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Conserved domains on  [gi|24652720|ref|NP_610677|]
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intersex [Drosophila melanogaster]

Protein Classification

Med29 domain-containing protein( domain architecture ID 10569012)

Med29 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med29 pfam11568
Mediator complex subunit 29; Mediator is a large complex of up to 33 proteins that is ...
 49-185 1.11e-69

Mediator complex subunit 29; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med29, along with Med11 and Med28, in mammals, is part of the core head-region of the complex. Med29 is the apparent orthologue of the Drosophila melanogaster Intersex protein, which interacts directly with, and functions as a transcriptional coactivator for, the DNA-binding transcription factor Doublesex, so it is likely that mammalian Med29 serves as a target for one or more DNA-binding transcriptional activators.


:

Pssm-ID: 431937  Cd Length: 138  Bit Score: 207.92  E-value: 1.11e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652720    49 KLDNISRVKSLLGPLRESMFLTIRSSAFALQQNNLADNLKRDTGAHHVPRFDKHLEDFYACCDQIEIHLKTAMQCLQQQN 128
Cdd:pfam11568   1 KLDPISKVKNLVPPLRESLVNLMKTAAQLLHQNSEVDNGLKKGDDSPVPRFDKSLEEFYSICDQIELHLKTAMECLSQLS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 24652720   129 SSNHYLPGPVTPMRMETFM-PDNAGPISYPTYLNTVRVHIQSAKDIHDTLISAAQNIS 185
Cdd:pfam11568  81 SSQRYLPGPVMPNRKEPFVdTQEIVQLSYPQYLNTVRSQIEYAKEIHDTLLDCAQKIS 138
 
Name Accession Description Interval E-value
Med29 pfam11568
Mediator complex subunit 29; Mediator is a large complex of up to 33 proteins that is ...
 49-185 1.11e-69

Mediator complex subunit 29; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med29, along with Med11 and Med28, in mammals, is part of the core head-region of the complex. Med29 is the apparent orthologue of the Drosophila melanogaster Intersex protein, which interacts directly with, and functions as a transcriptional coactivator for, the DNA-binding transcription factor Doublesex, so it is likely that mammalian Med29 serves as a target for one or more DNA-binding transcriptional activators.


Pssm-ID: 431937  Cd Length: 138  Bit Score: 207.92  E-value: 1.11e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652720    49 KLDNISRVKSLLGPLRESMFLTIRSSAFALQQNNLADNLKRDTGAHHVPRFDKHLEDFYACCDQIEIHLKTAMQCLQQQN 128
Cdd:pfam11568   1 KLDPISKVKNLVPPLRESLVNLMKTAAQLLHQNSEVDNGLKKGDDSPVPRFDKSLEEFYSICDQIELHLKTAMECLSQLS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 24652720   129 SSNHYLPGPVTPMRMETFM-PDNAGPISYPTYLNTVRVHIQSAKDIHDTLISAAQNIS 185
Cdd:pfam11568  81 SSQRYLPGPVMPNRKEPFVdTQEIVQLSYPQYLNTVRSQIEYAKEIHDTLLDCAQKIS 138
 
Name Accession Description Interval E-value
Med29 pfam11568
Mediator complex subunit 29; Mediator is a large complex of up to 33 proteins that is ...
 49-185 1.11e-69

Mediator complex subunit 29; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med29, along with Med11 and Med28, in mammals, is part of the core head-region of the complex. Med29 is the apparent orthologue of the Drosophila melanogaster Intersex protein, which interacts directly with, and functions as a transcriptional coactivator for, the DNA-binding transcription factor Doublesex, so it is likely that mammalian Med29 serves as a target for one or more DNA-binding transcriptional activators.


Pssm-ID: 431937  Cd Length: 138  Bit Score: 207.92  E-value: 1.11e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652720    49 KLDNISRVKSLLGPLRESMFLTIRSSAFALQQNNLADNLKRDTGAHHVPRFDKHLEDFYACCDQIEIHLKTAMQCLQQQN 128
Cdd:pfam11568   1 KLDPISKVKNLVPPLRESLVNLMKTAAQLLHQNSEVDNGLKKGDDSPVPRFDKSLEEFYSICDQIELHLKTAMECLSQLS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 24652720   129 SSNHYLPGPVTPMRMETFM-PDNAGPISYPTYLNTVRVHIQSAKDIHDTLISAAQNIS 185
Cdd:pfam11568  81 SSQRYLPGPVMPNRKEPFVdTQEIVQLSYPQYLNTVRSQIEYAKEIHDTLLDCAQKIS 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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