. Zebrafish Tsc1 reveals functional interactions between the cilium and the TOR pathway. DiBella LM, et al. Hum Mol Genet, 2009 Feb 15. PMID 19008302, Free PMC Article
    3. A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Sun Z, et al. Development, 2004 Aug. PMID 15269167
    4. Heat-induced masculinization in domesticated zebrafish is family-specific and yields a set of different gonadal transcriptomes. Ribas L, et al. Proc Natl Acad Sci U S A, 2017 Feb 7. PMID 28115725, Free PMC Article
    5. Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Shim H, et al. Nucleic Acids Res, 2016 Nov 16. PMID 27903883, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intraciliary transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pronephros development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    intraflagellar transport protein 81 homolog
    Names
    carnitine deficiency-associated gene expressed in ventricle 1
    larry

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002313.1 → NP_001002313.1  intraflagellar transport protein 81 homolog

      See identical proteins and their annotated locations for NP_001002313.1

      Status: PROVISIONAL

      Source sequence(s)
      AY618922
      UniProtKB/TrEMBL
      Q6IVW2
      Related
      ENSDARP00000015953.7, ENSDART00000004288.8
      Conserved Domains (2) summary
      COG1196
      Location:169 → 437
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:306 → 610
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      11642070..11681060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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