ix intersex [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ixprovided by FlyBase
Official Full Name: intersexprovided by FlyBase
Primary source: FLYBASE:FBgn0001276
Locus tag: Dmel_CG13201
See related: AllianceGenome:FB:FBgn0001276
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13201; Dmel\CG13201; IX; Med29; MED29
Summary: Enables DNA-binding transcription factor binding activity and transcription coregulator activity. Involved in genital disc development; regulation of transcription by RNA polymerase II; and sex determination. Part of mediator complex. Orthologous to human MED29 (mediator complex subunit 29). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (11359437..11360163, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7246942..7247668, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

function in male sex determination
Title: Genetic analysis of an intersex allele (ix5) that regulates sexual phenotype of both female and male Drosophila melanogaster.
IX and DSX(F) function in a complex, in which IX acts as a transcriptional co-factor for the DNA-binding DSX(F).
Title: intersex, a gene required for female sexual development in Drosophila, is expressed in both sexes and functions together with doublesex to regulate terminal differentiation.
The functional conservation and divergence of ix, a gene required for female differentiation, was studied.
Title: Functional conservation and divergence of intersex, a gene required for female differentiation in Drosophila melanogaster.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in female somatic sex determination	TAS Traceable Author Statement more info	PubMed
involved_in genital disc sexually dimorphic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived female genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex differentiation	TAS Traceable Author Statement more info	PubMed
involved_in somatic sex determination	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	IEA Inferred from Electronic Annotation more info
part_of mediator complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed