Lalba lactalbumin, alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lalbaprovided by RGD
Official Full Name: lactalbumin, alphaprovided by RGD
Primary source: RGD:2987
See related: EnsemblRapid:ENSRNOG00000010811 AllianceGenome:RGD:2987
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable lactose synthase activity and lysozyme activity. Predicted to be involved in lactose biosynthetic process. Predicted to be located in extracellular region. Predicted to be part of protein-containing complex. Orthologous to human LALBA (lactalbumin alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 5.1), Testes (RPKM 4.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (131504572..131520707, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (129625531..129628034, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (140088420..140096347, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mammary tissue from late pregnant Restricted rats had elevated alpha-lactalbumin, but not beta-casein mRNA.
Title: Uteroplacental insufficiency alters the mammary gland response to lactogenic hormones in vitro.

Submit: New GeneRIF Correction

General gene information

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Markers

D7Got145 (e-PCR)
- UniSTS:114695

D7Mit19 (e-PCR), detects polymorphism
- UniSTS:239956

AW208827 (e-PCR)
- UniSTS:180827

D7Wox22 (e-PCR)
- UniSTS:118004

D7Arb8 (e-PCR)
- UniSTS:239610

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables lactose synthase activity	IEA Inferred from Electronic Annotation more info
enables lactose synthase activity	ISO Inferred from Sequence Orthology more info
enables lysozyme activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in lactose biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lactose biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-lactalbumin

Names: lactose synthase B protein

NP_036726.1

EC 2.4.1.22

XP_063119053.1

EC 2.4.1.22

XP_063119054.1

EC 2.4.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012594.2 → NP_036726.1 alpha-lactalbumin precursor

See identical proteins and their annotated locations for NP_036726.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007, V01251

UniProtKB/Swiss-Prot

P00714, P00715

Related

ENSRNOP00000014457.1, ENSRNOT00000014456.5

Conserved Domains (1) summary

pfam00062
Location:20 → 137

Lys; C-type lysozyme/alpha-lactalbumin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

131504572..131520707 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262984.1 → XP_063119054.1 alpha-lactalbumin isoform X1

UniProtKB/TrEMBL

F1M7M1
XM_063262983.1 → XP_063119053.1 alpha-lactalbumin isoform X1

UniProtKB/TrEMBL

F1M7M1