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    Rab18 Rab18 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44360, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab18provided by FlyBase
    Official Full Name
    Rab18provided by FlyBase
    Primary source
    FLYBASE:FBgn0015794
    Locus tag
    Dmel_CG3129
    See related
    AllianceGenome:FB:FBgn0015794
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    24639915; AAF46057; CG3129; Dmel\CG3129; DmRab18; DRABR4; DRabRP4; O18337; Rab-r4; Rab-RP4; rab18; Rab18/RP4
    Summary
    Predicted to enable GTPase activity. Involved in macroautophagy. Located in Golgi apparatus; endoplasmic reticulum; and vacuole. Is expressed in several structures, including adult ensheathing glial cell; brain; imaginal disc; mushroom body; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in Warburg micro syndrome 3. Orthologous to human RAB18 (RAB18, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Rab18 in Genome Data Viewer
    Location:
    5A11-5A11; 1-12 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5670827..5671812, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5564860..5565845, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45520 Neighboring gene Sirtuin 4 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L35 Neighboring gene Trapped in endoderm 1

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction  
    involved_in intracellular protein transport  
    involved_in lipid droplet organization  
    involved_in macroautophagy PubMed 
    involved_in vesicle-mediated transport  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi apparatus PubMed 
    located_in autolysosome PubMed 
    located_in autophagosome PubMed 
    located_in early endosome PubMed 
    is_active_in endomembrane system  
    located_in endoplasmic reticulum PubMed 
    located_in neuronal cell body PubMed 
    located_in vesicle  

    General protein information

    Preferred Names
    Rab18
    Names
    CG3129-PA
    Rab18-PA
    rab-related protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5670827..5671812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080005.4 → NP_524744.2  Rab18 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524744.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18337, Q9W4A0
      Related
      FBpp0070814
      Conserved Domains (2) summary
      smart00175
      Location:6 → 166
      RAB; Rab subfamily of small GTPases
      cd01863
      Location:6 → 165
      Rab18; Rab GTPase family 18 (Rab18)
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