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Conserved domains on  [gi|161080573|ref|NP_728660|]
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draper, isoform B [Drosophila melanogaster]

Protein Classification

EMI and EGF_CA domain-containing protein( domain architecture ID 10540561)

EMI and EGF_CA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 26-92 3.58e-09

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


:

Pssm-ID: 462204  Cd Length: 69  Bit Score: 53.96  E-value: 3.58e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 161080573    26 PNICKRR--ELYNVDVVYTELQSFQERGSTWCVtFPPRCSTYRIKHRVVNKTKTIAKNRIVRDCCDGYI 92
Cdd:pfam07546    1 RNVCAYKvvSCVVVTGTESYVQPVYKPYLTWCA-GHRRCSTYRTTYRPAYRQVYKTVTRLEWRCCPGWG 68
gliding_CglD super family cl45602
adventurous gliding motility lipoprotein CglD;
451-579 5.04e-03

adventurous gliding motility lipoprotein CglD;


The actual alignment was detected with superfamily member NF033765:

Pssm-ID: 468178 [Multi-domain]  Cd Length: 1124  Bit Score: 41.07  E-value: 5.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161080573  451 CQNGAKCEPETGQCLCTA-----GWKNIKCDRPCDLNHF--GQDCAKVCDCHNnaACNPQNGSC------TCAAGWT--G 515
Cdd:NF033765  993 CKGKLVCNRTTDKCECPAdcgggGAPGQVCNTDRAVCAFtcAPDCGGTCGTFE--TCNTSTCACscvqsaTCAPGFKfdA 1070

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161080573  516 ERCERKCDTGKFghDCAQKCQCDFNnslACdatngRCVCKQDWGGVHCETNCRSGYYGenCDKV 579
Cdd:NF033765 1071 TACGCVCDTGAL--NCGSNYQADAN---AC-----ACACKDDCGGCGAGTKCNVSTCA--CEGI 1122
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 274-319 8.67e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam00053:

Pssm-ID: 473889  Cd Length: 49  Bit Score: 35.41  E-value: 8.67e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 161080573   274 CECY----KGAPCHHITGQCECPPGYRGERCfDECQLNTYGFNCSMTCDC 319
Cdd:pfam00053    1 CDCNphgsLSDTCDPETGQCLCKPGVTGRHC-DRCKPGYYGLPSDPPQGC 49
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 26-92 3.58e-09

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 53.96  E-value: 3.58e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 161080573    26 PNICKRR--ELYNVDVVYTELQSFQERGSTWCVtFPPRCSTYRIKHRVVNKTKTIAKNRIVRDCCDGYI 92
Cdd:pfam07546    1 RNVCAYKvvSCVVVTGTESYVQPVYKPYLTWCA-GHRRCSTYRTTYRPAYRQVYKTVTRLEWRCCPGWG 68
gliding_CglD NF033765
adventurous gliding motility lipoprotein CglD;
451-579 5.04e-03

adventurous gliding motility lipoprotein CglD;


Pssm-ID: 468178 [Multi-domain]  Cd Length: 1124  Bit Score: 41.07  E-value: 5.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161080573  451 CQNGAKCEPETGQCLCTA-----GWKNIKCDRPCDLNHF--GQDCAKVCDCHNnaACNPQNGSC------TCAAGWT--G 515
Cdd:NF033765  993 CKGKLVCNRTTDKCECPAdcgggGAPGQVCNTDRAVCAFtcAPDCGGTCGTFE--TCNTSTCACscvqsaTCAPGFKfdA 1070

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161080573  516 ERCERKCDTGKFghDCAQKCQCDFNnslACdatngRCVCKQDWGGVHCETNCRSGYYGenCDKV 579
Cdd:NF033765 1071 TACGCVCDTGAL--NCGSNYQADAN---AC-----ACACKDDCGGCGAGTKCNVSTCA--CEGI 1122
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 274-319 8.67e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 35.41  E-value: 8.67e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 161080573   274 CECY----KGAPCHHITGQCECPPGYRGERCfDECQLNTYGFNCSMTCDC 319
Cdd:pfam00053    1 CDCNphgsLSDTCDPETGQCLCKPGVTGRHC-DRCKPGYYGLPSDPPQGC 49
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 26-92 3.58e-09

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 53.96  E-value: 3.58e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 161080573    26 PNICKRR--ELYNVDVVYTELQSFQERGSTWCVtFPPRCSTYRIKHRVVNKTKTIAKNRIVRDCCDGYI 92
Cdd:pfam07546    1 RNVCAYKvvSCVVVTGTESYVQPVYKPYLTWCA-GHRRCSTYRTTYRPAYRQVYKTVTRLEWRCCPGWG 68
gliding_CglD NF033765
adventurous gliding motility lipoprotein CglD;
451-579 5.04e-03

adventurous gliding motility lipoprotein CglD;


Pssm-ID: 468178 [Multi-domain]  Cd Length: 1124  Bit Score: 41.07  E-value: 5.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161080573  451 CQNGAKCEPETGQCLCTA-----GWKNIKCDRPCDLNHF--GQDCAKVCDCHNnaACNPQNGSC------TCAAGWT--G 515
Cdd:NF033765  993 CKGKLVCNRTTDKCECPAdcgggGAPGQVCNTDRAVCAFtcAPDCGGTCGTFE--TCNTSTCACscvqsaTCAPGFKfdA 1070

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161080573  516 ERCERKCDTGKFghDCAQKCQCDFNnslACdatngRCVCKQDWGGVHCETNCRSGYYGenCDKV 579
Cdd:NF033765 1071 TACGCVCDTGAL--NCGSNYQADAN---AC-----ACACKDDCGGCGAGTKCNVSTCA--CEGI 1122
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 274-319 8.67e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 35.41  E-value: 8.67e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 161080573   274 CECY----KGAPCHHITGQCECPPGYRGERCfDECQLNTYGFNCSMTCDC 319
Cdd:pfam00053    1 CDCNphgsLSDTCDPETGQCLCKPGVTGRHC-DRCKPGYYGLPSDPPQGC 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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