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Conserved domains on  [gi|24582443|ref|NP_523499|]
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PDGF- and VEGF-related factor 2 [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF super family cl00116
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 204-281 3.61e-09

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


The actual alignment was detected with superfamily member cd00135:

Pssm-ID: 444701  Cd Length: 86  Bit Score: 53.14  E-value: 3.61e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582443 204 CRvPRPEVVHITRE----TNTFYSPRATILHRCSdkvGCCN-AGWTCQMKRNETVD---RVFDKVDGRSNEPIVISMENH 275
Cdd:cd00135   3 CK-PRETLVEISEElpdeTNTIFKPPCVEVKRCG---GCCNdESLECVPTETSNVTmqvLKISPKRKPRSKLVEISFEEH 78


                ....*.
gi 24582443 276 TECGCV 281
Cdd:cd00135  79 TECECR 84
 
Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 204-281 3.61e-09

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 53.14  E-value: 3.61e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582443 204 CRvPRPEVVHITRE----TNTFYSPRATILHRCSdkvGCCN-AGWTCQMKRNETVD---RVFDKVDGRSNEPIVISMENH 275
Cdd:cd00135   3 CK-PRETLVEISEElpdeTNTIFKPPCVEVKRCG---GCCNdESLECVPTETSNVTmqvLKISPKRKPRSKLVEISFEEH 78


                ....*.
gi 24582443 276 TECGCV 281
Cdd:cd00135  79 TECECR 84
PDGF pfam00341
PDGF/VEGF domain;
204-280 3.64e-08

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 50.36  E-value: 3.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582443   204 CRvPRPEVVHITRE----TNTFYSPRATILHRCSdkvGCCNA-GWTCQ----MKRNETVDRVFDKVDGRSNEPIVISMEN 274
Cdd:pfam00341   1 CK-PRETLVEIRRElpdeTNAFFKPSCVEVQRCS---GCCNDeGLECVptetHNVTMQVLKIEYAPRRPSPELVEVSFEE 76


                  ....*.
gi 24582443   275 HTECGC 280
Cdd:pfam00341  77 HVQCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 204-280 1.06e-07

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 48.96  E-value: 1.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582443    204 CRvPRPEVVHITRE----TNTFYSPRATILHRCSdkvGCCN-AGWTCQMKRNETVD-RVFDKVDGRSNEPIVISMENHTE 277
Cdd:smart00141   3 CK-PRETVVEVSREypdeTNFLFKPPCVTVKRCG---GCCNdEGLECVPTETSNVTmQLLEISRPLSQHLVEVSFEEHTK 78


                   ...
gi 24582443    278 CGC 280
Cdd:smart00141  79 CEC 81
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 204-291 1.11e-04

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 41.92  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582443  204 CRvPRPEVVHITRE----TNTFYSPRATILHRCSdkvGCCN-AGWTCQ--MKRNETVDRV---FDKVDGRSNEPIVISME 273
Cdd:PHA02661  48 CQ-PRDTVVQLSDEypgnTNDRYNPRCVTVRRCG---GCCNdESQICTptETSNVTVTVMltsVSGSTGATSNFQTISVE 123

                         90
                 ....*....|....*...
gi 24582443  274 NHTECGCvkvetRRKRSP 291
Cdd:PHA02661 124 EHTKCKC-----EFKTTP 136
 
Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 204-281 3.61e-09

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 53.14  E-value: 3.61e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582443 204 CRvPRPEVVHITRE----TNTFYSPRATILHRCSdkvGCCN-AGWTCQMKRNETVD---RVFDKVDGRSNEPIVISMENH 275
Cdd:cd00135   3 CK-PRETLVEISEElpdeTNTIFKPPCVEVKRCG---GCCNdESLECVPTETSNVTmqvLKISPKRKPRSKLVEISFEEH 78


                ....*.
gi 24582443 276 TECGCV 281
Cdd:cd00135  79 TECECR 84
PDGF pfam00341
PDGF/VEGF domain;
204-280 3.64e-08

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 50.36  E-value: 3.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582443   204 CRvPRPEVVHITRE----TNTFYSPRATILHRCSdkvGCCNA-GWTCQ----MKRNETVDRVFDKVDGRSNEPIVISMEN 274
Cdd:pfam00341   1 CK-PRETLVEIRRElpdeTNAFFKPSCVEVQRCS---GCCNDeGLECVptetHNVTMQVLKIEYAPRRPSPELVEVSFEE 76


                  ....*.
gi 24582443   275 HTECGC 280
Cdd:pfam00341  77 HVQCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 204-280 1.06e-07

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 48.96  E-value: 1.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582443    204 CRvPRPEVVHITRE----TNTFYSPRATILHRCSdkvGCCN-AGWTCQMKRNETVD-RVFDKVDGRSNEPIVISMENHTE 277
Cdd:smart00141   3 CK-PRETVVEVSREypdeTNFLFKPPCVTVKRCG---GCCNdEGLECVPTETSNVTmQLLEISRPLSQHLVEVSFEEHTK 78


                   ...
gi 24582443    278 CGC 280
Cdd:smart00141  79 CEC 81
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 204-291 1.11e-04

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 41.92  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582443  204 CRvPRPEVVHITRE----TNTFYSPRATILHRCSdkvGCCN-AGWTCQ--MKRNETVDRV---FDKVDGRSNEPIVISME 273
Cdd:PHA02661  48 CQ-PRDTVVQLSDEypgnTNDRYNPRCVTVRRCG---GCCNdESQICTptETSNVTVTVMltsVSGSTGATSNFQTISVE 123

                         90
                 ....*....|....*...
gi 24582443  274 NHTECGCvkvetRRKRSP 291
Cdd:PHA02661 124 EHTKCKC-----EFKTTP 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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