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    f forked [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32718, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fprovided by FlyBase
    Official Full Name
    forkedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262111
    Locus tag
    Dmel_CG42864
    See related
    AllianceGenome:FB:FBgn0262111
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12996; CG42864; CG5424; Dmel\CG42864; X1
    Old locus tag
    Dmel_CG12996; Dmel_CG5424
    Summary
    Predicted to enable actin filament binding activity. Involved in several processes, including chaeta morphogenesis; cuticle pattern formation; and imaginal disc-derived appendage morphogenesis. Predicted to be active in cytoplasm. Used to study autosomal recessive nonsyndromic deafness 36. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 36. Orthologous to several human genes including ESPN (espin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    15F4-15F7; 1-57 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17232942..17280964)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17126975..17174997)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fimbrin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. X-ray induced reversions of the mutant forked-3N in Drosophila melanogaster, a reappraisal. Green MM. Mutat Res, 1977 May. PMID 405581
    2. Drosophila forked locus. McLachlan A. Mol Cell Biol, 1986 Jan. PMID 3023816, Free PMC Article
    3. The Drosophila forked protein induces the formation of actin fiber bundles in vertebrate cells. Grieshaber S, et al. J Cell Sci, 1999 Jul. PMID 10362550
    4. PHENOTYPIC VARIATION AND PSEUDO-ALLELISM AT THE FORKED LOCUS IN Drosophila Melanogaster. Green MM. Proc Natl Acad Sci U S A, 1955 Jun 15. PMID 16589682, Free PMC Article
    5. A FURTHER ANALYSIS OF THE FORKED LOCUS IN DROSOPHILA MELANOGASTER. Green MM. Proc Natl Acad Sci U S A, 1956 Feb. PMID 16589821, Free PMC Article

    See all (230) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 17245916-17246073 mobile_element_type = transposon:G7{}4223

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in antennal morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaeta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cuticle pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing hair organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    forked
    Names
    CG42864-PB
    CG42864-PC
    CG42864-PD
    CG42864-PF
    CG42864-PG
    CG42864-PH
    CG42864-PI
    CG42864-PJ
    CG42864-PK
    f-PB
    f-PC
    f-PD
    f-PF
    f-PG
    f-PH
    f-PI
    f-PJ
    f-PK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17232942..17280964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201729.1 → NP_001188658.1  forked, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188658.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSB2
      Conserved Domains (4) summary
      cd00204
      Location:426 → 552
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:470 → 561
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:400 → 452
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:397 → 429
      ANK; ANK repeat [structural motif]

    2. NM_078660.2 → NP_523384.3  forked, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523384.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24341, Q9VX60
      Related
      FBpp0293024, FBtr0304062
      Conserved Domains (4) summary
      cd00204
      Location:72 → 198
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:116 → 207
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:46 → 98
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:43 → 75
      ANK; ANK repeat [structural motif]

    3. NM_001042819.3 → NP_001036284.1  forked, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036284.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHR2
      Conserved Domains (4) summary
      cd00204
      Location:558 → 684
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:602 → 693
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:565 → 618
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:566 → 595
      ANK; ANK repeat [structural motif]

    4. NM_001201731.2 → NP_001188660.1  forked, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188660.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSB3
      Conserved Domains (4) summary
      cd00204
      Location:401 → 527
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:445 → 536
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:375 → 427
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:372 → 404
      ANK; ANK repeat [structural motif]

    5. NM_176745.1 → NP_788918.1  forked, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788918.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24341, Q9VX60
      Related
      FBpp0293026, FBtr0304064
      Conserved Domains (4) summary
      cd00204
      Location:72 → 198
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:116 → 207
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:46 → 98
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:43 → 75
      ANK; ANK repeat [structural motif]

    6. NM_001201730.1 → NP_001188659.1  forked, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188659.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSQ2, Q24341
      Conserved Domains (4) summary
      cd00204
      Location:180 → 306
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:224 → 315
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:187 → 240
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:188 → 217
      ANK; ANK repeat [structural motif]

    7. NM_176746.1 → NP_788919.1  forked, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788919.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24341, Q86B49
      Related
      FBpp0293027, FBtr0304065
      Conserved Domains (4) summary
      cd00204
      Location:145 → 271
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:189 → 280
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:152 → 205
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:153 → 182
      ANK; ANK repeat [structural motif]

    8. NM_167563.2 → NP_728070.1  forked, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728070.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24340, Q9VX59
      Related
      FBpp0311215, FBtr0344942

    9. NM_176747.1 → NP_788920.2  forked, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788920.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86B48
      Related
      FBtr0304066
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MSB2 M9MSB2
    M9MSB3 M9MSB3
    M9MSQ2 M9MSQ2
    Q0KHR2 Q0KHR2
    Q24339 Q24339
    Q24340 Q24340
    Q24341 Q24341
    Q86B48 Q86B48
    Q86B49 Q86B49
    Q9VX59 Q9VX59
    Q9VX60 Q9VX60

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