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    Tmem100 transmembrane protein 100 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497979, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmem100provided by RGD
    Official Full Name
    transmembrane protein 100provided by RGD
    Primary source
    RGD:1560541
    See related
    EnsemblRapid:ENSRNOG00000002434 AllianceGenome:RGD:1560541
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in BMP signaling pathway; positive regulation of cell differentiation; and regulation of sensory perception of pain. Predicted to act upstream of or within several processes, including Notch signaling pathway; circulatory system development; and regulation of intracellular signal transduction. Predicted to be located in endoplasmic reticulum; perikaryon; and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Orthologous to human TMEM100 (transmembrane protein 100). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 1156.0) and Muscle (RPKM 127.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem100 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (75351891..75357748)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (74854779..74861147)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (77537340..77543710)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ankyrin-repeat and fibronectin type III domain containing 1 Neighboring gene uncharacterized LOC134480856 Neighboring gene uncharacterized LOC120095174 Neighboring gene uncharacterized LOC103693415 Neighboring gene phosphatidylcholine transfer protein Neighboring gene small integral membrane protein 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Distribution of TMEM100 in the mouse and human gastrointestinal tract--a novel marker of enteric nerves. Eisenman ST, et al. Neuroscience, 2013 Jun 14. PMID 23485812, Free PMC Article
    2. Generation of mice with a conditional and reporter allele for Tmem100. Moon EH, et al. Genesis, 2010 Nov. PMID 20848592
    3. Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. Weng HJ, et al. Neuron, 2015 Feb 18. PMID 25640077, Free PMC Article
    4. Impairment of endothelial-mesenchymal transformation during atrioventricular cushion formation in Tmem100 null embryos. Mizuta K, et al. Dev Dyn, 2015 Jan. PMID 25318679
    5. Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Somekawa S, et al. Proc Natl Acad Sci U S A, 2012 Jul 24. PMID 22783020, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108778

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within arterial endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to BMP stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endocardial cushion development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial to mesenchymal transition involved in endocardial cushion formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of sensory perception of pain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 100

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017479.1 → NP_001017479.1  transmembrane protein 100

      See identical proteins and their annotated locations for NP_001017479.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092577
      UniProtKB/Swiss-Prot
      Q569C0
      UniProtKB/TrEMBL
      A6HI10
      Related
      ENSRNOP00000110583.1, ENSRNOT00000128992.1
      Conserved Domains (1) summary
      pfam16311
      Location:1 → 133
      TMEM100; Transmembrane protein 100

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      75351891..75357748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269656.1 → XP_063125726.1  transmembrane protein 100 isoform X1

      UniProtKB/Swiss-Prot
      Q569C0
      UniProtKB/TrEMBL
      A6HI10

    2. XM_063269657.1 → XP_063125727.1  transmembrane protein 100 isoform X1

      UniProtKB/Swiss-Prot
      Q569C0
      UniProtKB/TrEMBL
      A6HI10

    3. XM_039086625.2 → XP_038942553.1  transmembrane protein 100 isoform X1

      UniProtKB/Swiss-Prot
      Q569C0
      UniProtKB/TrEMBL
      A6HI10
      Related
      ENSRNOP00000103983.1, ENSRNOT00000168821.1
      Conserved Domains (1) summary
      pfam16311
      Location:1 → 133
      TMEM100; Transmembrane protein 100
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q569C0.1 GenPept UniProtKB/Swiss-Prot:Q569C0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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