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    Camta2 calmodulin binding transcription activator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287462, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Camta2provided by RGD
    Official Full Name
    calmodulin binding transcription activator 2provided by RGD
    Primary source
    RGD:1311296
    See related
    EnsemblRapid:ENSRNOG00000004283 AllianceGenome:RGD:1311296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including DNA binding activity; histone deacetylase binding activity; and transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cardiac muscle hypertrophy in response to stress and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Orthologous to human CAMTA2 (calmodulin binding transcription activator 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 80.4), Kidney (RPKM 64.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Camta2 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55882071..55900575, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55383450..55401838, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57291192..57309638, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene profilin 1 Neighboring gene enolase 3 Neighboring gene sperm associated antigen 7 Neighboring gene inhibitor of CDK, cyclin A1 interacting protein 1 Neighboring gene small nucleolar RNA U3 Neighboring gene kinesin family member 1C Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor. Long C, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049392, Free PMC Article
    2. The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases. Song K, et al. Cell, 2006 May 5. PMID 16678093
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin-binding transcription activator 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105801.2 → NP_001099271.2  calmodulin-binding transcription activator 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6GE51
      Related
      ENSRNOP00000086530.1, ENSRNOT00000109888.2
      Conserved Domains (5) summary
      smart01076
      Location:34 → 150
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00204
      Location:712 → 810
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01833
      Location:535 → 615
      TIG; IPT/TIG domain
      pfam13637
      Location:712 → 776
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:711 → 754
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55882071..55900575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597100.3 → XP_017452589.1  calmodulin-binding transcription activator 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GE51, D3ZLG1
      Related
      ENSRNOP00000053461.4, ENSRNOT00000056622.5

    2. XM_039085484.2 → XP_038941412.1  calmodulin-binding transcription activator 2 isoform X2

      UniProtKB/TrEMBL
      A6HG91
      Related
      ENSRNOP00000086676.2, ENSRNOT00000116547.2
      Conserved Domains (5) summary
      PTZ00322
      Location:767 → 906
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      smart01076
      Location:57 → 173
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      sd00045
      Location:734 → 777
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:558 → 638
      TIG; IPT/TIG domain
      pfam12796
      Location:739 → 831
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_039085486.2 → XP_038941414.1  calmodulin-binding transcription activator 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZPC9
      Conserved Domains (5) summary
      PTZ00322
      Location:767 → 906
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      smart01076
      Location:57 → 173
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      sd00045
      Location:734 → 777
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:558 → 638
      TIG; IPT/TIG domain
      pfam12796
      Location:739 → 831
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_039085487.1 → XP_038941415.1  calmodulin-binding transcription activator 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GE51
      Conserved Domains (5) summary
      PTZ00322
      Location:743 → 882
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:710 → 753
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:534 → 614
      TIG; IPT/TIG domain
      pfam12796
      Location:715 → 807
      Ank_2; Ankyrin repeats (3 copies)
      cl04295
      Location:57 → 149
      CG-1; CG-1 domain

    5. XM_039085483.1 → XP_038941411.1  calmodulin-binding transcription activator 2 isoform X1

      UniProtKB/TrEMBL
      A6HG91
      Conserved Domains (5) summary
      PTZ00322
      Location:772 → 911
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      smart01076
      Location:57 → 178
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      sd00045
      Location:739 → 782
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:563 → 643
      TIG; IPT/TIG domain
      pfam12796
      Location:744 → 836
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_063268663.1 → XP_063124733.1  calmodulin-binding transcription activator 2 isoform X7

    7. XM_063268662.1 → XP_063124732.1  calmodulin-binding transcription activator 2 isoform X3

      Related
      ENSRNOP00000080026.2, ENSRNOT00000095887.2
    Nucleotide Protein Strain
    Heading Accession and Version

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