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    Pvf2 PDGF- and VEGF-related factor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33994, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Pvf2provided by FlyBase
    Official Full Name
    PDGF- and VEGF-related factor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031888
    Locus tag
    Dmel_CG13780
    See related
    AllianceGenome:FB:FBgn0031888
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13780; Dmel\CG13780; DmVEGF-2; PV2; Pvf; PVF; pvf2; PVF2; PVFs; VEGF; VEGF-2; Vegf27Cb; VEGF27Cb
    Summary
    Enables chemoattractant activity. Involved in several processes, including hemocyte migration; hemocyte proliferation; and positive regulation of cell size. Acts upstream of with a positive effect on neuron remodeling. Is active in extracellular space. Is expressed in several structures, including Malpighian tubule; Malpighian tubule primordium; cardiogenic mesoderm; gut section; and intestinal stem cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pvf2 in Genome Data Viewer
    Location:
    27E1-27E1; 2-25 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7069536..7084635, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7069536..7084635, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Menin 1 Neighboring gene Male specific transcript 27D Neighboring gene UDP-glycosyltransferase family 307 member A1 Neighboring gene Suppressor of exocyst mutations 1 Neighboring gene Nuf2 Neighboring gene long non-coding RNA:CR44611 Neighboring gene long non-coding RNA:CR46196 Neighboring gene PDGF- and VEGF-related factor 3 Neighboring gene long non-coding RNA:CR44612

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila model for microbiome research. Douglas AE. Lab Anim (NY), 2018 Jun. PMID 29795158, Free PMC Article
    2. Macrophage self-renewal is regulated by transient expression of PDGF- and VEGF-related factor 2. Bakopoulos D, et al. FEBS J, 2022 Jul. PMID 35066977
    3. Walking the walk: migration and other common themes in blood and vascular development. Traver D, et al. Cell, 2002 Mar 22. PMID 11955426
    4. A deregulated intestinal cell cycle program disrupts tissue homeostasis without affecting longevity in Drosophila. Petkau K, et al. J Biol Chem, 2014 Oct 10. PMID 25170078, Free PMC Article
    5. The Drosophila VEGF receptor homolog is expressed in hemocytes. Heino TI, et al. Mech Dev, 2001 Nov. PMID 11677054

    See all (147) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Macrophage self-renewal is regulated by transient expression of PDGF- and VEGF-related factor 2.
      Title: Macrophage self-renewal is regulated by transient expression of PDGF- and VEGF-related factor 2.
    2. Data show that Pvf2 and Pvf3 are not required for the directed migration of hemocytes, but act locally in epithelial cells to coordinate trans-epithelial migration of hemocytes.
      Title: The Drosophila platelet-derived growth factor and vascular endothelial growth factor-receptor related (Pvr) protein ligands Pvf2 and Pvf3 control hemocyte viability and invasive migration.
    3. An age-related increase in the expression of PVF2, a Drosophila homologue of human PDGF/VEGF, which was associated with and required for the age-related changes in midgut ISCs and progenitor cell populations.
      Title: Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chemoattractant activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vascular endothelial growth factor receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glial cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in hemocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hemocyte migration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in hemocyte migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in hemocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lymph gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of humoral immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell size IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PDGF- and VEGF-related factor 2
    Names
    CG13780-PA
    PDGF- and VEGF-receptor related factor 2
    Pvf2-PA
    VEGF-related factor 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7069536..7084635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078775.3 → NP_523499.2  PDGF- and VEGF-related factor 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523499.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95PU5, Q9VM43
      Related
      FBpp0079051
      Conserved Domains (1) summary
      cl00116
      Location:204 → 280
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VM43 Q9VM43

    Gene LinkOut

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