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    Dph4 Diphthamide biosynthesis 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40686, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Dph4provided by FlyBase
    Official Full Name
    Diphthamide biosynthesis 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0037350
    Locus tag
    Dmel_CG2911
    See related
    AllianceGenome:FB:FBgn0037350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2911; Dmel\CG2911
    Summary
    Predicted to enable ATPase activator activity. Orthologous to human DNAJC24 (DnaJ heat shock protein family (Hsp40) member C24). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dph4 in Genome Data Viewer
    Location:
    83B6-83B6; 3-47.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5622119..5624125, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1447841..1449847, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Antisense transcript of Rga Neighboring gene Regena Neighboring gene stable intronic sequence RNA 1 Neighboring gene antisense RNA:CR46135 Neighboring gene Another transcription unit Neighboring gene Spec2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein L13A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates. Deo A, et al. Sci Rep, 2024 Sep 6. PMID 39242711, Free PMC Article
    2. Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion. Cinà DP, et al. Am J Physiol Renal Physiol, 2019 Dec 1. PMID 31566424, Free PMC Article
    3. Release of promoter-proximal paused Pol II in response to histone deacetylase inhibition. Vaid R, et al. Nucleic Acids Res, 2020 May 21. PMID 32297950, Free PMC Article
    4. Signalling crosstalk at the leading edge controls tissue closure dynamics in the Drosophila embryo. Rousset R, et al. PLoS Genet, 2017 Feb. PMID 28231245, Free PMC Article
    5. RNAi-Mediated Reverse Genetic Screen Identified Drosophila Chaperones Regulating Eye and Neuromuscular Junction Morphology. Raut S, et al. G3 (Bethesda), 2017 Jul 5. PMID 28500055, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    diphthamide biosynthesis 4
    Names
    CG2911-PA
    CG2911-PB
    Dph4-PA
    Dph4-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5622119..5624125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104219.2 → NP_001097689.1  diphthamide biosynthesis 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097689.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XYG4, Q9VNE8
      Conserved Domains (2) summary
      pfam00226
      Location:3 → 72
      DnaJ; DnaJ domain
      pfam05207
      Location:135 → 179
      zf-CSL; CSL zinc finger

    2. NM_141302.3 → NP_649559.1  diphthamide biosynthesis 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649559.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XYG4, Q9VNE8
      Related
      FBpp0078389
      Conserved Domains (2) summary
      pfam00226
      Location:3 → 72
      DnaJ; DnaJ domain
      pfam05207
      Location:135 → 179
      zf-CSL; CSL zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2XYG4 Q2XYG4
    Q9VNE8 Q9VNE8

    Gene LinkOut

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