drpr draper [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: drprprovided by FlyBase
Official Full Name: draperprovided by FlyBase
Primary source: FLYBASE:FBgn0027594
Locus tag: Dmel_CG2086
See related: AllianceGenome:FB:FBgn0027594
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH03529; CED-1; CG18172; CG2086; CT41022; CT6730; Dmel\CG2086; Draper; Draper I; Drpr; DRPR
Summary: Enables phosphatidylserine binding activity. Involved in several processes, including autophagic cell death; cell competition in a multicellular organism; and engulfment of apoptotic cell. Located in several cellular components, including axon; plasma membrane; and postsynapse. Is expressed in several structures, including CNS glial cell; adult fat body; adult head; brain; and synaptic neuropil domain. Used to study myopathy and neurodegenerative disease. Human ortholog(s) of this gene implicated in congenital myopathy 10B and early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Orthologous to several human genes including MEGF10 (multiple EGF like domains 10) and MEGF11 (multiple EGF like domains 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 62B1-62B1; 3-1.0 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1715595..1731107, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1715595..1731107, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A form of muscular dystrophy associated with pathogenic variants in JAG2.
Title: A form of muscular dystrophy associated with pathogenic variants in JAG2.
Sleep Regulates Glial Plasticity and Expression of the Engulfment Receptor Draper Following Neural Injury.
Title: Sleep Regulates Glial Plasticity and Expression of the Engulfment Receptor Draper Following Neural Injury.
Glial Phagocytic Receptors Promote Neuronal Loss in Adult Drosophila Brain.
Title: Glial Phagocytic Receptors Promote Neuronal Loss in Adult Drosophila Brain.
We find that tubular muscle subtypes are particularly sensitive to Megf10/Drpr overexpression. Complementary genetic analyses show that Megf10/Drpr and Notch may interact to regulate myogenesis. Our findings provide a basis for investigating MEGF10 in muscle development using Drosophila.
Title: The impact of Megf10/Drpr gain-of-function on muscle development in Drosophila.
Spatial control of Draper receptor signaling initiates apoptotic cell engulfment.
Title: Spatial control of Draper receptor signaling initiates apoptotic cell engulfment.
During metamorphosis, Draper plays a critical role in apoptotic cell clearance by glia, whereas SIMU, which is mostly expressed in pupal macrophages outside the brain, is not involved in glial phagocytosis: Draper activates Drosophila c-Jun N-terminal kinase (dJNK) signaling predominantly in the ensheathing glia and astrocytes, where it is required for efficient removal of apoptotic neurons.
Title: Draper-mediated JNK signaling is required for glial phagocytosis of apoptotic neurons during Drosophila metamorphosis.
Glial clearance of damaged axons is significantly delayed in aged animals due to an age-dependent decline in translation of the critical glial recognition engulfment receptor Draper, which results from reduced phosphoinositide-3-kinase signalling.
Title: Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity.
This work identifies Draper-dependent activation of MMP-1 as a novel cascade required for proper glial clearance of severed axons.
Title: A novel Drosophila injury model reveals severed axons are cleared through a Draper/MMP-1 signaling cascade.
The glial engulfment receptor Draper is protective in a Drosophila model of Alzheimer's Disease.
Title: Glial Draper Rescues Aβ Toxicity in a Drosophila Model of Alzheimer's Disease.
INR signaling promotes glial phagocytic clearance of degenerating axons through regulation of Draper.
Title: Insulin-like Signaling Promotes Glial Phagocytic Clearance of Degenerating Axons through Regulation of Draper.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell competition in a multicellular organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis	TAS Traceable Author Statement more info	PubMed
involved_in phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response to wounding	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to axon injury	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: draper

Names: CG2086-PA; CG2086-PB; CG2086-PC; CG2086-PD; CG2086-PE; CG2086-PF; drpr-PA; drpr-PB; drpr-PC; drpr-PD; drpr-PE; drpr-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

1715595..1731107 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058102.3 → NP_477450.1 draper, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477450.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9Y151

Related

FBpp0072680

Conserved Domains (2) summary

pfam07546
Location:27 → 92

EMI; EMI domain

cl19567
Location:118 → 158

DSL; Delta serrate ligand
NM_167911.3 → NP_728660.2 draper, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728660.2

Status: REVIEWED

UniProtKB/Swiss-Prot

M9NEX8, Q1EC80, Q9W0A0, Q9W0A1

Conserved Domains (3) summary

pfam07546
Location:27 → 92

EMI; EMI domain

cl19567
Location:567 → 606

DSL; Delta serrate ligand

cl21504
Location:274 → 319

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
NM_001274348.1 → NP_001261277.1 draper, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261277.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBI3

Conserved Domains (2) summary

pfam07546
Location:27 → 92

EMI; EMI domain

cl19567
Location:567 → 606

DSL; Delta serrate ligand
NM_001259620.2 → NP_001246549.1 draper, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246549.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9Y151

Conserved Domains (2) summary

pfam07546
Location:27 → 92

EMI; EMI domain

cl19567
Location:118 → 158

DSL; Delta serrate ligand
NM_001274346.1 → NP_001261275.1 draper, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261275.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PDW5, Q9Y151

Conserved Domains (2) summary

pfam07546
Location:27 → 92

EMI; EMI domain

cl19567
Location:138 → 177

DSL; Delta serrate ligand
NM_001274347.1 → NP_001261276.1 draper, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261276.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGU6

Conserved Domains (3) summary

pfam07546
Location:27 → 92

EMI; EMI domain

cl19567
Location:567 → 606

DSL; Delta serrate ligand

cl21504
Location:274 → 319

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...